Symmetry principles help in creating better AI representations.
problem Creating efficient and generalizable AI representations.
method Using symmetry transformations to guide representation learning.
result Symmetry principles improve data efficiency and generalizability in AI.
This brief note highlights some basic concepts required toward understanding the evolution of machine learning and deep learning models. The note starts with an overview of artificial intelligence and its relationship to biological neuron that ultimately led to the evolution of todays intelligent models.
Recent developments in machine-learning algorithms have led to impressive performance increases in many traditional application scenarios of artificial intelligence research. In the area of deep reinforcement learning, deep learning functional architectures are combined with incremental learning schemes for sequential …
While deep learning has led to remarkable advances across diverse applications, it struggles in domains where the data distribution changes over the course of learning. In stark contrast, biological neural networks continually adapt to changing domains, possibly by leveraging complex molecular machinery to solve many t…
Computational Intelligence (CI) is a sub-branch of Artificial Intelligence paradigm focusing on the study of adaptive mechanisms to enable or facilitate intelligent behavior in complex and changing environments. There are several paradigms of CI [like artificial neural networks, evolutionary computations, swarm intelli…
AI enhances microbiology and microbiome research through machine learning.
problem Understanding microbial life and its impact on health and the environment.
method AI-driven approaches including machine learning and deep learning.
result Transformative role in enhancing microbial life understanding.
Stochasticity is key for machine learning's robustness and generalizability.
problem Machine learning's need for robustness and generalizability.
method Review of ML literature and biological intelligence.
result Stochasticity is a critical ingredient for intelligent systems in ML.
Fault-tolerant neural networks inspired by biological error correction codes.
problem Achieving reliable computation with unreliable neurons.
method Using biological error correction codes from grid cells in the mammalian cortex to develop a fault-tolerant neural network.
result Noisy biological neurons operate below a fault-tolerance threshold, suggesting a mechanism for reliable computation in the brain.
Mathematical framework using Riemannian geometry for intelligence and consciousness.
problem Lack of a unified mathematical framework for intelligence and consciousness.
method Conceptualizes intelligence as tokens in a high-dimensional space, using Riemannian geometry to describe structure and dynamics.
result Integrates geometric concepts to offer a unified framework for intelligence and consciousness.
Deep active inference agents learn complex environments using Monte-Carlo methods.
problem Understanding and modeling biological intelligence in complex, continuous state-spaces.
method Neural architecture for deep active inference agents using multiple forms of Monte-Carlo sampling.
result Deep active inference agents can learn environmental dynamics and plan future actions.
Ant colonies and boosting algorithms both reduce bias and variance through adaptive mechanisms.
problem Understanding the mathematical principles behind ensemble learning and ant colony behavior.
method Developed a formal mapping between AdaBoost's adaptive reweighting and ant recruitment dynamics.
result Proved that the fundamental theorem of weak learnability has a direct analog in colony decision-making.
This study shows how social insects and machine learning methods share a common mathematical framework.
problem Understanding how decentralized systems achieve optimal decision-making.
method Developed a rigorous mathematical framework to show isomorphism between ant colonies and ensemble machine learning.
result Demonstrated that ant colony decision-making and random forest learning implement identical variance reduction strategies through decorrelation of identical units.
A new model uses 'ghost units' to enable efficient backpropagation in deep neural networks.
problem How to achieve efficient backpropagation in deep neural networks with biological plausibility.
method Introduces 'ghost units' to cancel feedback, enabling efficient error backpropagation.
result Demonstrates that the model can approximate error gradients and achieve good performance on classification tasks.
Despite our extensive knowledge of biophysical properties of neurons, there is no commonly accepted algorithmic theory of neuronal function. Here we explore the hypothesis that single-layer neuronal networks perform online symmetric nonnegative matrix factorization (SNMF) of the similarity matrix of the streamed data. …
It is a long-standing challenge to enable an intelligent agent to learn in one environment and generalize to an unseen environment without further data collection and finetuning. In this paper, we consider a zero shot generalization problem setup that complies with biological intelligent agents' learning and generaliza…
Rapid advances of hardware-based technologies during the past decades have opened up new possibilities for Life scientists to gather multimodal data in various application domains (e.g., Omics, Bioimaging, Medical Imaging, and [Brain/Body]-Machine Interfaces), thus generating novel opportunities for development of dedi…
A new neural model evolves to learn at the synaptic level.
problem Lack of biologically realistic neural models in deep learning.
method Evolve individual neuron and synaptic models using ENUs.
result Evolved neural network learns complex tasks like a T-maze.
