Paper develops a framework to discover bioprocessing regulatory mechanisms using symbolic and statistical learning.
problem Challenges in modeling complex intracellular regulation, stochastic system behavior, and limited experimental data.
method Symbolic and statistical learning framework based on stochastic differential equations and Bayesian learning.
result Improved sample efficiency and robust model selection compared to state-of-the-art approaches.
This paper examines market misconduct in DeFi and proposes regulatory solutions.
problem Novel forms of market misconduct in DeFi.
method Comprehensive analysis, comparative study, empirical measurements, and tailored regulatory framework investigation.
result Identification of key areas for regulatory enhancement in DeFi.
New framework for adaptive clinical trials to address real-world challenges.
problem Real-world challenges in post-regulatory clinical trials.
method RFAN framework integrating regulatory constraints and treatment policy value.
result Empirical evaluation of RFAN's performance.
Over the last 23 years, the U.S. Securities and Exchange Commission has required over 34,000 companies to file over 165,000 annual reports. These reports, the so-called "Form 10-Ks," contain a characterization of a company's financial performance and its risks, including the regulatory environment in which a company op…
Optimizes insurance profits under regulatory constraints.
problem Maximizing profits while adhering to regulatory and risk policies.
method Developed a formalism for in-force business profit optimisation.
result Identified optimal asset allocation and annual opportunity cost.
The paper analyzes how leverage affects manipulation in event-linked markets, offering new insights into regulation.
problem Manipulation and insider information in leveraged event-linked markets.
method Develops a two-axis manipulation taxonomy and analyzes leverage's effects on market-price and outcome manipulation.
result Leverage scales market-price manipulation linearly but shifts the cost-benefit threshold for outcome manipulation.
SHARC explains machine learning risk models for regulatory capital, linking outputs to scenarios.
problem Inability to explain machine learning model outputs to regulatory bodies.
method SHAP-based explainability framework for Hybrid GPR-HS architecture and SVaR stress-testing.
result SHARC links SVaR outputs to scenario inputs, providing auditable traceability.
New framework makes ML methods compliant with regulations.
problem Ensuring ML methods meet regulatory standards.
method InfoGram and Admissible Machine Learning framework.
result Redesigns ML methods for regulatory compliance.
TNDE quantifies dynamic gene drivers from single-cell snapshots.
problem Reconstructing time-resolved regulatory effects in biological processes.
method Time-varying Network Driver Estimation (TNDE) using shared graph attention encoder and partial optimal transport.
result TNDE identifies stage-specific driver genes in mouse erythropoiesis.
RSI uses Bayesian inference to monitor compliance in rule-governed domains.
problem Structural obstacles in compliance monitoring, including unlabeled outcomes and selective withholding of evidence.
method Rule-State Inference (RSI) treats formalized rules as Bayesian priors and infers compliance states through mean-field variational inference.
result RSI delivers formal guarantees of adaptability, consistency, and convergence, validated on a synthetic enterprise benchmark.
LAGE is a systematic framework developed in Java. The motivation of LAGE is to provide a scalable and parallel solution to reconstruct Gene Regulatory Networks (GRNs) from continuous gene expression data for very large amount of genes. The basic idea of our framework is motivated by the philosophy of divideand-conquer.…
InfoSEM infers gene regulatory networks without GT labels, improving performance.
problem Inferring GRNs from gene expression data with high accuracy and avoiding biases.
method InfoSEM uses deep generative models with informative priors (textual gene embeddings).
result InfoSEM outperforms existing models by 38.5% across four datasets.
Paper proposes a new GPR-HS framework for accurate VCV estimation in global equity indices.
problem Accurate forecasting of Volatility-Covariance Matrix (VCV) for regulatory processes.
method Hybrid Gaussian Process Regression-Historical Simulation (GPR-HS) framework.
result GPR-HS framework achieves regulatory compliance and outperforms static VaR benchmarks.
In a market system, regulations are designed to prevent or rectify market failures that inhibit fair exchange, such as monopoly or transactions with hidden costs. Because regulations reduce profits to those possessing unfair advantage, these advantaged corporations (whether individuals, companies, or other collective o…
This research develops a new framework to measure AI investment returns considering both gains and risks.
problem Traditional ROI calculations fail to account for AI's dual impact on risk reduction and new exposures.
method Integrates ISO 42001 and regulatory exposure into a comprehensive financial framework using risk quantification methods.
result Accurate AI investment evaluation requires modeling both productivity gains and risk exposures.
