Machine learning for healthcare often trains models on de-identified datasets with randomly-shifted calendar dates, ignoring the fact that data were generated under hospital operation practices that change over time. These changing practices induce definitive changes in observed data which confound evaluations which do…
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48 results for “clinical deterioration”
Machine learning improves early detection of patient deterioration in Brazilian hospitals.
problem Challenges in recognizing clinical deterioration in hospital settings.
method Application of machine learning to analyze EHR data from multiple hospitals.
result Machine learning models outperformed traditional protocols by 25 percentage points in AUC.
Towards automated symptoms assessment in mental healthphysics.med-ph
Activity and motion analysis has the potential to be used as a diagnostic tool for mental disorders. However, to-date, little work has been performed in turning stratification measures of activity into useful symptom markers. The research presented in this thesis has focused on the identification of objective activity …
We developed an explainable artificial intelligence (AI) early warning score (xAI-EWS) system for early detection of acute critical illness. While maintaining a high predictive performance, our system explains to the clinician on which relevant electronic health records (EHRs) data the prediction is grounded. Acute cri…
Critically ill patients in regular wards are vulnerable to unanticipated clinical dete- rioration which requires timely transfer to the intensive care unit (ICU). To allow for risk scoring and patient monitoring in such a setting, we develop a novel Semi- Markov Switching Linear Gaussian Model (SSLGM) for the inpatient…
Personalized Risk Scoring for Critical Care Patients using Mixtures of Gaussian Process Expertscs.LG
We develop a personalized real time risk scoring algorithm that provides timely and granular assessments for the clinical acuity of ward patients based on their (temporal) lab tests and vital signs. Heterogeneity of the patients population is captured via a hierarchical latent class model. The proposed algorithm aims t…
Much work aims to explain a model's prediction on a static input. We consider explanations in a temporal setting where a stateful dynamical model produces a sequence of risk estimates given an input at each time step. When the estimated risk increases, the goal of the explanation is to attribute the increase to a few r…
Objectives: Electronic health records (EHRs) are only a first step in capturing and utilizing health-related data - the challenge is turning that data into useful information. Furthermore, EHRs are increasingly likely to include data relating to patient outcomes, functionality such as clinical decision support, and gen…
Machine learning classifies Parkinson's Disease stages from walker sensors data.
problem Limited cost-effective methods for quantitatively assessing Parkinson's Disease stages.
method Machine learning applied to walker-mounted sensors data, feature selection methods compared.
result Feature selection method using ANOVA provides similar accuracy to full feature set and is clinically interpretable.
Maintaining good cardiac function for as long as possible is a major concern for healthcare systems worldwide and there is much interest in learning more about the impact of different risk factors on cardiac health. The aim of this study is to analyze the impact of systolic blood pressure (SBP) on cardiac function whil…
After admission to emergency department (ED), patients with critical illnesses are transferred to intensive care unit (ICU) due to unexpected clinical deterioration occurrence. Identifying such unplanned ICU transfers is urgently needed for medical physicians to achieve two-fold goals: improving critical care quality a…
Novel framework identifies pump-specific deterioration rates using Bayesian hierarchical hazard modeling and causal discovery.
problem Challenges in asset management due to heterogeneous deterioration rates in pump equipment.
method Bayesian hierarchical hazard modeling with causal discovery, GPU-accelerated No-U-Turn Sampling (NUTS), and DirectLiNGAM.
result Identified striking heterogeneity in deterioration rates, with negative effects 400 times larger than positive effects.
Monitoring Model Deterioration with Explainable Uncertainty Estimation via Non-parametric Bootstrapcs.LG
The paper monitors model deterioration using uncertainty estimation.
problem Challenges in monitoring deployed machine learning models.
method Non-parametric bootstrapped uncertainty estimates and SHAP values.
result The approach detects model deterioration and uncertainty effectively.
Proposes a framework to explain KS deterioration in credit risk models.
problem Inconsistent and ad hoc diagnosis of KS decline in credit risk models.
method Counterfactual diagnostic framework attributing KS decline to sampling variability, portfolio composition, covariate shift, and residual deterioration.
result The proposed approach provides more interpretable and governance-relevant explanations than threshold-based review alone.
The estimation of optimal treatment regimes is of considerable interest to precision medicine. In this work, we propose a causal -nearest neighbor method to estimate the optimal treatment regime. The method roots in the framework of causal inference, and estimates the causal treatment effects within the nearest neig…
Proposes efficient algorithm for system-level I&M decisions under uncertainty.
problem Optimal management strategies for deteriorating civil engineering systems.
method Factored partially observable Markov decision process with Bayesian networks and DDMAC reinforcement learning.
result DDMAC policies offer substantial benefits over heuristic approaches in system-level cost optimization.