Study adapts AI research methods to analyze image augmentation impacts on neural network operations.
problem Understanding how image augmentation affects neural network performance and sensitivity.
method Adapted treatment-control paradigm, uses variance decomposition, Sobol indices, and Shapley values for sensitivity analysis.
result Visualizes and quantifies sensitivity to different image augmentation parameters.
There has been significant recent interest towards achieving highly efficient deep neural network architectures. A promising paradigm for achieving this is the concept of evolutionary deep intelligence, which attempts to mimic biological evolution processes to synthesize highly-efficient deep neural networks over succe…
This guide introduces machine learning for medical data analysis.
problem Handling large, complex datasets in healthcare.
method Explains common machine learning algorithms and tasks.
result Illustrates machine learning applications in healthcare.
Recent progress in artificial intelligence (AI) has renewed interest in building systems that learn and think like people. Many advances have come from using deep neural networks trained end-to-end in tasks such as object recognition, video games, and board games, achieving performance that equals or even beats humans …
Generative diffusion models mimic biological memory networks, encoding associative dynamics in deep neural weights.
problem Understanding long-term memory mechanisms in neuroscience and AI.
method Interpreting generative diffusion models as energy-based models and comparing them to Hopfield networks.
result Generative diffusion models can encode associative dynamics of Hopfield networks in deep neural weights.
The practical success of widely used machine learning (ML) and deep learning (DL) algorithms in Artificial Intelligence (AI) community owes to availability of large datasets for training and huge computational resources. Despite the enormous practical success of AI, these algorithms are only loosely inspired from the b…
Predictive coding networks use inference learning for efficient AI modeling.
problem Traditional AI methods struggle with complex neural patterns.
method Inference learning for hierarchical Bayesian inference models.
result PCNs outperform traditional BP methods in efficiency and flexibility.
The roundworm C. elegans exhibits robust escape behavior in response to rapidly rising temperature. The behavior lasts for a few seconds, shows history dependence, involves both sensory and motor systems, and is too complicated to model mechanistically using currently available knowledge. Instead we model the process p…
Animals excel at adapting their intentions, attention, and actions to the environment, making them remarkably efficient at interacting with a rich, unpredictable and ever-changing external world, a property that intelligent machines currently lack. Such an adaptation property relies heavily on cellular neuromodulation,…
A brain-inspired spiking Transformer reduces energy consumption and enhances interpretability.
problem Energy inefficiency and lack of interpretability in Transformer models.
method Spiking STDP Transformer using spike-timing-dependent plasticity (STDP) for self-attention.
result Achieves 94.35% and 78.08% accuracy on CIFAR-10 and CIFAR-100 datasets respectively, with 88.47% energy reduction.
Optimal algorithm selects biological models without prior info.
problem Determining the correct biological model without prior knowledge.
method Systems biology models and likelihood-free inference.
result Improved model selection performance over conventional methods.
Researchers develop flexible kernels for biological sequences with guaranteed reliability.
problem Challenges in applying machine learning to biological sequences, including unreliable methods.
method Theoretical analysis and development of modified kernels to ensure reliability and accuracy.
result Developed kernels that are universal, characteristic, and metrize the space of distributions for biological sequences.
Skip connections improve biologically-inspired learning rules.
problem Biologically-inspired learning rules often underperform compared to backpropagation.
method Introduced skip connections between intermediate layers in biologically-motivated learning rules.
result Skip connections can match the performance of backpropagation and are robust to hyper-parameters.
Novel tRSA combines geometry and topology for brain and model analysis.
problem Traditional RSA overlooks topological information in neural representations.
method Topological RSA (tRSA) using nonlinear monotonic transforms.
result Robust model comparisons and novel insights into neural computation.
New learning algorithm mimics biological neural networks.
problem Biologically implausible backpropagation for directed neural networks.
method Introduces new neuronal dynamics and learning rule for arbitrary architectures, sparsity-inducing pruning method, and dynamical-systems characterization.
result Prunes irrelevant connections and improves learning efficiency.
