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arXiv research

A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.

168,742 papers · 148 categories

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3.3%6.5%9.8%13.1% · Jan 201919922001200920172026
48 results for biological objects

The paper introduces a new method to measure the shape relations between biological objects using r-parallel sets.

problem The influence of neighboring objects on the shape and function of biological objects.
method The authors develop a theory based on spatial point processes to measure the geometrical interaction between objects.
result The proposed measures provide detailed information about the shape of individual objects and their interactions.

We solve a lifecycle model in which the consumer's chronological age does not move in lockstep with calendar time. Instead, biological age increases at a stochastic non-linear rate in time like a broken clock that might occasionally move backwards. In other words, biological age could actually decline. Our paper is ins…

2018-11-25abs ↗pdf ↗

LaMBO optimizes biological sequences using autoencoders and Bayesian optimization.

problem Bayesian optimization for drug design is limited by discrete, high-dimensional decision variables.
method Jointly trains denoising autoencoder with a Gaussian process head for gradient-based optimization in latent space.
result LaMBO outperforms genetic optimizers and requires no large pretraining corpus.

Biological neural network mimics CCA for multi-channel data.

problem Implementing CCA in a biologically plausible neural network.
method Derive an online CCA algorithm with local synaptic updates for multi-compartmental neurons.
result The derived neural network architecture and synaptic updates resemble cortical pyramidal neuron behavior.

Derives a biologically plausible neural network for Slow Feature Analysis.

problem Learning latent features from time series data.
method Starting from an SFA objective, derives Bio-SFA with a biologically plausible neural network implementation.
result Validates Bio-SFA on naturalistic stimuli, reproducing interesting properties of brain cells.

New method identifies key genes affecting phenotypes in biological systems.

problem Identifying genes that drive specific phenotypes in complex biological systems.
method Data-driven observability decomposition using Koopman operators.
result Koopman operator representation identifies genes that drive phenotypes.

Biological and cellular systems are often modeled as graphs in which vertices represent objects of interest (genes, proteins, drugs) and edges represent relational ties among these objects (binds-to, interacts-with, regulates). This approach has been highly successful owing to the theory, methodology and software that …

2017-03-14abs ↗pdf ↗

Deep learning algorithms for connectomics rely upon localized classification, rather than overall morphology. This leads to a high incidence of erroneously merged objects. Humans, by contrast, can easily detect such errors by acquiring intuition for the correct morphology of objects. Biological neurons have complicated…

2017-05-30abs ↗pdf ↗

C2G-Net improves image classification of similar objects like cells.

problem Classifying images with many similar objects efficiently and interpretably.
method Combines image compression and a CNN with reduced parameters.
result C2G-Net achieves similar accuracy to conventional CNNs but with reduced training time and improved interpretability.

Researchers develop flexible kernels for biological sequences with guaranteed reliability.

problem Challenges in applying machine learning to biological sequences, including unreliable methods.
method Theoretical analysis and development of modified kernels to ensure reliability and accuracy.
result Developed kernels that are universal, characteristic, and metrize the space of distributions for biological sequences.

New learning algorithm mimics biological neural networks.

problem Biologically implausible backpropagation for directed neural networks.
method Introduces new neuronal dynamics and learning rule for arbitrary architectures, sparsity-inducing pruning method, and dynamical-systems characterization.
result Prunes irrelevant connections and improves learning efficiency.

In many physical, statistical, biological and other investigations it is desirable to approximate a system of points by objects of lower dimension and/or complexity. For this purpose, Karl Pearson invented principal component analysis in 1901 and found 'lines and planes of closest fit to system of points'. The famous k…

2008-09-02abs ↗pdf ↗

SENA-discrepancy-VAE interprets latent causal factors in biological pathways.

problem Interpreting latent causal factors in biological pathways.
method SENA-discrepancy-VAE, a model based on discrepancy-VAE, that produces interpretable latent causal factors.
result Sena-discrepancy-VAE achieves comparable predictive performance with non-interpretable counterparts while providing biologically meaningful causal factors.

Paper uses transfer learning and Bayesian optimization to reduce DNA sequence design experiments.

problem Designing many similar DNA sequences for specific applications is expensive and time-consuming.
method Combines transfer learning with Bayesian optimization to reduce experiment count.
result Total number of experiments can be significantly reduced by sharing information between tasks.

A neural network approach for feature selection using mutual information.

problem Feature ranking and selection leading to sub-optimal solutions for class separability.
method Stochastic mutual information gradient estimation for dimensionality reduction.
result The network projects features onto an output space maximizing mutual information with class labels.

