Deep learning reduces artifacts in limited angle X-ray microscopy.
problem Artifacts in image reconstruction from limited angle data in TXM.
method Training a U-Net deep neural network from synthetic data to reduce artifacts.
result Significant improvement in image quality and structural similarity.
Bayesian calibration for BCP self-assembly models using image data and measure transport.
problem Calibrating models of BCP self-assembly from image data with aleatory uncertainty.
method Likelihood-free inference via measure transport and summary statistics.
result Expected information gains can be computed efficiently for model calibration.
The support recovery problem consists of determining a sparse subset of variables that is relevant in generating a set of observations. In this paper, we study the support recovery problem in the phase retrieval model consisting of noisy phaseless measurements, which arises in a diverse range of settings such as optica…
Fluorescence microscopy has enabled a dramatic development in modern biology. Due to its inherently weak signal, fluorescence microscopy is not only much noisier than photography, but also presented with Poisson-Gaussian noise where Poisson noise, or shot noise, is the dominating noise source. To get clean fluorescence…
Deep learning improves 3D microscopy resolution without matched target images.
problem Anisotropic resolution in volumetric fluorescence microscopy.
method Cycle-consistent generative adversarial network trained on unpaired 2D images.
result Enhanced axial resolution and restored details between imaging planes.
Convolutional neural networks (CNN) have achieved state of the art performance on both classification and segmentation tasks. Applying CNNs to microscopy images is challenging due to the lack of datasets labeled at the single cell level. We extend the application of CNNs to microscopy image classification and segmentat…
Method estimates section thickness and XY anisotropy in ssEM images.
problem Accurate 3D reconstructions require precise section thickness and XY anisotropy estimates.
method Non-parametric Bayesian regression of image statistics.
result Method has lower estimation error compared to existing methods.
We discuss recently emerging applications of the state-of-art deep learning methods on optical microscopy and microscopic image reconstruction, which enable new transformations among different modes and modalities of microscopic imaging, driven entirely by image data. We believe that deep learning will fundamentally ch…
Unified method for multi-defect microscopy image restoration with limited training data.
problem Challenges in applying deep learning methods due to limited training data for multi-defect microscopy images.
method Two-stage approach: data augmentation with GAN and conditional GAN training.
result Proposed method gives comparable or superior results to existing methods in image quality restoration.
A dataset of 10 molecule types for machine learning studies.
problem Lack of suitable datasets for machine learning in molecular imaging.
method Generated 2D cross-sectional projections of 10 molecule types from Molecular Dynamics trajectories.
result Benchmark dataset for machine learning, deep learning, and image processing in scattering, imaging, and microscopy.
Machine learning classifies colorectal tissue using photoacoustic microscopy.
problem Traditional diagnostic methods for colorectal cancer are limited in detail and painful.
method Machine learning applied to acoustic resolution photoacoustic microscopy.
result Machine learning accurately classified benign and malignant tissue.
DISPR uses diffusion models to predict 3D cell shapes from 2D images.
problem Predicting 3D cell shapes from 2D microscopy images.
method Diffusion model trained to predict 3D shapes from 2D microscopy images as a prior.
result Adding DISPR predictions to minority cell classes improves classification accuracy.
Sharp mapping properties and regularization for X-ray transform on disks of constant curvature.
problem Sharp mapping properties and regularization of X-ray transform.
method Derive functional relations and mapping properties using elliptic differential operators.
result Theoretical possibility of regularized inversions for X-ray transform.
Regularity results for geodesic X-ray transform on nonsmooth manifolds
problem Geodesic X-ray transform on nonsmooth simple manifolds
method Symbol smoothing arguments and pseudodifferential operators with low regularity symbols
result Improved injectivity results for Lp functions Local X-ray transform works well near boundaries in hyperbolic spaces.
problem Injectivity of X-ray transform near boundaries for hyperbolic metrics.
method Local injectivity proof for geodesic X-ray transform on asymptotically hyperbolic manifolds.
result Local injectivity near a boundary point for X-ray transform in dimensions 3 and higher, up to O(ρ5). Paper shows invertibility of tensor X-ray transform on certain manifolds.
problem Invertibility of tensor X-ray transform on asymptotically conic manifolds.
method Used 1-cusp pseudodifferential operator algebra and modified solenoidal gauge condition.
result Invertibility of tensor X-ray transform up to natural obstruction.
