Unified Bayesian framework for missing data imputation and prediction in clinical time series.
problem High prevalence of missing values in clinical time series data.
method Unified Bayesian recurrent framework for imputation and prediction.
result Strong performance gains over state-of-the-art methods on mortality prediction tasks.
TFM trains Neural SDEs without backpropagation, improving clinical time series modeling.
problem Modeling irregularly sampled time series in medicine.
method Trajectory Flow Matching (TFM) using flow matching for generative modeling.
result TFM improves performance on clinical time series datasets.
Sequence Transformer Networks improve mortality prediction in clinical time-series data.
problem Predicting in-hospital mortality from clinical time-series data.
method End-to-end trainable Sequence Transformer Networks that learn temporal and scaling invariances.
result Improves AUROC from 0.838 to 0.851 compared to a baseline CNN.
Unsupervised learning improves clinical predictions from medical time series.
problem Improving clinical decision making through unlabeled medical data.
method Evaluation of unsupervised representation learning on medical time series using sequence-to-sequence models.
result A forecasting Seq2Seq model with an attention mechanism achieves the best performance.
Study improves healthcare time series imputation by considering structured missingness.
problem Structured missingness in clinical data impacts time series imputation models.
method Analysis of different masking strategies on imputation methods using PhysioNet Challenge 2012 dataset.
result Masking choices significantly affect imputation accuracy and clinical prediction.
Late fusion of clinical notes and physiological data improves ICU mortality prediction.
problem Improving ICU mortality prediction using multimodal data.
method Late fusion of clinical notes and physiological time series data with a deep learning architecture.
result Late fusion approach provides statistically significant improvement in mortality prediction performance.
The study creates benchmarks for clinical time series data to evaluate machine learning models.
problem Lack of publicly available benchmark data sets for healthcare research.
method Proposed four clinical prediction benchmarks using MIMIC-III data, evaluated various deep supervision and multitask training methods.
result Demonstrated the effectiveness of deep supervision, multitask training, and data-specific architectural modifications on neural models.
Challenge hides and seeks privacy in clinical time-series data.
problem De-identifying clinical time-series data while preserving utility and privacy.
method Synthetic data generation to preserve temporal dynamics and limit re-identification risk.
result A novel competition tracks synthetic data generation and patient re-identification.
New method forecasts values and timing in irregular time series.
problem Forecasting values and timing in sparse, irregularly sampled multivariate time series.
method Proposes a novel approach for forecasting values and timing in irregular time series.
result Successfully forecasts values and timing in irregular time series.
The paper shows how the timing of prediction impacts model performance in healthcare.
problem The timing of prediction affects model performance in healthcare.
method The paper compares two prediction schemes: outcome-dependent and outcome-independent.
result An outcome-independent scheme outperforms an outcome-dependent scheme.
Clinical notes improve ICU patient condition prediction.
problem Predicting ICU patient outcomes and resource planning.
method Joint modeling of time series data and clinical notes.
result Significant improvement in mortality prediction, decompensation modeling, and length of stay forecasting.
Attention models outperform RNNs in clinical time series analysis.
problem Clinical time series analysis using deep learning models.
method Developed SAnD architecture using masked self-attention mechanism, positional encoding, and dense interpolation.
result Achieved state-of-the-art performance in all tasks on MIMIC-III benchmark datasets.
Model predicts treatment initiation from clinical data using patient-clinician relations.
problem Predicting treatment initiation from clinical time series data considering patient-clinician relations.
method Graph-Augmented Time-Sensitive Model using top eigenvectors of graph Laplacian.
result Relational similarity improves prediction over baselines, e.g., 5% improvement in AUPRC.
Proposes models to analyze irregular healthcare time series data.
problem Irregular timestamps in healthcare time series data.
method Data augmentation, temporal coarsening, MultiResolution Ensemble (MRE) model.
result Improves mAP on mortality prediction task from 51.53% to 53.92%.
Transfer learning improves clinical time series prediction with deep RNNs.
problem Training deep neural networks for clinical time series analysis requires large labeled data and expertise.
method Investigated transfer learning scenarios for deep RNNs: domain-adaptation and task-adaptation.
result Pre-trained deep models allow robust, efficient, and data-efficient clinical time series prediction.
