In this paper we present a method for simultaneously segmenting brain tumors and an extensive set of organs-at-risk for radiation therapy planning of glioblastomas. The method combines a contrast-adaptive generative model for whole-brain segmentation with a new spatial regularization model of tumor shape using convolut…
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48 results for “Radiation Therapy Planning”
Knowledge-based planning (KBP) is an automated approach to radiation therapy treatment planning that involves predicting desirable treatment plans before they are then corrected to deliverable ones. We propose a generative adversarial network (GAN) approach for predicting desirable 3D dose distributions that eschews th…
Proposes a framework for automated radiation therapy treatment planning with uncertainty quantification.
problem Quantifying uncertainties in dose-related quantities for automated treatment planning.
method Three-step pipeline: feature extraction, dose statistic prediction, and dose mimicking.
result Probabilistic treatment plans agree better with clinical counterparts than non-probabilistic ones.
Study improves confidence measures in medical imaging pipelines by addressing bias.
problem Bias in metric-based imaging pipelines compromises the efficiency of prediction intervals.
method Formalized symmetric and asymmetric CP formulations, analyzed bias effects, and validated empirically.
result Symmetric intervals are inflated by bias, while asymmetric intervals remain unaffected.
Machine Learning (ML) is proving extremely beneficial in many healthcare applications. In pediatric oncology, retrospective studies that investigate the relationship between treatment and late adverse effects still rely on simple heuristics. To assess the effects of radiation therapy, treatment plans are typically simu…
Gravitational waves are predicted by the general theory of relativity. In [6] D. Christodoulou showed that gravitational waves have a nonlinear memory. We proved in [3] that the electromagnetic field contributes at highest order to the nonlinear memory effect of gravitational waves. In the present paper, we study this …
Large Language Models-Enabled Digital Twins for Precision Medicine in Rare Gynecological Tumorscs.CL
Study uses LLMs to create personalized treatment plans for rare gynecological tumors.
problem Suboptimal management and poor prognosis due to low incidence and heterogeneity of rare gynecological tumors.
method Developed a digital twin system using LLMs to integrate clinical and biomarker data.
result LLM-enabled digital twins efficiently model individual patient trajectories and identify potential treatment options.
Develops a neural surrogate for proton dose calculation using Monte Carlo dropout uncertainty.
problem Computational demand in proton therapy workflows requiring repeated evaluations.
method Integrates Monte Carlo dropout into a neural network surrogate for fast, differentiable dose predictions and uncertainty quantification.
result Shows significant speedups over MC while retaining uncertainty information.
Develops regression trees for estimating cumulative incidence curves in competing risks.
problem Estimating cumulative incidence functions in competing risks settings.
method Uses augmented estimators of the Brier score risk to build and prune regression trees.
result Demonstrates the utility of the proposed methods through simulation studies and real data.
Computed tomography (CT) is widely used in screening, diagnosis, and image-guided therapy for both clinical and research purposes. Since CT involves ionizing radiation, an overarching thrust of related technical research is development of novel methods enabling ultrahigh quality imaging with fine structural details whi…
The classical multi-set split feasibility problem seeks a point in the intersection of finitely many closed convex domain constraints, whose image under a linear mapping also lies in the intersection of finitely many closed convex range constraints. Split feasibility generalizes important inverse problems including con…
A spacetime denotes a pure radiation field if its energy momentum tensor represents a situation in which all the energy is transported in one direction with the speed of light. In 1989, Wils and later in 1997 Ludwig and Edgar studied the physical properties of pure radiation metrics, which are conformally related to a …
The geometrical structures (in the sense of E. Cartan) are analyzed which underlie the gravitational radiation phenomenon. Among the results are : - the introduction of the adapted frame bundle to a congruence of isotropic hypersurfaces in a Lorentzian manifold, - the description of the reduced frame bundle which admit…
The paper integrates AI and expert knowledge to optimize radiotherapy decisions.
problem Optimizing radiation dose planning considering patient-specific information.
method Integrating Gaussian process models with deep neural networks to quantify uncertainty.
result Improves AI model performance and guides clinical decision making.