Machine learning speeds up FLIM analysis in biomedical research.
problem Complex, slow, and computationally expensive FLIM analysis.
method Machine learning techniques for faster and smarter FLIM data extraction and interpretation.
result Higher accuracy in classifying and segmenting FLIM images compared to conventional methods.
Deconvolution microscopy has been extensively used to improve the resolution of the widefield fluorescent microscopy. Conventional approaches, which usually require the point spread function (PSF) measurement or blind estimation, are however computationally expensive. Recently, CNN based approaches have been explored a…
Multi-StyleGAN simulates live cell microscopy imagery.
problem Costly and complex live cell experiments.
method Generative adversarial network (GAN) synthesizing multi-domain time-lapse images.
result Captures biophysical factors and time dependencies in cell imagery.
Study shows stability in X-ray transform on specific hyperbolic manifolds.
problem Stability of X-ray transform on asymptotically hyperbolic manifolds.
method Constructed a parametrix for the normal operator in 0-pseudodifferential calculus.
result Showed a stability estimate for the X-ray transform.
Study X-ray transform on conic spaces, proving injectivity under certain conditions.
problem Injectivity of geodesic X-ray transform on conic metrics.
method Injectivity under non-trapping and no conjugate point assumptions.
result Injectivity of geodesic X-ray transform for asymptotically conic metrics.
Malaria is a life-threatening disease affecting millions. Microscopy-based assessment of thin blood films is a standard method to (i) determine malaria species and (ii) quantitate high-parasitemia infections. Full automation of malaria microscopy by machine learning (ML) is a challenging task because field-prepared sli…
Injective X-ray transform on Heisenberg group for regular functions.
problem Injectivity of X-ray transform on sub-Riemannian manifolds.
method Group Fourier Transform and analysis of taming metrics.
result Sufficiently regular functions on Heisenberg group are determined by their line integrals.
Paper proves injectivity of non-abelian X-ray transform on certain spaces.
problem Injectivity of non-abelian X-ray transform on asymptotically hyperbolic spaces.
method Gauge equivalence for unitary connections and skew-Hermitian Higgs fields.
result Injectivity result for non-abelian X-ray transform over skew-Hermitian Higgs fields.
New method extracts biological concepts from cell microscopy images.
problem Extracting meaningful concepts from vision foundation models trained on cell microscopy images.
method Sparse dictionary learning (DL) combined with PCA whitening pre-processing.
result Successfully retrieved biologically meaningful concepts like cell types and genetic perturbations.
Study improves pollen detection in optical and holographic images using deep learning.
problem Improving pollen detection accuracy in holographic microscopy images.
method Used YOLOv8s for detection and MobileNetV3L for classification, addressing performance gaps through dataset expansion and automated labeling.
result Significant improvement in detection and classification performance on holographic images.
X-ray free-electron lasers (XFELs) are the only sources currently able to produce bright few-fs pulses with tunable photon energies from 100 eV to more than 10 keV. Due to the stochastic SASE operating principles and other technical issues the output pulses are subject to large fluctuations, making it necessary to char…
Early results in using convolutional neural networks (CNNs) on x-rays to diagnose disease have been promising, but it has not yet been shown that models trained on x-rays from one hospital or one group of hospitals will work equally well at different hospitals. Before these tools are used for computer-aided diagnosis i…
Prototype for adaptive electron microscopy scans reduces dose and time.
problem Reduce electron microscopy scan time and dose with minimal loss.
method Adaptive partial scanning with reinforcement learning.
result Reinforcement learning trained neural network optimizes scan paths.
X-rays are commonly performed imaging tests that use small amounts of radiation to produce pictures of the organs, tissues, and bones of the body. X-rays of the chest are used to detect abnormalities or diseases of the airways, blood vessels, bones, heart, and lungs. In this work we present a stochastic attention-based…
Deep-learning method estimates bone 3D structure from X-ray images.
problem Estimating bone 3D structure from X-ray images.
method Triplet loss-trained neural network selecting closest 3D bone shape from predefined set.
result Average RMS distance of 1.08 mm between predicted and true shapes.
X-ray transform on H-type groups solved, revealing function injectivity.
problem Injectivity in sub-Riemannian geometry.
method Fourier Slice Theorem adapted to H-type groups.
result Integrable functions on H-type groups are uniquely determined by their integrals over geodesics.
New method eliminates domain size restrictions for X-ray transform inversion.
problem Injectivity and stability of X-ray transform in convex domains.
method Semiclassical analysis to invert X-ray transform without small domain assumptions.
result Elimination of domain size restrictions for injectivity and stability.
