ChronoMID uses neural networks to classify bone disease in mice from micro-CT scans.
problem Classifying bone disease in mice from micro-CT scans.
method ChronoMID applies cross-modal convolutional neural networks to incorporate temporal information from timestamps and difference images.
result The top-performing model achieved 99.54% accuracy, significantly outperforming a baseline CNN.
Generative model boosts bone lesion classification with augmented data.
problem Class imbalance and limited training data for bone lesion classification.
method Cycle-consistent GAN for image patch translation across bones.
result Generative augmentation improves classifier performance on held-out test set.
A new algorithm discovers causal factors between T2DM and bone mineral density.
problem Discovering causal factors between T2DM and bone mineral density from clinical data.
method Prior-Knowledge-driven local Causal structure Learning (PKCL) algorithm.
result PKCL achieves more reliable results without long-standing medical experiments.
Paper uses deep learning to suppress bones on chest X-rays.
problem Improving pathologies classification by suppressing bones on chest X-rays.
method Conditional Generative Adversarial Network (GAN) and Haar 2D wavelet decomposition.
result Achieves state-of-the-art performance on bone suppression.
Method distinguishes genetic correlations from causation in GWAS.
problem Identifying causal relationships among genetically correlated traits.
method Mixed fourth moments to quantify causal relationships.
result Identified 30 putative genetically causal relationships across 52 traits.
X-rays are commonly performed imaging tests that use small amounts of radiation to produce pictures of the organs, tissues, and bones of the body. X-rays of the chest are used to detect abnormalities or diseases of the airways, blood vessels, bones, heart, and lungs. In this work we present a stochastic attention-based…
Deep learning model diagnoses celiac disease severity from intestinal biopsy images.
problem Diagnosing celiac disease severity from biopsy images, especially mild cases.
method Deep residual networks trained on a modified Marsh score histological scoring system.
result Model achieved AUC > 0.96 in all classes for CD severity classification.
Deep-learning method estimates bone 3D structure from X-ray images.
problem Estimating bone 3D structure from X-ray images.
method Triplet loss-trained neural network selecting closest 3D bone shape from predefined set.
result Average RMS distance of 1.08 mm between predicted and true shapes.
Characterizes graphs with Lin-Lu-Yau curvature at least one and explores bone-idle graphs.
problem Characterizing graphs with specific curvature properties.
method Study of Ollivier-Ricci curvature and Lin-Lu-Yau curvature, exploration of regular graphs, and exact formula derivation.
result Characterizes edges that are bone-idle in regular graphs and provides a complete characterization of 4-regular bone-idle graphs.
Six AI solutions accurately detect growth plate planes in mice bone scans.
problem Manual, time-consuming, and variable bone growth plate detection in micro-CT scans.
method Prepared and annotated a dataset of 3D μCT scans, organized a challenge, and developed six computer vision solutions.
result Achieved mean absolute error of 1.91±0.87 planes from ground truth.
Modeling bone microarchitecture adaptation using geometric flows.
problem Bone microarchitecture adaptation modeling.
method Advection and mean curvature flow model with a sphere as a test case.
result Closed-form solution for sphere under advection and mean curvature flow.
RRN accurately identifies landmarks in CMF bones without segmentation.
problem Accurately identifying landmarks in craniomaxillofacial bones without segmentation.
method End-to-end RRN architecture using dense-block units for landmark imputation.
result RRN achieves <2 mm RMS error in landmarking.
This paper presents the first deep reinforcement learning (DRL) framework to estimate the optimal Dynamic Treatment Regimes from observational medical data. This framework is more flexible and adaptive for high dimensional action and state spaces than existing reinforcement learning methods to model real-life complexit…
Curvature formulas on regular graphs identified bone idle edges and graphs.
problem Understanding curvature in regular graphs and identifying bone idle edges.
method Explicit formulas for Lin-Lu-Yau and Ollivier-Ricci curvatures derived from graph parameters.
result Equality condition on regular graphs for Ollivier-Ricci curvature and characterization of bone idle edges.
This paper uses deep learning to estimate flow fields from OCT images for laser ablation control.
problem Automatic control of laser bone ablation using 4D OCT images.
method Semi-supervised convolutional neural network for 2.5D scene flow estimation.
result Scene flow estimation enables markerless tracking and automated laser ablation control.
