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168,742 papers · 148 categories

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8162331 · Oct 201919922001200920172026
48 results for brain connectomics

Large bundles of myelinated axons, called white matter, anatomically connect disparate brain regions together and compose the structural core of the human connectome. We recently proposed a method of measuring the local integrity along the length of each white matter fascicle, termed the local connectome. If communicat…

2018-04-22abs ↗pdf ↗

In statistical connectomics, the quantitative study of brain networks, estimating the mean of a population of graphs based on a sample is a core problem. Often, this problem is especially difficult because the sample or cohort size is relatively small, sometimes even a single subject. While using the element-wise sampl…

2016-09-06abs ↗pdf ↗

We present two related methods for deriving connectivity-based brain atlases from individual connectomes. The proposed methods exploit a previously proposed dense connectivity representation, termed continuous connectivity, by first performing graph-based hierarchical clustering of individual brains, and subsequently a…

2018-08-10abs ↗pdf ↗

Functional MRI (fMRI) and diffusion MRI (dMRI) are non-invasive imaging modalities that allow in-vivo analysis of a patient's brain network (known as a connectome). Use of these technologies has enabled faster and better diagnoses and treatments of neurological disorders and a deeper understanding of the human brain. R…

2016-11-26abs ↗pdf ↗

R-PLS improves analysis of brain functional connectivity matrices.

problem Improving analysis of functional connectivity matrices in brain imaging.
method Introducing R-PLS, a generalization of PLS for symmetric positive definite matrices.
result R-PLS identifies key functional connections in brain imaging datasets.

Framework integrates brain connectivity data for clinical predictions.

problem Predicting clinical outcomes from brain connectivity data.
method Structurally-regularized Dynamic Dictionary Learning (sr-DDL) and LSTM-ANN block.
result Framework outperforms state-of-the-art approaches in clinical outcome prediction.

Unified model learns joint and individual features from brain imaging data.

problem Integrating structural and functional connectivity data for behavioral phenotypes.
method Cross-Modal Joint-Individual Variational Network (CM-JIVNet) with multi-head attention fusion.
result CM-JIVNet outperforms in cross-modal reconstruction and behavioral trait prediction.

A new mathematical approach detects frequency-based alterations in brain networks.

problem Understanding disease-relevant brain alterations through network analysis.
method Proposes a novel connectome harmonic analysis framework using common harmonic waves learned from Stiefel manifolds.
result Identifies more significant and reproducible network dysfunction patterns in Alzheimer's disease.

Paper proposes a novel method to estimate differential networks using additional knowledge.

problem Estimating differential statistical dependency networks in high-dimensional data with limited samples.
method Integrates various sources of knowledge beyond data samples to improve differential network estimation.
result Achieves sharp asymptotic convergence rate and improved differential network estimation.

Study predicts gender from brain FC at multiple scales using deep learning and Bayesian methods.

problem Predicting gender from brain functional connectivity.
method Deep learning and Bayesian deep learning applied to brain FC data from 1003 healthy adults.
result Bayesian deep learning provides accurate predictions and uncertainty information.

GFA model uncovers brain-behavior associations in incomplete data sets.

problem Incomplete data sets and lack of robust statistical inferences.
method Hierarchical Bayesian model that handles missing data and models modality-specific associations.
result GFA identified four relevant shared factors and predicted non-imaging measures from brain connectivity.

Develops a new tensor model for clustering with degree correction.

problem Clustering with unknown degree heterogeneity in multiway data.
method Degree-corrected tensor block model with estimation guarantees.
result Demonstrates an intrinsic statistical-to-computational gap for tensors of order three or greater.

The paper characterizes brain states and transitions using functional MRI data.

problem Characterizing the dynamic reconfiguration of neural systems in brain states.
method Bayesian model-based characterization of latent brain states and posterior predictive discrepancy using the latent block model.
result The model detects transitions between latent brain states and identifies distinctive community patterns in task-fMRI data.

Method predicts brain regions for neuroimaging phenotypes.

problem Predicting phenotypes from brain networks without static community structure.
method Supervised community detection using block-structured regularization and ADMM optimization.
result The method identifies task-specific brain regions that improve phenotype prediction.

