Paper develops deep learning for predicting clinical endpoints from diverse medical records.
problem Predicting clinical endpoints from heterogeneous, irregularly visiting medical records.
method Proposes a novel model with a new gate to control visiting rates of different events.
result Model effectively predicts death and abnormal lab tests with real-world clinical data.
Deep learning predicts Alzheimer's Disease progression with high accuracy.
problem Predicting multiple aspects of Alzheimer's Disease progression.
method Unsupervised deep learning on 1908 patients' 18-month clinical data.
result Model accurately predicts ADAS-Cog scores and identifies word recall as a predictor.
Methods for prediction and tolerance intervals in non-normal models.
problem Constructing prediction and tolerance intervals for non-normal data.
method Two approaches: pivotal quantity approximation and confidence interval for mean.
result Intuitive, simple, efficient methods with proper operating characteristics.
Proposes a new framework for evaluating diagnostic models with multiple co-primary endpoints.
problem Overoptimistic assessments of predictive performance in automated medical testing devices.
method Multiple testing framework for diagnostic accuracy studies with co-primary endpoints, using a parametric simultaneous test procedure and Bayesian approach to determine optimal number of models.
result Our approach leads to a better final diagnostic model and increased statistical power.
Generative AI models improve clinical trial data by generating survival outcomes.
problem Generating valid survival outcomes for clinical trials with synthetic data.
method A variational autoencoder (VAE) that jointly generates mixed-type covariates and survival outcomes.
result The method outperforms GAN baselines on fidelity, utility, and privacy metrics.
Random shuffle method boosts HF dataset size 10-21 times.
problem Narrow dataset cardinality in HF clinical studies.
method Random shuffle method to enhance dataset size.
result Enhanced HF dataset size 10-21 times.
Inpatient2Vec learns representations for inpatients with multi-layer self-attention.
problem Lack of specialized RL methods for inpatient data with strong temporal relations and consistent diagnoses.
method Inpatient2Vec uses a multi-layer self-attention mechanism with two training tasks to learn medical activity, hospital day, and diagnosis representations for inpatients.
result Inpatient2Vec outperforms baselines on semantic similarity and clinical events prediction tasks.
Predicts clinical events using a landmark approach with machine learning for large biomarker histories.
problem Dynamic prediction of clinical events from large biomarker histories.
method Landmark approach extended to endogenous markers history combined with machine learning methods for survival data.
result Superlearner combining regularized regressions and random survival forests outperforms standard survival models.
TA-CQR predicts regression intervals with exact coverage, splitting miscoverage between endpoints.
problem Predicting regression intervals with exact coverage under reporting constraints.
method TA-CQR uses tail allocation to parameterize the oracle, estimating the allocation by searching quantile cores and applying nonnegative additive split-conformal calibration.
result TA-CQR achieves exact finite-sample marginal coverage under exchangeability, with theoretical guarantees on calibration and length.
The paper predicts diseases using both clinical and genomics data.
problem Clinical predictions using genomics data are not common.
method Integrated clinical and genomics datasets, machine learning, Principal Component Analysis for feature selection.
result 73% accuracy in predicting 75 disease classes.
Objective: The advent of Electronic Medical Records (EMR) with large electronic imaging databases along with advances in deep neural networks with machine learning has provided a unique opportunity to achieve milestones in automated image analysis. Optical coherence tomography (OCT) is the most commonly obtained imagin…
We propose a non-parametric link prediction algorithm for a sequence of graph snapshots over time. The model predicts links based on the features of its endpoints, as well as those of the local neighborhood around the endpoints. This allows for different types of neighborhoods in a graph, each with its own dynamics (e.…
Improved model predicts ICU readmission and mortality with interpretable results.
problem Lack of clinically interpretable predictions from deep learning models on clinical notes.
method Augmented a convolutional model with an attention mechanism for clinical note prediction.
result Attention mechanism improves prediction performance while providing interpretable results.
Machine learning aids in clinical prediction tasks.
problem Improving accuracy in clinical predictions.
method Introduction to machine learning concepts and algorithms, followed by practical application to clinical datasets.
result Demonstrated the application of machine learning models to clinical prediction problems.
Model learns hierarchical EHR representation for clinical outcome prediction.
problem Capturing temporal patterns in irregular clinical event sequences.
method Proposes differentiated mechanisms to model events at different time scales, learning hierarchical representations.
result Significantly improves clinical outcome prediction, achieving AUC scores of 0.94 and 0.90 for death and ICU admission respectively.
