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arXiv research

A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.

168,694 papers · 148 categories

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25507499 · Jun 202019922001200920172026
48 results for biological modules

Proposes a novel network-based neighborhood regression for biological systems.

problem Lack of comprehensive analysis on biological modules using both global and local network data.
method Develops a community-wise least square optimization approach to analyze gene modules and their regulatory strength.
result Achieves exact minimax optimality and linear consistency in identifying gene module associations.

Modulating masks improve lifelong reinforcement learning.

problem Catastrophic forgetting and task interference in lifelong reinforcement learning.
method Adapted modulating masks for deep lifelong reinforcement learning (LRL) with PPO and IMPALA agents.
result Superior performance in both discrete and continuous RL tasks compared to LRL baselines.

Optimal transport embedding learns feature sets efficiently.

problem Learning on sets of features with long-range dependencies and few labeled data.
method Parametrized fixed-size embedding that aggregates features according to optimal transport plan.
result Achieves state-of-the-art results on protein fold recognition and chromatin profiles.

The key idea of current deep learning methods for dense prediction is to apply a model on a regular patch centered on each pixel to make pixel-wise predictions. These methods are limited in the sense that the patches are determined by network architecture instead of learned from data. In this work, we propose the dense…

2017-05-24abs ↗pdf ↗

Motivation: The rapid growth of diverse biological data allows us to consider interactions between a variety of objects, such as genes, chemicals, molecular signatures, diseases, pathways and environmental exposures. Often, any pair of objects--such as a gene and a disease--can be related in different ways, for example…

2017-08-10abs ↗pdf ↗

NIPA aims to translate brain learning mechanisms into scalable Bayesian inference.

problem Scalable Bayesian inference for large-scale statistical machine learning problems.
method Neural-inspired algorithm combining model-based, model-free, and episodic-control modules.
result Advances Bayesian methods and facilitates their application to deep learning.

Sparse Singular Value Decomposition (SVD) models have been proposed for biclustering high dimensional gene expression data to identify block patterns with similar expressions. However, these models do not take into account prior group effects upon variable selection. To this end, we first propose group-sparse SVD model…

2018-07-28abs ↗pdf ↗

Enhances SNNs for spatio-temporal feature extraction.

problem Insufficient temporal dependencies in existing SNN synaptic structures.
method Integrates temporal convolution and attention mechanisms into synaptic connections.
result Improves SNN performance on classification tasks.

The paper improves DFA for CNN and RNN training to match BP accuracy.

problem Low accuracy in CNN and RNN training using DFA.
method Divide network into modules, apply DFA within, use sparse backward weight, and incorporate dilated convolution and sparse matrix multiplication.
result Achieves BP-level accuracy in CNN and RNN training.

Researchers develop flexible kernels for biological sequences with guaranteed reliability.

problem Challenges in applying machine learning to biological sequences, including unreliable methods.
method Theoretical analysis and development of modified kernels to ensure reliability and accuracy.
result Developed kernels that are universal, characteristic, and metrize the space of distributions for biological sequences.

New learning algorithm mimics biological neural networks.

problem Biologically implausible backpropagation for directed neural networks.
method Introduces new neuronal dynamics and learning rule for arbitrary architectures, sparsity-inducing pruning method, and dynamical-systems characterization.
result Prunes irrelevant connections and improves learning efficiency.

SENA-discrepancy-VAE interprets latent causal factors in biological pathways.

problem Interpreting latent causal factors in biological pathways.
method SENA-discrepancy-VAE, a model based on discrepancy-VAE, that produces interpretable latent causal factors.
result Sena-discrepancy-VAE achieves comparable predictive performance with non-interpretable counterparts while providing biologically meaningful causal factors.

Scalable GPLVM reduces complexity in scRNA-seq data, accounting for technical and biological confounders.

problem Complexity and confounders in scRNA-seq data hamper interpretation.
method Extended Gaussian process latent variable model (GPLVM) to handle large datasets.
result Framework reconstructs latent signatures and captures disease-specific gene expression.