Automatic segmentation of auditory ossicles from CT images using Ricci curvature.
problem Automatic diagnosis of ossicles' diseases from 3D CT images of the head.
method Proposes a completely automatic method that locates and segments ossicles without manual labels or templates, using Ricci curvature in an energy function.
result Performance of the proposed method using discrete Forman-Ricci curvature is superior to state-of-the-art methods.
Bayesian CNN estimates uncertainty in bone age prediction.
problem Uncertainty quantification in age estimation models.
method Variational Inference for Bayesian CNNs.
result Model uncertainty distinguished from data uncertainty.
The automatic segmentation of human knee cartilage from 3D MR images is a useful yet challenging task due to the thin sheet structure of the cartilage with diffuse boundaries and inhomogeneous intensities. In this paper, we present an iterative multi-class learning method to segment the femoral, tibial and patellar car…
Paper uses optimal transport for low-dimensional representation of leukemia flow cytometry data.
problem Detecting minimal residual disease in leukemia patients using flow cytometry data.
method Optimal transport for dimensionality reduction and visualization of multi-patient flow cytometry datasets.
result OT-based approach provides a more informative two-dimensional representation of leukemia MRD.
Concept bottleneck models enable concept manipulation for model interpretation.
problem Training models to directly predict labels without intermediate concepts.
method Train models to predict intermediate concepts at training time, then use these concepts to predict labels.
result Concept bottleneck models achieve competitive accuracy with standard models while enabling concept manipulation.
Magnetic resonance imaging (MRI) has been proposed as a complimentary method to measure bone quality and assess fracture risk. However, manual segmentation of MR images of bone is time-consuming, limiting the use of MRI measurements in the clinical practice. The purpose of this paper is to present an automatic proximal…
Unified framework for Bayesian online learning in changing conditions.
problem Probabilistic online learning in non-stationary environments.
method BONE framework with three modelling choices and two algorithmic choices.
result Framework allows for reinterpreting and proposing new methods.
New method classifies reticulocytes from red blood cells without labels.
problem Classifying reticulocytes from mature red blood cells without fluorescent labels.
method Unsupervised machine learning on morpho-rheological markers.
result Promising results in classifying reticulocytes from mature red blood cells.
With the help of transfer entropy, we analyze information flows between communities of complex networks. We show that the transfer entropy provides a coherent description of interactions between communities, including non-linear interactions. To put some flesh on the bare bones, we analyze transfer entropies between co…
We build CSI-Net, a unified Deep Neural Network~(DNN), to learn the representation of WiFi signals. Using CSI-Net, we jointly solved two body characterization problems: biometrics estimation (including body fat, muscle, water, and bone rates) and person recognition. We also demonstrated the application of CSI-Net on tw…
Optimization framework for reconstructing missing mandible segments.
problem Missing mandible geometry in jaw reconstructive surgeries.
method Conditional variational autoencoder (CVAE) with weighted multi-target probabilistic solution.
result Statistically significant performance improvement over CVAE.
Multifractal analysis is one of the important approaches that enables us to measure the complexity of various data via the scaling properties. We compare the most common techniques used for multifractal exponents estimation from both theoretical and practical point of view. Particularly, we discuss the methods based on…
DPVis integrates HMMs into visualizations for disease progression analysis.
problem Challenges in interpreting HMMs for disease progression modeling.
method Design study with clinical experts, visualizations of HMM parameters and outcomes.
result DPVis successfully evaluates and summarizes disease progression models.
SS3M learns disease phenotypes from few labels.
problem Lack of supervised data for disease phenotyping.
method Semi-Supervised Mixed Membership Model (SS3M).
result SS3M learns interpretable disease phenotypes.
Bayesian hypergraph inference models disease pathways from EHR data.
problem Modeling rare diseases influenced by shared risk factors.
method Bayesian hypergraph inference framework reframing multi-disease modeling.
result Interpretable disease pathways and well-calibrated uncertainty quantification.
System recommends disease treatments based on big data and cloud computing.
problem Inaccurate disease classification and treatment recommendations due to complex symptoms and multi-pathogenesis.
method DPCA for disease-symptom clustering, Apriori for D-D and D-T rules, parallel Apache Spark implementation.
result Effective disease-symptom clustering and accurate treatment recommendations for inexperienced doctors.
Model learns disease self-representations for drug repositioning.
problem Drug repositioning for disease treatment.
method Enforces proximity in disease self-representations to preserve human phenome network structure.
result Method outperforms state-of-the-art approaches and produces biologically interpretable disease self-representations.