Machine learning predicts patient recruitment for clinical trials.
problem Improving patient recruitment prediction for clinical trials.
method Machine learning methods applied to historical clinical trial data.
result Reduced prediction error compared to current industry standards.
Cancer survival prediction is an active area of research that can help prevent unnecessary therapies and improve patient's quality of life. Gene expression profiling is being widely used in cancer studies to discover informative biomarkers that aid predict different clinical endpoint prediction. We use multiple modalit…
QGMS framework detects market endpoints using geometric patterns.
problem Identifying market endpoints in large-scale movements.
method Hybrid of geometric pattern recognition and quantitative modeling.
result Consistently identifies market endpoints before major reversals.
This study shows unstructured clinical notes can improve mortality prediction.
problem Lack of effective use of unstructured clinical notes in mortality prediction.
method Used a hierarchical architecture with convolutional and recurrent layers to predict in-hospital mortality from unprocessed clinical notes.
result Achieved higher metrics in mortality prediction compared to structured data approaches.
Late fusion of clinical notes and physiological data improves ICU mortality prediction.
problem Improving ICU mortality prediction using multimodal data.
method Late fusion of clinical notes and physiological time series data with a deep learning architecture.
result Late fusion approach provides statistically significant improvement in mortality prediction performance.
Method predicts biomarker trajectories with uncertainty bands for Alzheimer's disease.
problem Uncertainty in biomarker predictions poses risks in clinical deployment.
method Conformal prediction for randomly-timed biomarker trajectories.
result Conformal bands achieve desired coverage and are tighter than baseline.
Novel metrics improve machine learning models for ICU patient care.
problem Predicting vital sign trajectories for early detection of adverse events.
method Developed novel performance metrics aligned with clinical contexts, validated on simulated and real datasets, and optimized neural networks using these metrics.
result Neural networks trained with these metrics excel in predicting clinically significant events.
Deep learning predicts heart failure readmission from clinical notes.
problem Predicting and preventing heart failure readmission.
method Convolutional Neural Networks (CNN) trained on clinical notes.
result Deep learning models outperform traditional machine learning methods in readmission prediction.
AI predicts medical specialty diagnostic choices from EHR records.
problem Predicting timely medical specialty diagnostic workups for patients.
method Ensemble of feed-forward neural networks trained on EHR data.
result Significantly higher accuracy compared to traditional checklists.
Predictive models identify patients at risk of severe COVID-19.
problem Identifying patients at risk of severe COVID-19 to ease healthcare strain.
method Machine learning on routinely collected clinical data.
result Models predict positive SARS-CoV-2 tests, hospitalizations, and critical care with high accuracy.
The paper shows how the timing of prediction impacts model performance in healthcare.
problem The timing of prediction affects model performance in healthcare.
method The paper compares two prediction schemes: outcome-dependent and outcome-independent.
result An outcome-independent scheme outperforms an outcome-dependent scheme.
New method stabilizes deep learning models for clinical risk prediction.
problem Stability issues in deep learning models for clinical risk prediction.
method Bootstrapping-based regularisation framework embedded in deep neural networks.
result Improved prediction stability across multiple datasets.
Study improves healthcare time series imputation by considering structured missingness.
problem Structured missingness in clinical data impacts time series imputation models.
method Analysis of different masking strategies on imputation methods using PhysioNet Challenge 2012 dataset.
result Masking choices significantly affect imputation accuracy and clinical prediction.
Predict sepsis early from EHR data with aggregated clinical events.
problem Predict sepsis from clinical data in EHR with temporal interactions.
method Aggregates heterogeneous clinical events, captures temporal interactions with LSTM.
result Achieved high utility score (0.321) in PhysioNet/Computing in Cardiology Challenge 2019.
Language models improve clinical prediction models using EHR data.
problem Limited patient data for training clinical prediction models.
method Using patient representation schemes from natural language processing.
result 3.5% mean improvement in AUROC on five prediction tasks.
Enhances clinical trial predictions by quantifying uncertainty.
problem Uncertainty in medical diagnosis and drug discovery predictions.
method Selective classification integrated with Hierarchical Interaction Network (HINT).
result Significant improvement in PR-AUC, F1, ROC-AUC, and overall accuracy.
Unsupervised learning improves clinical predictions from medical time series.
problem Improving clinical decision making through unlabeled medical data.
method Evaluation of unsupervised representation learning on medical time series using sequence-to-sequence models.
result A forecasting Seq2Seq model with an attention mechanism achieves the best performance.
