Developed a new algorithm to improve dynamic treatment regimens.
problem Non-convergence of Q-learning-based Q-shared algorithm in dynamic treatment regimens.
method Penalized Q-shared algorithm to address convergence issues.
result The penalized Q-shared algorithm converges and outperforms the original in various settings.
RL algorithms with medical integration improve personalized treatment recommendations.
problem Developing effective personalized treatment strategies for chronic diseases.
method Integrating medical knowledge into RL algorithms for DTR.
result Enhanced treatment recommendations with increased confidence.
New algorithm estimates treatment effects for more efficient contextual bandits.
problem Contextual bandits struggle with action-independent reward redundancies.
method Reduces contextual bandits to heterogeneous treatment effect estimation.
result Heterogeneous treatment effect estimation leads to more efficient model estimation.
Develops statistical inference for ML-discovered heterogeneous treatment effects.
problem ML algorithms may fail to accurately ascertain heterogeneous treatment effects in practical settings.
method Neyman's repeated sampling framework, dividing sample into groups, estimating average treatment effects, constructing confidence intervals.
result Valid methodology for estimating and testing heterogeneous treatment effects without relying on ML algorithm properties.
Causal Interaction Trees identify treatment subgroup effects in observational data.
problem Identifying subgroups with enhanced treatment effects in observational studies.
method Extending Classification and Regression Trees with subgroup-specific treatment effect estimators.
result The proposed algorithms enhance treatment effect heterogeneity in subgroups.
Develops algorithm to find subgroups with different treatment effects in HIV patients.
problem Estimating treatment effects in EHR data with challenges like time-varying confounding.
method SDLD algorithm combining generalized interaction tree and longitudinal targeted maximum likelihood estimation.
result Identifies subgroups of HIV patients at higher risk of weight gain with dolutegravir-containing ARTs.
Algorithm uncovers treatment effect heterogeneity in educational RD designs.
problem Discovering sources of treatment effect heterogeneity in regression discontinuity designs.
method Causal supervised machine learning algorithm to build a 'regression discontinuity tree'.
result Algorithm uncovers various sources of heterogeneity in the impact of attending a better secondary school.
Proposes a generalized causal tree for handling multiple treatments in uplift modeling.
problem Handling multiple treatments in uplift modeling.
method Generalizes causal tree algorithm to handle multiple discrete and continuous-valued treatments.
result Demonstrates improved performance over existing methods in experiments and real data examples.
Paper tackles estimating individual treatment effects from observational data.
problem Estimating the difference between outcomes with and without treatment from single observation.
method Formulated as inference from hidden variables, uses a model of four causal populations, proposes ECM algorithm.
result ECM algorithm provides better performance compared to baseline methods on synthetic and real-world data.
In both the fields of computer science and medicine there is very strong interest in developing personalized treatment policies for patients who have variable responses to treatments. In particular, I aim to find an optimal personalized treatment policy which is a non-deterministic function of the patient specific cova…
A new algorithm learns optimal personalized treatment plans online with low regret.
problem Learning optimal dynamic treatment regimes in an online setting.
method Developed a novel algorithm balancing exploration and exploitation for rate-optimal regret.
result Guaranteed rate-optimal regret for linear transition and reward models.
Understanding the effect of a particular treatment or a policy pertains to many areas of interest, ranging from political economics, marketing to healthcare. In this paper, we develop a non-parametric algorithm for detecting the effects of treatment over time in the context of Synthetic Controls. The method builds on c…
Proposes a new method to estimate continuous treatment policies and match treatments effectively.
problem Current methods struggle with continuous treatment policies and complex matching.
method Formulates treatment effectiveness as a parametrizable model, using deep learning for optimization.
result Significant improvement in treatment effectiveness and matching efficiency.
New algorithms bound treatment effects with unmeasured confounding.
problem Estimating causal effects when confounding is unmeasured.
method Formulate causal effects as objective functions in optimization, using stochastic methods and Monte Carlo.
result Efficient algorithms for bounded treatment effects in complex settings.
New methods optimize personalized treatment assignment in trials with many arms.
problem Poor performance of standard methods in trials with many treatment arms.
method Regularized and clustered joint assignment forest algorithm.
result Gains in predicting arm-wise outcomes and utility gains from personalization.
Paper tackles CATE estimation with missing treatment info.
problem Challenges in estimating CATE with missing treatment information.
method Developed MTRNet, a novel CATE estimation algorithm using domain adaptation.
result Improves CATE estimation over state-of-the-art methods.