Regulating crypto and DeFi for inclusive economic advancement.
problem Innovative financial systems pose challenges to traditional regulatory frameworks.
method Formulating regulatory structures that balance innovation and consumer protection.
result Regulatory frameworks are essential for leveraging crypto and DeFi for inclusive economic growth.
DASH simplifies neural networks for gene regulatory dynamics using domain knowledge.
problem Pruning neural networks for gene regulatory dynamics lacks biologically meaningful structure learning.
method DASH uses domain-specific structural information to guide network pruning, leading to sparser, better interpretable models.
result DASH outperforms general pruning methods in gene regulatory network inference, yielding deeper insights.
Efficiently infers gene regulatory networks from spatial data.
problem Inferring spatially-varying gene regulatory networks.
method Proposed an efficient optimization problem for SV-GMRFs.
result Solves large-scale SV-GMRF problems in minutes.
Within the Own Risk and Solvency Assessment framework, the Solvency II directive introduces the need for insurance undertakings to have efficient tools enabling the companies to assess the continuous compliance with regulatory solvency requirements. Because of the great operational complexity resulting from each comple…
Develops probabilistic models for gene regulatory network inference.
problem Challenges in reconstructing gene regulatory networks from genome-wide data.
method Two complementary frameworks: PMF-GRN and GLM-Prior.
result Probabilistic inference refines regulatory estimates with quantified uncertainty.
This research assesses uncertainty quantification and sensitivity analysis for DTs in nuclear fuel performance.
problem Understanding the reliability and performance of advanced nuclear fuels using DTs.
method Introduces ML-based uncertainty quantification and sensitivity analysis methods applied to BISON fuel performance code.
result Demonstrates the effectiveness of DTs in multi-criteria decision-making for nuclear fuel performance.
Research creates a taxonomy to bridge AI security and regulatory gaps.
problem Disciplinary disconnect between technical and legal teams in AI risk assessment.
method Developed an AI System Threat Vector Taxonomy with 9 domains and 53 sub-threats.
result Empirically validated and aligned with ISO/IEC 42001 controls and NIST AI RMF functions.
Robust machine learning models improve DNA regulatory sequence prediction under various shifts.
problem Real-world applications of DNA regulatory sequence prediction involve shifts not captured by standard i.i.d. assumptions.
method Introduces a robustness framework combining simulation benchmarks and real data analysis.
result Models remain accurate and calibrated under mild shifts but show higher error and miscalibration under strong shifts.
Survey examines agentic AI in finance, highlighting its autonomy and challenges.
problem Autonomous AI systems in finance and their implications.
method Systematic review of research, technical architectures, market applications, and governance frameworks.
result Agentic AI offers enhanced market efficiency but introduces new risks.
Neural GDEs improve graph prediction by blending discrete structures and differential equations.
problem Dynamic graph prediction challenges in irregularly sampled data.
method Continuous-depth graph neural networks (GNNs) with Neural GDEs.
result Neural GDEs enhance performance across various applications.
Regshock visualizes financial risks to help regulators manage systemic shocks.
problem Managing systemic risks in financial networks.
method Risk-island visualization algorithm and regshock visual exploration approach.
result Demonstrated improved risk management and control capabilities.
The aim of this paper is to introduce a synthetic ALM model that catches the main specificity of life insurance contracts. First, it keeps track of both market and book values to apply the regulatory profit sharing rule. Second, it introduces a determination of the crediting rate to policyholders that is close to the p…
Formally verifies fairness and uniformity in financial market trades.
problem Ensuring fairness and uniformity in automated trading systems.
method Formal definition and verification in Coq proof assistant.
result Properties of double-sided auction mechanisms verified.
SEISM tests neural network features for regulatory genomics.
problem Testing neural network features for regulatory genomics.
method Selective inference procedure for sequence motifs.
result Sampling under specific parameters characterizes composite null hypothesis.
Study uses LLMs to simplify financial regulation interpretation.
problem Complex financial regulations are hard to interpret and implement.
method Developed prompts to guide LLMs in extracting key information from regulations.
result GPT-4 outperforms other LLMs in processing and executing regulatory requirements.
regvis.net offers a visual survey of regulatory visualization.
problem Lack of a comprehensive resource for regulatory visualization.
method Collection and manual tagging of 80+ publications, creation of a searchable webpage.
result First publication set tailored for regulatory visualization.
Framework for realistic insurance liability valuation.
problem Economic realism in insurance liability valuation.
method Replication approach of no-arbitrage theory, considering capital and fulfillment conditions.
result Identifies conditions for market price recovery and extends production for insolvency.