Despite significant recent progress, machine vision systems lag considerably behind their biological counterparts in performance, scalability, and robustness. A distinctive hallmark of the brain is its ability to automatically discover and model objects, at multiscale resolutions, from repeated exposures to unlabeled c…

2019-09-30abs ↗pdf ↗

Scalable GPLVM reduces complexity in scRNA-seq data, accounting for technical and biological confounders.

problem Complexity and confounders in scRNA-seq data hamper interpretation.
method Extended Gaussian process latent variable model (GPLVM) to handle large datasets.
result Framework reconstructs latent signatures and captures disease-specific gene expression.

DeepSIBA predicts biological effects of chemical structures using graph neural networks.

problem Predicting biological effects of chemical structures for drug discovery.
method Siamese Graph Convolutional Neural Networks for structure-biological effect mapping.
result Highly accurate predictions of biological effects for structurally dissimilar compounds.

Neural networks have shown great potential in many applications like speech recognition, drug discovery, image classification, and object detection. Neural network models are inspired by biological neural networks, but they are optimized to perform machine learning tasks on digital computers. The proposed work explores…

2017-10-30abs ↗pdf ↗

Proposes a novel network-based neighborhood regression for biological systems.

problem Lack of comprehensive analysis on biological modules using both global and local network data.
method Develops a community-wise least square optimization approach to analyze gene modules and their regulatory strength.
result Achieves exact minimax optimality and linear consistency in identifying gene module associations.

AR algorithm simplifies backpropagation with improved scalability and biological plausibility.

problem Improving backpropagation algorithms for complex neural networks and biological plausibility.
method Introducing learnable backwards weights and avoiding nonlinear derivative computations; relaxing frozen feedforward pass assumption.
result Simplified AR algorithm maintains performance on complex CNN architectures and challenging datasets.

Paper optimizes aquaculture feeding and harvesting strategies for profit maximization.

problem Maximizing farm profit through optimal feeding and harvesting decisions under stochastic price dynamics.
method Developed a simplified aquaculture model and two numerical solution approaches: finite difference scheme and PINN-based method combined with DeepOS algorithm.
result PINN-based method achieves comparable accuracy to finite differences but is more scalable.

Algorithm optimizes biological sequences using bootstrapped training with a score-conditioned generator.

problem Optimizing biological sequences for a black-box score function.
method Bootstrapped training of score-conditioned generator (BootGen) algorithm.
result Our method outperforms competitive baselines on biological sequential design tasks.

Fault-tolerant neural networks inspired by biological error correction codes.

problem Achieving reliable computation with unreliable neurons.
method Using biological error correction codes from grid cells in the mammalian cortex to develop a fault-tolerant neural network.
result Noisy biological neurons operate below a fault-tolerance threshold, suggesting a mechanism for reliable computation in the brain.

Probabilistic graphical models (PGMs) have become a popular tool for computational analysis of biological data in a variety of domains. But, what exactly are they and how do they work? How can we use PGMs to discover patterns that are biologically relevant? And to what extent can PGMs help us formulate new hypotheses t…

2007-06-14abs ↗pdf ↗

The biological plausibility of the backpropagation algorithm has long been doubted by neuroscientists. Two major reasons are that neurons would need to send two different types of signal in the forward and backward phases, and that pairs of neurons would need to communicate through symmetric bidirectional connections. …

2018-08-14abs ↗pdf ↗

New learning rules for wide neural networks without backpropagation.

problem Training wide neural networks efficiently and without backpropagation.
method Input-weight alignment driven by gradient descent in the NTK regime.
result Biologically-motivated learning rules equivalent to backpropagation in wide networks.

We introduce bio-inspired artificial neural networks consisting of neurons that are additionally characterized by spatial positions. To simulate properties of biological systems we add the costs penalizing long connections and the proximity of neurons in a two-dimensional space. Our experiments show that in the case wh…

2019-10-07abs ↗pdf ↗

Graph auto-encoder predicts unobserved node features from biological networks and omics data.

problem Integrating biological networks and continuous node features for better prediction.
method Graph neural networks and feature auto-encoders trained on feature reconstruction.
result Graph feature auto-encoder outperforms auto-encoders trained on graph reconstruction for predicting unobserved node features.

Unified framework improves gene prioritization in disease studies.

problem Identifying genes involved in diseases using heterogeneous biological data.
method Network propagation-based gene prioritization with integrated biological information.
result Significant improvements in prioritizing genes not identified by traditional methods.