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arXiv research

A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.

168,695 papers · 148 categories

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205410615820 · Jun 202019922001200920172026
48 results for clinical settings

A novel dose-finding design for cancer clinical trials using level set estimation.

problem Finding the maximum tolerated dose (MTD) in phase I cancer clinical trials.
method Proposes a novel dose-finding design based on level set estimation (LSE) to determine the next dose.
result The proposed LSE design achieves higher accuracy in estimating the MTD and lower risk of overdosing compared to existing designs.

AI predicts medical specialty diagnostic choices from EHR records.

problem Predicting timely medical specialty diagnostic workups for patients.
method Ensemble of feed-forward neural networks trained on EHR data.
result Significantly higher accuracy compared to traditional checklists.

A new hybrid federated learning algorithm for combining clinical and omics data.

problem Combining clinical and omics data in federated learning settings.
method Reformulated Kernel Regularized Least Squares algorithm for hybrid federated learning.
result Validation of two variants of the hybrid algorithm on well-established datasets.

Copula-based fusion improves breast cancer risk stratification.

problem Combining clinical and genomic risk scores using simple rules fails to capture their joint relationship.
method Used copulas to model the joint relationship between clinical and genomic risk scores.
result Copula-based fusion improves risk stratification, identifying subgroups with the worst prognosis.

A new method uses asymmetric Shapley values to assess gene importance in clinical prediction models.

problem Clinical prediction models struggle with assessing the importance of high-dimensional features like genomics.
method Derive efficient algorithms to compute local and global asymmetric Shapley values for a mixed-dimensional prediction model.
result Asymmetric Shapley values provide a more suitable alternative to quantify feature importance in clinical prediction models.

Study improves healthcare time series imputation by considering structured missingness.

problem Structured missingness in clinical data impacts time series imputation models.
method Analysis of different masking strategies on imputation methods using PhysioNet Challenge 2012 dataset.
result Masking choices significantly affect imputation accuracy and clinical prediction.

New method detects biomarker-treatment interactions in clinical trials.

problem Detecting interactions between high-dimensional biomarkers and treatments in randomized trials.
method Two-stage penalized regression screening using ridge regression for multivariate screening.
result Ridge regression screening provides greater power than traditional methods in correlated data.

Study examines biases in clinical word embeddings, revealing performance gaps across groups.

problem Biases in clinical word embeddings leading to performance differences across groups.
method Pretrained BERT models on MIMIC-III, fill-in-the-blank method, fairness evaluation on clinical tasks.
result Classifiers trained from BERT representations exhibit statistically significant differences in performance across groups.

Convolutional neural network improves assertion detection in multi-label clinical text.

problem Detecting assertions in multi-label clinical text with rich descriptions.
method Developed a CNN architecture for multi-label scope detection.
result At least 12% improvement over state-of-the-art on multi-label clinical text.

Unified model combines neural networks and dictionary learning for clinical predictions from brain data.

problem Predicting clinical severity from brain imaging data.
method Combines neural networks with dictionary learning to model patient-specific and shared features.
result Unified model outperforms state-of-the-art methods in predicting clinical severity.

Framework predicts clinical severity from rs-fMRI data using network optimization.

problem Predicting clinical severity from rs-fMRI data.
method Joint network optimization framework combining sparse subnetworks and linear regression.
result Framework outperforms standard methods and identifies clinically relevant ASD networks.

Paper tackles robust batched bandits for heavy-tailed rewards.

problem Clinical trials and other applications with heavy-tailed rewards.
method Proposes robust batched bandit algorithms for heavy-tailed rewards in finite-arm and Lipschitz-continuous settings.
result Heavier-tailed rewards require fewer batches for near-optimal regret in the instance-independent regime and Lipschitz setting.

Study uses interviews to automatically detect BD and BPD with good accuracy.

problem Challenges in distinguishing BD and BPD from clinical interviews.
method Developed a multi-modal dataset and used a linear classifier with selected features from interviews.
result Different sets of features characterize BD and BPD, providing insights into their differences.

Health care is one of the most exciting frontiers in data mining and machine learning. Successful adoption of electronic health records (EHRs) created an explosion in digital clinical data available for analysis, but progress in machine learning for healthcare research has been difficult to measure because of the absen…

2017-03-22abs ↗pdf ↗

Method predicts biomarker trajectories with uncertainty bands for Alzheimer's disease.

problem Uncertainty in biomarker predictions poses risks in clinical deployment.
method Conformal prediction for randomly-timed biomarker trajectories.
result Conformal bands achieve desired coverage and are tighter than baseline.

New method uses probabilistic independence to discover disease signatures from medical records.

problem Insufficiently precise diagnosis of clinical disease leading to treatment failures.
method Unsupervised machine learning using probabilistic independence to disentangle disease patterns.
result Inferred 2000 clinical disease signatures from medical records, improving cancer prediction.

In healthcare, patient risk stratification models are often learned using time-series data extracted from electronic health records. When extracting data for a clinical prediction task, several formulations exist, depending on how one chooses the time of prediction and the prediction horizon. In this paper, we show how…

2018-11-29abs ↗pdf ↗

TFM trains Neural SDEs without backpropagation, improving clinical time series modeling.

problem Modeling irregularly sampled time series in medicine.
method Trajectory Flow Matching (TFM) using flow matching for generative modeling.
result TFM improves performance on clinical time series datasets.

Detection of interactions between treatment effects and patient descriptors in clinical trials is critical for optimizing the drug development process. The increasing volume of data accumulated in clinical trials provides a unique opportunity to discover new biomarkers and further the goal of personalized medicine, but…

2017-12-21abs ↗pdf ↗

Clinical notes contain a large amount of clinically valuable information that is ignored in many clinical decision support systems due to the difficulty that comes with mining that information. Recent work has found success leveraging deep learning models for the prediction of clinical outcomes using clinical notes. Ho…

2019-10-30abs ↗pdf ↗

New method stabilizes deep learning models for clinical risk prediction.

problem Stability issues in deep learning models for clinical risk prediction.
method Bootstrapping-based regularisation framework embedded in deep neural networks.
result Improved prediction stability across multiple datasets.

TrialGraph uses graph machine learning to improve clinical trial design and predict side effects.

problem Complexity and cost in clinical trials hinder drug development.
method Curated clinical trial data set converted to graph-structured formats, applied graph machine learning algorithms.
result MetaPath2Vec algorithm performed exceptionally well, improving prediction accuracy.

Study improves mortality prediction in hospital patients using comprehensive feature engineering.

problem Accurate prediction of all-cause in-hospital mortality in healthcare.
method Comprehensive feature engineering approach using vital signs, laboratory results, and demographic data.
result Random Forest model achieved highest performance with AUC of 0.94, significantly outperforming other models.

Much work aims to explain a model's prediction on a static input. We consider explanations in a temporal setting where a stateful dynamical model produces a sequence of risk estimates given an input at each time step. When the estimated risk increases, the goal of the explanation is to attribute the increase to a few r…

2019-07-10abs ↗pdf ↗

pmsims R package uses Gaussian process for flexible sample size estimation in clinical models.

problem Determining adequate sample size for clinical prediction models.
method Simulation-based Gaussian process search for flexible sample size estimation.
result Gaussian process-based method produces more stable sample size estimates, especially in challenging settings.

Study adaptive clinical trial methods for identifying patient subpopulations with treatment benefit.

problem Adaptive identification of patient subpopulations with treatment benefit in clinical trials.
method Proposes AdaGGI and AdaGCPI meta-algorithms for subpopulation construction.
result Empirical investigation of AdaGGI and AdaGCPI performance across various simulation scenarios.