Extracts biological context from biomedical texts to associate with events.
problem Identifying biological context and associating it with biochemical events in texts.
method Analyzed an annotated corpus and developed classifiers using syntactic, distance, and frequency features.
result Developed and evaluated classifiers for context-event association.
The paper explores metrics and models for analyzing biological shapes.
problem Analyzing biological shapes using mathematical metrics.
method Review of Riemannian metrics and evolution equations, focusing on diffeomorphic shape analysis.
result Introduction of a new class of metrics involving optimization of a growth tensor.
Biological networks are a very convenient modelling and visualisation tool to discover knowledge from modern high-throughput genomics and postgenomics data sets. Indeed, biological entities are not isolated, but are components of complex multi-level systems. We go one step further and advocate for the consideration of …
Scalable GPLVM reduces complexity in scRNA-seq data, accounting for technical and biological confounders.
problem Complexity and confounders in scRNA-seq data hamper interpretation.
method Extended Gaussian process latent variable model (GPLVM) to handle large datasets.
result Framework reconstructs latent signatures and captures disease-specific gene expression.
BaGGLS models biological interactions using Bayesian shrinkage for interpretability.
problem Interpreting complex interactions in high-dimensional biological data.
method Bayesian group global-local shrinkage prior with variational approximation.
result BaGGLS outperforms other methods in interaction detection and scalability.
New methods improve uncertainty quantification in dynamic biological systems.
problem Uncertainty in dynamic biological models due to nonlinearity and parameter sensitivity.
method Conformal inference methods for non-asymptotic guarantees.
result Enhanced robustness and scalability for diverse biological data structures.
Hexnet framework enhances image processing with hexagonal structures.
problem Improve image processing systems with biological-inspired hexagonal structures.
method Develops a hexagonal deep learning framework (Hexnet) for image processing.
result Hexnet surpasses current hexagonal image processing systems and artificial neural networks.
Exclusive Group Lasso improves feature selection in correlated biological data.
problem Correlated features hinder Lasso performance in biological classification problems.
method Proposes and solves the exclusive group Lasso, combining stability selection and random group allocation.
result Exclusive Group Lasso outperforms Lasso in comprehensive selection of informative features.
Networks are ubiquitous in biology and computational approaches have been largely investigated for their inference. In particular, supervised machine learning methods can be used to complete a partially known network by integrating various measurements. Two main supervised frameworks have been proposed: the local appro…
Automated tests detect interactions in unstructured data.
problem Detecting interactions between latent variables in low-dimensional systems.
method Derive two interaction tests based on pairwise interventions and integrate them into an active learning pipeline.
result Tests can identify more known biological interactions than random search and standard active learning baselines.
New method trains neural networks with local error signals, outperforming global methods.
problem Training neural networks with global error signals.
method Layer-wise training with local error signals.
result Layer-wise training with local error signals can approach state-of-the-art performance.
engGNN combines external and generated graphs to improve disease classification and biomarker discovery.
problem Challenges in integrating omics data due to high dimensionality and small sample sizes.
method Dual-graph framework that integrates external biological networks with data-driven generated graphs.
result engGNN outperforms state-of-the-art methods in disease classification and biomarker discovery.
Intratumor heterogeneity is often manifested by vascular compartments with distinct pharmacokinetics that cannot be resolved directly by in vivo dynamic imaging. We developed tissue-specific compartment modeling (TSCM), an unsupervised computational method of deconvolving dynamic imaging series from heterogeneous tumor…
Proposes CCCVAE for better single-cell clustering with cell-cell communication.
problem Improving single-cell RNA sequencing clustering by incorporating cell-cell communication.
method Integrates cell-cell communication into a variational autoencoder framework.
result Empirical results show CCCVAE outperforms standard VAEs in clustering performance.
DASH simplifies neural networks for gene regulatory dynamics using domain knowledge.
problem Pruning neural networks for gene regulatory dynamics lacks biologically meaningful structure learning.
method DASH uses domain-specific structural information to guide network pruning, leading to sparser, better interpretable models.
result DASH outperforms general pruning methods in gene regulatory network inference, yielding deeper insights.
Predicting the biological function of molecules, be it proteins or drug-like compounds, from their atomic structure is an important and long-standing problem. Function is dictated by structure, since it is by spatial interactions that molecules interact with each other, both in terms of steric complementarity, as well …
A neural network learns word-referent associations across various contexts.
problem Learning word-referent associations in different contexts.
method A biologically inspired multi-layered architecture that takes images and phonemes as input, builds representations, and adjusts prototypes based on current context.
result The model achieves up to 78% accuracy in ambiguous situations and mimics human learning patterns.
