AI predicts medical specialty diagnostic choices from EHR records.
problem Predicting timely medical specialty diagnostic workups for patients.
method Ensemble of feed-forward neural networks trained on EHR data.
result Significantly higher accuracy compared to traditional checklists.
The paper integrates AI and expert knowledge to optimize radiotherapy decisions.
problem Optimizing radiation dose planning considering patient-specific information.
method Integrating Gaussian process models with deep neural networks to quantify uncertainty.
result Improves AI model performance and guides clinical decision making.
Clinical AI models fail to transfer between sites due to site-specific practices.
problem Clinical AI models perform poorly at new sites.
method Identify and isolate site-specific clinical practices affecting data distribution.
result A potential solution to improve model transferability.
Framework for AI healthcare products from concept to market.
problem Failure of AI products to reach clinics despite promising potential.
method Decision-making framework for AI healthcare product development.
result Guides through a three-phase process to market launch of validated AI products.
The paper introduces sanity tests to detect spurious correlations in AI-guided radiology systems.
problem Detecting when AI systems perform well on development data for the wrong reasons.
method Design and implementation of sanity tests to identify spurious correlations.
result Sanity tests can identify spurious correlations in AI-guided radiology systems.
Improved AI lung ultrasound segmentation using expert confidence values.
problem Label uncertainty in lung ultrasound due to subjective interpretation by radiologists.
method Designing a data annotation protocol capturing expert confidence, training AI on binarized labels with confidence thresholds.
result Improved AI segmentation and better clinical outcomes (e.g., S/F oxygenation ratio estimation, patient readmission prediction).
AI detects heart disease from ECGs with improved interpretability and performance.
problem Undiagnosed structural heart disease due to high cost and accessibility of echocardiography.
method Generalized additive model integrating clinically meaningful ECG predictors.
result Improved AUROC, AUPRC, and F1 score compared to deep-learning baselines.
Study evaluates how framing affects machine learning models for sepsis prediction.
problem Understanding and reporting framing is crucial for AI technology success.
method Four different approaches applied to AI models of sepsis prediction.
result On-clinical-demand framing showed the lowest missing values and best temporal dependencies.
Study investigates how machine learning models degrade over time, leading to patient safety issues.
problem Overtime degradation of machine learning models in clinical settings.
method Used MIMIC-IV dataset to train models replicating commercial approaches, observing and analyzing degradation over a decade.
result An RNN model built on Epic features degrades from 0.729 AUC to 0.525 AUC over a decade, highlighting technical and clinical drift as root causes.
The study evaluates AI model performance measures for medical use.
problem Selecting appropriate performance measures for AI models in medical practice.
method Assessed 32 performance measures across five domains for binary outcomes.
result 17 measures are both proper and reflect decision-analytic performance.
AI enhances personalized drug development and decision-making in pharma.
problem Traditional drug development lacks personalized treatment plans.
method Application of AI in drug discovery, clinical trials, and post-marketing assessment.
result AI improves personalized medicine, optimizing health outcomes.
Generative AI models improve clinical trial data by generating survival outcomes.
problem Generating valid survival outcomes for clinical trials with synthetic data.
method A variational autoencoder (VAE) that jointly generates mixed-type covariates and survival outcomes.
result The method outperforms GAN baselines on fidelity, utility, and privacy metrics.
Exploring a new method to explain AI models in medical devices.
problem Lack of explainability in AI models used in medical devices.
method Using the Jacobian matrix to measure model response stability to small perturbations.
result A first step towards a perturbation-based explanation of AI models.
We developed an explainable artificial intelligence (AI) early warning score (xAI-EWS) system for early detection of acute critical illness. While maintaining a high predictive performance, our system explains to the clinician on which relevant electronic health records (EHRs) data the prediction is grounded. Acute cri…
Aims to integrate AI and modelling for patient health forecasting.
problem Personalized, precise treatment plans for patients.
method Graph neural network (GNNs) and generative adversarial network (GANs) for probabilistic simulations.
result Demonstrated integration of molecular data for predicting physiological state evolution.
