Optimized biopharmaceutical seed train design reduces variability and saves time.
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Understanding the morphological changes of primary neuronal cells induced by chemical compounds is essential for drug discovery. Using the data from a single high-throughput imaging assay, a classification model for predicting the biological activity of candidate compounds was introduced. The image recognition model wh…
Optimizes biomanufacturing processes with a new digital twin calibration method.
Multi-domain learning (MDL) aims at obtaining a model with minimal average risk across multiple domains. Our empirical motivation is automated microscopy data, where cultured cells are imaged after being exposed to known and unknown chemical perturbations, and each dataset displays significant experimental bias. This p…
Enhances content moderation with culturally-aware models.
Cultural activity is an inherent aspect of urban life and the success of a modern city is largely determined by its capacity to offer generous cultural entertainment to its citizens. To this end, the optimal allocation of cultural establishments and related resources across urban regions becomes of vital importance, as…
Breiman's two cultures reconciled through blending statistical thinking.
Examines algorithmic modeling across three cultures.
Social interactions and personal tastes shape our consumption behavior of cultural products. In this study, we present a computational model of a cultural market and we aim to analyze the behavior of the consumer population as an emergent phenomena. Our results suggest that the final market shares of cultural products …
Breiman discusses two statistical cultures, advocating for more research on 'before' and 'after' the black box.
Breiman (2001) proposed to statisticians awareness of two cultures: 1. Parametric modeling culture, pioneered by R.A.Fisher and Jerzy Neyman; 2. Algorithmic predictive culture, pioneered by machine learning research. Parzen (2001), as a part of discussing Breiman (2001), proposed that researchers be aware of many cultu…
Rapid identification of bacteria is essential to prevent the spread of infectious disease, help combat antimicrobial resistance, and improve patient outcomes. Raman optical spectroscopy promises to combine bacterial detection, identification, and antibiotic susceptibility testing in a single step. However, achieving cl…
Profiling cellular phenotypes from microscopic imaging can provide meaningful biological information resulting from various factors affecting the cells. One motivating application is drug development: morphological cell features can be captured from images, from which similarities between different drug compounds appli…
Commentary on Rashomon Effect complicating model selection.
One of the fundamental questions of cultural evolutionary research is how individual-level processes scale up to generate population-level patterns. Previous studies in music have revealed that frequency-based bias (e.g. conformity and novelty) drives large-scale cultural diversity in different ways across domains and …
We study the relationship between national culture and the disposition effect by investigating international differences in the degree of investors' disposition effect. We utilize brokerage data of 387,993 traders from 83 countries and find great variation in the degree of the disposition effect across the world. We fi…
Recent work has studied the emergence of language among deep reinforcement learning agents that must collaborate to solve a task. Of particular interest are the factors that cause language to be compositional -- i.e., express meaning by combining words which themselves have meaning. Evolutionary linguists have found th…
Town hall discusses AI's impact on statistics, culture, and training.
The development of real-time affect detection models often depends upon obtaining annotated data for supervised learning by employing human experts to label the student data. One open question in annotating affective data for affect detection is whether the labelers (i.e., human experts) need to be socio-culturally sim…
Weak supervision challenges black-box models, suggesting fusion of modeling cultures.
Study introduces KorFinMTEB for Korean financial texts, revealing model limitations.
The Audio/Visual Emotion Challenge and Workshop (AVEC 2019) "State-of-Mind, Detecting Depression with AI, and Cross-cultural Affect Recognition" is the ninth competition event aimed at the comparison of multimedia processing and machine learning methods for automatic audiovisual health and emotion analysis, with all pa…
Paper develops a framework to discover bioprocessing regulatory mechanisms using symbolic and statistical learning.
The study finds solar terms significantly impact China's stock market returns and volatility.
There is a growing need for fast and accurate methods for testing developmental neurotoxicity across several chemical exposure sources. Current approaches, such as in vivo animal studies, and assays of animal and human primary cell cultures, suffer from challenges related to time, cost, and applicability to human physi…
The surfaces of many cultural heritage objects were embellished with various patterns, especially curve patterns. In practice, most of the unearthed cultural heritage objects are highly fragmented, e.g., sherds of potteries or vessels, and each of them only shows a very small portion of the underlying full design, with…
The presence of bacteria or fungi in the bloodstream of patients is abnormal and can lead to life-threatening conditions. A computational model based on a bidirectional long short-term memory artificial neural network, is explored to assist doctors in the intensive care unit to predict whether examination of blood cult…
We introduce MosAIc, an interactive web app that allows users to find pairs of semantically related artworks that span different cultures, media, and millennia. To create this application, we introduce Conditional Image Retrieval (CIR) which combines visual similarity search with user supplied filters or "conditions". …
Recently, mobile operators in many developing economies have launched "Mobile Money" platforms that deliver basic financial services over the mobile phone network. While many believe that these services can improve the lives of the poor, a consistent difficulty has been identifying individuals most likely to benefit fr…
The paper argues for a social-economic approach to AI development.
Encouraging sustainable mobility patterns is at the forefront of policymaking at all scales of governance as the collective consciousness surrounding climate change continues to expand. Not every community, however, possesses the necessary economic or socio-cultural capital to encourage modal shifts away from private m…
Introduces MPR to measure and optimize representation across intersectional groups in retrieval.
Kernel testing compares cell states in single-cell data.
Popular culture has contemplated societies of thinking machines for generations, envisioning futures from utopian to dystopian. These futures are, arguably, here now-we find ourselves at the doorstep of technology that can at least simulate the appearance of thinking, acting, and feeling. The real question is: now what…
Cell detection and cell type classification from biomedical images play an important role for high-throughput imaging and various clinical application. While classification of single cell sample can be performed with standard computer vision and machine learning methods, analysis of multi-label samples (region containi…
Forest Fire Clustering discovers cell types from single-cell data.
Proposes CCCVAE for better single-cell clustering with cell-cell communication.
Matching cells over time has long been the most difficult step in cell tracking. In this paper, we approach this problem by recasting it as a classification problem. We construct a feature set for each cell, and compute a feature difference vector between a cell in the current frame and a cell in a previous frame. Then…
Improved GPLVM model for single-cell RNA-seq data.
Spin networks are at the core of quantum gravity. Our aim is to plug the mathematical community at large into the procedures turn to create a finite quantum theory of general relativity. For this, because of the different cultural backgraund, we would like to change the tack: to relate discrete (combinatorial) objects …
A Human-in-the-Loop Bayesian Optimization framework for constraint-aware bioprocess development.
The study identifies all possible vector field structures on specific 2D shapes.
New model identifies cell-specific genes for cancer prognosis.
MarkerMap selects key genes for cell type analysis in single-cell RNA-seq.
Proposes CXNs for neural network computations on cell complexes.
In recent years, the advances in single-cell RNA-seq techniques have enabled us to perform large-scale transcriptomic profiling at single-cell resolution in a high-throughput manner. Unsupervised learning such as data clustering has become the central component to identify and characterize novel cell types and gene exp…
New metric scores perturbations across populations, not cells, improving model comparison.
Cataloging the neuronal cell types that comprise circuitry of individual brain regions is a major goal of modern neuroscience and the BRAIN initiative. Single-cell RNA sequencing can now be used to measure the gene expression profiles of individual neurons and to categorize neurons based on their gene expression profil…