The majority of cancer treatments end in failure due to Intra-Tumor Heterogeneity (ITH). ITH in cancer is represented by clonal evolution where different sub-clones compete with each other for resources under conditions of Darwinian natural selection. Predicting the growth of these sub-clones within a tumour is among t…
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A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.
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48 results for “clonal evolution”
CN-SBM clusters cancer samples and regions based on copy number variants.
problem Clonal evolution in cancer monitored by noisy copy number variants.
method Probabilistic framework using bipartite categorical block model.
result Improved model fit and clinically relevant subtypes identified.
Bayesian optimization of antibodies learns from immune system evolution.
problem Efficiently optimizing antibody sequences in a large space of possibilities.
method Bayesian optimization guided by a generative model of evolving antibody sequences.
result CloneBO optimizes antibodies more efficiently than previous methods.
Statistical machine learning methods, especially nonparametric Bayesian methods, have become increasingly popular to infer clonal population structure of tumors. Here we describe the treeCRP, an extension of the Chinese restaurant process (CRP), a popular construction used in nonparametric mixture models, to infer the …
Hippocampal dentate granule cells are among the few neuronal cell types generated throughout adult life in mammals. In the normal brain, new granule cells are generated from progenitors in the subgranular zone and integrate in a typical fashion. During the development of epilepsy, granule cell integration is profoundly…
High-throughput sequencing allows the detection and quantification of frequencies of somatic single nucleotide variants (SNV) in heterogeneous tumor cell populations. In some cases, the evolutionary history and population frequency of the subclonal lineages of tumor cells present in the sample can be reconstructed from…
Generative Distribution Embeddings learn multiscale representations of distributions.
problem Learning representations of entire distributions for multiscale reasoning.
method Introducing GDE framework that lifts autoencoders to the space of distributions, using conditional generative models and distributional invariance.
result GDEs learn predictive sufficient statistics embedded in Wasserstein space, recovering distances and trajectories for Gaussian and Gaussian mixture distributions.
The calculus correspondence has been known to exist between generic pedal evolutions and generic wave front evolutions. In this paper, we first extend the known results on the calculus correspondence to evolutions with multi-parameters, and then give applications of calculus correspondence. Moreover, we discuss the pos…
Study material evolution using groupoids to track intrinsic properties.
problem Tracking material evolution without considering the whole body.
method Construct a groupoid encoding intrinsic properties and characteristic foliations.
result Define the evolution equation for material points.
The paper studies circular evolutes and involutes of framed curves in Euclidean space.
problem Investigating properties of framed curves and their evolutes and involutes.
method Definition and analysis of circular evolutes and involutes of framed curves, properties of normal surfaces, and their relations.
result Circular evolutes and involutes of framed curves are opposite operations under suitable assumptions, similar to fronts in the Euclidean plane.
The paper studies curve evolution using the PLR equation and its solutions.
problem Investigating the evolution of space curves governed by the PLR equation.
method Examined the Lund-Regge evolution and derived its representation in the Frenet frame, aligning with the Lax system of the PLR equation. Developed a construction method for curve families via the Sym formula.
result Described the Lund-Regge evolution corresponding to Date multi-soliton solutions to the PLR equation.
The paper defines evolutes and involutes for framed curves and their properties.
problem Defining evolutes and involutes for framed curves with singular points.
method Using the theory of framed curves and Bertrand type curves.
result Conditions for evolutes and involutes being inverse operations of framed curves.
Study the geometry and dynamics of skew evolutes and involutes, related to bicycle kinematics.
problem Understanding the geometry and dynamics of skew evolutes and involutes.
method Investigate the skew evolute and involute maps, comparing them to bicycle kinematics.
result The skew evolute and involute maps have properties analogous to bicycle kinematics.
The evolute of a smooth curve in an m-dimensional Euclidean space is the locus of centers of its osculating spheres, and the evolute of a spatial polygon is the polygon whose consecutive vertices are the centers of the spheres through the consecutive (m+1)-tuples of vertices of the original polygon. We study the iterat…
ccc-Autoevolutesmath.DG
ccc-Autoevolutes are closed curves congruent to their evolutes, constructed via symmetry.
problem Constructing closed curves congruent to their evolutes.
method Modified Frenet equation, numerical solutions, symmetry.
result Found the smallest autoevolute as a trefoil knot.
Study evolutes of curves with varying smoothness.
problem Understanding evolutes of curves with low smoothness.
method Analyzing the relationship between curve smoothness and evolute regularity.
result Evolutes have one less order of smoothness than the parent curve in generic cases.