We develop a model to cluster time-series data with interval censoring, improving disease phenotyping.
problem Noise and interval censoring hinder clustering in disease phenotyping.
method Deep generative, continuous-time model that clusters time-series data while correcting for censorship.
result Our model corrects for interval censoring and recovers known clinical subtypes.
Transfer learning improves clinical time series prediction with limited data.
problem Training deep RNNs for clinical tasks requires large labeled data and tuning.
method Transfer learning from pre-trained RNNs on multiple tasks to new tasks.
result Features from pre-trained RNNs improve model performance and robustness.
A new imputation model for clinical data captures both cross-sectional and temporal correlations.
problem Missing values in multivariable time series clinical data.
method Integrates Gaussian processes with mixture models and individualized mixing weights.
result The proposed model provides more accurate imputation than benchmarks on real-world and synthetic datasets.
New deep learning model tackles sparse clinical data.
problem Sparse and irregularly sampled multivariate time series in EHRs.
method Semi-parametric interpolation network followed by prediction network.
result Improved mortality and length of stay predictions.
Improved patient risk stratification with relaxed parameter sharing in clinical time-series data.
problem Learning time-varying relationships in clinical time-series data with limited training data.
method Proposed a novel RNN formulation based on a mixture model with relaxed parameter sharing over time.
result Relaxed parameter sharing leads to improved patient risk stratification performance in settings with limited data.
Kernel TCK_IM tackles missing data in EHR time series, improving analysis.
problem Missing data complicates analysis of EHR time series.
method TCK_IM kernel using ensemble learning of mixed mode Bayesian mixture models.
result TCK_IM kernel effectively exploits missing data without imputation.
Unsupervised method detects surgical site infections from blood samples.
problem Detecting surgical site infections from blood samples without labeled data.
method Powerful kernels for multivariate time series with missing data handling.
result Framework shows superior performance compared to baselines.
MedGP improves online patient health status prediction using clinical and lab covariates.
problem Real-time monitoring of hospital patients for accurate health status inference.
method Bayesian nonparametric Gaussian process regression with a sparse kernel.
result MedGP significantly improves online prediction accuracy for patient health status across different disease subgroups and studies.
We demonstrate a simple strategy to cope with missing data in sequential inputs, addressing the task of multilabel classification of diagnoses given clinical time series. Collected from the pediatric intensive care unit (PICU) at Children's Hospital Los Angeles, our data consists of multivariate time series of observat…
Enhances generative model for clinical data privacy and accuracy.
problem Data privacy in electronic patient records.
method Improves a time-series generative model with privacy safeguards.
result DP-TimeGAN achieves a mean authenticity of 0.778 on the CKD dataset.
Proposes a novel imputation network for clinical time series data.
problem Missing value imputation in clinical time series data with sparsity, irregularity, and high-dimensionality.
method Variational-recurrent imputation network that considers correlated features, temporal dynamics, and uncertainty.
result The proposed method outperformed state-of-the-art methods on real-world EHR datasets.
BrainCast predicts whole-brain fMRI time series from short scans.
problem Short scans reduce fMRI data quality and statistical power.
method Spatio-temporal forecasting framework for fMRI time series.
result BrainCast improves fMRI time series quality and prediction.
New algorithm improves imputation of missing clinical data.
problem Missing data in longitudinal healthcare studies.
method MedImpute algorithm for imputing continuous and categorical features in multivariate panel data.
result Significant improvements in imputation accuracy and model performance.
Novel model improves clinical risk prediction by transferring knowledge between tasks over time.
problem Negative transfer in multi-task learning for clinical risk prediction.
method Temporal Probabilistic Asymmetric Multi-Task Learning (TPAMTL).
result Significantly outperforms various deep learning models for time-series prediction.
Paper presents forecasting models for platelet demand.
problem Managing platelet demand and supply is challenging due to variability and short shelf life.
method Utilized ARIMA, Prophet, lasso regression, and LSTM networks on a clinical dataset.
result Multivariate approaches generally have higher accuracy, but simpler ARIMA can suffice with sufficient data.
CoI framework models clinical feature interactions, revealing temporal dependencies and enhancing transparency.
problem Capturing latent, time-varying dependencies among clinical features in time-series data.
method Chain-of-Influence (CoI) framework constructs an explicit, time-unfolded graph of feature interactions.
result Achieves state-of-the-art predictive performance (AUROC of 0.960 on CKD progression and 0.950 on ICU mortality).