Study improves deep learning chest X-ray models by incorporating lateral views.
problem Lack of lateral views in training datasets limits deep learning performance.
method Used PadChest dataset with multiple views to explore merging methods.
result Incorporating lateral views increases model performance for 32 labels.
Study proper sampling for X-ray transforms on simple surfaces.
problem Proper discretizing and sampling issues related to geodesic X-ray transforms on simple surfaces.
method Provide minimal sampling rates for faithful reconstruction, quantify sampling quality, and predict artifacts.
result Minimal sampling rates and artifact prediction for geodesic X-ray transforms on simple surfaces.
UDVD uses deep learning to denoise videos without supervision.
problem Lack of clean video data for training deep learning models.
method UDVD is a CNN trained solely on noisy video data, adapting to local motion.
result UDVD performs as well as supervised methods, even with limited training data.
A novel method detects multiple mitosis events and mitigates annotation gaps in phase-contrast microscopy.
problem Detecting multiple mitosis events and handling annotation gaps in closely placed cells.
method Estimating a spatiotemporal likelihood map via 3DCNN to detect multiple mitosis events and mitigate annotation gaps.
result Our method outperformed compared methods in terms of F1-score using a challenging dataset.
To improve the performance of classical generative adversarial network (GAN), Wasserstein generative adversarial networks (W-GAN) was developed as a Kantorovich dual formulation of the optimal transport (OT) problem using Wasserstein-1 distance. However, it was not clear how cycleGAN-type generative models can be deriv…
Paper solves injectivity of X-ray transform on surfaces.
problem Injectivity of non-Abelian X-ray transform on surfaces.
method Factorization theorem for Loop Groups, energy methods, scalar holomorphic integrating factors.
result Extends results to arbitrary Lie groups.
New proof of injectivity for broken non-abelian X-ray transform in Minkowski space.
problem Injectivity of broken non-abelian X-ray transform in Minkowski space.
method Stability estimate considering gauge, light-sink connections, Bayesian inversion.
result Consistent recovery of light-sink connections from noisy data.
Enhanced X-ray polarimetry with deep learning for better exposure times.
problem Improving sensitivity of X-ray telescopic observations with imaging polarimeters.
method A weighted maximum likelihood combination of predictions from a deep ensemble of ResNet convolutional neural networks trained on Monte Carlo event simulations.
result Improves effective exposure times by ~45% for power-law source spectra.
These are lecture notes for the course "Analysis and X-ray tomography". The course is a broad overview of various tools in analysis that can be used to study X-ray tomography. The focus is on tools and ideas, not so much on technical details and minimal assumptions. Only very basic functional analysis is assumed as bac…
Study X-ray transform on manifolds, desingularize, and improve mapping properties.
problem Characterize mapping properties of X-ray transform and its adjoint on manifolds with strictly convex boundary.
method Use b-fibrations, desingularize, and apply Melrose's Pushforward Theorem to analyze polyhomogeneous functions.
result Improved mapping properties of X-ray transform and its adjoint, recovering sharp results.
We show that the existence of a function in L1 with constant geodesic X-ray transform imposes geometrical restrictions on the manifold. The boundary of the manifold has to be umbilical and in the case of a strictly convex Euclidean domain, it must be a ball. Functions with constant geodesic X-ray transform always …
Unique continuation for X-ray transforms of one-forms with partial data.
problem Proving unique continuation for X-ray transforms of one-forms with limited data.
method Proved unique continuation for the normal operator of X-ray transforms of one-forms, leading to partial data results.
result Unique continuation for X-ray transforms of one-forms with partial data.
Improves spline quality and accuracy in computational microscopy.
problem Detecting slender, overlapping structures in microscopy images.
method Differentiable rendering approach for spline refinement.
result Achieves high reliability and sub-pixel accuracy.
Guillarmou extends X-ray transform to magnetic and thermostat flows.
problem Stability of magnetic X-ray transforms.
method Generalizes normal operator to thermostat and magnetic flows, proving ellipticity.
result Elliptic pseudodifferential operators of order -1 for generalized normal operators.
New insights into X-ray transform on hyperbolic disk, with functional relations and range characterizations.
problem Understanding the X-ray transform on hyperbolic geometry.
method Derived new singular value decompositions, range characterizations, and intertwining relations with wedge-type differential operators.
result Sharp understanding of boundary behavior and invertibility settings for the X-ray transform.