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arXiv research

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130259389518 · Jun 202019922001200920172026
48 results for clinical predictions

Clinical notes contain a large amount of clinically valuable information that is ignored in many clinical decision support systems due to the difficulty that comes with mining that information. Recent work has found success leveraging deep learning models for the prediction of clinical outcomes using clinical notes. Ho…

2019-10-30abs ↗pdf ↗

Late fusion of clinical notes and physiological data improves ICU mortality prediction.

problem Improving ICU mortality prediction using multimodal data.
method Late fusion of clinical notes and physiological time series data with a deep learning architecture.
result Late fusion approach provides statistically significant improvement in mortality prediction performance.

In this chapter, we provide a brief overview of applying machine learning techniques for clinical prediction tasks. We begin with a quick introduction to the concepts of machine learning and outline some of the most common machine learning algorithms. Next, we demonstrate how to apply the algorithms with appropriate to…

2019-09-19abs ↗pdf ↗

Method predicts biomarker trajectories with uncertainty bands for Alzheimer's disease.

problem Uncertainty in biomarker predictions poses risks in clinical deployment.
method Conformal prediction for randomly-timed biomarker trajectories.
result Conformal bands achieve desired coverage and are tighter than baseline.

Novel metrics improve machine learning models for ICU patient care.

problem Predicting vital sign trajectories for early detection of adverse events.
method Developed novel performance metrics aligned with clinical contexts, validated on simulated and real datasets, and optimized neural networks using these metrics.
result Neural networks trained with these metrics excel in predicting clinically significant events.

AI predicts medical specialty diagnostic choices from EHR records.

problem Predicting timely medical specialty diagnostic workups for patients.
method Ensemble of feed-forward neural networks trained on EHR data.
result Significantly higher accuracy compared to traditional checklists.

New method stabilizes deep learning models for clinical risk prediction.

problem Stability issues in deep learning models for clinical risk prediction.
method Bootstrapping-based regularisation framework embedded in deep neural networks.
result Improved prediction stability across multiple datasets.

Study improves healthcare time series imputation by considering structured missingness.

problem Structured missingness in clinical data impacts time series imputation models.
method Analysis of different masking strategies on imputation methods using PhysioNet Challenge 2012 dataset.
result Masking choices significantly affect imputation accuracy and clinical prediction.

SARD improves deep learning clinical prediction performance.

problem Deep learning models struggle to match linear models in healthcare predictions.
method Reverse Distillation to initialize deep models, combined with contextual and temporal embeddings.
result SARD outperforms state-of-the-art methods on clinical prediction outcomes.

Unified model combines neural networks and dictionary learning for clinical predictions from brain data.

problem Predicting clinical severity from brain imaging data.
method Combines neural networks with dictionary learning to model patient-specific and shared features.
result Unified model outperforms state-of-the-art methods in predicting clinical severity.

In healthcare, patient risk stratification models are often learned using time-series data extracted from electronic health records. When extracting data for a clinical prediction task, several formulations exist, depending on how one chooses the time of prediction and the prediction horizon. In this paper, we show how…

2018-11-29abs ↗pdf ↗

Study improves mortality prediction in hospital patients using comprehensive feature engineering.

problem Accurate prediction of all-cause in-hospital mortality in healthcare.
method Comprehensive feature engineering approach using vital signs, laboratory results, and demographic data.
result Random Forest model achieved highest performance with AUC of 0.94, significantly outperforming other models.

A new method uses asymmetric Shapley values to assess gene importance in clinical prediction models.

problem Clinical prediction models struggle with assessing the importance of high-dimensional features like genomics.
method Derive efficient algorithms to compute local and global asymmetric Shapley values for a mixed-dimensional prediction model.
result Asymmetric Shapley values provide a more suitable alternative to quantify feature importance in clinical prediction models.

Clinical notes are a rich source of information about patient state. However, using them to predict clinical events with machine learning models is challenging. They are very high dimensional, sparse and have complex structure. Furthermore, training data is often scarce because it is expensive to obtain reliable labels…

2017-05-19abs ↗pdf ↗

CoI framework models clinical feature interactions, revealing temporal dependencies and enhancing transparency.

problem Capturing latent, time-varying dependencies among clinical features in time-series data.
method Chain-of-Influence (CoI) framework constructs an explicit, time-unfolded graph of feature interactions.
result Achieves state-of-the-art predictive performance (AUROC of 0.960 on CKD progression and 0.950 on ICU mortality).