Defines horocyclic evolutes, parallels, and involutes of spacelike frontals in hyperbolic 2-space.
problem None explicitly stated; focuses on definitions and relations.
method Using enveloid theorem, defines horocyclic parallel and involute as normal envelopes of horocycles.
result Investigates relations among horocyclic evolutes, parallels, and involutes.
Study on focal surfaces and evolutes of framed curves in hyperbolic 3-space using Legendrian duality.
problem Investigate differential geometry properties of framed curves, including singular points.
method Use Legendrian dualities to analyze focal surfaces and evolutes of hyperbolic framed curves.
result Show the relationship among focal surfaces, evolutes, and dual surfaces of evolutes.
Abstract In this paper, definition of involute-evolute curve couple in Galilean space is given and some well-known theorems for the involute-evolute curves are obtained in 3-dimensional Galilean space.
Geometric approach to Dirac operator evolution on spacetimes.
problem Constructing the Cauchy evolution operator for Lorentzian Dirac operators.
method Realizing the operator as a sum of oscillatory integrals, relating to Feynman propagator.
result Relating Cauchy evolution operators to Feynman propagators and constructing Hadamard states.
Abstract reviews symmetry and reduction in dynamical systems.
problem Understanding symmetries and reductions in dynamical systems.
method Algebraic formulation for dynamics of physical systems.
result Describes a reduction procedure for classical and quantum evolutions.
Which factor dominates the industry evolution? A synergy analysis based on China's ICT industryphysics.soc-ph
Industry evolution caused by various reasons, among which technology progress driving industry development has been approved, but with the new trend of industry convergence, inter-industry convergence also plays an increasing important role. This paper plans to probe the industry synergetic evolution mechanism based on…
The paper extends a spectral evolution model for link prediction in evolving networks.
problem Link prediction in evolving networks.
method Approximated eigenvalue trajectories using Rayleigh quotient and extrapolation.
result Learning algorithms based on approximated trajectories outperform traditional methods.
We consider the Ricci flow for simply connected nilmanifolds, which translates to a Ricci flow on the space of nilpotent metric Lie algebras. We consider the evolution of the inner product and the evolution of structure constants, as well as the evolution of these quantities modulo rescaling. We set up systems of O.D.E…
In this paper, we get the time evolution equations of the curvature and torsion of the evolving spacelike curves in the Minkowski space. Also, we give inextensible evolutions of timelike ruled surfaces that are produced by the timelike normal and spacelike binormal vector fields of spacelike curve and derive the necess…
We conjecture explicit evolution formulas for Khovanov polynomials for pretzel knots in some regions in the windings space. Our description is exhaustive for genera 1 and 2. As previously observed, evolution at T != -1 is not fully smooth: it switches abruptly at the boundaries between different regions. We reveal that…
We relate the total curvature and the isoperimetric deficit of a curve in a two-dimensional space of constant curvature with the area enclosed by the evolute of . We provide also a Gauss-Bonnet theorem for a special class of evolutes.
Unified framework for non-uniform materials evolving over time.
problem Dealing with non-uniform materials evolving over time.
method Constructing a material groupoid and material distribution.
result Unified framework for general non-uniform evolution materials.
Using available data from the New York stock market (NYSM) we test four different bi-parametric models to fit the correspondent volume-price distributions at each -minute lag: the Gamma distribution, the inverse Gamma distribution, the Weibull distribution and the log-normal distribution. The volume-price data, whi…
Study on evolutes and focal surfaces of pseudo-spherical framed immersions in anti-de Sitter space.
problem Investigating singularities of evolutes and focal surfaces of pseudo-spherical framed immersions.
method Introduced pseudo-spherical non-null framed curves, defined moving frames, and analyzed evolutes and focal surfaces.
result Evolutes of pseudo-spherical framed immersions are the sets of singular points of their focal surfaces.
Automated hyperparameter tuning aspires to facilitate the application of machine learning for non-experts. In the literature, different optimization approaches are applied for that purpose. This paper investigates the performance of Differential Evolution for tuning hyperparameters of supervised learning algorithms for…
State evolution beyond first-order methods I: Rigorous predictions and finite-sample guaranteesmath.ST
New method predicts state evolution for non-first-order algorithms on nonconvex problems.
problem Analyzing nonconvex optimization problems with random data.
method Developed a state evolution for a broader class of algorithms including first-order and saddle point updates.
result Established rigorous state evolution predictions and finite-sample guarantees for non-first-order methods.
