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168,657 papers · 148 categories

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55109164218 · Jun 202019922001200920172026
48 results for biomedical research

Enhancement attacks can falsely improve machine learning model performance in biomedical research.

problem The trustworthiness of machine learning in biomedical research is threatened by enhancement attacks.
method Developed two techniques to enhance prediction performance with minimal changes to features.
result Falsely improved classifiers' accuracy from 50% to almost 100% while maintaining high feature similarities.

Review of modern computational optimal transport methods for biomedical applications.

problem Efficient computation of optimal transport for big data.
method Regularization-based and projection-based computational methods.
result Advancements in computational optimal transport methods for biomedical research.

Model predicts future term connections in biomedical research.

problem Capturing temporal dynamics and unobserved connections in biomedical term relationships.
method Variational inference model for positive-unlabeled learning on dynamic graphs.
result Model effectively predicts term relationships in real-world datasets.

Machine learning speeds up FLIM analysis in biomedical research.

problem Complex, slow, and computationally expensive FLIM analysis.
method Machine learning techniques for faster and smarter FLIM data extraction and interpretation.
result Higher accuracy in classifying and segmenting FLIM images compared to conventional methods.

Study improves LLMs for PPI analysis by addressing uncertainty.

problem Uncertainty in LLM predictions for PPIs.
method Fine-tuned LLaMA-3 and BioMedGPT models, LoRA ensembles, Bayesian LoRA for UQ.
result Competitive PPI identification performance across diverse disease contexts.

Deep learning methods have shown extraordinary potential for analyzing very diverse biomedical data, but their dissemination beyond developers is hindered by important computational hurdles. We introduce ImJoy (https://imjoy.io/), a flexible and open-source browser-based platform designed to facilitate widespread reuse…

2019-05-30abs ↗pdf ↗

Proposes a novel method to identify complex effects in multi-view datasets.

problem Challenges in analyzing multi-view biomedical datasets with complex interactions.
method Generalized kernel machine approach considering marginal and joint effects of features from different views.
result Effective identification of higher-order composite effects in multi-view datasets.

Proposes a framework for causal inference with processed outcomes in biomedical research.

problem Impact of intra-subject processing on inter-subject statistical inference in biomedical research.
method Semiparametric framework with multiply robust estimators and step-down procedure for high-dimensional inference.
result Superior performance of the proposed approach demonstrated through simulations and application to autism research.

Biomedical research papers use significantly different language and jargon when compared to typical English text, which reduces the utility of pre-trained NLP models in this domain. Meanwhile Medline, a database of biomedical abstracts, introduces nearly a million new documents per-year. Applications that could benefit…

2020-02-13abs ↗pdf ↗

A rigorous ML pipeline for binary classification in biomedical studies, focusing on pancreatic cancer.

problem Handling bias in ML models for complex biomedical data.
method Customizable ML analysis pipeline with 9 algorithms, hyperparameter optimization, and thorough evaluation.
result Comparison of ML algorithms to ExSTraCS, highlighting interpretability and bias handling.

Biomedical documents such as Electronic Health Records (EHRs) contain a large amount of information in an unstructured format. The data in EHRs is a hugely valuable resource documenting clinical narratives and decisions, but whilst the text can be easily understood by human doctors it is challenging to use in research …

2019-12-18abs ↗pdf ↗

Automated digital twin discovery from biological data improves drug discovery and personalized medicine.

problem Developing reliable digital twins from noisy, incomplete biological data.
method Symbolic and sparse regression, Bayesian frameworks, deep learning, and large language models.
result Sparse regression generally outperforms symbolic regression, especially with Bayesian frameworks.

This manuscript addresses the problem of the automatic lesion boundary detection in dermoscopy, using deep neural networks. An approach is based on the adaptation of the U-net convolutional neural network with skip connections for lesion boundary segmentation task. I hope this paper could serve, to some extent, as an e…

2018-11-23abs ↗pdf ↗

Quantum neural networks improve causal inference in biomedical studies, especially for small samples.

problem Addressing selection bias in comparing surgical techniques using observational data.
method Developed QNN-based propensity score models focusing on four key covariates (Age, Sex, Stage, BMI). Employed a linear ZFeatureMap for data encoding, SummedPaulis for predictions, and CMA-ES for optimization. Integrated noise modeling to enhance predictive stability.
result QNNs, particularly with noise-aware strategies, outperformed classical models in small samples, achieving AUC up to 0.750 for n=100.