SENA-discrepancy-VAE interprets latent causal factors in biological pathways.
problem Interpreting latent causal factors in biological pathways.
method SENA-discrepancy-VAE, a model based on discrepancy-VAE, that produces interpretable latent causal factors.
result Sena-discrepancy-VAE achieves comparable predictive performance with non-interpretable counterparts while providing biologically meaningful causal factors.
Deep learning applied to biological data mining.
problem Mining complex biological data from diverse sources.
method Artificial neural networks, deep learning architectures.
result Deep learning techniques improve pattern recognition in biological data.
Biological networks are a very convenient modelling and visualisation tool to discover knowledge from modern high-throughput genomics and postgenomics data sets. Indeed, biological entities are not isolated, but are components of complex multi-level systems. We go one step further and advocate for the consideration of …
Scalable GPLVM reduces complexity in scRNA-seq data, accounting for technical and biological confounders.
problem Complexity and confounders in scRNA-seq data hamper interpretation.
method Extended Gaussian process latent variable model (GPLVM) to handle large datasets.
result Framework reconstructs latent signatures and captures disease-specific gene expression.
DeepSIBA predicts biological effects of chemical structures using graph neural networks.
problem Predicting biological effects of chemical structures for drug discovery.
method Siamese Graph Convolutional Neural Networks for structure-biological effect mapping.
result Highly accurate predictions of biological effects for structurally dissimilar compounds.
New methods improve uncertainty quantification in dynamic biological systems.
problem Uncertainty in dynamic biological models due to nonlinearity and parameter sensitivity.
method Conformal inference methods for non-asymptotic guarantees.
result Enhanced robustness and scalability for diverse biological data structures.
Proposes a novel network-based neighborhood regression for biological systems.
problem Lack of comprehensive analysis on biological modules using both global and local network data.
method Develops a community-wise least square optimization approach to analyze gene modules and their regulatory strength.
result Achieves exact minimax optimality and linear consistency in identifying gene module associations.
AI learns market manipulation through simulation, suggesting regulation.
problem Regulating AI to prevent market manipulation.
method Used a genetic algorithm in an artificial market simulation.
result AI discovered market manipulation as an optimal strategy.
A promising paradigm for achieving highly efficient deep neural networks is the idea of evolutionary deep intelligence, which mimics biological evolution processes to progressively synthesize more efficient networks. A crucial design factor in evolutionary deep intelligence is the genetic encoding scheme used to simula…
AR algorithm simplifies backpropagation with improved scalability and biological plausibility.
problem Improving backpropagation algorithms for complex neural networks and biological plausibility.
method Introducing learnable backwards weights and avoiding nonlinear derivative computations; relaxing frozen feedforward pass assumption.
result Simplified AR algorithm maintains performance on complex CNN architectures and challenging datasets.
We solve a lifecycle model in which the consumer's chronological age does not move in lockstep with calendar time. Instead, biological age increases at a stochastic non-linear rate in time like a broken clock that might occasionally move backwards. In other words, biological age could actually decline. Our paper is ins…
Enhances sequence memory capacity in neural networks.
problem Limited sequence capacity in Hopfield-like neural networks.
method Introducing a nonlinear interaction term and a generalized pseudoinverse rule.
result Significantly increased sequence capacity with novel scaling laws.
Algorithm optimizes biological sequences using bootstrapped training with a score-conditioned generator.
problem Optimizing biological sequences for a black-box score function.
method Bootstrapped training of score-conditioned generator (BootGen) algorithm.
result Our method outperforms competitive baselines on biological sequential design tasks.
MoleculeSTM learns from molecule structures and texts for better drug design.
problem Lack of integration between chemical structures and textual knowledge in AI drug discovery.
method Jointly learns chemical structures and texts via contrastive learning, using a large dataset.
result MoleculeSTM achieves state-of-the-art performance in zero-shot tasks like structure-text retrieval and molecule editing.
Artificial intelligence has impacted many aspects of human life. This paper studies the impact of artificial intelligence on economic theory. In particular we study the impact of artificial intelligence on the theory of bounded rationality, efficient market hypothesis and prospect theory.
Paper develops a framework to discover bioprocessing regulatory mechanisms using symbolic and statistical learning.
problem Challenges in modeling complex intracellular regulation, stochastic system behavior, and limited experimental data.
method Symbolic and statistical learning framework based on stochastic differential equations and Bayesian learning.
result Improved sample efficiency and robust model selection compared to state-of-the-art approaches.