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arXiv research

A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.

168,694 papers · 148 categories

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151303454605 · Jun 202019922001200920172026
48 results for cell states

NESS improves neighbor embedding for smooth cell-state transitions in single-cell data.

problem Challenges in extracting smooth, low-dimensional representations from noisy single-cell data.
method Builds on PCS framework to develop NESS, a stable machine learning approach.
result NESS consistently yields useful biological insights across diverse single-cell datasets.

A new method for state estimation on complex networks.

problem Reconstructing latent dynamics from multivariate time-series on topological cell complexes.
method Topology-aware state space framework derived from stochastic partial differential equations, with state evolution following heat-like topological diffusion.
result The proposed method successfully recovers latent states and topological structures in real-world networks.

The Linear Attention Recurrent Neural Network (LARNN) is a recurrent attention module derived from the Long Short-Term Memory (LSTM) cell and ideas from the consciousness Recurrent Neural Network (RNN). Yes, it LARNNs. The LARNN uses attention on its past cell state values for a limited window size kk. The formulas ar…

2018-08-16abs ↗pdf ↗

SnapMMD forecasts cell differentiation outcomes from snapshot data.

problem Forecasting cell differentiation outcomes from limited snapshot data.
method SnapMMD learns dynamics by directly fitting the joint distribution of state measurements and observation time with MMD loss, allowing for unknown and state-dependent volatilities.
result SnapMMD delivers accurate forecasts and an R2-style statistic for diagnosing fit.

Forest Fire Clustering discovers cell types from single-cell data.

problem Discovering cell types from large-scale single-cell sequencing data.
method Iterative label propagation and parallelized Monte Carlo simulation.
result Forest Fire Clustering outperforms state-of-the-art methods on diverse benchmarks.

Extends NAS to learn both intra-cell and inter-cell architectures for language modeling.

problem Limited NAS systems restrict search to recurrent or convolutional cells.
method Designs a joint learning method to perform intra-cell and inter-cell NAS simultaneously.
result Significantly outperforms a strong baseline on PTB and WikiText data.

We develop a latent variable model and an efficient spectral algorithm motivated by the recent emergence of very large data sets of chromatin marks from multiple human cell types. A natural model for chromatin data in one cell type is a Hidden Markov Model (HMM); we model the relationship between multiple cell types by…

2015-06-04abs ↗pdf ↗

We introduce Independently Recurrent Long Short-term Memory cells: IndyLSTMs. These differ from regular LSTM cells in that the recurrent weights are not modeled as a full matrix, but as a diagonal matrix, i.e.\ the output and state of each LSTM cell depends on the inputs and its own output/state, as opposed to the inpu…

2019-03-19abs ↗pdf ↗

We study the problem of instance segmentation in biological images with crowded and compact cells. We formulate this task as an integer program where variables correspond to cells and constraints enforce that cells do not overlap. To solve this integer program, we propose a column generation formulation where the prici…

2017-09-21abs ↗pdf ↗

In this work we present a modification in the conventional flow of information through a LSTM network, which we consider well suited for RNNs in general. The modification leads to a iterative scheme where the computations performed by the LSTM cell are repeated over a constant input and cell state values, while updatin…

2018-07-11abs ↗pdf ↗

The process of morphogenesis, which can be defined as an evolution of the form of an organism, is one of the most intriguing mysteries in the life sciences. It is clear, that gene expression patterns cannot explain the development of the precise geometry of an organism and its parts in space. Here, we suggest a set of …

2012-05-05abs ↗pdf ↗

LSTMs and GRUs are the most common recurrent neural network architectures used to solve temporal sequence problems. The two architectures have differing data flows dealing with a common component called the cell state (also referred to as the memory). We attempt to enhance the memory by presenting a modification that w…

2018-08-04abs ↗pdf ↗

Deep learning identifies transcriptomic patterns and cell types associated with SARS-CoV-2 infection and COVID-19 severity.

problem Understanding how SARS-CoV-2 varies in infecting and causing severe COVID-19.
method Developed a new approach to generating self-supervised edge features, using Graph Attention Networks (GAT) and Set Transformer.
result Achieved state-of-the-art performance in predicting disease state of individual cells using single-cell RNA sequencing data.

CT improves neural network performance on cell complex data.

problem Improving predictive performance of neural networks on complex data.
method Introducing the Cellular Transformer (CT) that generalizes graph-based transformers to cell complexes.
result CT achieves state-of-the-art performance on cell complex datasets without complex enhancements.

TIMELY improves consistency in labeling blood cell images.

problem Inconsistent labeling of blood cells in microscopy images leads to unreliable diagnoses.
method TIMELY combines pseudotime inference and hidden Markov trees to correct labeling mistakes.
result TIMELY outperforms baseline methods in identifying and correcting inconsistent labels.

SimCD simultaneously clusters cells and identifies differential gene expression in scRNA-seq data.

problem Separate clustering and differential expression analysis for scRNA-seq data leads to suboptimal results.
method Develops SimCD, a unified hierarchical gamma-negative binomial model for simultaneous cell clustering and differential expression analysis.
result SimCD outperforms existing methods in discovering cell clusters and capturing dynamic expression changes.

