Few-shot cell segmentation from diverse sources to target domain.
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Novel framework for whole-slide blood cell segmentation.
We study the problem of instance segmentation in biological images with crowded and compact cells. We formulate this task as an integer program where variables correspond to cells and constraints enforce that cells do not overlap. To solve this integer program, we propose a column generation formulation where the prici…
This study automates blood cell classification using computer vision.
We introduce a novel Deep Learning framework, which quantitatively estimates image segmentation quality without the need for human inspection or labeling. We refer to this method as a Quality Assurance Network -- QANet. Specifically, given an image and a `proposed' corresponding segmentation, obtained by any method inc…
This paper provides a stratification of semi-algebraic sets in the plane with finitely many geodesic segments.
Algorithm generates adaptive confidence sets for instance segmentation with guaranteed coverage.
Improves U-Net for scale equivariance in semantic segmentation.
There are various algorithms and methodologies used for automated screening of cervical cancer by segmenting and classifying cervical cancer cells into different categories. This study presents a critical review of different research papers published that integrated AI methods in screening cervical cancer via different…
Convolutional neural networks (CNN) have achieved state of the art performance on both classification and segmentation tasks. Applying CNNs to microscopy images is challenging due to the lack of datasets labeled at the single cell level. We extend the application of CNNs to microscopy image classification and segmentat…
Determining the localization of specific protein in human cells is important for understanding cellular functions and biological processes of underlying diseases. Among imaging techniques, high-throughput fluorescence microscopy imaging is an efficient biotechnology to stain the protein of interest in a cell. In this w…
DVNet efficiently segments large neurovascular datasets using skip connections.
Analysis of flow cytometry data is an essential tool for clinical diagnosis of hematological and immunological conditions. Current clinical workflows rely on a manual process called gating to classify cells into their canonical types. This dependence on human annotation limits the rate, reproducibility, and complexity …
C2G-Net improves image classification of similar objects like cells.
Cellular Electron Cryo-Tomography (CECT) is a powerful 3D imaging tool for studying the native structure and organization of macromolecules inside single cells. For systematic recognition and recovery of macromolecular structures captured by CECT, methods for several important tasks such as subtomogram classification a…
Cellular Electron Cryo-Tomography (CECT) is a powerful imaging technique for the 3D visualization of cellular structure and organization at submolecular resolution. It enables analyzing the native structures of macromolecular complexes and their spatial organization inside single cells. However, due to the high degree …
Deep feature fusion improves mitosis counting accuracy.
This paper proposes grid cells encode position via a conformal isometric embedding of 2D physical space.
Electron Cryo-Tomography (ECT) allows 3D visualization of subcellular structures at the submolecular resolution in close to the native state. However, due to the high degree of structural complexity and imaging limits, the automatic segmentation of cellular components from ECT images is very difficult. To complement an…
Malaria is a female anopheles mosquito-bite inflicted life-threatening disease which is considered endemic in many parts of the world. This article focuses on improving malaria detection from patches segmented from microscopic images of red blood cell smears by introducing a deep convolutional neural network. Compared …
New framework segments 3D scenes using neural algorithms and sub-Riemannian geometry.
Analysis of histopathology slides is a critical step for many diagnoses, and in particular in oncology where it defines the gold standard. In the case of digital histopathological analysis, highly trained pathologists must review vast whole-slide-images of extreme digital resolution ( pixels) across multiple…
The visual systems of many mammals, including humans, is able to integrate the geometric information of visual stimuli and to perform cognitive tasks already at the first stages of the cortical processing. This is thought to be the result of a combination of mechanisms, which include feature extraction at single cell l…
Glioma is one of the most common types of brain tumors; it arises in the glial cells in the human brain and in the spinal cord. In addition to having a high mortality rate, glioma treatment is also very expensive. Hence, automatic and accurate segmentation and measurement from the early stages are critical in order to …
Clouds frequently cover the Earth's surface and pose an omnipresent challenge to optical Earth observation methods. The vast majority of remote sensing approaches either selectively choose single cloud-free observations or employ a pre-classification strategy to identify and mask cloudy pixels. We follow a different st…
In this paper, we introduce a new gait segmentation method based on accelerometer data and develop a new distance function between two time series, showing novel and effectiveness in simultaneously identifying user and adversary. Comparing with the normally used Neural Network methods, our approaches use geometric feat…
We consider polyhedra and 4-polytopes in Minkowski spacetime - in particular, null polyhedra with zero volume, and 4-polytopes that have such polyhedra as their hyperfaces. We present the basic properties of several classes of null-faced 4-polytopes: 4-simplices, "tetrahedral diamonds" and 4-parallelotopes. We propose …
Kernel testing compares cell states in single-cell data.
Generative models have achieved impressive results in many domains including image and text generation. In the natural sciences, generative models have led to rapid progress in automated drug discovery. Many of the current methods focus on either 1-D or 2-D representations of typically small, drug-like molecules. Howev…
New algorithm for computing Veech groups from translation surfaces.
This study reviews and evaluates clustering methods for single-cell RNA-seq data.
Cell detection and cell type classification from biomedical images play an important role for high-throughput imaging and various clinical application. While classification of single cell sample can be performed with standard computer vision and machine learning methods, analysis of multi-label samples (region containi…
Forest Fire Clustering discovers cell types from single-cell data.
Proposes CCCVAE for better single-cell clustering with cell-cell communication.
Matching cells over time has long been the most difficult step in cell tracking. In this paper, we approach this problem by recasting it as a classification problem. We construct a feature set for each cell, and compute a feature difference vector between a cell in the current frame and a cell in a previous frame. Then…
Improved GPLVM model for single-cell RNA-seq data.
Cluster LOCO: A model-agnostic feature importance score for interpreting cluster outputs
The study identifies all possible vector field structures on specific 2D shapes.
New model identifies cell-specific genes for cancer prognosis.
MarkerMap selects key genes for cell type analysis in single-cell RNA-seq.
Proposes CXNs for neural network computations on cell complexes.
New metric scores perturbations across populations, not cells, improving model comparison.
Cataloging the neuronal cell types that comprise circuitry of individual brain regions is a major goal of modern neuroscience and the BRAIN initiative. Single-cell RNA sequencing can now be used to measure the gene expression profiles of individual neurons and to categorize neurons based on their gene expression profil…
The process of morphogenesis, which can be defined as an evolution of the form of an organism, is one of the most intriguing mysteries in the life sciences. It is clear, that gene expression patterns cannot explain the development of the precise geometry of an organism and its parts in space. Here, we suggest a set of …
Hippocampal dentate granule cells are among the few neuronal cell types generated throughout adult life in mammals. In the normal brain, new granule cells are generated from progenitors in the subgranular zone and integrate in a typical fashion. During the development of epilepsy, granule cell integration is profoundly…
NESS improves neighbor embedding for smooth cell-state transitions in single-cell data.
New model clusters cells and individuals, revealing genetic influences on cell types.
Cell-based NAS search spaces are redundant and lack novelty.