Better neural arithmetic logic units improve cell counting model generalization.
problem Neural networks struggle with high cell counts outside training data range.
method Introduced Neural Arithmetic Logic Units (NALU) for arithmetic operations in existing architectures.
result Improved cell counting accuracy for higher numeric ranges with better generalization.
Automatically counts microglial cells in rat spinal cord images, providing precise counts and uncertainty estimates.
problem Counting microglial cells in small, heterogeneous datasets is time-consuming and requires extensive training.
method Pre-processing to filter images, designing a non-parametric, non-linear kernel counter, providing uncertainty estimation.
result The method can provide precise counts and uncertainty estimates in small datasets, even with expert opinions.
We construct a small regular cellular decomposition of the Fulton MacPherson operad FM2 that is compatible with the operad composition. The cells are indexed by trees with edges of two colors and vertices labelled by cells of the cacti operad. We compute the generating functions counting the cells, that are algebrai…
TIMELY improves consistency in labeling blood cell images.
problem Inconsistent labeling of blood cells in microscopy images leads to unreliable diagnoses.
method TIMELY combines pseudotime inference and hidden Markov trees to correct labeling mistakes.
result TIMELY outperforms baseline methods in identifying and correcting inconsistent labels.
Method improves microbial biomass yield estimation from noisy data.
problem Estimating microbial biomass yields from noisy cell counts and substrate measurements.
method Probabilistic macrochemical modeling to relax cell weight assumptions and improve robustness.
result Model provides accurate uncertainty estimates of key parameters.
SimCD simultaneously clusters cells and identifies differential gene expression in scRNA-seq data.
problem Separate clustering and differential expression analysis for scRNA-seq data leads to suboptimal results.
method Develops SimCD, a unified hierarchical gamma-negative binomial model for simultaneous cell clustering and differential expression analysis.
result SimCD outperforms existing methods in discovering cell clusters and capturing dynamic expression changes.
In this paper we examine a possible reason for the LSTM outperforming the GRU on language modeling and more specifically machine translation. We hypothesize that this has to do with counting. This is a consistent theme across the literature of long term dependence, counting, and language modeling for RNNs. Using the si…
Each woman living in the United States has about 1 in 8 chance of developing invasive breast cancer. The mitotic cell count is one of the most common tests to assess the aggressiveness or grade of breast cancer. In this prognosis, histopathology images must be examined by a pathologist using high-resolution microscopes…
Motivation: Single cell transcriptome sequencing (scRNA-Seq) has become a revolutionary tool to study cellular and molecular processes at single cell resolution. Among existing technologies, the recently developed droplet-based platform enables efficient parallel processing of thousands of single cells with direct coun…
Counting is a fundamental task in biomedical imaging and count is an important biomarker in a number of conditions. Estimating the uncertainty in the measurement is thus vital to making definite, informed conclusions. In this paper, we first compare a range of existing methods to perform counting in medical imaging and…
Flow Matching for count data improves sample quality and efficiency.
problem Mapping between count distributions across batches or time points in high-dimensional count data.
method count-FM, a flow-matching framework based on a continuous-time birth-death process with local unit jumps.
result count-FM achieves better sample quality than representative baselines while using fewer parameters.
Researchers found all embeddings of Kuratowski graphs on a double torus.
problem Characterizing embeddings of Kuratowski graphs K3,3 and K5 on the double torus. method Constructive approach using Burnside's Lemma and automorphism groups.
result 14 orientable and 17 non-orientable 2-cell embeddings of K5 on the double torus. New model generates realistic single-cell gene expression data.
problem Generating realistic single-cell gene expression profiles is challenging.
method scLDM, a latent diffusion model using Diffusion Transformers and linear interpolants.
result Superior performance in generating realistic single-cell gene expression data.
Counting and classifying blood cells is an important diagnostic tool in medicine. Support Vector Machines are increasingly popular and efficient and could replace artificial neural network systems. Here a method to classify blood cells is proposed using SVM. A set of statistics on images are implemented in C++. The MPE…
Researchers infer gene activity in dividing cells, accounting for protein inheritance and division history.
problem Inferring protein production kinetics in dividing cells due to protein inheritance and division history.
method Adapted conditional normalizing flows to approximate intractable likelihoods from simulated data.
result Glc3 gene is mostly inactive under stress, with brief and transient expression.
