The paper explores metrics and models for analyzing biological shapes.
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Oja's rule improves neural network training without engineered tricks.
Theory models nonlinear soft tissue elasticity and remodeling using extended Finsler geometry.
Cooperation is a persistent behavioral pattern of entities pooling and sharing resources. Its ubiquity in nature poses a conundrum. Whenever two entities cooperate, one must willingly relinquish something of value to the other. Why is this apparent altruism favored in evolution? Classical solutions assume a net fitness…
Rapid advances of hardware-based technologies during the past decades have opened up new possibilities for Life scientists to gather multimodal data in various application domains (e.g., Omics, Bioimaging, Medical Imaging, and [Brain/Body]-Machine Interfaces), thus generating novel opportunities for development of dedi…
Optimizes harvesting in biopharmaceutical fermentation with limited data.
EB-VAE combines tumor growth and dropout data for personalized treatment response modeling.
We collect and analyze the data for working time, life expectancy, and the pair output and infrastructure of industrializing nations. During S-functional recovery from disaster the pair's time shifts yield 25 years for the infrastructure's physical lifetime. At G7 level the per capita outputs converge and the time shif…
Optimal algorithm selects biological models without prior info.
Specialization and diversification are two major strategies that complex systems might exploit. Given a fixed amount of resources, the question is whether to invest this in elements that respond in a correlated manner to external perturbations, or to build a diversified system with groups of elements that respond in a …
Researchers develop flexible kernels for biological sequences with guaranteed reliability.
Metric anomalies arising from a distribution of point defects (intrinsic interstitials, vacancies, point stacking faults), thermal deformation, biological growth, etc. are well known sources of material inhomogeneity and internal stress. By emphasizing the geometric nature of such anomalies we seek their representation…
New learning algorithm mimics biological neural networks.
SENA-discrepancy-VAE interprets latent causal factors in biological pathways.
Study identifies stable configurations of intertwined threads with repulsive interactions.
Biological networks are a very convenient modelling and visualisation tool to discover knowledge from modern high-throughput genomics and postgenomics data sets. Indeed, biological entities are not isolated, but are components of complex multi-level systems. We go one step further and advocate for the consideration of …
Scalable GPLVM reduces complexity in scRNA-seq data, accounting for technical and biological confounders.
DeepSIBA predicts biological effects of chemical structures using graph neural networks.
SSRCA simplifies ABM sensitivity analysis using machine learning.
New methods improve uncertainty quantification in dynamic biological systems.
Proposes a novel network-based neighborhood regression for biological systems.
Develops adaptive algorithms for sustainable fertilizer use in agriculture.
AR algorithm simplifies backpropagation with improved scalability and biological plausibility.
We solve a lifecycle model in which the consumer's chronological age does not move in lockstep with calendar time. Instead, biological age increases at a stochastic non-linear rate in time like a broken clock that might occasionally move backwards. In other words, biological age could actually decline. Our paper is ins…
In many domains, scientists build complex simulators of natural phenomena that encode their hypotheses about the underlying processes. These simulators can be deterministic or stochastic, fast or slow, constrained or unconstrained, and so on. Optimizing the simulators with respect to a set of parameter values is common…
Algorithm optimizes biological sequences using bootstrapped training with a score-conditioned generator.
Backpropagation is the workhorse of deep learning, however, several other biologically-motivated learning rules have been introduced, such as random feedback alignment and difference target propagation. None of these methods have produced a competitive performance against backpropagation. In this paper, we show that bi…
Fault-tolerant neural networks inspired by biological error correction codes.
Probabilistic graphical models (PGMs) have become a popular tool for computational analysis of biological data in a variety of domains. But, what exactly are they and how do they work? How can we use PGMs to discover patterns that are biologically relevant? And to what extent can PGMs help us formulate new hypotheses t…
Recent technological advancements in data acquisition tools allowed life scientists to acquire multimodal data from different biological application domains. Broadly categorized in three types (i.e., sequences, images, and signals), these data are huge in amount and complex in nature. Mining such an enormous amount of …
New learning rules for wide neural networks without backpropagation.
We present an analysis of the problem of identifying biological context and associating it with biochemical events in biomedical texts. This constitutes a non-trivial, inter-sentential relation extraction task. We focus on biological context as descriptions of the species, tissue type and cell type that are associated …
We introduce bio-inspired artificial neural networks consisting of neurons that are additionally characterized by spatial positions. To simulate properties of biological systems we add the costs penalizing long connections and the proximity of neurons in a two-dimensional space. Our experiments show that in the case wh…
Graph auto-encoder predicts unobserved node features from biological networks and omics data.
Quantitatively predicting phenotype variables by the expression changes in a set of candidate genes is of great interest in molecular biology but it is also a challenging task for several reasons. First, the collected biological observations might be heterogeneous and correspond to different biological mechanisms. Seco…
In this work, we perform an exploratory study on synthesizing deep neural networks using biological synaptic strength distributions, and the potential influence of different distributions on modelling performance particularly for the scenario associated with small data sets. Surprisingly, a CNN with convolutional layer…
Biological neural network mimics CCA for multi-channel data.
High-dimensional data acquired from biological experiments such as next generation sequencing are subject to a number of confounding effects. These effects include both technical effects, such as variation across batches from instrument noise or sample processing, or institution-specific differences in sample acquisiti…
ODBAE detects complex phenotypes in biological data.
The process of morphogenesis, which can be defined as an evolution of the form of an organism, is one of the most intriguing mysteries in the life sciences. It is clear, that gene expression patterns cannot explain the development of the precise geometry of an organism and its parts in space. Here, we suggest a set of …
BioBO optimizes gene perturbation design using Bayesian optimization with biological priors.
New learning rules from information bottleneck improve deep learning without precise labels.
New method estimates SDE parameters efficiently using WCE and SGD.
Recent developments in machine-learning algorithms have led to impressive performance increases in many traditional application scenarios of artificial intelligence research. In the area of deep reinforcement learning, deep learning functional architectures are combined with incremental learning schemes for sequential …
BaGGLS models biological interactions using Bayesian shrinkage for interpretability.
Proposes a new neural network architecture inspired by biology to improve learning and information flow.
New method extracts biological concepts from cell microscopy images.
New test identifies specific biological parameters for personalized CVD detection.