Deep RL improves blood glucose control for T1D patients.
problem Managing blood glucose levels for people with type 1 diabetes.
method Developed deep reinforcement learning techniques for automated blood glucose control.
result Deep RL approach outperforms baseline control algorithms, reducing glycemic risk and hypoglycemia.
Computational Drug Repositioning (CDR) is the task of discovering potential new indications for existing drugs by mining large-scale heterogeneous drug-related data sources. Leveraging the patient-level temporal ordering information between numeric physiological measurements and various drug prescriptions provided in E…
Gaussian Process model improves blood glucose prediction using contextual data.
problem Improving blood glucose prediction with contextual information.
method Gaussian Process model combining blood glucose and contextual data.
result Gaussian Process model outperforms common methods and blood glucose values alone.
Deep neural network predicts blood glucose levels for diabetes patients.
problem Diabetes patients need to anticipate hyperglycaemia and hypoglycaemia.
method Used a sequential model with LSTM and Bi-LSTM layers to predict blood glucose levels.
result The proposed network outperforms baseline methods in predicting blood glucose levels.
Modeling T2DM patients' blood glucose with ML for better insulin control.
problem Managing blood glucose levels in T2DM patients with insulin.
method Markov Decision Process (MDP) with model-based reinforcement learning.
result Optimal insulin treatment policy derived from MDP solution.
Study predicts blood glucose levels from infrequent measurements.
problem Predicting blood glucose levels from infrequent measurements.
method Proposed post-prediction methods to improve accuracy of machine learning models.
result Post-prediction methods marginally improve blood glucose prediction accuracy.
New method estimates effects of multiple nutrients on blood glucose.
problem Estimating physiological response to multiple nutrient treatments.
method Convolution-based multi-output Gaussian process model.
result Improved prediction accuracy and better interpretation of individual nutrient effects.
New model predicts blood glucose in diabetics with improved accuracy.
problem Forecasting blood glucose in type 1 diabetics with high accuracy.
method Integrates machine learning with existing biomedical model to capture time-varying dynamics.
result Improved long-term forecasting of blood glucose up to 6 hours.
Machine learning detects subtle glucose changes for early diabetes diagnosis.
problem Challenging early-stage diabetes diagnosis due to subtle glucose changes.
method Applied machine learning to synthetic glucose profiles generated by a biophysical model.
result High accuracy (above 85%) in detecting insulin resistance using various neural networks.
Deep multi-output models predict blood glucose trajectories more accurately.
problem Accurately predicting blood glucose levels over multiple time steps.
method Proposed multi-output deep architectures for multi-step forecasting.
result Improved performance compared to existing methods (4.87 vs. 5.31 APE).
Study finds RNNs predict STBG better than ARIMA, useful for diabetes patients.
problem Improving short-term blood glucose prediction for diabetes management.
method Investigated Recurrent Neural Networks (RNNs) and compared them to ARIMA for STBG prediction.
result Population-based RNN model outperforms ARIMA across various prediction horizons.
Framework generates personalized insulin treatment strategies using deep models.
problem Developing optimal personalized treatment strategies for diabetes patients.
method Combines deep generative time series models with decision theory.
result Demonstrated improved personalized insulin treatment strategies for diabetes patients.
Paper predicts daytime hypoglycemia using CGM data and CART.
problem Accurately predicting daytime hypoglycemia to prevent dangerous situations.
method Classification and Regression Tree (CART) applied to CGM data.
result Model detects almost 80% of hypoglycemic events 15 min in advance.
CTRNNs improve blood glucose forecasting in ICU, outperforming traditional models.
problem Forecasting blood glucose in ICU with irregular measurements.
method Continuous time autoregressive recurrent neural networks (CTRNNs) using neural ODE or neural flow layers.
result CTRNNs generally outperform traditional autoregressive models in probabilistic forecasting of blood glucose.
Study aims to predict meal-to-meal blood glucose for T1D patients.
problem Accurately predict future blood glucose levels from current features.
method Applied machine learning algorithms to a new T1D dataset.
result Most accurate predictor achieved an errL1 loss of 2.70 mmol/L.
New method estimates personalized treatment plans for mobile health.
problem Personalized treatment plans for patients with type 1 diabetes.
method Reinforcement learning for minute-by-minute decision making.
result Proposed method consistent and asymptotically normal.
Paper uses rare-event simulation to analyze personalized AP controllers for T1D patients.
problem Rare adverse events in personalized AP controllers for T1D patients.
method Generative models of patient characteristics, FDA-approved T1D simulator, rare-event simulation.
result 72,000x speedup in simulation speed and 2-10x increase in adverse condition sampling.