Complex architectures of biological neural circuits, such as parallel processing pathways, has been behaviorally implicated in many cognitive studies. However, the theoretical consequences of circuit complexity on neural computation have only been explored in limited cases. Here, we introduce a mechanism by which direc…
PepCVAE designs novel antimicrobial peptides using a semi-supervised VAE.
problem Designing novel antimicrobial peptides for next-generation antimicrobial resistance solutions.
method Semi-supervised variational autoencoder (VAE) model that learns latent and antimicrobial attribute spaces from unlabeled and labeled data.
result PepCVAE generates novel AMPs with higher long-range diversity and closer to biological peptide distribution.
Optimal algorithm selects biological models without prior info.
problem Determining the correct biological model without prior knowledge.
method Systems biology models and likelihood-free inference.
result Improved model selection performance over conventional methods.
Study adapts AI research methods to analyze image augmentation impacts on neural network operations.
problem Understanding how image augmentation affects neural network performance and sensitivity.
method Adapted treatment-control paradigm, uses variance decomposition, Sobol indices, and Shapley values for sensitivity analysis.
result Visualizes and quantifies sensitivity to different image augmentation parameters.
New methods learn causal networks from high-dimensional time series data.
problem Understanding complex dynamic systems with limited data and knowledge.
method Combination of Gaussian processes and abstract network modeling.
result Learn causal relations and synthesize causal networks from high-dimensional time series data.
Researchers develop flexible kernels for biological sequences with guaranteed reliability.
problem Challenges in applying machine learning to biological sequences, including unreliable methods.
method Theoretical analysis and development of modified kernels to ensure reliability and accuracy.
result Developed kernels that are universal, characteristic, and metrize the space of distributions for biological sequences.
Skip connections improve biologically-inspired learning rules.
problem Biologically-inspired learning rules often underperform compared to backpropagation.
method Introduced skip connections between intermediate layers in biologically-motivated learning rules.
result Skip connections can match the performance of backpropagation and are robust to hyper-parameters.
New learning algorithm mimics biological neural networks.
problem Biologically implausible backpropagation for directed neural networks.
method Introduces new neuronal dynamics and learning rule for arbitrary architectures, sparsity-inducing pruning method, and dynamical-systems characterization.
result Prunes irrelevant connections and improves learning efficiency.
Unified view of context in machine learning models.
problem Exploring context in machine learning models.
method Decompose observation into context-free and context-sensitive parts.
result Significant performance boost in sentence embedding models.
Spatially positioned neurons in neural networks mimic biological systems.
problem Creating neural networks that can perform multiple tasks efficiently.
method Added spatial positions and proximity penalties to artificial neurons.
result Neurons naturally cluster, each responsible for a specific task.
SENA-discrepancy-VAE interprets latent causal factors in biological pathways.
problem Interpreting latent causal factors in biological pathways.
method SENA-discrepancy-VAE, a model based on discrepancy-VAE, that produces interpretable latent causal factors.
result Sena-discrepancy-VAE achieves comparable predictive performance with non-interpretable counterparts while providing biologically meaningful causal factors.
The paper models retirement spending using biological age instead of chronological age.
problem Retirement spending varies at the same chronological age.
method Developed a stochastic mortality model to adjust for biological age.
result Optimal consumption rates derived using biological age.
Deep learning applied to biological data mining.
problem Mining complex biological data from diverse sources.
method Artificial neural networks, deep learning architectures.
result Deep learning techniques improve pattern recognition in biological data.
New neural network learns adaptive behaviors inspired by neuromodulation.
problem Current AI lacks the ability to adapt to changing environments.
method Inspired by cellular neuromodulation, a new deep neural network architecture is designed.
result Neuromodulation-based networks improve adaptation in meta-reinforcement learning tasks.
NESS improves neighbor embedding for smooth cell-state transitions in single-cell data.
problem Challenges in extracting smooth, low-dimensional representations from noisy single-cell data.
method Builds on PCS framework to develop NESS, a stable machine learning approach.
result NESS consistently yields useful biological insights across diverse single-cell datasets.