New algorithm improves causal effect estimation for continuous treatments.
problem Observational causal inference with continuous treatments.
method End-to-end entropy balancing for maximizing causal inference accuracy.
result Our algorithm estimates causal effect more accurately than baseline.
Paper proposes robust methods for estimating optimal treatment rules with censored survival data.
problem Estimating optimal treatment rules for censored survival data.
method Developed two robust criteria and a sampling-based difference-of-convex algorithm for learning optimal treatment rules.
result Proposed methods show improved performance compared to existing methods in simulations and real data.
Neural network feature optimization for causal inference.
problem Estimating heterogeneous treatment effects from data.
method Genetic algorithm optimization of intermediate neural network layers for feature representations.
result Retains useful features for outcome prediction even if related to treatment assignment.
Framework assesses variable importance for heterogeneous treatment effects.
problem High-risk domains need reliable methods to assess treatment effect heterogeneity.
method Inferential framework based on Shapley values and semiparametric theory.
result Valid inference on variable importance for heterogeneous treatment effects.
New boundary treatment improves accuracy for complex PDEs.
problem Order reduction in high-order IMEX schemes for multidimensional PDEs.
method Novel boundary treatment algorithms for Cartesian meshes, treating implicit-explicit stages similarly to interior points.
result Recovery of designed order of convergence by numerical verification.
A new meta-algorithm for estimating the conditional average treatment effects is proposed in the paper. The main idea underlying the algorithm is to consider a new dataset consisting of feature vectors produced by means of concatenation of examples from control and treatment groups, which are close to each other. Outco…
New test for binary treatment effects using kernel methods.
problem Testing distributional effects of binary treatments.
method Kernel-based doubly-robust test, avoiding permutations.
result Valid type-I error with computational efficiency.
Study optimal and equitable encouragement policies for treatment adherence.
problem Optimal treatment adherence policies in the presence of human non-adherence.
method Covariate-conditional no-direct-effect model of encouragement; tractable policy characterizations under constraints.
result Induced treatment take-up is the fairness target, not recommendation rates.
Efficiently find near-optimal medical treatments with less trial and error.
problem Finding effective medical treatments through trial and error.
method Formalizes the problem, uses a causal inference framework, and proposes model-based dynamic programming and greedy algorithms.
result Our methods compare favorably to model-free reinforcement learning, offering a more transparent trade-off between search time and treatment efficacy.
Given two possible treatments, there may exist subgroups who benefit greater from one treatment than the other. This problem is relevant to the field of marketing, where treatments may correspond to different ways of selling a product. It is similarly relevant to the field of public policy, where treatments may corresp…
Paper derives policy rules from observational data for hepatitis C treatment.
problem Improving treatment guidelines for HIV/HCV co-infected patients.
method Weighted K-means algorithm for estimating CATEs, decision tree implementation.
result Identifies a subgroup with high spontaneous HCV clearance rate.
Much attention has been devoted recently to the development of machine learning algorithms with the goal of improving treatment policies in healthcare. Reinforcement learning (RL) is a sub-field within machine learning that is concerned with learning how to make sequences of decisions so as to optimize long-term effect…
Algorithm identifies interpretable subgroups with elevated treatment effects.
problem Estimating high-dimensional, uninterpretable CATE results.
method Rule sets summarizing CATE estimates, optimizing subgroup size and effect size.
result Frontier of Pareto optimal rule sets for subgroup identification.
New framework estimates treatment effects in extreme data.
problem Hindered by unavailability of counterfactual outcomes and rarity of extreme data.
method Proposes a new framework based on extreme value theory.
result Quantifies treatment effects using tail decay rates of potential outcomes.
In the context of individual-level causal inference, we study the problem of predicting whether someone will respond or not to a treatment based on their features and past examples of features, treatment indicator (e.g., drug/no drug), and a binary outcome (e.g., recovery from disease). As a classification task, the pr…
R2P method identifies homogeneous and heterogeneous subgroups for better treatment effect estimation.
problem Current subgroup analysis methods are weak in identifying homogeneous and heterogeneous subgroups and lack confidence estimates.
method R2P uses an arbitrary ITE estimator and quantifies uncertainty robustly.
result R2P produces more homogeneous and heterogeneous partitions than other methods.
