Study analyzes how blood pressure impacts cardiac health.
problem Impact of blood pressure on cardiac function.
method Combines deep learning and variational autoencoder for interpretable biomarkers.
result Identifies key factors and patterns of cardiac adaptation.
Study evaluates uncertainty in BP estimation from PPG signals under domain shift.
problem Uncertainty quantification in healthcare, especially for cuffless BP estimation.
method Compared deep ensembles, Monte Carlo dropout, and various recalibration techniques.
result Deep ensembles provide stronger robustness under domain shift.
Determining whether hypotensive patients in intensive care units (ICUs) should receive fluid bolus therapy (FBT) has been an extremely challenging task for intensive care physicians as the corresponding increase in blood pressure has been hard to predict. Our study utilized regression models and attention-based recurre…
Framework improves health by planning actionable treatment processes.
problem Developing objective treatment processes in clinical settings.
method Surrogate Bayesian model combined with ML for personalized health improvement.
result Computed treatment processes are actionable and consistent with clinical knowledge.
GRU-D detects age-specific missing patterns in vital signs.
problem Temporal missingness in clinical time series data.
method Gated recurrent unit with decay mechanisms (GRU-D) trained on MIMIC-IV vital signs.
result GRU-D achieves AUROC 0.780 and AUPRC 0.810 on bootstrapped data.
Study forecasts aortic pressure with deep learning models.
problem Forecasting noisy, non-stationary aortic pressure.
method Used deep learning models, specifically recurrent neural networks with Legendre Memory Unit, on 25 Hz time series data.
result Recurrent neural networks with Legendre Memory Unit achieved the best performance with an overall forecasting error of 1.8 mmHg.
Patient subtyping based on temporal observations can lead to significantly nuanced subtyping that acknowledges the dynamic characteristics of diseases. Existing methods for subtyping trajectories treat the evolution of clinical observations as a homogeneous process or employ data available at regular intervals. In real…
Improved functional data modeling with modern imputation methods.
problem Estimating complex non-linear models with sparsely and irregularly sampled functional data.
method Modified multiple imputation methods combining MissForest and Local Linear Forest.
result New imputation methods produce better estimates than existing methods.
Framework for imputing missing heart data to simulate brain-heart interactions.
problem Lack of multi-modal patient data representing heart and brain processes.
method Probabilistic framework for joint cardiac data imputation and mechanistic model personalization.
result Accurate imputation of missing cardiac features in incomplete datasets.
Objective: Predict individual septic children's personalized physiologic responses to vasoactive titrations by training a Recurrent Neural Network (RNN) using EMR data. Materials and Methods: This study retrospectively analyzed EMR of patients admitted to a pediatric ICU from 2009 to 2017. Data included charted time se…
Deep network clusters hospital patients' vital signs.
problem Sparse and irregularly collected vital sign data.
method Deep interpolation network for latent representation extraction.
result Extracted 7 distinct clusters from vital sign data.
We consider the problem in precision health of grouping people into subpopulations based on their degree of vulnerability to a risk factor. These subpopulations cannot be discovered with traditional clustering techniques because their quality is evaluated with a supervised metric: the ease of modeling a response variab…
Existing methods for arterial blood pressure (BP) estimation directly map the input physiological signals to output BP values without explicitly modeling the underlying temporal dependencies in BP dynamics. As a result, these models suffer from accuracy decay over a long time and thus require frequent calibration. In t…
The paper develops a method to optimize individualized treatment rules for cost-effectiveness.
problem Developing cost-effective individualized treatment rules for healthcare policy.
method Using conditional random forest and net-monetary-benefit (NMB) to estimate optimal CE-ITR.
result The approach optimizes healthcare resource allocation by maximizing health gains and minimizing costs.
We train and validate a semi-supervised, multi-task LSTM on 57,675 person-weeks of data from off-the-shelf wearable heart rate sensors, showing high accuracy at detecting multiple medical conditions, including diabetes (0.8451), high cholesterol (0.7441), high blood pressure (0.8086), and sleep apnea (0.8298). We compa…
Neural network predicts falls in elderly people up to 10 minutes in advance.
problem Falls prevention in elderly people, especially in aging societies.
method Gated Recurrent Unit (GRU) based neural networks model using heart rate and mean blood pressure signals.
result Predicted syncope occurrence approximately 10 minutes before manual markers.