DeepSIBA predicts biological effects of chemical structures using graph neural networks.

problem Predicting biological effects of chemical structures for drug discovery.
method Siamese Graph Convolutional Neural Networks for structure-biological effect mapping.
result Highly accurate predictions of biological effects for structurally dissimilar compounds.

AR algorithm simplifies backpropagation with improved scalability and biological plausibility.

problem Improving backpropagation algorithms for complex neural networks and biological plausibility.
method Introducing learnable backwards weights and avoiding nonlinear derivative computations; relaxing frozen feedforward pass assumption.
result Simplified AR algorithm maintains performance on complex CNN architectures and challenging datasets.

We solve a lifecycle model in which the consumer's chronological age does not move in lockstep with calendar time. Instead, biological age increases at a stochastic non-linear rate in time like a broken clock that might occasionally move backwards. In other words, biological age could actually decline. Our paper is ins…

2018-11-25abs ↗pdf ↗

Algorithm optimizes biological sequences using bootstrapped training with a score-conditioned generator.

problem Optimizing biological sequences for a black-box score function.
method Bootstrapped training of score-conditioned generator (BootGen) algorithm.
result Our method outperforms competitive baselines on biological sequential design tasks.

Fault-tolerant neural networks inspired by biological error correction codes.

problem Achieving reliable computation with unreliable neurons.
method Using biological error correction codes from grid cells in the mammalian cortex to develop a fault-tolerant neural network.
result Noisy biological neurons operate below a fault-tolerance threshold, suggesting a mechanism for reliable computation in the brain.

Probabilistic graphical models (PGMs) have become a popular tool for computational analysis of biological data in a variety of domains. But, what exactly are they and how do they work? How can we use PGMs to discover patterns that are biologically relevant? And to what extent can PGMs help us formulate new hypotheses t…

2007-06-14abs ↗pdf ↗

We propose rectified factor networks (RFNs) to efficiently construct very sparse, non-linear, high-dimensional representations of the input. RFN models identify rare and small events in the input, have a low interference between code units, have a small reconstruction error, and explain the data covariance structure. R…

2015-02-23abs ↗pdf ↗

New learning rules for wide neural networks without backpropagation.

problem Training wide neural networks efficiently and without backpropagation.
method Input-weight alignment driven by gradient descent in the NTK regime.
result Biologically-motivated learning rules equivalent to backpropagation in wide networks.

Central Pattern Generators (CPGs) are biological neural circuits capable of producing coordinated rhythmic outputs in the absence of rhythmic input. As a result, they are responsible for most rhythmic motion in living organisms. This rhythmic control is broadly applicable to fields such as locomotive robotics and medic…

2019-01-06abs ↗pdf ↗

We introduce bio-inspired artificial neural networks consisting of neurons that are additionally characterized by spatial positions. To simulate properties of biological systems we add the costs penalizing long connections and the proximity of neurons in a two-dimensional space. Our experiments show that in the case wh…

2019-10-07abs ↗pdf ↗

Graph auto-encoder predicts unobserved node features from biological networks and omics data.

problem Integrating biological networks and continuous node features for better prediction.
method Graph neural networks and feature auto-encoders trained on feature reconstruction.
result Graph feature auto-encoder outperforms auto-encoders trained on graph reconstruction for predicting unobserved node features.

Deep Belief Network predicts lncRNA-disease associations with high accuracy.

problem Accurately identifying lncRNA-disease associations to understand lncRNA functionality and disease mechanism.
method Proposes a DBN-based model using heterogeneous networks and DBN for feature learning.
result Obtained AUC of 0.96 and AUPR of 0.967 on standard dataset.

Biological neural network mimics CCA for multi-channel data.

problem Implementing CCA in a biologically plausible neural network.
method Derive an online CCA algorithm with local synaptic updates for multi-compartmental neurons.
result The derived neural network architecture and synaptic updates resemble cortical pyramidal neuron behavior.