In this brief sequel to a previous article, we recall the notion of a cut cellular surface (CCS), being a surface with boundary, which is cut in a specified way to be represented in the plane, and is composed of 0-, 1- and 2-cells. We obtain invariants of CCS's under Pachner-like moves on the cellular structure, by cou…
Recently V. Krushkal and D. Renardy generalized the Tutte polynomial from graphs to cell complexes. We show that evaluating this polynomial at the origin gives the number of cellular spanning trees in the sense of A. Duval, C. Klivans, and J. Martin. Moreover, after a slight modification, the Tutte-Krushkal-Renardy pol…
We introduce the notion of a cut cellular surface (CCS), being a surface with boundary, which is cut in a specified way to be represented in the plane, and is composed of 0-, 1- and 2-cells. We obtain invariants of CCS's under Pachner-like moves on the cellular structure, by counting colourings of the 1-cells with elem…
Develops a new neural spike train decoding framework using topological data.
problem Decoding neural spike trains from head direction and grid cells.
method Combines simplicial complex discovery with deep learning to capture higher-order connectivity.
result Demonstrates effectiveness on head direction and trajectory prediction datasets.
New hypergraph method improves scRNA-seq clustering.
problem Loss of higher-order information and overestimation in coexpression networks.
method Conceptualizing scRNA-seq data as hypergraphs and proposing novel clustering methods.
result Proposed methods outperform existing methods on simulated and real datasets.
The paper improves Fisher-Pitman tests for Poisson mixtures, detecting autism-related genes.
problem Detecting differentially expressed genes between autism and control subjects.
method Nonparametric Poisson mixtures and Fisher-Pitman permutation tests.
result The tests reveal genes missed by common methods, demonstrating rate optimality.
This article introduces planar ribbons, Vergili ribbon complexes and ribbon nerves in Alexandroff-Hopf-Whitehead CW (Closure finite Weak) topological spaces. A {\em planar ribbon} (briefly, {ribbon}) in a CW space is the closure of a pair of nesting, non-concentric filled cycles that includes the boundary but does not …
USP test improves on Pearson's chi-squared and G-test for independence.
problem Deficiencies in Pearson's chi-squared and G-test for independence. method USP test based on U-statistic estimator of population dependence measure. result USP test controls size, handles small cell counts, and detects minimal violations of independence.
Proposes PSCCA for estimating correlations and canonical correlations in sparse count data.
problem Estimating correlations and canonical correlations in sparse count data from next-generation sequencing.
method Probabilistic approach for sparse count data sets (PSCCA).
result PSCCA outperforms other methods in estimating true correlations and canonical correlations at the natural parameter level.
This article introduces vortex nerve complexes in CW (Closure finite Weak) topological spaces, which first appeared in works by P. Alexandroff, H. Hopf and J.H.C. Whitehead during the 1930s. A vortex nerve is a CW complex containing one or more intersecting path-connected cycles. Each vortex nerve has its own distincti…
Manual count of mitotic figures, which is determined in the tumor region with the highest mitotic activity, is a key parameter of most tumor grading schemes. It can be, however, strongly dependent on the area selection due to uneven mitotic figure distribution in the tumor section.We aimed to assess the question, how s…
Foraminifera are single-celled marine organisms, which may have a planktic or benthic lifestyle. During their life cycle they construct shells consisting of one or more chambers, and these shells remain as fossils in marine sediments. Classifying and counting these fossils have become an important tool in e.g. oceanogr…
Paper introduces ZIPTF and C-ZIPTF for better tensor factorization of zero-inflated count data.
problem Inefficient tensor factorization for zero-inflated count data, especially in scRNA-seq.
method Zero Inflated Poisson Tensor Factorization (ZIPTF) and Consensus Zero Inflated Poisson Tensor Factorization (C-ZIPTF).
result ZIPTF and C-ZIPTF improve tensor factorization accuracy and consistency for zero-inflated count data.
The paper tackles extrapolation of gene knockouts effects on RNA counts.
problem Modeling effects of gene knockouts on RNA counts for new perturbations.
method Formulated as a latent variable model with additive perturbation effects, proved identifiability, proposed PDAE for estimation.
result PDAE can accurately predict effects of unseen but identifiable perturbations.
The study analyzes local minima in ReLU networks and finds low probability of bad local minima.
problem Understanding the existence and probability of local minima in ReLU networks.
method Theoretical analysis combined with linear programming and experiments on MNIST and CIFAR-10 datasets.
result No bad differentiable local minima found almost everywhere in weight space.
The paper examines topological features of ReLU networks and their relation to decision boundaries and training loss.
problem Understanding the topological structure of ReLU neural network activation patterns.
method Polytope decomposition of feature space, Fiedler partition of dual graph, homology computation of cellular decomposition.
result The Fiedler partition of the dual graph correlates with decision boundaries in binary classification tasks, and similar patterns in training loss and polyhedral cell-count emerge in regression tasks.
