Firms delay write-downs for adverse macroeconomic and industry outcomes but not for firm-specific issues.
problem Timeliness of write-downs for adverse macroeconomic and industry outcomes versus firm-specific issues.
method Comparative analysis of write-downs driven by macroeconomic and industry outcomes versus firm-specific outcomes.
result Firms delay write-downs for adverse macroeconomic and industry outcomes but not for firm-specific issues.
MLHO predicts COVID-19 adverse outcomes using past medical records.
problem Predicting adverse outcomes after COVID-19 infection.
method Iterative feature and algorithm selection, sequential representation mining.
result Mean AUC ROC of 0.91 for mortality prediction.
Study finds non-adherence to schizophrenia meds leads to earlier adverse events.
problem Impact of medication non-adherence on adverse outcomes in schizophrenia patients.
method Survival analysis, causal inference methods (T-learner, S-learner, nearest neighbor matching), different amounts of longitudinal information.
result Non-adherence to schizophrenia meds advances adverse events by 1 to 4 months.
Improved model predicts ICU readmission and mortality with interpretable results.
problem Lack of clinically interpretable predictions from deep learning models on clinical notes.
method Augmented a convolutional model with an attention mechanism for clinical note prediction.
result Attention mechanism improves prediction performance while providing interpretable results.
PHASE predicts surgical complications from physiological signals.
problem Predicting adverse surgical outcomes from physiological signals.
method Self-supervised transfer learning for physiological signals.
result PHASE outperforms other approaches in predicting five surgical complications.
Study shows informed traders harm market makers but price discovery benefits outweigh costs.
problem Informed traders' impact on market makers' profitability.
method Agent-based model with heterogeneous learning agents, multi-agent reinforcement learning.
result Informed market order flow is harmful when aggregate informedness is low but beneficial as it increases.
Cluster analysis aims at separating patients into phenotypically heterogenous groups and defining therapeutically homogeneous patient subclasses. It is an important approach in data-driven disease classification and subtyping. Acute coronary syndrome (ACS) is a syndrome due to sudden decrease of coronary artery blood f…
Modern treatments for Type 1 diabetes (T1D) use devices known as artificial pancreata (APs), which combine an insulin pump with a continuous glucose monitor (CGM) operating in a closed-loop manner to control blood glucose levels. In practice, poor performance of APs (frequent hyper- or hypoglycemic events) is common en…
Machine learning improves CAD management outcomes.
problem Current CAD guidelines do not account for patient-specific characteristics.
method Developed binary classifiers and regression models using patient data.
result Improved health outcomes by 24.11% compared to standard care.
With the increased availability of large databases of electronic health records (EHRs) comes the chance of enhancing health risks screening. Most post-marketing detections of adverse drug reaction (ADR) rely on physicians' spontaneous reports, leading to under reporting. To take up this challenge, we develop a scalable…
The paper proposes a method to identify subgroups with different treatment effects in time-to-event data.
problem Identifying subgroups with differential treatment effects in time-to-event data.
method A mixture model with structured sparsity regularization and novel inference procedure.
result The method effectively recovers sparse phenotypes across real-world clinical studies.
Holdout set improves risk score accuracy without biasing predictions.
problem Updating risk scores can lead to biased estimates when directly applied.
method Use a holdout set of non-intervention population to update risk scores.
result Optimal holdout size reduces adverse outcomes to optimal level.
Fairness measures fail in predictive settings that intentionally shift outcomes.
problem Fairness measures fail in performative prediction settings.
method Formalized concept shift and counterfactual outcomes.
result Predictors that are fair during training become unfair during deployment.
There is tremendous interest in precision medicine as a means to improve patient outcomes by tailoring treatment to individual characteristics. An individualized treatment rule formalizes precision medicine as a map from patient information to a recommended treatment. A treatment rule is defined to be optimal if it max…
Deep learning clusters patient time-series data for better prognosis.
problem Clustering time-series data for patient phenotyping and prognosis.
method Deep predictive clustering with novel loss functions for future outcome distribution.
result Model achieves superior clustering performance and identifies meaningful patient subgroups.
Risk-aware linear bandits optimize against adverse outcomes.
problem Optimizing decisions under risk in sequential decision-making problems.
method Proposed an optimistic UCB algorithm for contextual bandits with convex loss minimization.
result Regret guarantees similar to generalized linear bandits with convex optimization at each round.