Comparison of statistical post-processing methods for probabilistic NWP forecasts of solar radiationstat.AP
The increased usage of solar energy places additional importance on forecasts of solar radiation. Solar panel power production is primarily driven by the amount of solar radiation and it is therefore important to have accurate forecasts of solar radiation. Accurate forecasts that also give information on the forecast u…
We define pure radiation metrics with parallel rays to be n-dimensional pseudo-Riemannian metrics that admit a parallel null line bundle K and whose Ricci tensor vanishes on vectors that are orthogonal to K. We give necessary conditions in terms of the Weyl, Cotton and Bach tensors for a pseudo-Riemannian metric to be …
Patients suffering from obstructive sleep apnea are mainly treated with continuous positive airway pressure (CPAP). Good compliance with this therapy is broadly accepted as more than 4h of CPAP average use nightly. Although it is a highly effective treatment, compliance with this therapy is problematic to achieve with …
Develops a risk score to assist ECMO planning for critically ill patients with viral or unspecified pneumonia.
problem Lack of a risk score to guide ECMO planning for critically ill patients.
method Leverages machine learning to develop the PEER score.
result PEER score predicts mortality and decompensation in patients eligible for ECMO.
In this paper, the radiation field is defined for solutions to Einstein vacuum equations which are close to Minkowski space-time with spacial dimension . The regularity properties and asymptotic behavior of those Einstein vacuum solutions are established at the same time. In particular, the map from Cauchy int…
As a generalization of the Schwarzschild solution, Vaidya presented a radiating metric to develop a model of the exterior of a star including its radiation field, called Vaidya metric. The present paper deals with the investigation on the curvature properties of Vaidya metric. It is shown that Vaidya metric can be cons…
We discuss our recent work [4] in which gravitational radiation was studied by evaluating the Wang-Yau quasi-local mass of surfaces of fixed size at the infinity of both axial and polar perturbations of the Schwarzschild spacetime, à la Chandrasekhar [1].
The past few decades has seen increased interest in the application of social robots to interventions for Autism Spectrum Disorder as behavioural coaches [4]. We consider that robots embedded in therapies could also provide quantitative diagnostic information by observing patient behaviours. The social nature of ASD sy…
Paper proves existence of Hadamard states for Maxwell equations.
problem Proving existence of Hadamard states for Maxwell equations on spacetime.
method Introducing Cauchy radiation gauge and new Hodge decomposition.
result Existence of Hadamard states for Maxwell equations proven.
We find two conditions related to the {\it news functions} of the Bondi's radiating vacuum spacetimes. We provide a complete proof of the positivity of the Bondi mass by using Schoen-Yau's method under one condition and by using Witten's method under another condition.
With millimeter wave wireless communications, the resulting radiation reflects on most visible objects, creating rich multipath environments, namely in urban scenarios. The radiation captured by a listening device is thus shaped by the obstacles encountered, which carry latent information regarding their relative posit…
In a vacuum spacetime equips with the Bondi's radiating metric which is asymptotically flat at spatial infinity including gravitational radiation ({\bf Condition D}), we establish the relation between the ADM total linear momentum and the Bondi momentum. The relation between the ADM total energy and the Bondi mass in t…
Study reconstructs Riemannian metric from Cherenkov radiation in complex media.
problem Reconstructing internal geometry of inhomogeneous anisotropic targets.
method Mathematical model of waves in medium, including vector-valued wave operator and phase velocity.
result Riemannian metric inside a bounded region can be reconstructed from boundary measurements of Cherenkov radiation.
New Galilean spacetimes found as pp-wave reductions.
problem Understanding isotropic homogeneous Galilean spacetimes.
method Null reductions of pp-wave spacetimes.
result Found novel torsional Galilean spacetimes.
Rigidity theorem shows massless hyperboloidal data embeds into Minkowski space.
problem Characterizing massless initial data sets in General Relativity.
method Precise decay estimates for spinors on harmonic level sets.
result Asymptotically hyperboloidal IDS with zero mass embed isometrically into Minkowski space.
The paper challenges the smooth null infinity model by constructing counter-examples and showing non-smoothness of null infinity.
problem The structure of gravitational radiation near infinity, particularly at smooth null infinity.
method Constructing solutions to the spherically symmetric Einstein-Scalar field equations and analyzing asymptotic behavior.
result The asymptotic expansion of the derivative of the scalar field near null infinity contains logarithmic terms, indicating non-smoothness.
On the relation between ADM and Bondi energy-momenta III -- perturbed radiative spatial infinitygr-qc
In a vacuum spacetime equipped with the Bondi's radiating metric which is asymptotically flat at spatial infinity including gravitational radiation ({\bf Condition D}), we establish the relation between the ADM total energy-momentum and the Bondi energy-momentum for perturbed radiative spatial infinity. The perturbatio…
Over 150,000 new people in the United States are diagnosed with colorectal cancer each year. Nearly a third die from it (American Cancer Society). The only approved noninvasive diagnosis tools currently involve fecal blood count tests (FOBTs) or stool DNA tests. Fecal blood count tests take only five minutes and are av…
New method provides reliable probabilistic bounds for VUR detection.
problem Detect VUR in children without radiation exposure.
method Machine learning with probabilistic bounds for conditional probability.
result Guaranteed bounds contain well-calibrated probabilities.
