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2579 · Jul 202019922001200920172026
48 results for cell-type taxonomy

New system constructs cell-type taxonomy across multiple samples.

problem Challenges in matching clusters from different datasets.
method Combines Optimal Transport with Relaxed Marginal Constraints (OT-RMC) for simultaneous alignment of clusters across multiple samples.
result Highly accurate annotation of cell types and sample-level feature extraction.

New model identifies cell-specific genes for cancer prognosis.

problem No statistical model to integrate multiscale cancer data.
method Bayesian generalized promotion time cure models (GPTCMs).
result Improves cancer prognosis by identifying cell-specific genes.

MarkerMap selects key genes for cell type analysis in single-cell RNA-seq.

problem Selecting informative genes from large single-cell RNA-seq datasets is challenging and computationally intensive.
method MarkerMap is a generative model that identifies minimal gene sets explaining cell type variability.
result MarkerMap outperforms existing methods in both supervised and unsupervised marker selection.

We develop a latent variable model and an efficient spectral algorithm motivated by the recent emergence of very large data sets of chromatin marks from multiple human cell types. A natural model for chromatin data in one cell type is a Hidden Markov Model (HMM); we model the relationship between multiple cell types by…

2015-06-04abs ↗pdf ↗

Forest Fire Clustering discovers cell types from single-cell data.

problem Discovering cell types from large-scale single-cell sequencing data.
method Iterative label propagation and parallelized Monte Carlo simulation.
result Forest Fire Clustering outperforms state-of-the-art methods on diverse benchmarks.

New model clusters cells and individuals, revealing genetic influences on cell types.

problem Clustering nested data with group-level and observation-level variables.
method Nested Atoms Model (NAM), Bayesian nonparametric approach.
result Identifies clusters of genetically similar individuals with homogeneous cell-type profiles.

Recent developments in high throughput profiling of individual neurons have spurred data driven exploration of the idea that there exist natural groupings of neurons referred to as cell types. The promise of this idea is that the immense complexity of brain circuits can be reduced, and effectively studied by means of i…

2019-11-06abs ↗pdf ↗

GraphDINO learns neuronal morphologies from unlabeled data.

problem Unsupervised learning of neuronal morphologies from unlabeled data.
method Transformer-based approach with novel attention mechanism and data augmentation.
result GraphDINO yields morphological clusterings on par with expert classification.

Several real problems ranging from text classification to computational biology are characterized by hierarchical multi-label classification tasks. Most of the methods presented in literature focused on tree-structured taxonomies, but only few on taxonomies structured according to a Directed Acyclic Graph (DAG). In thi…

2014-06-17abs ↗pdf ↗

Clustering methods based on deep neural networks have proven promising for clustering real-world data because of their high representational power. In this paper, we propose a systematic taxonomy of clustering methods that utilize deep neural networks. We base our taxonomy on a comprehensive review of recent work and v…

2018-01-23abs ↗pdf ↗

We investigate sets of financial non-redundant and nonsynchronously recorded time series. The sets are composed by a number of stock market indices located all over the world in five continents. By properly selecting the time horizon of returns and by using a reference currency we find a meaningful taxonomy. The detect…

2000-01-19abs ↗pdf ↗

Donor-aware scRNA-seq benchmarks improve classification accuracy in inflammatory bowel disease.

problem Influenza disease classification from scRNA-seq data is prone to donor-level confounding.
method Developed and evaluated three feature representations across two IBD cohorts.
result Compartment-stratified CLR composition and GatedStructuralCFN embeddings outperform linear models in classification accuracy.

In this paper, a taxonomy for memory networks is proposed based on their memory organization. The taxonomy includes all the popular memory networks: vanilla recurrent neural network (RNN), long short term memory (LSTM ), neural stack and neural Turing machine and their variants. The taxonomy puts all these networks und…

2018-05-01abs ↗pdf ↗

TXtract extracts structured knowledge from thousands of product categories.

problem Extracting structured knowledge from diverse product categories in e-commerce.
method TXtract uses a taxonomy-aware model with category conditional self-attention and multi-task learning.
result TXtract outperforms state-of-the-art approaches by up to 10% in F1 and 15% in coverage across all categories.

Owners of a web-site are often interested in analysis of groups of users of their site. Information on these groups can help optimizing the structure and contents of the site. In this paper we use an approach based on formal concepts for constructing taxonomies of user groups. For decreasing the huge amount of concepts…

2009-05-09abs ↗pdf ↗

New taxonomy reveals different detection limits for various types of fraud.

problem Existing fraud detection treats all fraud as the same, ignoring its diverse forms.
method Introduced an observation-mechanism taxonomy with five fraud classes.
result Separate estimation by fraud class outperforms pooled estimation.

Being an unsupervised machine learning and data mining technique, biclustering and its multimodal extensions are becoming popular tools for analysing object-attribute data in different domains. Apart from conventional clustering techniques, biclustering is searching for homogeneous groups of objects while keeping their…

2017-02-17abs ↗pdf ↗

Research creates a taxonomy to bridge AI security and regulatory gaps.

problem Disciplinary disconnect between technical and legal teams in AI risk assessment.
method Developed an AI System Threat Vector Taxonomy with 9 domains and 53 sub-threats.
result Empirically validated and aligned with ISO/IEC 42001 controls and NIST AI RMF functions.

Deep learning identifies transcriptomic patterns and cell types associated with SARS-CoV-2 infection and COVID-19 severity.

problem Understanding how SARS-CoV-2 varies in infecting and causing severe COVID-19.
method Developed a new approach to generating self-supervised edge features, using Graph Attention Networks (GAT) and Set Transformer.
result Achieved state-of-the-art performance in predicting disease state of individual cells using single-cell RNA sequencing data.

TIMELY improves consistency in labeling blood cell images.

problem Inconsistent labeling of blood cells in microscopy images leads to unreliable diagnoses.
method TIMELY combines pseudotime inference and hidden Markov trees to correct labeling mistakes.
result TIMELY outperforms baseline methods in identifying and correcting inconsistent labels.

This work tackles manifold regression onto hyperbolic space for tree classification and taxonomy extension.

problem Performing manifold-valued regression onto an hyperbolic space for tree classification and taxonomy extension.
method Formulated as a manifold regression task in hyperbolic space, proposed a parametric deep learning model and a non-parametric kernel method.
result Hyperbolic-based estimators significantly outperform Euclidean space methods in taxonomy expansion.

The quantitative aspirations of economists and financial analysts have for many years been based on the belief that it should be possible to build models of economic systems - and financial markets in particular - that are as predictive as those in physics. While this perspective has led to a number of important breakt…

2010-03-13abs ↗pdf ↗