Accelerated gradient method's stability deteriorates exponentially with steps.
problem Algorithmic stability of Nesterov's accelerated gradient method.
method Analysis of two notions of algorithmic stability for Nesterov's accelerated gradient method.
result Stability of Nesterov's accelerated method deteriorates exponentially with the number of gradient steps.
Federated CTMC model estimates bridge deterioration hazards without sharing raw data.
problem Bridge inspection data privacy and cross-organizational data sharing constraints.
method Federated CTMC hazard model with local optimization and FedAvg aggregation.
result Federated model converges on global benchmark parameters without data transfer.
Training on some out-of-distribution data improves generalization error before it deteriorates.
problem Generalization error improves with some out-of-distribution data but deteriorates with more.
method Synthetic datasets and deep networks on computer vision benchmarks.
result Non-monotonic trend in generalization error with OOD samples.
Artificial Neural Networks and Adaptive Neuro-fuzzy Models for Prediction of Remaining Useful Lifecs.LG
The U.S. water distribution system contains thousands of miles of pipes constructed from different materials, and of various sizes, and age. These pipes suffer from physical, environmental, structural and operational stresses, causing deterioration which eventually leads to their failure. Pipe deterioration results in …
The paper predicts diseases using both clinical and genomics data.
problem Clinical predictions using genomics data are not common.
method Integrated clinical and genomics datasets, machine learning, Principal Component Analysis for feature selection.
result 73% accuracy in predicting 75 disease classes.
Clinical notes contain a large amount of clinically valuable information that is ignored in many clinical decision support systems due to the difficulty that comes with mining that information. Recent work has found success leveraging deep learning models for the prediction of clinical outcomes using clinical notes. Ho…
The Lasso is a computationally efficient regression regularization procedure that can produce sparse estimators when the number of predictors (p) is large. Oracle inequalities provide probability loss bounds for the Lasso estimator at a deterministic choice of the regularization parameter. These bounds tend to zero if …
Clinical AI models fail to transfer between sites due to site-specific practices.
problem Clinical AI models perform poorly at new sites.
method Identify and isolate site-specific clinical practices affecting data distribution.
result A potential solution to improve model transferability.
System suggests clinical concepts in real-time for faster note creation.
problem Efficiently creating structured clinical notes with minimal keystrokes.
method Contextual autocompletion using shallow neural networks.
result Reduces keystrokes by 67% in real hospital environments.
The paper develops a method to predict the latent deterioration phase in limit order books before stress is observed.
problem Limit order books can transition rapidly from stable to stressed conditions, making it difficult to detect the latent deterioration phase.
method The paper formalizes a three-regime causal data-generating process and proposes a trigger-based detector combining MAX aggregation of complementary signal channels, a rising-edge condition, and adaptive thresholding.
result The proposed method achieves mean lead-time of +18.6 timesteps with perfect precision and moderate coverage, outperforming classical change-point and microstructure baselines.
We introduce SparseVM, a method that registers clinical-quality 3D MR scans both faster and more accurately than previously possible. Deformable alignment, or registration, of clinical scans is a fundamental task for many clinical neuroscience studies. However, most registration algorithms are designed for high-resolut…
AI predicts medical specialty diagnostic choices from EHR records.
problem Predicting timely medical specialty diagnostic workups for patients.
method Ensemble of feed-forward neural networks trained on EHR data.
result Significantly higher accuracy compared to traditional checklists.
Aiming for Relevancecs.LG
Novel metrics improve machine learning models for ICU patient care.
problem Predicting vital sign trajectories for early detection of adverse events.
method Developed novel performance metrics aligned with clinical contexts, validated on simulated and real datasets, and optimized neural networks using these metrics.
result Neural networks trained with these metrics excel in predicting clinically significant events.
Machine learning predicts patient recruitment for clinical trials.
problem Improving patient recruitment prediction for clinical trials.
method Machine learning methods applied to historical clinical trial data.
result Reduced prediction error compared to current industry standards.
Learning Hierarchical Representations of Electronic Health Records for Clinical Outcome Predictioncs.LG
Clinical outcome prediction based on the Electronic Health Record (EHR) plays a crucial role in improving the quality of healthcare. Conventional deep sequential models fail to capture the rich temporal patterns encoded in the longand irregular clinical event sequences. We make the observation that clinical events at a…
Study quantifies firm risks from nature decline, showing significant equity losses.
problem Estimating the financial impact of nature deterioration on companies.
method Developed metrics (Country Degradation Index, Nature Risk Score) and assessed five environmental hazards.
result Global equities lose 26.8% in a nature decline scenario, with worst firms losing 75%.