Despite significant advances in artificial intelligence (AI) for computer vision, its application in medical imaging has been limited by the burden and limits of expert-generated labels. We used images from optical coherence tomography angiography (OCTA), a relatively new imaging modality that measures perfusion of the…
The ubiquity of systems using artificial intelligence or "AI" has brought increasing attention to how those systems should be regulated. The choice of how to regulate AI systems will require care. AI systems have the potential to synthesize large amounts of data, allowing for greater levels of personalization and preci…
In the modern healthcare system, rapidly expanding costs/complexity, the growing myriad of treatment options, and exploding information streams that often do not effectively reach the front lines hinder the ability to choose optimal treatment decisions over time. The goal in this paper is to develop a general purpose (…
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related deaths worldwide. Most CRC deaths are the result of progression of metastases. The assessment of metastases is done using the RECIST criterion, which is time consuming and subjective, as clinicians need to manually me…
KM-GPT automates IPD reconstruction from KM plots with high accuracy and scalability.
problem Manual digitization of IPD from KM plots is error-prone and lacks scalability.
method KM-GPT integrates advanced image preprocessing, multi-modal reasoning, and iterative reconstruction algorithms.
result KM-GPT generates high-quality IPD without manual input or intervention, achieving superior accuracy.
New method explains survival analysis models using median-SHAP.
problem Need for explainable AI in medical applications, especially for survival analysis.
method Introduces median-SHAP for explaining survival analysis models.
result Conventionally used mean anchor point can lead to misleading interpretations; median-SHAP provides a better approach.
AI4COVID-19 app diagnoses COVID-19 from cough samples.
problem Scalable screening tool for COVID-19 testing.
method Transfer learning and multi-pronged AI architecture.
result AI4COVID-19 can distinguish COVID-19 coughs from others.
AI generates a sequence of death causes from hospital records.
problem Accurate death reporting for vital statistics and policy formulation.
method Neural machine translation models to generate causal chains, incorporating medical domain knowledge.
result Achieved 16.04 BLEU score for generating accurate causal chains.
Paper detects bias in AI medical models using CART.
problem Ensuring fairness in AI medical decision support systems.
method Uses Classification and Regression Trees (CART) algorithm to identify bias.
result Validated the CART approach in both synthetic and real-world data.
AI enhances microbiology and microbiome research through machine learning.
problem Understanding microbial life and its impact on health and the environment.
method AI-driven approaches including machine learning and deep learning.
result Transformative role in enhancing microbial life understanding.
Deep learning ensemble improves Alzheimer vs. Mild Cognitive Impairment diagnosis.
problem Differentiating Alzheimer Disease from Mild Cognitive Impairment.
method Hybrid deep learning ensemble framework using MRI slices, pretrained models, and stacked ensemble learning.
result State-of-the-art accuracy (99.21%) for Alzheimer vs. Mild Cognitive Impairment classification.
Survey reviews explainability in AI for healthcare, emphasizing trust and transparency.
problem Lack of transparency hinders AI adoption in healthcare.
method Comprehensive literature review to guide explainable AI design.
result Quantitative evaluation metrics are needed for some explainability properties.
Visualizes deep generative models for drug design.
problem Limited visualization tools for deep generative models in drug discovery.
method Proposes a visualization framework for deep graph generative models.
result Interactive visualization and molecular optimization tools.
Online symptom checkers have significant potential to improve patient care, however their reliability and accuracy remain variable. We hypothesised that an artificial intelligence (AI) powered triage and diagnostic system would compare favourably with human doctors with respect to triage and diagnostic accuracy. We per…
Study investigates XAI methods in clinical gait analysis.
problem Limited understanding of machine learning models in healthcare.
method XAI methods, specifically Layer-wise Relevance Propagation (LRP), to explain ML predictions.
result Explanations from LRP show promising statistical and clinical relevance.
AIS algorithm improves heavy-tailed distribution estimation.
problem Inconsistent estimators and slow convergence in AIS for heavy-tailed distributions.
method Adapts Student-t proposal distributions by matching escort moments and minimizing α-divergence.
result Improves estimation accuracy for heavy-tailed distributions.
Infrastructure monitors AI/ML radiology models across multiple sites.
problem Monitoring and improving AI/ML radiology models across multiple sites.
method Interactive radiology reporting, centralized cloud system, post-marketing surveillance.
result Efficient monitoring and iterative development of AI/ML models without radiologist burden.
The paper proposes a method to calibrate healthcare AI models for reliability and interpretability.
problem Characterizing model reliability and enabling introspection of model behavior in clinical decision making.
method A calibration-driven learning method combined with interpretability techniques based on counterfactual reasoning.
result Demonstrates the effectiveness of the proposed approach using a lesion classification problem with dermoscopy images.
