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arXiv research

A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.

168,695 papers · 148 categories

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7152229 · Jun 202019922001200920172026
48 results for cell cultures

Optimized biopharmaceutical seed train design reduces variability and saves time.

problem Designing robust biotechnological processes with cell cultures.
method Coupling uncertainty-based upstream simulation and Bayes optimization using Gaussian processes.
result Optimized seed train design results in lower cell density variability and reduced process duration.

Optimizes biomanufacturing processes with a new digital twin calibration method.

problem Lack of interpretability and sample efficiency in traditional DoE methods.
method Developed a computational approach to calibrate Bio-SoS digital twin model.
result Guides sample-efficient and interpretable DoEs by quantifying sub-model parameter estimation errors.

Multi-domain learning (MDL) aims at obtaining a model with minimal average risk across multiple domains. Our empirical motivation is automated microscopy data, where cultured cells are imaged after being exposed to known and unknown chemical perturbations, and each dataset displays significant experimental bias. This p…

2019-03-21abs ↗pdf ↗

Examines algorithmic modeling across three cultures.

problem Tackles algorithmic modeling in different cultural contexts.
method Uses parametric regressions, interpretable algorithms, and complex algorithms.
result Extension of Leo Breiman's thesis to include cultural differences.

Social interactions and personal tastes shape our consumption behavior of cultural products. In this study, we present a computational model of a cultural market and we aim to analyze the behavior of the consumer population as an emergent phenomena. Our results suggest that the final market shares of cultural products …

2007-07-16abs ↗pdf ↗

Breiman discusses two statistical cultures, advocating for more research on 'before' and 'after' the black box.

problem Statistical modeling lacks exploration of processes before and after the 'black box'.
method Analyzes Breiman's visual metaphor of two statistical cultures.
result Promotes the importance of studying the 'before' and 'after' of data transformations.

Profiling cellular phenotypes from microscopic imaging can provide meaningful biological information resulting from various factors affecting the cells. One motivating application is drug development: morphological cell features can be captured from images, from which similarities between different drug compounds appli…

2017-11-02abs ↗pdf ↗

We study the relationship between national culture and the disposition effect by investigating international differences in the degree of investors' disposition effect. We utilize brokerage data of 387,993 traders from 83 countries and find great variation in the degree of the disposition effect across the world. We fi…

2019-08-30abs ↗pdf ↗

Study introduces KorFinMTEB for Korean financial texts, revealing model limitations.

problem Limited evaluation benchmarks for low-resource domains, especially Korean.
method Developed KorFinMTEB, a tailored benchmark for Korean financial texts.
result Models perform better on translated benchmarks than on domain-specific ones.

Paper develops a framework to discover bioprocessing regulatory mechanisms using symbolic and statistical learning.

problem Challenges in modeling complex intracellular regulation, stochastic system behavior, and limited experimental data.
method Symbolic and statistical learning framework based on stochastic differential equations and Bayesian learning.
result Improved sample efficiency and robust model selection compared to state-of-the-art approaches.

The study finds solar terms significantly impact China's stock market returns and volatility.

problem Investigating the effect of solar terms on China's stock market.
method Regression framework, analyzing multiple solar terms and their impact on return and volatility.
result Solar terms 1, 3, and 4 cause significant positive returns, while 8, 11, and 14 bring high volatility.

Introduces MPR to measure and optimize representation across intersectional groups in retrieval.

problem Harmful stereotypes, cultural erasure, and social disparities in image search and retrieval.
method Develops MPR metric, practical estimation methods, theoretical guarantees, and optimization algorithms.
result Optimizing MPR yields more proportional representation across multiple intersectional groups, often with minimal retrieval accuracy compromise.

Popular culture has contemplated societies of thinking machines for generations, envisioning futures from utopian to dystopian. These futures are, arguably, here now-we find ourselves at the doorstep of technology that can at least simulate the appearance of thinking, acting, and feeling. The real question is: now what…

2019-08-30abs ↗pdf ↗

Forest Fire Clustering discovers cell types from single-cell data.

problem Discovering cell types from large-scale single-cell sequencing data.
method Iterative label propagation and parallelized Monte Carlo simulation.
result Forest Fire Clustering outperforms state-of-the-art methods on diverse benchmarks.

Proposes CCCVAE for better single-cell clustering with cell-cell communication.

problem Improving single-cell RNA sequencing clustering by incorporating cell-cell communication.
method Integrates cell-cell communication into a variational autoencoder framework.
result Empirical results show CCCVAE outperforms standard VAEs in clustering performance.

Matching cells over time has long been the most difficult step in cell tracking. In this paper, we approach this problem by recasting it as a classification problem. We construct a feature set for each cell, and compute a feature difference vector between a cell in the current frame and a cell in a previous frame. Then…

2012-07-13abs ↗pdf ↗

Improved GPLVM model for single-cell RNA-seq data.

problem Lack of effective scalable models for clustering cell types in large-scale single-cell RNA-seq data.
method Introduces amortized stochastic variational Bayesian GPLVM (BGPLVM) tailored for single-cell RNA-seq.
result Matches the performance of scVI on synthetic and real-world datasets and reveals more interpretable latent structures.

Spin networks are at the core of quantum gravity. Our aim is to plug the mathematical community at large into the procedures turn to create a finite quantum theory of general relativity. For this, because of the different cultural backgraund, we would like to change the tack: to relate discrete (combinatorial) objects …

2000-11-05abs ↗pdf ↗

A Human-in-the-Loop Bayesian Optimization framework for constraint-aware bioprocess development.

problem Bioprocess development
method Pareto Front Guided Sampling (PFGS) with Bayesian Optimization (BO)
result Systematic identification of high-performing, feasibility-compliant, and perturbation-resilient operating conditions.

The study identifies all possible vector field structures on specific 2D shapes.

problem Optimal discrete gradient vector fields on surfaces with 1-2 critical cells.
method Analysis of discrete vector fields on 2D shapes with minimal critical cells.
result All possible structures of discrete Morse functions on specified shapes.

New model identifies cell-specific genes for cancer prognosis.

problem No statistical model to integrate multiscale cancer data.
method Bayesian generalized promotion time cure models (GPTCMs).
result Improves cancer prognosis by identifying cell-specific genes.

MarkerMap selects key genes for cell type analysis in single-cell RNA-seq.

problem Selecting informative genes from large single-cell RNA-seq datasets is challenging and computationally intensive.
method MarkerMap is a generative model that identifies minimal gene sets explaining cell type variability.
result MarkerMap outperforms existing methods in both supervised and unsupervised marker selection.

New metric scores perturbations across populations, not cells, improving model comparison.

problem Single-cell perturbation data overlaps, making per-cell accuracy unreliable.
method Average per-cell probability vectors over all cells of a perturbation to form a population profile and rank candidate perturbations.
result Classifier Discrimination Score (CDS) identifies true perturbation more reliably than pseudobulk-based scores.