Optimum in Convex Hulls (OCH) generalizes clinical trial results to broader populations.
problem Clinical trials exclude confounding but limit recruitment; observational data are more inclusive but suffer from confounding.
method OCH uses convex hulls of conditional expectations or densities to approximate the true treatment effect from both observational and trial data.
result OCH estimates the treatment effect with state-of-the-art accuracy in terms of both expectations and densities.
We present nonparametric algorithms for estimating optimal individualized treatment rules. The proposed algorithms are based on the XGBoost algorithm, which is known as one of the most powerful algorithms in the machine learning literature. Our main idea is to model the conditional mean of clinical outcome or the decis…
Following related work in law and policy, two notions of disparity have come to shape the study of fairness in algorithmic decision-making. Algorithms exhibit treatment disparity if they formally treat members of protected subgroups differently; algorithms exhibit impact disparity when outcomes differ across subgroups,…
IntelligentPooling improves treatment decisions in mHealth.
problem Optimizing treatment decisions in mobile health with limited data and non-stationary responses.
method Generalized Thompson-Sampling bandit algorithms to IntelligentPooling, addressing differential response, limited data, and non-stationary responses.
result IntelligentPooling achieves 26% lower regret compared to state-of-the-art methods.
New method quantifies variable importance in causal forests for treatment effect heterogeneity.
problem Lack of understanding how input variables affect treatment effect heterogeneity in causal forests.
method Developed a new importance variable algorithm for causal forests based on the drop and relearn principle.
result Shows how to handle forest retraining without a confounding variable and introduces a corrective term for confounders.
Practitioners in medicine, business, political science, and other fields are increasingly aware that decisions should be personalized to each patient, customer, or voter. A given treatment (e.g. a drug or advertisement) should be administered only to those who will respond most positively, and certainly not to those wh…
Estimates individualized treatment effects using shared RBF-net neurons.
problem Identifying differential treatment effects based on covariates.
method Non-parametric radial basis function (RBF)-nets with shared hidden neurons in a Bayesian framework.
result Demonstrated through simulations and real data, the method identifies interesting treatment effects.
It is crucial to provide compatible treatment schemes for a disease according to various symptoms at different stages. However, most classification methods might be ineffective in accurately classifying a disease that holds the characteristics of multiple treatment stages, various symptoms, and multi-pathogenesis. More…
Improves representation learning for individual treatment effect estimation.
problem Estimating individual treatment effects with high accuracy.
method Introduces a structure keeper to maintain correlation between baseline covariates and representations, trains a discriminator to balance representation and information loss.
result Proposed SMRL algorithm minimizes treatment estimation error and outperforms state-of-the-art methods.
In this paper, we study the design and analysis of experiments conducted on a set of units over multiple time periods where the starting time of the treatment may vary by unit. The design problem involves selecting an initial treatment time for each unit in order to most precisely estimate both the instantaneous and cu…
Precision oncology, the genetic sequencing of tumors to identify druggable targets, has emerged as the standard of care in the treatment of many cancers. Nonetheless, due to the pace of therapy development and variability in patient information, designing effective protocols for individual treatment assignment in a sam…
Bayesian model ranks treatments in multi-response experiments.
problem Identifying the best treatment among competing ideal properties.
method Bayesian approach with Markov Chain Monte Carlo algorithm.
result Reliable inference of treatment ranks in practice.
TSCI estimates treatment effects using machine learning and data-adaptive methods for invalid instruments.
problem Estimating treatment effects with invalid instruments.
method Two-stage algorithm: first stage uses machine learning for nonlinearities, second stage selects and projects out instrument violations.
result Effective treatment effect estimation even with invalid instruments.
Optimizes treatment allocation in networks considering indirect effects.
problem Finding optimal treatment allocation in network settings with interference.
method OTAPI: Optimizing Treatment Allocation in the Presence of Interference, integrating causal estimators into IM algorithms.
result OTAPI outperforms classic IM and UM approaches on synthetic and semi-synthetic datasets.
Study compares methods for treatment assignment, finding A-learner best for playlist generation.
problem Treatment assignment in various applications.
method Three classes of algorithms: O-learner, E-learner, A-learner.
result Optimizing for outcomes or causal effects does not lead to optimal treatment assignments.
The paper introduces a privacy-preserving method for estimating treatment effects that maintains accuracy.
problem Estimating heterogeneous treatment effects in sensitive data while protecting privacy.
method A general meta-algorithm for CATE estimation with differential privacy guarantees, using sample splitting and parallel composition.
result The meta-algorithm maintains accuracy even with differential privacy, showing that most accuracy loss is due to variance increase.