Paper uses RL to optimize daily step distribution for better health biomarkers.
problem Lack of personalized PA distribution recommendations for health biomarkers.
method Developed an offline reinforcement learning algorithm to learn optimal PA distributions.
result Learned optimal policy suggests more consistent daily steps and tailored recommendations.
In this paper, a Wide Learning architecture is proposed that attempts to automate the feature engineering portion of the machine learning (ML) pipeline. Feature engineering is widely considered as the most time consuming and expert knowledge demanding portion of any ML task. The proposed feature recommendation approach…
When devising a course of treatment for a patient, doctors often have little quantitative evidence on which to base their decisions, beyond their medical education and published clinical trials. Stanford Health Care alone has millions of electronic medical records (EMRs) that are only just recently being leveraged to i…
According to the WHO, Cerebrovascular Stroke, or CS, is the second largest cause of death worldwide. Current diagnosis of CS relies on labor and cost intensive neuroimaging techniques, unsuitable for areas with inadequate access to quality medical facilities. Thus, there is a great need for an efficient diagnosis alter…
Gaussian Process model improves blood glucose prediction using contextual data.
problem Improving blood glucose prediction with contextual information.
method Gaussian Process model combining blood glucose and contextual data.
result Gaussian Process model outperforms common methods and blood glucose values alone.
We develop a prediction-based prescriptive model for learning optimal personalized treatments for patients based on their Electronic Health Records (EHRs). Our approach consists of: (i) predicting future outcomes under each possible therapy using a robustified nonlinear model, and (ii) adopting a randomized prescriptiv…
New method improves IV estimation with many weak and invalid instruments.
problem Identification in linear IV models with unknown validity.
method Non-convex penalized approaches, surrogate sparsest penalty.
result Advantages over other IV estimators in selection consistency and weak IV strength conditions.
This study automates blood cell classification using computer vision.
problem Automated detection and classification of white blood cells.
method Color-based segmentation, morphological processing, feature extraction, PCA, Unsupervised and Supervised learning algorithms, Deep Convolutional Neural Networks.
result Identification of robust algorithms for automated blood cell classification.
Study of red blood cells using elastic surface theory.
problem Understanding the shape of red blood cells.
method Used Helfrich-Canham functional to model red blood cells as elastic surfaces.
result Cassinian ovals, except for the round sphere, do not solve the shape equation.
KOOW method provides optimal covariate balance for continuous treatments.
problem Estimating effects of continuous treatments with robustness to model misspecification and extreme weights.
method Kernel Optimal Orthogonality Weighting (KOOW) using convex optimization.
result KOOW provides optimal covariate balance and controls for extreme weights.
CST-YOLO improves blood cell detection with YOLOv7 and CNN-Swin Transformer.
problem Small-scale object detection in blood cells.
method YOLOv7 architecture enhanced with CNN-Swin Transformer, W-ELAN, MCS, CatConv.
result CST-YOLO achieves 92.7%, 95.6%, and 91.1% mAP@0.5 on three blood cell datasets.
Machine learning model diagnoses COVID-19 from routine blood tests.
problem Difficulty in diagnosing COVID-19 due to inconsistent blood parameter changes.
method Constructed a machine learning model using 5,333 patients with various infections and 160 COVID-19-positive patients.
result Cross-validated AUC of 0.97, sensitivity of 81.9%, specificity of 97.9%.
Advances in computational science offer a principled pipeline for predictive modeling of cardiovascular flows and aspire to provide a valuable tool for monitoring, diagnostics and surgical planning. Such models can be nowadays deployed on large patient-specific topologies of systemic arterial networks and return detail…
We aim to produce predictive models that are not only accurate, but are also interpretable to human experts. Our models are decision lists, which consist of a series of if...then... statements (e.g., if high blood pressure, then stroke) that discretize a high-dimensional, multivariate feature space into a series of sim…
Novel framework for whole-slide blood cell segmentation.
problem Semantic segmentation of whole-slide blood cell images.
method Convolutional encoder-decoder framework with VGG-16 feature extraction.
result Outstanding accuracy (97.18% global accuracy) in classwise segmentation.
The Helfrich functional, denoted by H^{c_0}, is a mathematical expression proposed by Helfrich (1973) for the natural free energy carried by an elastic phospholipid bilayer. Helfrich theorises that idealised elastic phospholipid bilayers minimise H^{c_0} among all possible configurations. The functional integrates a sp…
The paper surveys pressure metrics in geometry and dynamics.
problem Understanding pressure metrics in various deformation spaces.
method Survey and discussion of pressure semi-norms and their degeneracy loci.
result Discussion of pressure semi-norms and their degeneracy loci in quasi-Blaschke products.