Estimates unknown population sizes using the hypergeometric distribution.
problem Estimating discrete distributions with unknown population sizes and category sizes.
method Proposes a novel solution using the hypergeometric likelihood, accounting for a data generating process with a latent variable.
result Empirically demonstrates superior performance in estimating population sizes and learning latent spaces compared to other methods.
New model estimates sparse transport maps for high-dimensional data.
problem Estimating optimal transport maps in high-dimensional spaces.
method Proposes a new model using a family of translation invariant costs and sparsity-inducing norms.
result Sparse transport maps that apply Occam's razor to reduce complexity.
Kernel testing compares cell states in single-cell data.
problem Comparing non-linear cell states in single-cell data.
method Kernel-based testing framework for non-linear distribution comparison.
result Identifies subtle population variations in cell states.
Cell detection and cell type classification from biomedical images play an important role for high-throughput imaging and various clinical application. While classification of single cell sample can be performed with standard computer vision and machine learning methods, analysis of multi-label samples (region containi…
Forest Fire Clustering discovers cell types from single-cell data.
problem Discovering cell types from large-scale single-cell sequencing data.
method Iterative label propagation and parallelized Monte Carlo simulation.
result Forest Fire Clustering outperforms state-of-the-art methods on diverse benchmarks.
Proposes CCCVAE for better single-cell clustering with cell-cell communication.
problem Improving single-cell RNA sequencing clustering by incorporating cell-cell communication.
method Integrates cell-cell communication into a variational autoencoder framework.
result Empirical results show CCCVAE outperforms standard VAEs in clustering performance.
Matching cells over time has long been the most difficult step in cell tracking. In this paper, we approach this problem by recasting it as a classification problem. We construct a feature set for each cell, and compute a feature difference vector between a cell in the current frame and a cell in a previous frame. Then…
Improved GPLVM model for single-cell RNA-seq data.
problem Lack of effective scalable models for clustering cell types in large-scale single-cell RNA-seq data.
method Introduces amortized stochastic variational Bayesian GPLVM (BGPLVM) tailored for single-cell RNA-seq.
result Matches the performance of scVI on synthetic and real-world datasets and reveals more interpretable latent structures.
The study identifies all possible vector field structures on specific 2D shapes.
problem Optimal discrete gradient vector fields on surfaces with 1-2 critical cells.
method Analysis of discrete vector fields on 2D shapes with minimal critical cells.
result All possible structures of discrete Morse functions on specified shapes.
Many applications in data analysis begin with a set of points in a Euclidean space that is partitioned into clusters. Common tasks then are to devise a classifier deciding which of the clusters a new point is associated to, finding outliers with respect to the clusters, or identifying the type of clustering used for th…
Characterizes Lamé equations with finite monodromy on flat tori.
problem Classifying Lamé equations with finite monodromy on flat tori.
method Combining dessin d'enfants with geometry of spherical tori to prove existence and provide descriptions.
result Finiteness of (B,τ) for given (n,M) with not∈frac12+Z and explicit counting formula. New model identifies cell-specific genes for cancer prognosis.
problem No statistical model to integrate multiscale cancer data.
method Bayesian generalized promotion time cure models (GPTCMs).
result Improves cancer prognosis by identifying cell-specific genes.
MarkerMap selects key genes for cell type analysis in single-cell RNA-seq.
problem Selecting informative genes from large single-cell RNA-seq datasets is challenging and computationally intensive.
method MarkerMap is a generative model that identifies minimal gene sets explaining cell type variability.
result MarkerMap outperforms existing methods in both supervised and unsupervised marker selection.
Proposes CXNs for neural network computations on cell complexes.
problem Performing neural network computations on complex topological spaces.
method Introduces a message passing scheme and a unified encoder-decoder framework for cell complexes.
result Generalizes message passing to cell complexes and provides a cell2vec representation.
In recent years, the advances in single-cell RNA-seq techniques have enabled us to perform large-scale transcriptomic profiling at single-cell resolution in a high-throughput manner. Unsupervised learning such as data clustering has become the central component to identify and characterize novel cell types and gene exp…
New metric scores perturbations across populations, not cells, improving model comparison.
problem Single-cell perturbation data overlaps, making per-cell accuracy unreliable.
method Average per-cell probability vectors over all cells of a perturbation to form a population profile and rank candidate perturbations.
result Classifier Discrimination Score (CDS) identifies true perturbation more reliably than pseudobulk-based scores.
Cataloging the neuronal cell types that comprise circuitry of individual brain regions is a major goal of modern neuroscience and the BRAIN initiative. Single-cell RNA sequencing can now be used to measure the gene expression profiles of individual neurons and to categorize neurons based on their gene expression profil…