Visual system compares and evaluates machine learning models for clinical data predictions.

problem Challenges in comparing and evaluating different machine learning models for medical predictions.
method Developed a visual analytics system to compare and evaluate multiple models' prediction criteria and consistency.
result Demonstrated the effectiveness of the visual analytics system in assisting clinicians and researchers.

Study examines impact of fairness penalties on clinical risk prediction models.

problem Widespread health disparities in machine learning-guided clinical decision-making.
method Empirical study across multiple databases, outcomes, and sensitive attributes.
result Penalizing fairness violations nearly universally degrades model performance and fairness metrics.

Neural model predicts survival outcomes and reveals feature relationships.

problem Predicting time-to-event outcomes and understanding feature relationships in clinical data.
method Survival and topic modeling combined in a neural network framework.
result Neural survival-supervised topic models achieve competitive accuracy with interpretability.

New method uses probabilistic independence to discover disease signatures from medical records.

problem Insufficiently precise diagnosis of clinical disease leading to treatment failures.
method Unsupervised machine learning using probabilistic independence to disentangle disease patterns.
result Inferred 2000 clinical disease signatures from medical records, improving cancer prediction.

Machine learning is bringing a paradigm shift to healthcare by changing the process of disease diagnosis and prognosis in clinics and hospitals. This development equips doctors and medical staff with tools to evaluate their hypotheses and hence make more precise decisions. Although most current research in the literatu…

2019-10-18abs ↗pdf ↗

New diagnostics detect variability in individual risk estimates from machine learning models in healthcare.

problem Variability in individual risk estimates from machine learning models in healthcare, leading to unreliable treatment decisions.
method Proposed evaluation framework using empirical prediction interval width and empirical decision flip rate diagnostics.
result Randomness in optimization and initialization can lead to substantial individual-level variability in risk estimates, affecting clinical decisions.

Framework predicts clinical severity from rs-fMRI data using network optimization.

problem Predicting clinical severity from rs-fMRI data.
method Joint network optimization framework combining sparse subnetworks and linear regression.
result Framework outperforms standard methods and identifies clinically relevant ASD networks.

Framework integrates brain connectivity data for clinical predictions.

problem Predicting clinical outcomes from brain connectivity data.
method Structurally-regularized Dynamic Dictionary Learning (sr-DDL) and LSTM-ANN block.
result Framework outperforms state-of-the-art approaches in clinical outcome prediction.

Novel model improves clinical risk prediction by transferring knowledge between tasks over time.

problem Negative transfer in multi-task learning for clinical risk prediction.
method Temporal Probabilistic Asymmetric Multi-Task Learning (TPAMTL).
result Significantly outperforms various deep learning models for time-series prediction.

Extends nonlinear filtering to predictable jump times.

problem Filtering with jumps in both signal and observation, especially when jump times are known.
method Derive Kushner-Stratonovich and Zakai equations for predictable discontinuities.
result Extends classical nonlinear filtering results to a setting with predictable discontinuities.

CASCADE improves uncertainty communication in Parkinson's disease medication management.

problem Uncertainty in clinical decision-making for Parkinson's disease patients.
method CASCADE uses a novel conformal prediction framework to adaptively scale prediction intervals based on classification uncertainty.
result CASCADE produces more efficient and robust prediction intervals for Parkinson's disease patients.

Feature engineering remains a major bottleneck when creating predictive systems from electronic medical records. At present, an important missing element is detecting predictive regular clinical motifs from irregular episodic records. We present Deepr (short for Deep record), a new end-to-end deep learning system that …

2016-07-26abs ↗pdf ↗

The paper proposes a method to predict the performance of data-driven algorithms using surrogate models.

problem Improving the performance prediction of data-driven knowledge discovery algorithms.
method Surrogate-assisted performance prediction using evolutionary modeling of clinical pathways.
result The proposed approach provides interpretable prediction of algorithm performance and quality.

Graph-based framework predicts ADR signals from clinical data.

problem Detecting ADRs in post-market surveillance using clinical data.
method Developed a Drug-disease graph with Graph Neural Network for ADR signal prediction.
result Improved AUROC and AUPRC performance (0.795 and 0.775) compared to other algorithms.