DeepSIBA predicts biological effects of chemical structures using graph neural networks.
problem Predicting biological effects of chemical structures for drug discovery.
method Siamese Graph Convolutional Neural Networks for structure-biological effect mapping.
result Highly accurate predictions of biological effects for structurally dissimilar compounds.
Proposes a novel network-based neighborhood regression for biological systems.
problem Lack of comprehensive analysis on biological modules using both global and local network data.
method Develops a community-wise least square optimization approach to analyze gene modules and their regulatory strength.
result Achieves exact minimax optimality and linear consistency in identifying gene module associations.
The green area of economy is the key of healthy living. It is necessary to convene economic and ecologic framework to establish a market attentive to drastic reduction of emissions damaging our climate and landscapes in rural areas, to the protection of biological diversity of the planet, to stop producing nuclear wast…
AR algorithm simplifies backpropagation with improved scalability and biological plausibility.
problem Improving backpropagation algorithms for complex neural networks and biological plausibility.
method Introducing learnable backwards weights and avoiding nonlinear derivative computations; relaxing frozen feedforward pass assumption.
result Simplified AR algorithm maintains performance on complex CNN architectures and challenging datasets.
Study identifies cancer genes through graph anomaly analysis of protein interactions.
problem Insufficient modeling of biological information in protein interaction networks for cancer gene identification.
method Proposes HIerarchical-Perspective Graph Neural Network (HIPGNN) to detect weight heterogeneity and spectral flattening in cancer gene nodes.
result HIPGNN detects weight heterogeneity and spectral flattening, leading to improved cancer gene identification.
TransST improves spatial transcriptomics data analysis by identifying cell clusters and biomarkers.
problem Low resolution and insufficient sequencing depth in spatial transcriptomics data.
method Transfer learning framework to adaptively leverage external cell-labeled information.
result TransST successfully identifies five biologically meaningful cell clusters and separates adipose tissues from connective issues.
Algorithm optimizes biological sequences using bootstrapped training with a score-conditioned generator.
problem Optimizing biological sequences for a black-box score function.
method Bootstrapped training of score-conditioned generator (BootGen) algorithm.
result Our method outperforms competitive baselines on biological sequential design tasks.
In this work a new way to calculate the multivariate joint entropy is presented. This measure is the basis for a fast information-theoretic based evaluation of gene relevance in a Microarray Gene Expression data context. Its low complexity is based on the reuse of previous computations to calculate current feature rele…
Fault-tolerant neural networks inspired by biological error correction codes.
problem Achieving reliable computation with unreliable neurons.
method Using biological error correction codes from grid cells in the mammalian cortex to develop a fault-tolerant neural network.
result Noisy biological neurons operate below a fault-tolerance threshold, suggesting a mechanism for reliable computation in the brain.
This thesis tackles data fusion issues across different biological scales and types.
problem Heterogeneity in data types and scales in systems biology.
method Developed statistical methods to fuse heterogeneous data sets.
result Advantages of proposed methods assessed through simulations and real data analysis.
Probabilistic graphical models (PGMs) have become a popular tool for computational analysis of biological data in a variety of domains. But, what exactly are they and how do they work? How can we use PGMs to discover patterns that are biologically relevant? And to what extent can PGMs help us formulate new hypotheses t…
DBNs improve accuracy of biological ODE models with missing data.
problem Uncertainty in biological ODE models with missing data.
method Converted ODE models to DBNs and used Particle Filtering for parameter estimation.
result DBNs can accurately infer model variables with missing data.
METCC learns distances to control confounders in high-dimensional data.
problem Technical and biological confounders in high-dimensional biological data.
method Contrastive metric learning using a non-linear triplet network.
result METCC outperforms linear methods in classifying biological samples.
Cellina uses supervised disentanglement to predict cell behavior in tissues.
problem Querying counterfactuals on tissue graphs
method Cellina framework using supervised disentanglement
result Outperforms spatially-informed and non-spatial competitors
Improves prediction performance on biological data by controlling confounding factors.
problem Challenges in statistical learning due to confounding variables in biological data.
method ONION for removing confounding covariates and DANN for penalizing confounder information.
result Significant improvements in generalization performance on simulated and empirical patient data.
New learning rules for wide neural networks without backpropagation.
problem Training wide neural networks efficiently and without backpropagation.
method Input-weight alignment driven by gradient descent in the NTK regime.
result Biologically-motivated learning rules equivalent to backpropagation in wide networks.