Study evaluates saliency maps on artificial data with different backgrounds.
problem Objective evaluation of saliency methods on artificial data with varying backgrounds.
method Developed a framework to generate artificial data with synthetic lesions and a known ground truth map, evaluated two data sets with different backgrounds (Perlin noise and 2D brain MRI slices).
result Heatmaps vary strongly between saliency methods and backgrounds.
Study reveals AI skin cancer classifiers underperform for darker skin phototypes, advocating for fairness auditing.
problem AI bias in dermatology, particularly for darker skin phototypes.
method Predictive Representativity (PR) framework, evaluating classifiers on HAM10000 and BOSQUE Test sets.
result Substantial performance disparities by skin phototype, highlighting AI bias.
The paper advocates for interpretable, accountable, reproducible machine learning in medicine.
problem Black box models in medicine lack transparency and regulatory approval.
method Intrinsically interpretable modeling approaches and collaborative learning paradigms.
result Interpretable machine learning models can support clinical decisions and gain regulatory approval.
Bayesian approach models neurodegenerative diseases without clinical labels.
problem Personalized, predictive modeling of neurodegenerative diseases.
method Probabilistic programmed deep kernel learning combining Gaussian processes and neural networks.
result Surpasses deep learning in accuracy and timeliness of predicting neurodegeneration.
CASCADE improves uncertainty communication in Parkinson's disease medication management.
problem Uncertainty in clinical decision-making for Parkinson's disease patients.
method CASCADE uses a novel conformal prediction framework to adaptively scale prediction intervals based on classification uncertainty.
result CASCADE produces more efficient and robust prediction intervals for Parkinson's disease patients.
A new COVID-19 CT dataset helps develop AI diagnosis models.
problem Lack of publicly available COVID-19 CT datasets due to privacy issues.
method Built an open-sourced COVID-CT dataset and developed AI diagnosis methods.
result Developed AI diagnosis models achieving high accuracy and performance.
AI tool automates blood segmentation from head CT scans after SAH.
problem Accurate volumetric assessment of SAH patients for clinical and prognostic implications.
method Transformer-based Swin UNETR architecture for noncontrast CT scans.
result High accuracy and robust performance across internal and external validation cohorts.
AI improves precision health through adaptive interventions.
problem Improving healthcare through personalized and dynamic treatments.
method Reinforcement learning (RL) for adaptive interventions in digital health.
result RL shows promise in dynamic healthcare problems.
The hypothesis that computational models can be reliable enough to be adopted in prognosis and patient care is revolutionizing healthcare. Deep learning, in particular, has been a game changer in building predictive models, thus leading to community-wide data curation efforts. However, due to inherent variabilities in …
AI framework uses multi-omics data to personalize cancer treatment suggestions.
problem Leveraging AI for personalized cancer treatment based on complex patient characteristics.
method Modular machine learning framework trained on diverse multi-omics technologies.
result Superior performance in personalized counterfactual treatment suggestions.
New method optimizes multiple objectives in A/B testing for AI and clinical trials.
problem Minimizing cumulative regret, maximizing CATE, and ensuring differential privacy in large-scale experiments.
method ConSE and DP-ConSE algorithms for sequential segmentation and elimination, achieving Pareto-optimal frontier.
result Privacy comes 'for free' in our framework, with only asymptotically negligible costs to regret and accuracy.
Method extracts time-localized clusters to explain deep learning models in ECG analysis.
problem Limited understanding of deep learning models in ECG analysis.
method Extracts time-localized clusters from model's internal representations.
result Enhances trust in AI-driven diagnostics and reveals clinically relevant patterns.
DNA sequencing to identify genetic variants is becoming increasingly valuable in clinical settings. Assessment of variants in such sequencing data is commonly implemented through Bayesian heuristic algorithms. Machine learning has shown great promise in improving on these variant calls, but the input for these is still…
Discovering oral cavity cancer (OCC) at an early stage is an effective way to increase patient survival rate. However, current initial screening process is done manually and is expensive for the average individual, especially in developing countries worldwide. This problem is further compounded due to the lack of speci…
Hybrid AI and rule-based framework de-identifies medical imaging data.
problem De-identifying medical imaging data to protect PHI and PII.
method Combines rule-based and AI techniques with uncertainty quantification.
result Robust performance across benchmark datasets and regulatory standards.