New framework learns blood sample MTS representations with missing data.
problem Missing data in clinical time series.
method Combines autoencoder with TCK kernel for missing data.
result Improved classification of blood samples with missing data.
A new unsupervised contrastive learning framework improves time series representation learning.
problem Lack of labeled data in time series data.
method Proposes an unsupervised contrastive learning framework using a novel contrastive loss and data augmentation.
result Framework outperforms other approaches on univariate and multivariate time series, and benefits transfer learning.
Linear Dynamical System (LDS) is an elegant mathematical framework for modeling and learning multivariate time series. However, in general, it is difficult to set the dimension of its hidden state space. A small number of hidden states may not be able to model the complexities of a time series, while a large number of …
Medical researchers are coming to appreciate that many diseases are in fact complex, heterogeneous syndromes composed of subpopulations that express different variants of a related complication. Time series data extracted from individual electronic health records (EHR) offer an exciting new way to study subtle differen…
FIT evaluates time series model feature importance quantifying distributional shift.
problem Lack of explanations for time series models in high-stakes applications.
method FIT framework quantifies feature importance based on distributional shift using KL-divergence.
result FIT identifies important time points and observations superiorly compared to baselines.
SigTime learns interpretable signatures from time series data.
problem Discovering meaningful patterns in time series data with high complexity and limited interpretability.
method Jointly trains two Transformer models using shapelet-based and feature engineering representations.
result Learned shapelets serve as interpretable signatures for time series classification.
Deep learning clusters patient time-series data for better prognosis.
problem Clustering time-series data for patient phenotyping and prognosis.
method Deep predictive clustering with novel loss functions for future outcome distribution.
result Model achieves superior clustering performance and identifies meaningful patient subgroups.
This paper proposes a nonparametric Bayesian method for exploratory data analysis and feature construction in continuous time series. Our method focuses on understanding shared features in a set of time series that exhibit significant individual variability. Our method builds on the framework of latent Diricihlet alloc…
We explain increases in clinical risk predictions over time.
problem Tackling the challenge of explaining dynamic risk increases in clinical settings.
method Developed methods to extend static attribution techniques to dynamic settings, addressing challenges specific to time-series data.
result Identified and addressed challenges specific to dynamic risk estimation, improving clinical alert explanations.
End-to-end classifier predicts sepsis from clinical data.
problem Predicting sepsis onset from clinical data with high accuracy.
method Multitask Gaussian process RNN classifier for multivariate time series.
result Outperforms baselines, improving AUC and PRC.
GANs generate realistic ECG signals for medical research.
problem Privacy concerns in sharing medical data.
method Developed GAN architectures to generate synthetic ECG signals.
result GANs can generate diverse, structurally similar synthetic ECG signals.
A new CA-GAN architecture improves minority class data generation in health datasets.
problem Algorithmic bias due to health data poverty and underrepresentation of minority groups.
method Proposes CA-GAN architecture to address shortcomings of resampling and GAN-based approaches.
result CA-GAN outperforms SMOTE and WGAN-GP* in generating authentic minority class data and maintaining original distribution.
The paper uses learned prototypes to explain deep learning models for time-series data.
problem Lack of explainable AI in deep learning models for high-risk decisions.
method Learned prototypes in latent space of deep learning models.
result Prototypes improve classification decisions and provide explainable insights.
The study uncovers invariant features in healthcare models that traditional methods overlook.
problem Discovering overlooked invariant features in healthcare models.
method Empirical learning of transformations minimizing Wasserstein distance and adding similarity regularization.
result LSTM models and BioBERT reveal invariant features not previously recognized.
Framework predicts patient risk progression over time.
problem Predicting how patient risk changes over time.
method Supervised contrastive learning framework with embedding properties.
result Framework outperforms baselines in mortality and cognitive impairment datasets.
Proposes GRU-ODE-Bayes for modeling irregularly observed time series.
problem Challenges of modeling sporadically observed multidimensional time series.
method Continuous-time GRU, Bayesian update network, Fokker-Planck dynamics.
result Demonstrates superior performance on synthetic and real-world data.
Self-supervised learning improves representation from EEG signals without labels.
problem Limited supervised data for EEG signal analysis.
method Predicting temporal context from unlabeled EEG time series.
result Self-supervised approach outperforms supervised methods in low data regimes.