We study the evolution equations for a regularized version of Dirac-geodesics, which are the one-dimensional version of Dirac-harmonic maps. We show that for the regularization being sufficiently large, the evolution equations subconverge to a regularized Dirac-geodesic. In the end, we discuss the limiting process of r…
EvoNet predicts the evolution of dynamic graphs using a graph neural network and recurrent architecture.
problem Predicting the evolution of dynamic graphs is challenging and underexplored.
method EvoNet uses a graph neural network and recurrent architecture to predict the evolution of dynamic graphs.
result EvoNet effectively predicts the evolution of dynamic graphs on both artificial and real-world datasets.
The paper studies geometric constants under modified Ricci flows with variable parameters.
problem Understanding geometric constants under variable coupling parameters in Ricci flows.
method Introduced modified Ricci flows with variable coefficients, derived evolution formulas, and proved monotonicity conditions.
result Conditions for maintaining monotonicity of geometric constants under modified Ricci flows.
A new method evolves point clouds using B-splines for smooth surfaces.
problem Evolution of smooth surfaces from discrete point clouds.
method Adaptive Lagrangian B-spline framework for geometric evolution.
result Efficient and accurate reproduction of surface evolution phenomena.
The evolution operator connecting the Lagrangian and Hamiltonian formalisms for contact systemsmath-ph
This paper extends the evolution operator to contact mechanics, linking Lagrangian and Hamiltonian formulations.
problem Translating the evolution operator to contact mechanics for mechanical systems with dissipation.
method Using the evolution operator K to connect Lagrangian and Hamiltonian formalisms in contact mechanics.
result The evolution operator provides a geometric description of evolution equations and relates constraints.
In this paper we study smooth solutions to a fractional mean curvature flow equation. We establish a comparison principle and consequences such as uniqueness and finite extinction time for compact solutions. We also establish evolutions equations for fractional geometric quantities that yield preservation of certain qu…
Global Functional calculus, lower/upper bounds and evolution equations on manifolds with boundarymath.AP
Global calculus for manifolds with boundary, solving evolution problems.
problem Global solvability of evolution problems on manifolds with boundary.
method Established global functional calculus and Gårding inequality for pseudo-differential operators without local coordinates.
result Global solvability for a class of evolution problems.
We give new results concerning the Frobenius integrability and solution of evolution equations admitting travelling wave solutions. In particular, we give a powerful result which explains the extraordinary integrability of some of these equations. We also discuss "local" conservations laws for evolution equations in ge…
Study evolution equations on Lie groupoids using Fourier integral operators.
problem Solving evolution equations on Lie groupoids.
method Developed calculus of Fourier integral operators and used them to study the fundamental solution of the evolution equation.
result Developed a method to find the fundamental solution of the evolution equation on Lie groupoids.
Characterizes optimal-speed quantum state evolution Hamiltonians.
problem Optimal-speed unitary time evolution of pure and quasi-pure quantum states.
method Construction of the manifold of pure states and isometry with flag manifold, characterization of equigeodesic vectors.
result Hamiltonians generating optimal-speed time evolution are fully characterized by equigeodesic vectors of the flag manifold.
We study the evolution equations for a regularized version of Dirac-harmonic maps from closed Riemannian surfaces. We establish the existence of a global weak solution for the regularized problem, which is smooth away from finitely many singularities. Moreover, we discuss the convergence of the evolution equations and …
This paper studies the critical dynamics of random surfaces, focusing on area and genus evolution.
problem Understanding the time evolution of random surfaces and their genus.
method Analyzes the dynamics of area and genus using Cox-Ingersoll-Ross process and critical phenomena.
result The genus of surfaces evolves into two phases: planar surfaces and foamy surfaces.
This paper gives two methods for constructing associative 3-folds in R^7, based around the fundamental idea of evolution equations, and uses these methods to construct examples of these geometric objects. The paper is a generalisation of the work by Joyce in math.DG/0008021, math.DG/0008155, math.DG/0010036 and math.DG…
Random forests classify Pokemon names based on evolutionary status.
problem Classifying Pokemon names into pre-evolution and post-evolution categories.
method Trained random forests using sound symbolism from Pokemon names, conducted experiments with human participants.
result Random forests outperform human participants in classifying Pokemon names.
Develops robust methods for infinite-dimensional stochastic processes.
problem Measuring covariations in stochastic evolution equations in infinite dimensions.
method Asymptotic theory for jump robust measurement of covariations.
result Identifies scaling limits for realized covariations.
In this paper, we take into account the opinion of involute-evolute curves which lie on fully surfaces and by taking into account the Darboux frames of them we illustrate these curves as special involute-evolute partner D-curves in E3. Besides, we find the relations between the normal curvatures, the geodesic curvature…