Natural language processing predicts AKI onset in ICU patients.
problem Early detection of AKI in ICU patients to improve outcomes.
method Clinical notes were processed to generate word and concept embeddings. Five classifiers and a deep learning model were used to predict AKI.
result The best model achieved an AUC of 0.779 for predicting AKI onset.
SARD improves deep learning clinical prediction performance.
problem Deep learning models struggle to match linear models in healthcare predictions.
method Reverse Distillation to initialize deep models, combined with contextual and temporal embeddings.
result SARD outperforms state-of-the-art methods on clinical prediction outcomes.
Causal ML predicts treatment outcomes, aiding personalized medicine.
problem Predicting individualized treatment effects for personalized medicine.
method Flexible, data-driven methods using causal inference with clinical trial and real-world data.
result Causal ML allows for estimating individualized treatment effects.
This research uses machine learning to identify Alzheimer's disease subtypes and predict progression.
problem Heterogeneity in Alzheimer's disease clinical manifestations and progression rate limit personalized care and treatment planning.
method Unsupervised and supervised machine learning approaches applied to ADNI data.
result Identification of patient subtypes and prediction of disease progression zones.
AI system predicts acute critical illness from EHRs with explainability.
problem Lack of clinical interpretability in AI predictions for acute critical illness.
method Developed an explainable AI early warning score (xAI-EWS) system.
result System provides clinicians with insights into EHR data explaining predictions.
Unified model combines neural networks and dictionary learning for clinical predictions from brain data.
problem Predicting clinical severity from brain imaging data.
method Combines neural networks with dictionary learning to model patient-specific and shared features.
result Unified model outperforms state-of-the-art methods in predicting clinical severity.
Deep RL optimizes lab test scheduling for better patient outcomes and cost savings.
problem Redundant lab tests lead to cost and patient discomfort.
method Deep reinforcement learning for optimal scheduling.
result Deep RL policy outperforms heuristic scheduling in both accuracy and cost.
Proposes clustering as a new evaluation method for clinical knowledge embedding.
problem Traditional Link Prediction evaluation protocol loses information and harms model accuracy.
method Proposes Clustering Evaluation Protocol as an alternative.
result Experimental results show the proposed protocol can potentially replace Link Prediction.
Unified Bayesian framework for missing data imputation and prediction in clinical time series.
problem High prevalence of missing values in clinical time series data.
method Unified Bayesian recurrent framework for imputation and prediction.
result Strong performance gains over state-of-the-art methods on mortality prediction tasks.
LRF framework predicts and interprets longitudinal response trajectories.
problem Sparse and irregular data in longitudinal studies.
method Longitudinal Random Forest (LRF) framework with adaptive node-wise trajectory estimation.
result LRF outperforms competing methods in predicting and interpreting longitudinal trajectories.
Study improves mortality prediction in hospital patients using comprehensive feature engineering.
problem Accurate prediction of all-cause in-hospital mortality in healthcare.
method Comprehensive feature engineering approach using vital signs, laboratory results, and demographic data.
result Random Forest model achieved highest performance with AUC of 0.94, significantly outperforming other models.
A new method uses asymmetric Shapley values to assess gene importance in clinical prediction models.
problem Clinical prediction models struggle with assessing the importance of high-dimensional features like genomics.
method Derive efficient algorithms to compute local and global asymmetric Shapley values for a mixed-dimensional prediction model.
result Asymmetric Shapley values provide a more suitable alternative to quantify feature importance in clinical prediction models.
Clinical notes are a rich source of information about patient state. However, using them to predict clinical events with machine learning models is challenging. They are very high dimensional, sparse and have complex structure. Furthermore, training data is often scarce because it is expensive to obtain reliable labels…
CoI framework models clinical feature interactions, revealing temporal dependencies and enhancing transparency.
problem Capturing latent, time-varying dependencies among clinical features in time-series data.
method Chain-of-Influence (CoI) framework constructs an explicit, time-unfolded graph of feature interactions.
result Achieves state-of-the-art predictive performance (AUROC of 0.960 on CKD progression and 0.950 on ICU mortality).
AdaCare learns health status from biomarkers across multiple time scales.
problem Lack of explicit extraction of historical biomarker variation and adaptability to diverse patient conditions.
method Scale-adaptive feature extraction and recalibration for interpretability.
result AdaCare achieves state-of-the-art prediction accuracy and provides interpretable results.
Model predicts patient trajectories and interventions from EMR data.
problem Forecasting patient outcomes from EMR data.
method Deep state space generative model capturing latent state dynamics.
result Model outperforms state-of-the-art methods on real EMR data.