Predicting blood lactate levels helps manage ICU patients without invasive tests.
problem Predict blood lactate levels accurately in ICU patients without invasive tests.
method Defined a benchmark problem, evaluated different prediction algorithms, and investigated missing value imputation methods.
result Promising prediction results show the potential of machine learning in ICU care.
Proposes Deep LTMLE for estimating dynamic treatment effects in longitudinal studies.
problem Estimating counterfactual mean outcomes under dynamic treatment policies in longitudinal settings.
method Uses a transformer architecture with temporal-difference learning for initial estimation, followed by TMLE correction and statistical inference.
result Demonstrates superior performance in complex, long-term scenarios compared to existing methods.
Paper introduces a new metric for deforming surfaces with parabolics.
problem Deformation spaces of quasifuchsian groups with parabolics.
method Developed a mapping class group invariant pressure metric on QF(S).
result Hausdorff dimension of limit sets varies analytically over QF(S).
Develops a tool to identify abnormal blood smear results based on CBC tests.
problem Manual review of blood smears by technologists is time-consuming and inconsistent.
method Cost-sensitive Lasso-penalized additive logistic regression combined with stability selection.
result The tool correctly identifies true cutoff values for abnormal smear results.
This paper describes the Pressure Ulcers Online Website, which is a first step solution towards a new and innovative platform for helping people to detect, understand and manage pressure ulcers. It outlines the reasons why the project has been developed and provides a central point of contact for pressure ulcer analysi…
A deep learning network was used to predict future blood glucose levels, as this can permit diabetes patients to take action before imminent hyperglycaemia and hypoglycaemia. A sequential model with one long-short-term memory (LSTM) layer, one bidirectional LSTM layer and several fully connected layers was used to pred…
The study examines entropy and pressure at infinity in negatively curved manifolds, linking them to strong positive recurrence.
problem Investigating strong positive recurrence in negatively curved manifolds.
method Defining and comparing entropy and pressure at infinity through different measures.
result Strong positive recurrence potentials admit finite Gibbs measures.
Mathematical model describes how red blood cells return to equilibrium.
problem How red blood cells regain equilibrium after deformation.
method Gradient flow of the Canham-Helfrich functional, proving global existence and convergence for spheres and axisymmetric tori.
result Global existence and convergence of smooth solutions for spheres and axisymmetric tori under specific energy conditions.
Deep learning speeds up pressure prediction in carbon storage reservoirs.
problem Accurately forecasting reservoir pressure in geologic carbon storage projects with sparse well data.
method Combining InSAR surface displacement data with deep learning and data assimilation techniques.
result Workflow can predict reservoir pressure with high efficiency and uncertainty quantification.
Study pressure metrics for cusped Hitchin representations.
problem Characterize cusped Hitchin representations of Fuchsian groups.
method Develop pressure metrics associated to fundamental weights and roots.
result New pressure metrics for Hilbert length when d=3. New method classifies reticulocytes from red blood cells without labels.
problem Classifying reticulocytes from mature red blood cells without fluorescent labels.
method Unsupervised machine learning on morpho-rheological markers.
result Promising results in classifying reticulocytes from mature red blood cells.
Detecting aggressive cancer tumors using ctDNA dynamics from few blood samples.
problem Early multi-cancer detection using circulating tumor DNA (ctDNA) levels.
method Combines continuous time Markov modelling and Signature theory for efficient testing procedures.
result Correctly addresses the challenge of data scarcity in cancer monitoring.
New method estimates effects of multiple nutrients on blood glucose.
problem Estimating physiological response to multiple nutrient treatments.
method Convolution-based multi-output Gaussian process model.
result Improved prediction accuracy and better interpretation of individual nutrient effects.
Study improves mortality prediction in hospital patients using comprehensive feature engineering.
problem Accurate prediction of all-cause in-hospital mortality in healthcare.
method Comprehensive feature engineering approach using vital signs, laboratory results, and demographic data.
result Random Forest model achieved highest performance with AUC of 0.94, significantly outperforming other models.
AI system predicts acute critical illness from EHRs with explainability.
problem Lack of clinical interpretability in AI predictions for acute critical illness.
method Developed an explainable AI early warning score (xAI-EWS) system.
result System provides clinicians with insights into EHR data explaining predictions.