Robust Bayesian inference improves model performance on discrete data.
problem Misspecification of discrete-valued models leads to poor inference and prediction.
method Total Variation Distance (TVD) for discrepancy, efficient estimator and inference method.
result Our approach significantly improves predictive performance on various data.
The dearth of prescribing guidelines for physicians is one key driver of the current opioid epidemic in the United States. In this work, we analyze medical and pharmaceutical claims data to draw insights on characteristics of patients who are more prone to adverse outcomes after an initial synthetic opioid prescription…
CovidCare uses EMR data to predict patient outcomes in emerging epidemics.
problem Intelligent prognosis for patients with emerging infectious diseases during rapid epidemics.
method Transfer learning and knowledge distillation from existing EMR data.
result CovidCare outperforms baseline methods in predicting patient length of stay.
Study prenatal PM2.5 exposure and 4th grade reading scores, identifying critical windows of susceptibility.
problem Understanding the impact of prenatal PM2.5 exposure on educational outcomes.
method Developed a locally adaptive Bayesian regression model with B-spline basis expansion and dynamic shrinkage priors.
result Prenatal PM2.5 exposure during early and late pregnancy is most adverse for 4th grade reading scores.
Machine learning approaches have been effective in predicting adverse outcomes in different clinical settings. These models are often developed and evaluated on datasets with heterogeneous patient populations. However, good predictive performance on the aggregate population does not imply good performance for specific …
Sparse rewards with different magnitudes speed up learning in model-based reinforcement learning.
problem Speeding up learning in model-based reinforcement learning methods.
method Add uniformly sampled reward values to sparse binary rewards during training.
result Training can be more efficient and faster with less variability.
auton-survival simplifies survival analysis for healthcare data.
problem Handling censored time-to-event data in healthcare.
method Open-source package for survival regression, adjustment, counterfactual estimation, phenotyping, and treatment effects.
result Demonstrates auton-survival's ability to support complex health and epidemiological questions.
Study liquidity provision in decentralized exchanges considering risk aversion and replication costs.
problem Economic viability of liquidity provision in decentralized exchanges (DEXs).
method Formulated strategic interactions as a sequential game with risk-averse LP, traders, and arbitrageurs.
result DEX liquidity depth is crucial for risk management, influenced by risk aversion and replication costs.
Study fills and adverse selection effects on trading strategy simulation.
problem Effects of fill probabilities and adverse fills on trading strategy simulation.
method Stochastic optimal control market-making problem, empirical evidence on liquid futures contracts.
result Fill probabilities and adverse fills significantly affect trading strategy performance.
Databases of electronic health records (EHRs) are increasingly used to inform clinical decisions. Machine learning methods can find patterns in EHRs that are predictive of future adverse outcomes. However, statistical models may be built upon patterns of health-seeking behavior that vary across patient subpopulations, …
Nearly one-half of all trades in financial markets are executed by high-speed, autonomous computer programs -- a type of trading often called high-frequency trading (HFT). Although evidence suggests that HFT increases the efficiency of markets, it is unclear how or why it produces this outcome. Here we create a simple …
CASTER predicts drug interactions using chemical substructures.
problem Identifying potential drug-drug interactions during drug design.
method CASTER uses sequential pattern mining, auto-encoding, and dictionary learning to predict DDIs.
result CASTER outperformed state-of-the-art models and provided interpretable predictions.
Lapse-supported life insurance exacerbates adverse selection risks.
problem Lapse-supported life insurance increases adverse selection costs.
method Modeling 'Term to 100' contracts and analyzing three methods of managing lapse surplus.
result Adverse selection losses can be almost unlimited under certain conditions.
Optimal fees protect passive LPs in AMMs under varying market conditions.
problem Adverse selection losses in AMMs are not offset by static trading fees.
method Dynamic reduced-form model with parallel AMM and CEX, large-scale simulations, real market data analysis.
result Optimal AMM fees are stable under normal conditions but high in volatile periods to protect LPs.
Develops a deep survival model for causal inference in longitudinal studies.
problem Estimating treatment effects on time-to-event outcomes in observational studies with time-dependent covariates.
method TCS model using potential outcomes framework and ensemble of recurrent subnetworks.
result Identifies conditional average treatment effects and individual treatment effect heterogeneity over time.