Neural system optimizes glucose levels in diabetics.
problem Limited research on continuous glucose maintenance devices.
method Differential predictive control with neural policy and differentiable modeling.
result Improves glucose level optimization in real-time.
Paper proposes a DRL-based controller for networked AP systems that reduces communication frequency.
problem Reduce communication frequency in networked AP systems while maintaining control performance.
method Develops a DRL-based controller that avoids explicit update timing learning, using a semi-Markov decision process (SMDP).
result Improves communication efficiency without sacrificing control performance.
New method estimates treatment-response curves with covariate and timing measurement errors.
problem Estimating treatment impact on continuous temporal response with covariate measurement errors.
method Combines parametric response functions and sparse Gaussian process for baseline trend, considering both treatment covariates and timing errors.
result Significant improvements in estimation accuracy and prediction for diet impact on blood glucose measurements.
Study discovers patterns in insulin needs for T1D patients.
problem Finding the right insulin dose and time for T1D patients is challenging.
method Used OpenAPS Data Commons dataset and time series techniques like matrix profile and multi-variate clustering.
result Identified temporal patterns in insulin needs driven by factors like carbohydrates and possibly others.
Hybrid model learns interpretable meal-level glycemic control.
problem Lack of flexible, interpretable meal-level glycemic control methods.
method Hybrid variational autoencoder grounding latent space to mechanistic differential equation.
result Unsupervised representation discovers separation between individuals based on disease severity.
Modeling glucose distribution changes over time using neural ODEs.
problem Analyzing how continuous glucose distribution changes over time in diabetic patients.
method Combines Gaussian mixture, MMD, and Neural ODE to model temporal evolution of glucose distribution.
result Highly interpretable model detects subtle distribution shifts and remains computationally efficient.
Paper uses RL to optimize daily step distribution for better health biomarkers.
problem Lack of personalized PA distribution recommendations for health biomarkers.
method Developed an offline reinforcement learning algorithm to learn optimal PA distributions.
result Learned optimal policy suggests more consistent daily steps and tailored recommendations.
New framework predicts 5-year glucose values with missing data.
problem Significant missing data in longitudinal glucose studies.
method Reproducing Kernel Hilbert Spaces (RKHS) with missing responses analysis.
result Identifies new factors affecting long-term glucose evolution.
CUDA optimized neural network predicts HbA1c from joint mobility and anthropometrics.
problem Early detection and accurate diagnosis of diabetes.
method Parallelized neural network using CUDA and C++ on Nvidia GPUs.
result Achieved high accuracy (95.65% on training, 86.67% on testing for males; 97.73% on training, 66.67% on testing for females).
HAD-Net forecasts glucose levels with insights into insulin and carbs diffusion.
problem Inaccurate predictions in glucose level forecasting without context understanding.
method Hybrid model combining deep learning and physiological models, using recurrent attention network.
result Achieves competitive performance in glucose level forecasting with plausible diffusion insights.
New algorithms learn sparse dictionaries from incomplete data.
problem Learning dictionaries from incomplete data.
method Iterative descent algorithm with initialization using extra samples.
result Provable polynomial-time algorithms for dictionary learning from incomplete data.
A method models continuous-time glucose distributions in children with diabetes.
problem Capturing subtle temporal changes in glucose distributions.
method Probabilistic framework using Gaussian mixtures and neural ODEs.
result Detects treatment-related improvements in glucose dynamics.
Paper presents estimators for entropy and information in probabilistic models.
problem Estimating entropy and mutual information in high dimensions is challenging.
method EEVI uses importance sampling with proposal distributions like amortized variational inference and sequential Monte Carlo.
result EEVI delivers accurate upper and lower bounds on information quantities.
Study improves mortality prediction in hospital patients using comprehensive feature engineering.
problem Accurate prediction of all-cause in-hospital mortality in healthcare.
method Comprehensive feature engineering approach using vital signs, laboratory results, and demographic data.
result Random Forest model achieved highest performance with AUC of 0.94, significantly outperforming other models.
A framework detects nonlinear and interaction effects in epidemiological data with uncertainty quantification.
problem Lack of reliable inference for ML-discovered nonlinearities and interactions in epidemiological data.
method Combines Bayesian sparse regression, tree ensembles, and Shapley values.
result Valid uncertainty quantification for feature effects at the individual level.
