This study examines the presence of the day-of-the-week effect on daily returns of biotechnology stocks over a 16-year period from January 2002 to December 2015. Using daily returns from the NASDAQ Biotechnology Index (NBI), we find that the stock returns were the lowest on Mondays, and compared to the Mondays the stoc…
On-device research index
arXiv research
A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.
169,051 papers · 148 categories
Trend · papers per month
24 results for “biotechnology”
In the domain of technology startups, biotechnology has often been considered as specific. Their unique technology content, the type of founders and managers they have, the amount of venture capital they raise, the time it takes them to reach an exit as well as the technology clusters they belong to are seen as such un…
The paper shows incorrect mean-variance analysis methods should be avoided.
problem Incorrect ex post mean-variance analysis methods in financial studies.
method Illustrates incorrect methods using 2014 biotech ETF data.
result Ex post mean-variance analysis should not be done as generally practiced.
Holistic Bioprocess Development Across Scales Using Multi-Fidelity Batch Bayesian Optimizationq-bio.QM
Bayesian optimization speeds up bioprocess development across scales.
problem Costly and complex bioprocess development across scales and biocatalyst selection.
method Multi-fidelity batch Bayesian optimization framework integrating Gaussian Processes and mixed-variable optimization.
result Reduction in experimental costs and increased yield in bioprocess optimization.
In this paper, we propose an innovative investment framework incorporating asset allocation and class diversification oriented specifically for the biotechnology industry. With growing interests and capitalization in multiple biotech markets, investors require a more dynamic method of managing their assets within indiv…
TUNet improves protein classification in cell images.
problem Classifying specific proteins in human cells using microscopy images.
method TUNet model incorporating segmentation maps for improved classification.
result TUNet achieves competitive performance in protein classification.
We propose a novel information-theoretic approach for Bayesian optimization called Predictive Entropy Search (PES). At each iteration, PES selects the next evaluation point that maximizes the expected information gained with respect to the global maximum. PES codifies this intractable acquisition function in terms of t…
New method steers protein design towards desired properties.
problem Challenges in designing proteins with specific structures and properties.
method Feynman-Kac framework applied to RFdiffusion models with guiding potentials.
result Significant improvement in predicted interface energetics and binder designability.
Biotech IPOs in Q1 2021: advanced degrees, clinical trials, and IP key.
problem Identifying traits of biotech startups that go public.
method Database of biotech IPOs, analysis of leadership, technology, clinical trials, and financing.
result Advanced degrees, clinical trials, and IP are important for biotech startups.
Controlling false discoveries in high-dimensional situations: Boosting with stability selectionstat.ML
Modern biotechnologies often result in high-dimensional data sets with much more variables than observations (n p). These data sets pose new challenges to statistical analysis: Variable selection becomes one of the most important tasks in this setting. We assess the recently proposed flexible framework for variab…
Smoothed fitness landscape improves protein optimization.
problem Infeasibility of combinatorially large protein sequence space.
method Formulate protein fitness as a graph signal, smooth using Tikunov regularization, and optimize with Gibbs sampling.
result 2.5 fold fitness improvement over training set.
BoGA combines evolutionary search with Bayesian optimization for efficient protein design.
problem Designing novel proteins with specific characteristics is challenging due to sequence space complexity.
method BoGA integrates a genetic algorithm with Bayesian optimization to efficiently explore sequence space.
result BoGA accelerates discovery of high-confidence binders for diverse protein design objectives.
Tweet Influence on Market Trends: Analyzing the Impact of Social Media Sentiment on Biotech Stocksq-fin.ST
Study examines how social media sentiment impacts biotech stocks.
problem Understanding the impact of social media on biotech stock prices.
method VADER sentiment analysis, ARIMA, and VAR models were used to forecast stock market performance.
result Complex interplay between tweet sentiment and stock market performance was identified.
Valuing Post-Revenue Biopharmaceutical Assets with Pfizer's Current Portfolio as a Case Studyq-fin.PR
This study improves valuation of post-revenue biopharmaceutical assets using Pfizer's data.
problem Accurate valuation of post-revenue drug assets in biotech and pharma.
method Historical sales data analysis to forecast future sales and calculate Net Present Value.
result Demonstrates a method for more informed investment decisions in biotech and pharma.
Machine learning identifies potential drugs for COVID-19.
problem Finding effective treatments for COVID-19.
method Trained neural network models on virus protein sequences and antiviral drugs.
result Identified potential drug candidates for treating COVID-19.
Bayesian Neural Networks improve high-dimensional level set estimation.
problem Scalability issue in existing LSE methods for high-dimensional inputs.
method Bayesian Neural Networks with information-based acquisition functions.
result Proposed method achieves better results than state-of-the-art approaches.
Patents and intellectual property assets as non-fungible tokens: key technologies and challengesq-fin.GN
This paper explores using NFTs for patents, offering a framework and addressing challenges.
problem Lack of research in applying NFT to intellectual property, especially patents.
method Developed a layered conceptual NFT-based patent framework.
result Promotes transparency and liquidity in patent markets.
LEARNA uses deep reinforcement learning to design RNA sequences.
problem Designing RNA molecules to satisfy structural constraints.
method LEARNA employs deep reinforcement learning to train a policy network for RNA design.
result LEARNA achieves new state-of-the-art performance in RNA Design benchmarks.
BioFinBERT analyzes sentiment of biotech press releases and financial text around inflection points.
problem Analyzing sentiment of biotech press releases and financial text around inflection points.
method Finetuning BioBERT on financial datasets to create BioFinBERT for sentiment analysis.
result BioFinBERT accurately analyzes sentiment of biotech press releases and financial text around inflection points.
This paper uses bandit theory and Thompson Sampling to optimize protein sequences.
problem Optimizing protein sequences using machine learning and directed evolution.
method Proposes a Thompson Sampling-guided Directed Evolution (TS-DE) framework.
result TS-DE achieves a nearly optimal Bayesian regret of order .
Optimized biopharmaceutical seed train design reduces variability and saves time.
problem Designing robust biotechnological processes with cell cultures.
method Coupling uncertainty-based upstream simulation and Bayes optimization using Gaussian processes.
result Optimized seed train design results in lower cell density variability and reduced process duration.
MutaGAN predicts mutations of evolving protein populations using GANs.
problem Predicting mutations in evolving protein populations.
method Generative adversarial networks (GANs) with recurrent neural networks (RNNs).
result MutaGAN generates complete protein sequences with mutations.
Research predicts healthcare index movements using historical OHLC data.
problem Predicting the directional movement of healthcare indices based on historical data.
method Supervised classification task with a one-step-ahead rolling window, using a diverse feature set including OHLC ratios.
result Robust predictive performance with accuracy exceeding 0.8 and Matthews correlation coefficients above 0.6, highlighting the importance of nowcasting features.
Economic returns of research: the Pareto law and its implicationscond-mat.stat-mech
At what level should government or companies support research? This complex multi-faceted question encompasses such qualitative bonus as satisfying natural human curiosity, the quest for knowledge and the impact on education and culture, but one of its most scrutinized component reduces to the assessment of economic pe…