Background. Real-world data show that approximately 50% of psoriasis patients treated with a biologic agent will discontinue the drug because of loss of efficacy. History of previous therapy with another biologic, female sex and obesity were identified as predictors of drug discontinuations, but their individual predic…
ICU readmission is associated with longer hospitalization, mortality and adverse outcomes. An early recognition of ICU re-admission can help prevent patients from worse situation and lower treatment cost. As the abundance of Electronics Health Records (EHR), it is popular to design clinical decision tools with machine …
Recent progress in deep learning is revolutionizing the healthcare domain including providing solutions to medication recommendations, especially recommending medication combination for patients with complex health conditions. Existing approaches either do not customize based on patient health history, or ignore existi…
The paper explains credit decisions using Shapley decomposition for adverse actions.
problem Identifying predictors responsible for adverse credit decisions.
method Develops a simple and intuitive approach based on Shapley decomposition for models with low-order interactions.
result Shows the approach generalizes to Shapley decomposition and Baseline Shapley.
Developing an Agent-Based Model to Mitigate Adverse Selection in Uniswap v3 Liquidity Providers
problem Adverse selection in Uniswap v3 liquidity providers
method Agent-Based Model incorporating blockchain microstructure and volatility dynamics
result Dynamic fee schedules improve hedged Profit and Loss for liquidity providers
Study Nash competition among dealers quoting prices to clients with unknown trading motives.
problem Adverse selection and inventory costs in dealer-client interactions.
method Analyzes one-shot Nash competition with unknown client type and inventory constraints.
result Unique symmetric Nash equilibrium exists and can be characterized by a nonlinear ODE.
This paper improves change-point detection for complex data streams using denoising score matching.
problem Timely identification of distributional shifts in high-dimensional, complex data streams.
method Score-based CUSUM change-point detection with denoising score matching.
result Denoising score matching enhances detection power by effectively controlling noise scale.
This paper is split in three parts: first we use labelled trade data to exhibit how market participants accept or not transactions via limit orders as a function of liquidity imbalance; then we develop a theoretical stochastic control framework to provide details on how one can exploit his knowledge on liquidity imbala…
We study the problem of detecting adverse drug events in electronic healthcare records. The challenge in this work is to aggregate heterogeneous data types involving diagnosis codes, drug codes, as well as lab measurements. An earlier framework proposed for the same problem demonstrated promising predictive performance…
Study tests if deep hedging differs from delta hedging in a GARCH market model.
problem Whether deep hedging includes speculative components in a GARCH market.
method Tested in a GARCH-based market model, comparing deep hedging and delta hedging.
result The difference between deep hedging and delta hedging is speculative if risk measure does not prioritize adverse outcomes.
Detecting real-time price impact in algo trading
problem Identifying the impact of traders' actions on market prices
method Measuring timing synchronicity between trader actions and adverse market events
result Detecting price impact on a per-action basis
AI traders learn to exploit meta-orders from slower traders, increasing their profits.
problem Adverse selection of medium-frequency traders by high-frequency AI agents.
method Reinforcement learning in a Hawkes LOB model, with impulse control and PPO.
result AI agents can learn to capitalize on meta-orders, increasing their profits.
Algorithmic risk assessments are increasingly used to help humans make decisions in high-stakes settings, such as medicine, criminal justice and education. In each of these cases, the purpose of the risk assessment tool is to inform actions, such as medical treatments or release conditions, often with the aim of reduci…
Patients who suffer an acute coronary syndrome are at elevated risk for adverse cardiovascular events such as myocardial infarction and cardiovascular death. Accurate assessment of this risk is crucial to their course of care. We focus on estimating a patient's risk of cardiovascular death after an acute coronary syndr…
Study compares deep learning stock trading strategies in adverse market conditions.
problem Comparing deep learning models for stock trading performance in extreme market downturns.
method Reconstructed three deep learning models and compared their strategies through trading simulations.
result Deep learning models, especially LSTM, can mitigate losses in severe market downturns.
Sunshine trading theory predicts lower execution costs and liquidity provision through explicit preannouncements, but evidence is scarce in traditional markets.
problem Adverse selection on liquidity provision
method Reconstructing metaorders and comparing them with visible TWAP executions
result Visible TWAPs face lower execution costs and leave a smaller permanent price impact compared to hidden metaorders.
Current clinical practice to monitor patients' health follows either regular or heuristic-based lab test (e.g. blood test) scheduling. Such practice not only gives rise to redundant measurements accruing cost, but may even lead to unnecessary patient discomfort. From the computational perspective, heuristic-based test …