New MMD estimators detect differences in missing paired data.
problem Handling missing data in matched pairs with complex distributions.
method Maximum mean discrepancy (MMD) estimators for complex data with missing values.
result Valid and consistent estimators detect differences in data distributions.
CBDL uses credal sets to improve uncertainty quantification in deep learning.
problem Uncertainty in predictions and robustness to distribution shifts in deep learning.
method Train an infinite ensemble of Bayesian Neural Networks using credal sets.
result CBDL distinguishes between aleatoric and epistemic uncertainties and quantifies them better than single BNNs.
Research proposes a risk-free machine learning model for COVID screening from routine blood tests.
problem Rapid antigen tests have low sensitivity and are not suitable for widespread screening.
method Stacked Ensemble Machine Learning model using routine blood tests.
result 100% accuracy, precision, recall and F1-score in identifying COVID patients.
New algorithm learns from sparse data to make decisions in high dimensions.
problem Learning optimal actions from high-dimensional data streams.
method Structured contextual multi-armed bandit (CMAB) with relevance learning.
result Time-averaged regret goes to zero with smooth reward dependence.
This study automates blood cell classification using computer vision.
problem Automated detection and classification of white blood cells.
method Color-based segmentation, morphological processing, feature extraction, PCA, Unsupervised and Supervised learning algorithms, Deep Convolutional Neural Networks.
result Identification of robust algorithms for automated blood cell classification.
RETAIN model improves glucose forecasting for diabetics, offering both accuracy and interpretability.
problem Inability of deep learning models to interpret their predictions in healthcare.
method Two-level attention mechanism in a recurrent neural network (RETAIN) architecture.
result RETAIN model achieves comparable accuracy to LSTM and FCN models while being highly interpretable.
Study of red blood cells using elastic surface theory.
problem Understanding the shape of red blood cells.
method Used Helfrich-Canham functional to model red blood cells as elastic surfaces.
result Cassinian ovals, except for the round sphere, do not solve the shape equation.
CST-YOLO improves blood cell detection with YOLOv7 and CNN-Swin Transformer.
problem Small-scale object detection in blood cells.
method YOLOv7 architecture enhanced with CNN-Swin Transformer, W-ELAN, MCS, CatConv.
result CST-YOLO achieves 92.7%, 95.6%, and 91.1% mAP@0.5 on three blood cell datasets.
Machine learning model diagnoses COVID-19 from routine blood tests.
problem Difficulty in diagnosing COVID-19 due to inconsistent blood parameter changes.
method Constructed a machine learning model using 5,333 patients with various infections and 160 COVID-19-positive patients.
result Cross-validated AUC of 0.97, sensitivity of 81.9%, specificity of 97.9%.
Novel framework for whole-slide blood cell segmentation.
problem Semantic segmentation of whole-slide blood cell images.
method Convolutional encoder-decoder framework with VGG-16 feature extraction.
result Outstanding accuracy (97.18% global accuracy) in classwise segmentation.
Predicting blood lactate levels helps manage ICU patients without invasive tests.
problem Predict blood lactate levels accurately in ICU patients without invasive tests.
method Defined a benchmark problem, evaluated different prediction algorithms, and investigated missing value imputation methods.
result Promising prediction results show the potential of machine learning in ICU care.
Develops a tool to identify abnormal blood smear results based on CBC tests.
problem Manual review of blood smears by technologists is time-consuming and inconsistent.
method Cost-sensitive Lasso-penalized additive logistic regression combined with stability selection.
result The tool correctly identifies true cutoff values for abnormal smear results.
Study predicts blood pressure response to fluid bolus therapy with high accuracy.
problem Predicting successful response to fluid bolus therapy in hypotensive ICU patients.
method Used attention-based LSTM and GRU neural networks on a large ICU database.
result Stacked LSTM with attention mechanism achieved highest accuracy of 0.852.
Mathematical model describes how red blood cells return to equilibrium.
problem How red blood cells regain equilibrium after deformation.
method Gradient flow of the Canham-Helfrich functional, proving global existence and convergence for spheres and axisymmetric tori.
result Global existence and convergence of smooth solutions for spheres and axisymmetric tori under specific energy conditions.
New method classifies reticulocytes from red blood cells without labels.
problem Classifying reticulocytes from mature red blood cells without fluorescent labels.
method Unsupervised machine learning on morpho-rheological markers.
result Promising results in classifying reticulocytes from mature red blood cells.
New framework learns blood sample MTS representations with missing data.
problem Missing data in clinical time series.
method Combines autoencoder with TCK kernel for missing data.
result Improved classification of blood samples with missing data.