Generative model predicts multiple brain graphs from one, preserving topology.

problem Predicting multiple brain graphs from a single one, preserving topology.
method MultiGraphGAN architecture, graph adversarial auto-encoder, cluster-specific decoders, topological loss.
result Significantly outperformed variants in multi-view brain graph generation.

Unified model combines neural networks and dictionary learning for clinical predictions from brain data.

problem Predicting clinical severity from brain imaging data.
method Combines neural networks with dictionary learning to model patient-specific and shared features.
result Unified model outperforms state-of-the-art methods in predicting clinical severity.

Stochastic encoding improves gender classification of brain networks from UK Biobank data.

problem Complexity and bias in interpreting deep learning models of brain connectivity.
method Stochastic encoding in ensemble of CNNs, multivariate balancing algorithm.
result AUROC of 0.8459, with resting-state data more accurate than task data.

Enhances disease progression modeling using LLMs for complex brain connectivity.

problem Inaccurate predictions of disease spread due to oversimplified brain connectivity models.
method Uses LLMs to synthesize multi-modal relationships and learn disease trajectories from longitudinal data.
result Superior prediction accuracy and interpretability compared to traditional methods.

While statistical analysis of a single network has received a lot of attention in recent years, with a focus on social networks, analysis of a sample of networks presents its own challenges which require a different set of analytic tools. Here we study the problem of classification of networks with labeled nodes, motiv…

2017-01-27abs ↗pdf ↗

The application of deep learning (DL) models to the decoding of cognitive states from whole-brain functional Magnetic Resonance Imaging (fMRI) data is often hindered by the small sample size and high dimensionality of these datasets. Especially, in clinical settings, where patient data are scarce. In this work, we demo…

2019-07-02abs ↗pdf ↗

The application of deep learning (DL) models to neuroimaging data poses several challenges, due to the high dimensionality, low sample size and complex temporo-spatial dependency structure of these datasets. Even further, DL models act as as black-box models, impeding insight into the association of cognitive state and…

2018-10-23abs ↗pdf ↗

ST-GCN improves rs-fMRI prediction accuracy by modeling spatio-temporal graph connectivity.

problem Existing rs-fMRI methods neglect functional connectivity or temporal dynamics.
method Spatio-temporal graph convolutional network (ST-GCN) trained on BOLD time series.
result ST-GCN predicts gender and age more accurately than common methods.

ACERL embeds networks into a low-dimensional space preserving structural and semantic properties.

problem Challenges in brain connectivity data analysis with subject-specific, high-dimensional, and sparse networks.
method Contrastive learning of augmented network pairs with adaptive random masking.
result Achieves minimax optimal convergence rate for edge representation learning.

Paper introduces a new method to identify brain hubs using both structural and functional connectivity.

problem Hub node identification in brain networks using only functional connectivity.
method Graph signal processing framework that models functional activity as graph signals on structural connectivity.
result The proposed GraFHub framework identifies hub nodes more accurately than conventional methods.

Proposes tests to control confounding bias in predictive models.

problem Lack of non-parametric tests for confounding bias in predictive modeling.
method Partial and full confounder tests for probing null hypotheses of unconfounded and fully confounded models.
result Reveals previously unreported or hard-to-correct confounders in machine learning models.

We present semiparametric spectral modeling of the complete larval Drosophila mushroom body connectome. Motivated by a thorough exploratory data analysis of the network via Gaussian mixture modeling (GMM) in the adjacency spectral embedding (ASE) representation space, we introduce the latent structure model (LSM) for n…

2017-05-09abs ↗pdf ↗

Numerous social, medical, engineering and biological challenges can be framed as graph-based learning tasks. Here, we propose a new feature based approach to network classification. We show how dynamics on a network can be useful to reveal patterns about the organization of the components of the underlying graph where …

2017-05-30abs ↗pdf ↗

The use of brain images as markers for diseases or behavioral differences is challenged by the small effects size and the ensuing lack of power, an issue that has incited researchers to rely more systematically on large cohorts. Coupled with resolution increases, this leads to very large datasets. A striking example in…

2015-11-16abs ↗pdf ↗