Discovering associations is of central importance in scientific practices. Currently, most researches consider only linear association measured by correlation coefficient, which has its theoretical limitations. In this paper, we propose a new method for discovering association with copula entropy -- a universal applica…

2019-07-29abs ↗pdf ↗

Locally sparse neural networks improve interpretability for biomedical tabular data.

problem Overfitting and lack of interpretability in neural networks for tabular biomedical data.
method Locally sparse neural network with a gating network to select relevant features.
result The method outperforms state-of-the-art models in synthetic and real-world biomedical datasets.

ROOFS helps researchers select robust biomarker features from complex data.

problem Challenges in feature selection for biomarker discovery and clinical models.
method ROOFS is a Python package that benchmarks multiple feature selection methods on user data.
result ROOFS identifies a filter method as optimal for identifying predictors of lung cancer resistance.

Method integrates logical rules into neural multi-hop reasoning for drug repurposing.

problem Capturing long-range dependencies in biomedical data.
method Combines logical rules with neural multi-hop reasoning using reinforcement learning.
result Our method outperforms baseline methods in drug repurposing tasks.

Entity linking is the task of linking mentions of named entities in natural language text, to entities in a curated knowledge-base. This is of significant importance in the biomedical domain, where it could be used to semantically annotate a large volume of clinical records and biomedical literature, to standardized co…

2019-11-21abs ↗pdf ↗

SigTime learns interpretable signatures from time series data.

problem Discovering meaningful patterns in time series data with high complexity and limited interpretability.
method Jointly trains two Transformer models using shapelet-based and feature engineering representations.
result Learned shapelets serve as interpretable signatures for time series classification.

Paper proposes a new method for estimating treatment effects using interpretable deep learning models.

problem Estimating treatment effects from observational data with interpretability.
method Proposes a novel objective function using energy distance balancing score and neural additive models for improved interpretability.
result Demonstrates superior performance over state-of-the-art methods in semi-synthetic experiments.

The paper advocates for interpretable, accountable, reproducible machine learning in medicine.

problem Black box models in medicine lack transparency and regulatory approval.
method Intrinsically interpretable modeling approaches and collaborative learning paradigms.
result Interpretable machine learning models can support clinical decisions and gain regulatory approval.

Method cleans noisy training labels for biomedical data.

problem Accurately labeling biomedical data is challenging.
method Reliability-based training data cleaning with inductive conformal prediction.
result Significant enhancements in classification performance across multiple tasks.

HOoD detects near-out-of-distribution groups in correlated biomedical assays.

problem Detecting near-out-of-distribution cases in biased or incomplete data.
method Projects correlated measurements through a trained model and uses permutation-based hypothesis tests.
result HOoD reliably identifies OoD groups, outperforming other detectors.

Deep learning has shown its great promise in various biomedical image segmentation tasks. Existing models are typically based on U-Net and rely on an encoder-decoder architecture with stacked local operators to aggregate long-range information gradually. However, only using the local operators limits the efficiency and…

2018-12-10abs ↗pdf ↗

Many machine learning models can be attacked with adversarial examples, i.e. inputs close to correctly classified examples that are classified incorrectly. However, most research on adversarial attacks to date is limited to vectorial data, in particular image data. In this contribution, we extend the field by introduci…

2019-08-25abs ↗pdf ↗

Classification of seizure type is a key step in the clinical process for evaluating an individual who presents with seizures. It determines the course of clinical diagnosis and treatment, and its impact stretches beyond the clinical domain to epilepsy research and the development of novel therapies. Automated identific…

2019-12-10abs ↗pdf ↗

CARVE validates clustering results using resampling and stability analysis.

problem Inconsistent and unreliable clustering results due to algorithm, preprocessing, and kk sensitivity.
method CARVE uses resampling-based validation and stability analysis to evaluate multiple clustering algorithms and hyperparameters.
result CARVE consistently recovers near-optimal clusterings and finer biological structure.

VICatMix clusters categorical biomedical data efficiently and selects relevant variables.

problem Efficient clustering of high-dimensional categorical biomedical data.
method Variational Bayesian finite mixture model with variational inference.
result Improves clustering accuracy and variable selection on noisy, high-dimensional data.