CST-YOLO improves blood cell detection with YOLOv7 and CNN-Swin Transformer.

problem Small-scale object detection in blood cells.
method YOLOv7 architecture enhanced with CNN-Swin Transformer, W-ELAN, MCS, CatConv.
result CST-YOLO achieves 92.7%, 95.6%, and 91.1% mAP@0.5 on three blood cell datasets.

New features from early battery cycles predict lifetime with high accuracy.

problem Accurately predicting battery lifetime under varying conditions is challenging due to manufacturing variability and usage-dependent degradation.
method Extracted features from regularly scheduled reference performance tests and used them to predict battery lifetime using a hierarchical Bayesian regression model.
result Demonstrated a lifetime prediction of in-distribution cells with 15.1% mean absolute percentage error using only the first 15% of data.

Selecting the right drugs for the right patients is a primary goal of precision medicine. In this manuscript, we consider the problem of cancer drug selection in a learning-to-rank framework. We have formulated the cancer drug selection problem as to accurately predicting 1). the ranking positions of sensitive drugs an…

2018-01-23abs ↗pdf ↗

A novel criterion selects optimal distance metrics for cell profile analysis.

problem Determining the most accurate distance metric for high-dimensional cell profiles.
method Generalized proposition and corollaries to evaluate and select distance metrics.
result Wasserstein and cosine similarity metrics are optimal for general cases.

Better neural arithmetic logic units improve cell counting model generalization.

problem Neural networks struggle with high cell counts outside training data range.
method Introduced Neural Arithmetic Logic Units (NALU) for arithmetic operations in existing architectures.
result Improved cell counting accuracy for higher numeric ranges with better generalization.

New method learns cell trajectories and network interactions from single-cell data.

problem Network inference in systems biology from steady-state data.
method Min-entropy estimation for stochastic dynamics, leveraging both temporal and perturbational data.
result Jointly learns cellular trajectories and network interactions.

sgdGMF efficiently estimates generalized matrix factorization models for single-cell RNA sequencing data.

problem Challenges in dimensionality reduction for large single-cell RNA sequencing datasets.
method Scalable adaptive stochastic gradient descent algorithm for generalized matrix factorization models.
result sgdGMF outperforms existing methods in scalability and accuracy for large datasets.

Recurrent Neural Networks (RNN), Long Short-Term Memory Networks (LSTM), and Memory Networks which contain memory are popularly used to learn patterns in sequential data. Sequential data has long sequences that hold relationships. RNN can handle long sequences but suffers from the vanishing and exploding gradient probl…

2019-04-18abs ↗pdf ↗

It is shown how the coherent states permit to find different geometrical objects as the geodesics, the conjugate locus, the cut locus, the Calabi's diastasis and its domain of definition, the Euler-Poincaré characteristic, the number of Borel-Morse cells, the Kodaira embedding theorem.

1997-08-01abs ↗pdf ↗

There are time series that are amenable to recurrent neural network (RNN) solutions when treated as sequences, but some series, e.g. asynchronous time series, provide a richer variation of feature types than current RNN cells take into account. In order to address such situations, we introduce a unified RNN that handle…

2018-09-24abs ↗pdf ↗

The paper introduces a new σσ-LSTM cell for volatility forecasting using stylized facts.

problem Lack of explainability and stylized knowledge in neural network volatility modeling.
method Introduces a new σσ-LSTM cell with a stochastic processing layer, designed to incorporate stylized facts about volatility.
result Shows good out-of-sample forecasting performance with the σσ-LSTM cell.

Accurate and robust cell nuclei classification is the cornerstone for a wider range of tasks in digital and Computational Pathology. However, most machine learning systems require extensive labeling from expert pathologists for each individual problem at hand, with no or limited abilities for knowledge transfer between…

2016-06-02abs ↗pdf ↗

LOT framework embeds high-dimensional cell data into interpretable Euclidean space.

problem Lack of interpretable methods for high-dimensional cell data.
method Adapts Linear Optimal Transport (LOT) to irregular point clouds.
result Accurate and interpretable classification and synthetic data generation.

Long Short-Term Memory (LSTM) infers the long term dependency through a cell state maintained by the input and the forget gate structures, which models a gate output as a value in [0,1] through a sigmoid function. However, due to the graduality of the sigmoid function, the sigmoid gate is not flexible in representing m…

2019-05-25abs ↗pdf ↗

Complex numbers have long been favoured for digital signal processing, yet complex representations rarely appear in deep learning architectures. RNNs, widely used to process time series and sequence information, could greatly benefit from complex representations. We present a novel complex gated recurrent cell, which i…

2018-06-21abs ↗pdf ↗

Novel framework predicts cell responses to perturbations using GRNs.

problem Predicting cellular responses to perturbations for drug discovery and personalized therapeutics.
method Graph variational Bayesian causal inference framework with refined GRNs and robust estimator.
result Enhanced model performance and robust estimation of perturbation effects.