With the maturation of metabolomics science and proliferation of biobanks, clinical metabolic profiling is an increasingly opportunistic frontier for advancing translational clinical research. Automated Machine Learning (AutoML) approaches provide exciting opportunity to guide feature selection in agnostic metabolic pr…
Skin cancer is one of the most common types of cancer around the world. For this reason, over the past years, different approaches have been proposed to assist detect it. Nonetheless, most of them are based only on dermoscopy images and do not take into account the patient clinical information. In this work, first, we …
Study develops a new algorithm for assessing clinical trial abstracts.
problem Limited tools for assessing qualitative statements in clinical research.
method Developed a three-class sentiment classification algorithm using BERT model.
result Algorithm achieved 91.3% classification accuracy and 0.92 macro F1-Score.
Negation detection in Dutch clinical texts: an evaluation of rule-based and machine learning methodscs.CL
Improved negation detection in Dutch clinical texts using machine learning.
problem Extracting negation from clinical text for better model development.
method Comparison of rule-based and machine learning methods (biLSTM, RoBERTa).
result BiLSTM and RoBERTa models outperform rule-based method in F1 score, precision, and recall.
The paper explores using historical data to improve clinical trial analysis by optimizing covariate weights.
problem Limited covariates in small clinical trials reduce the effectiveness of analysis.
method Leverage historical data to pre-specify covariate weights as a composite covariate.
result A composite covariate improves the cost/benefit ratio and reduces overfitting in small clinical trials.
Alzheimer's disease (AD) is a degenerative brain disease impairing a person's ability to perform day to day activities. The clinical manifestations of Alzheimer's disease are characterized by heterogeneity in age, disease span, progression rate, impairment of memory and cognitive abilities. Due to these variabilities, …
Wastewater infrastructure systems deteriorate over time due to a combination of physical and chemical factors. Failure of this significant infrastructure could affect important social, environmental, and economic impacts. Furthermore, recognizing the optimized timeline for inspection of sewer pipelines are challenging …
Study examines biases in clinical word embeddings, revealing performance gaps across groups.
problem Biases in clinical word embeddings leading to performance differences across groups.
method Pretrained BERT models on MIMIC-III, fill-in-the-blank method, fairness evaluation on clinical tasks.
result Classifiers trained from BERT representations exhibit statistically significant differences in performance across groups.
Learning Curves for Continual Learning in Neural Networks: Self-Knowledge Transfer and Forgettingstat.ML
Study on neural networks' performance in sequential task learning.
problem Understanding the performance of neural networks in sequential task learning.
method Theoretical analysis of generalization performance in continual learning using statistical mechanical analysis of kernel ridge-less regression.
result Characteristic transitions from positive to negative transfer observed in neural networks.
Study improves healthcare time series imputation by considering structured missingness.
problem Structured missingness in clinical data impacts time series imputation models.
method Analysis of different masking strategies on imputation methods using PhysioNet Challenge 2012 dataset.
result Masking choices significantly affect imputation accuracy and clinical prediction.
New method detects biomarker-treatment interactions in clinical trials.
problem Detecting interactions between high-dimensional biomarkers and treatments in randomized trials.
method Two-stage penalized regression screening using ridge regression for multivariate screening.
result Ridge regression screening provides greater power than traditional methods in correlated data.
In this chapter, we provide a brief overview of applying machine learning techniques for clinical prediction tasks. We begin with a quick introduction to the concepts of machine learning and outline some of the most common machine learning algorithms. Next, we demonstrate how to apply the algorithms with appropriate to…
Improved language model for French clinical reports achieves state-of-the-art performance in medical NLP tasks.
problem Lack of specialized language models for French clinical reports.
method Adapted a general pre-trained language model (CamemBERT) to French clinical reports using a corpus of 21M reports.
result Pretrained and fine-tuned models improved F1-score by 3 percentage points on APMed task.
The recent adoption of Electronic Health Records (EHRs) by health care providers has introduced an important source of data that provides detailed and highly specific insights into patient phenotypes over large cohorts. These datasets, in combination with machine learning and statistical approaches, generate new opport…
Late fusion of clinical notes and physiological data improves ICU mortality prediction.
problem Improving ICU mortality prediction using multimodal data.
method Late fusion of clinical notes and physiological time series data with a deep learning architecture.
result Late fusion approach provides statistically significant improvement in mortality prediction performance.
Deep learning analyzes healthcare provider actions and patient outcomes.
problem Understanding provider behavior in non-randomized healthcare settings.
method Deep causal behavioral policy learning (DC-BPL) using transformer architecture.
result Optimal provider policies identified for specific patient types.