We study the Bondi-Sachs rockets with nonzero cosmological constant. We observe that the acceleration of the systems arises naturally in the asymptotic symmetries of (anti-) de Sitter spacetimes. Assuming the validity of the concepts of energy and mass previously introduced in asymptotically flat spacetimes, we find th…
When a spacetime takes Bondi radiating metric, and is vacuum and asymptotically flat at spatial infinity which ensures the positive mass theorem, we prove that the standard ADM energy-momentum is the past limit of the Bondi energy-momentum. We also derive a formula relating the ADM energy-momentum of any asymptotically…
Learning Compact Physics-Aware Delayed Photocurrent Models Using Dynamic Mode Decompositionphysics.comp-ph
Compact models learn photocurrent dynamics from radiation-induced excess carrier density.
problem Accurate but computationally expensive physics-based photocurrent models for semiconductor devices.
method Dynamic Mode Decomposition (DMD) for learning reduced order models from internal state data.
result Physics-aware, compact delayed photocurrent models accurately approximate internal excess carrier dynamics.
The purpose of this paper is to prove the uniqueness theorem of solutions of eigenvalue equations on one end of Riemannian manifolds for drift Laplacians, including the standard Laplacian as a special case; we shall impose "a sort of radiation condition" at infinity on solutions. We shall also provide several Riemannia…
Machine Learning on graph-structured data is an important and omnipresent task for a vast variety of applications including anomaly detection and dynamic network analysis. In this paper, a deep generative model is introduced to capture continuous probability densities corresponding to the nodes of an arbitrary graph. I…
Medical imaging is playing a more and more important role in clinics. However, there are several issues in different imaging modalities such as slow imaging speed in MRI, radiation injury in CT and PET. Therefore, accelerating MRI, reducing radiation dose in CT and PET have been ongoing research topics since their inve…
Performance of nuclear threat detection systems based on gamma-ray spectrometry often strongly depends on the ability to identify the part of measured signal that can be attributed to background radiation. We have successfully applied a method based on Principal Component Analysis (PCA) to obtain a compact null-space m…
More than 200 generic drugs approved by the U.S. Food and Drug Administration for non-cancer indications have shown promise for treating cancer. Due to their long history of safe patient use, low cost, and widespread availability, repurposing of generic drugs represents a major opportunity to rapidly improve outcomes f…
Segmentation is essential for medical image analysis tasks such as intervention planning, therapy guidance, diagnosis, treatment decisions. Deep learning is becoming increasingly prominent for segmentation, where the lack of annotations, however, often becomes the main limitation. Due to privacy concerns and ethical co…
In this paper, we provide an elementary, unified treatment of two distinct blue-shift instabilities for the scalar wave equation on a fixed Kerr black hole background: the celebrated blue-shift at the Cauchy horizon (familiar from the strong cosmic censorship conjecture) and the time-reversed red-shift at the event hor…
Bayesian model for cost-effectiveness analysis with subgroup discovery.
problem Statistical challenges in cost-effectiveness analysis, especially with non-random treatment assignment and censored data.
method Developed a nonparametric Bayesian model using Dirichlet and Gamma processes to estimate cost-survival distributions and identify cost-effectiveness subgroups.
result Identified and estimated policy-relevant causal CEA estimands using a Bayesian nonparametric g-computation procedure.
Researchers resolved ambiguities in gravitational radiation charges.
problem Ambiguities in charges related to gravitational radiation.
method Addressed supertranslation ambiguities in classical and extended BMS algebras.
result Proposed and proved an invariant charge free from supertranslation ambiguity.
A Machine Learning alternative to placebo-controlled clinical trials upon new diseases: A primerq-bio.QM
New disease drug trials use ML to predict best therapy.
problem Developing new drugs faster than usual clinical trials.
method Use Neural Network to predict drug effects from patient data.
result Neural Network outperforms traditional placebo-controlled trials.
Challenge aims to develop automated meningioma MRI segmentation models.
problem Lack of automated, objective tools for meningioma assessment.
method Develop and evaluate models on largest annotated dataset.
result Improved care of patients with meningioma through automated segmentation.
This study's objective was to segment spinal metastases in diagnostic MR images using a deep learning-based approach. Segmentation of such lesions can present a pivotal step towards enhanced therapy planning and validation, as well as intervention support during minimally invasive and image-guided surgeries like radiof…