COHORTNEY groups web users based on activity patterns.
arXiv research
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ODVICE augments EHR cohorts using ontology to improve analysis robustness.
Cohort analysis speeds up Bitcoin blockchain data queries.
We introduce a variable importance measure to quantify the impact of individual input variables to a black box function. Our measure is based on the Shapley value from cooperative game theory. Many measures of variable importance operate by changing some predictor values with others held fixed, potentially creating unl…
Cohort effects are important factors in determining the evolution of human mortality for certain countries. Extensions of dynamic mortality models with cohort features have been proposed in the literature to account for these factors under the generalised linear modelling framework. In this paper we approach the proble…
Study identifies 1,012 persistent wallet cohorts on Solana pump.fun, showing coordinated buying behavior.
Brain imaging analysis on clinically acquired computed tomography (CT) is essential for the diagnosis, risk prediction of progression, and treatment of the structural phenotypes of traumatic brain injury (TBI). However, in real clinical imaging scenarios, entire body CT images (e.g., neck, abdomen, chest, pelvis) are t…
Enhancing spectral embedding for low-dimensional embeddings in rare disease cohorts
Treatment recommendations within Clinical Practice Guidelines (CPGs) are largely based on findings from clinical trials and case studies, referred to here as research studies, that are often based on highly selective clinical populations, referred to here as study cohorts. When medical practitioners apply CPG recommend…
Deep neural networks improve sleep stage classification across diverse datasets.
Causal analysis reveals regional discrepancies in TOPCAT trial results.
Typical cohorts in brain imaging studies are not large enough for systematic testing of all the information contained in the images. To build testable working hypotheses, investigators thus rely on analysis of previous work, sometimes formalized in a so-called meta-analysis. In brain imaging, this approach underlies th…
The Lee Carter modelling framework is widely used because of its simplicity and robustness despite its inability to model specific cohort effects. A large number of extensions have been proposed that model cohort effects but there is no consensus. It is difficult to simultaneously account for cohort effects and age-adj…
Develops a new method to model overlapping asymmetric datasets effectively.
Research aims to ensure fair classification across explicit and implicit sensitive features.
At this moment, databanks worldwide contain brain images of previously unimaginable numbers. Combined with developments in data science, these massive data provide the potential to better understand the genetic underpinnings of brain diseases. However, different datasets, which are stored at different institutions, can…
Motivation: How do we integratively analyze large-scale multi-platform genomic data that are high dimensional and sparse? Furthermore, how can we incorporate prior knowledge, such as the association between genes, in the analysis systematically? Method: To solve this problem, we propose a Scalable Network Constrained T…
Develops a GP framework for age and year-specific mortality surfaces.
Proposes a new model for mortality forecasting considering age groups and cohort effects.
CAT framework improves AI medical screening fairness and reliability.
Mean-field approximations simplify insurance liability calculations.
The exploitation of large-scale population data has the potential to improve healthcare by discovering and understanding patterns and trends within this data. To enable high throughput analysis of cardiac imaging data automatically, a pipeline should comprise quality monitoring of the input images, segmentation of the …
Paper uses RNN to predict SaaS user lifetime value.
Federated survival analysis outperforms local and centralized training, with RSF offering the best balance of discrimination, calibration, and robustness.
We propose a nonparametric model for time series with missing data based on low-rank matrix factorization. The model expresses each instance in a set of time series as a linear combination of a small number of shared basis functions. Constraining the functions and the corresponding coefficients to be nonnegative yields…
A new method for variable importance measures without impossible data.
Deep neural networks are a family of computational models that have led to a dramatical improvement of the state of the art in several domains such as image, voice or text analysis. These methods provide a framework to model complex, non-linear interactions in large datasets, and are naturally suited to the analysis of…
Quantitative CT predicts ILD patterns and prognosis.
Advances in molecular "omics'" technologies have motivated new methodology for the integration of multiple sources of high-content biomedical data. However, most statistical methods for integrating multiple data matrices only consider data shared vertically (one cohort on multiple platforms) or horizontally (different …
A new method combines multiple cancer datasets to improve analysis.
Transformers simplify modeling of small longitudinal cohort data by reducing parameters and incorporating attention mechanisms.
In systems biomedicine, an experimenter encounters different potential sources of variation in data such as individual samples, multiple experimental conditions, and multi-variable network-level responses. In multiparametric cytometry, which is often used for analyzing patient samples, such issues are critical. While c…
Statistical machine learning methods are increasingly used for neuroimaging data analysis. Their main virtue is their ability to model high-dimensional datasets, e.g. multivariate analysis of activation images or resting-state time series. Supervised learning is typically used in decoding or encoding settings to relate…
Randomized Controlled Trials (RCTs) are the gold standard for comparing the effectiveness of a new treatment to the current one (the control). Most RCTs allocate the patients to the treatment group and the control group by uniform randomization. We show that this procedure can be highly sub-optimal (in terms of learnin…
Donor-aware scRNA-seq benchmarks improve classification accuracy in inflammatory bowel disease.
Compact formulas for evaluating insurance policies' risks.
Time series models such as dynamical systems are frequently fitted to a cohort of data, ignoring variation between individual entities such as patients. In this paper we show how these models can be personalised to an individual level while retaining statistical power, via use of multi-task learning (MTL). To our knowl…
The paper presents a systematic review of state-of-the-art approaches to identify patient cohorts using electronic health records. It gives a comprehensive overview of the most commonly de-tected phenotypes and its underlying data sets. Special attention is given to preprocessing of in-put data and the different modeli…
Over the last few years, traffic data has been exploding and the transportation discipline has entered the era of big data. It brings out new opportunities for doing data-driven analysis, but it also challenges traditional analytic methods. This paper proposes a new Divide and Combine based approach to do K means clust…
Deep learning (DL) methods have in recent years yielded impressive results in medical imaging, with the potential to function as clinical aid to radiologists. However, DL models in medical imaging are often trained on public research cohorts with images acquired with a single scanner or with strict protocol harmonizati…
The paper presents a method for analyzing shape graphs using specific features.
Approaches for testing sets of variants, such as a set of rare or common variants within a gene or pathway, for association with complex traits are important. In particular, set tests allow for aggregation of weak signal within a set, can capture interplay among variants, and reduce the burden of multiple hypothesis te…
Paper develops NN models for diabetes screening using NHANES data.
Digital risk scores predict depression and anxiety over 10 years.
Study compares neural and statistical models for Parkinson's disease progression from voice data.
Contextualized ML learns context-dependent effects using deep learning.
The paper compares two methods for handling missing data in causal discovery.
There is growing interest in the design of pension annuities that insure against idiosyncratic longevity risk while pooling and sharing systematic risk. This is partially motivated by the desire to reduce capital and reserve requirements while retaining the value of mortality credits; see for example Piggott, Valdez an…