Bayesian model identifies health disparities in disease progression.
problem Health disparities bias disease progression models.
method Interpretable Bayesian model accounting for three disparities.
result Model identifies and corrects for health disparities.
DKT transfers biomarker information between neurodegenerative diseases.
problem Estimating biomarker trajectories in rare neurodegenerative diseases with limited data.
method DKT is a joint-disease generative model that transfers biomarker progressions from common neurodegenerative diseases to rare ones.
result DKT estimates plausible multimodal biomarker trajectories in rare diseases like PCA using only unimodal data.
Paper uses GANs for efficient rare disease detection.
problem Efficient detection of rare diseases with limited labeled data.
method Semi-supervised learning with GANs.
result Best precision-recall scores compared to baseline techniques.
This research uses machine learning to identify Alzheimer's disease subtypes and predict progression.
problem Heterogeneity in Alzheimer's disease clinical manifestations and progression rate limit personalized care and treatment planning.
method Unsupervised and supervised machine learning approaches applied to ADNI data.
result Identification of patient subtypes and prediction of disease progression zones.
Bayesian meta-learning predicts Alzheimer's disease progression.
problem Predicting individual Alzheimer's disease progression from limited data.
method Bayesian meta-learning approach that dynamically predicts disease score distributions.
result Bayesian meta-learner outperforms single-task models and deterministic meta-learners, especially for long-term predictions.
VGAE learns gene-disease associations from networks, predicting disease-genes.
problem Predicting gene-disease associations from disease-gene networks.
method Introducing VGAE, a variational graph auto-encoder for disease-gene prediction.
result VGAE and C-VGAE outperform baseline methods in disease-gene prediction.
Elucidating the genetic basis of human diseases is a central goal of genetics and molecular biology. While traditional linkage analysis and modern high-throughput techniques often provide long lists of tens or hundreds of disease gene candidates, the identification of disease genes among the candidates remains time-con…
Deep Belief Network predicts lncRNA-disease associations with high accuracy.
problem Accurately identifying lncRNA-disease associations to understand lncRNA functionality and disease mechanism.
method Proposes a DBN-based model using heterogeneous networks and DBN for feature learning.
result Obtained AUC of 0.96 and AUPR of 0.967 on standard dataset.
Enhances disease progression modeling using LLMs for complex brain connectivity.
problem Inaccurate predictions of disease spread due to oversimplified brain connectivity models.
method Uses LLMs to synthesize multi-modal relationships and learn disease trajectories from longitudinal data.
result Superior prediction accuracy and interpretability compared to traditional methods.
For many complex diseases, there is a wide variety of ways in which an individual can manifest the disease. The challenge of personalized medicine is to develop tools that can accurately predict the trajectory of an individual's disease, which can in turn enable clinicians to optimize treatments. We represent an indivi…
Efficient deep learning model classifies fractures from X-rays.
problem Manual X-ray examination of fractures is time-consuming and error-prone.
method Robust training loop using transfer learning and latest dataset.
result Model achieves superior performance in less than ten epochs.
A method to explain disease transformation using biomarker covariance matrices.
problem Understanding disease transformation from a healthy baseline.
method Modeling healthy and disease states of biomarker covariance matrices to characterize perturbations.
result Disease perturbs the biomarker covariance structure, allowing for mechanistic explanations and individual patient prognosis.
Modeling disease progression in irregularly observed patients.
problem Irregular patient observation in healthcare databases.
method Continuous-time hidden Markov model with generalized linear model.
result Interpretable model of healthcare utilization events.
Paper predicts multiple types of miRNA-disease associations using tensor decomposition.
problem Predicting miRNA-disease associations, especially multi-type ones.
method Represented miRNA-disease-type triplets as a tensor and used Tensor Decomposition methods.
result Tensor Decomposition methods improve a recent baseline by up to 38% in top-1 F1.
The technique of Formal Concept Analysis is applied to a dataset describing the traits of rodents, with the goal of identifying zoonotic disease carriers,or those species carrying infections that can spillover to cause human disease. The concepts identified among these species together provide rules-of-thumb about the …
Paper uses TDA for automated Parkinson's disease classification and severity assessment.
problem Manual diagnosis of neurological diseases is time-consuming and inaccurate.
method Combines Topological Data Analysis (TDA) with machine learning on postural shift data.
result Proposes a stable and accurate method for classifying Parkinson's disease.