VERAFI improves financial AI by verifying calculations and compliance.
problem Financial AI systems generate errors and violations during reasoning.
method VERAFI combines dense retrieval, reranking, and automated reasoning policies.
result VERAFI achieves 94.7% factual correctness, 81% relative improvement.
Tackling climate change is at the top of many agendas. In this context, emission trading schemes are considered as promising tools. The regulatory framework for an emission trading scheme introduces a market for emission allowances and creates a need for risk management by appropriate financial contracts. In this work,…
This paper presents a novel analysis of two feed-in tariffs (FIT) under market and regulatory uncertainty, namely a sliding premium with cap and floor and a minimum price guarantee. Regulatory uncertainty is modeled with a Poisson process, whereby a jump event may reduce the tariff before the signature of the contract.…
New framework detects crypto wash trading using liquidity measures.
problem Detecting and monitoring wash trading in crypto assets.
method Developed a new framework to detect wash trading through real-time liquidity fluctuation measures.
result Joint elevation in liquidity jump and diffusion indicates wash trading in crypto assets.
Study optimizes insurance liability cash flows with regulatory capital requirements.
problem Valuation of insurance liabilities under regulatory capital constraints.
method Multiple-prior optimal stopping theory applied to insurance liabilities, considering hypothetical transfer and repeated capital requirements.
result Proposes a valuation functional for non-replicable cash flows, incorporating a margin for regulatory capital considerations.
Paper constructs a CRRIX index to assess cryptocurrency market risks from regulatory changes.
problem Lack of indices quantifying regulatory risks in cryptocurrencies.
method CRRIX index based on news coverage frequency, using Latent Dirichlet Allocation and Hellinger distance.
result CRRIX successfully captures major policy-changing moments and synchronizes with market volatility.
Facing the FRTB, banks need to allocate their capital to each business units or risk positions to evaluate the capital efficiency of their strategies. This paper proposes two computationally efficient allocation methods which are weighted according to liquidity horizon. Both methods provide more stable and less negativ…
Framework for AI healthcare products from concept to market.
problem Failure of AI products to reach clinics despite promising potential.
method Decision-making framework for AI healthcare product development.
result Guides through a three-phase process to market launch of validated AI products.
New method constructs confidence bands for ODE models with unknown regulatory effects.
problem Building confidence bands for ODE models with unknown regulatory relations is challenging.
method Localized kernel learning approach combined with de-biasing method.
result The constructed confidence band has the desired asymptotic coverage probability and accurately recovers the regulatory network.
Proposes a new method for determining LGD discount rates based on cost of capital.
problem Determining an appropriate discount rate for LGD estimation.
method Market-consistent pricing of defaulted loan portfolios to infer discount rates.
result Discount rates reflect both undiversifiable risk and time value of money.
This thesis examines the accuracy of scaling VaR estimates for longer holding periods.
problem The accuracy of VaR estimates for longer holding periods using the square root of time rule.
method Examined VaR scaling for longer holding periods using empirical analysis.
result Scaling can provide good estimates of VaR but may lead to significant losses over time.
Gene regulatory networks play a crucial role in controlling an organism's biological processes, which is why there is significant interest in developing computational methods that are able to extract their structure from high-throughput genetic data. Many of these computational methods are designed to infer individual …
Funding is a cost to trading desks that they see as an input. Current FVA-related literature reflects this by also taking funding costs as an input, usually constant, and always risk-neutral. However, this funding curve is the output from a Treasury point of view. Treasury must consider Regulatory-required liquidity bu…
Framework evaluates post-hoc interpretability methods in time-series classification.
problem Lack of suitable post-hoc interpretability methods for time-series classification.
method Proposes a framework with quantitative metrics to assess interpretability methods.
result Addresses several drawbacks of existing methods, including dependence on human judgement and data distribution shift.
A new method infers causal gene regulatory networks from parallel CRISPR interventions and transcriptomic data.
problem Learning causal gene regulatory networks from observational data is complicated by lack of identifiability and a combinatorial solution space.
method A continuous optimization framework that leverages observational and interventional data to infer a single causal structure, assuming a linear Structural Equation Model (SEM).
result A provably consistent estimator of the true DAG under mild assumptions.
Simple method calculates WWR for regulatory and accounting purposes.
problem Estimating WWR for regulatory and accounting capital requirements.
method Model-independent approach using integral expressions and component calibration.
result WWR effects for FVA are significantly more material than for CVA.