Study uses multi-task Bayesian optimization to speed up SVM hyperparameter tuning for nodules diagnosis.
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System converts 3D lung nodule images into embeddings for retrieval.
Computed tomography (CT) generates a stack of cross-sectional images covering a region of the body. The visual assessment of these images for the identification of potential abnormalities is a challenging and time consuming task due to the large amount of information that needs to be processed. In this article we propo…
Convolutional Neural Networks (CNNs) require a large amount of annotated data to learn from, which is often difficult to obtain in the medical domain. In this paper we show that the sample complexity of CNNs can be significantly improved by using 3D roto-translation group convolutions (G-Convs) instead of the more conv…
Machine learning approaches hold great potential for the automated detection of lung nodules in chest radiographs, but training the algorithms requires vary large amounts of manually annotated images, which are difficult to obtain. Weak labels indicating whether a radiograph is likely to contain pulmonary nodules are t…
Motivated by the problem of computer-aided detection (CAD) of pulmonary nodules, we introduce methods to propagate and fuse uncertainty information in a multi-stage Bayesian convolutional neural network (CNN) architecture. The question we seek to answer is "can we take advantage of the model uncertainty provided by one…
Generating large quantities of quality labeled data in medical imaging is very time consuming and expensive. The performance of supervised algorithms for various tasks on imaging has improved drastically over the years, however the availability of data to train these algorithms have become one of the main bottlenecks f…
Lung cancer is the leading cause of cancer-related death worldwide. Early diagnosis of pulmonary nodules in Computed Tomography (CT) chest scans provides an opportunity for designing effective treatment and making financial and care plans. In this paper, we consider the problem of diagnostic classification between beni…
Machine learning applications in medical imaging are frequently limited by the lack of quality labeled data. In this paper, we explore the self training method, a form of semi-supervised learning, to address the labeling burden. By integrating reinforcement learning, we were able to expand the application of self train…
A novel approach for 3D lung nodule segmentation using adaptive ROI and multi-view residual learning.
Computed tomography (CT) examinations are commonly used to predict lung nodule malignancy in patients, which are shown to improve noninvasive early diagnosis of lung cancer. It remains challenging for computational approaches to achieve performance comparable to experienced radiologists. Here we present NoduleX, a syst…
U-Det improves lung nodule segmentation in CT images.
3D Axial-Attention improves lung nodule classification accuracy.
Different types of Convolutional Neural Networks (CNNs) have been applied to detect cancerous lung nodules from computed tomography (CT) scans. However, the size of a nodule is very diverse and can range anywhere between 3 and 30 millimeters. The high variation of nodule sizes makes classifying them a difficult and cha…
Purpose: Lung nodules have very diverse shapes and sizes, which makes classifying them as benign/malignant a challenging problem. In this paper, we propose a novel method to predict the malignancy of nodules that have the capability to analyze the shape and size of a nodule using a global feature extractor, as well as …
Paper reduces false positives in lung nodule detection using deep learning on point clouds.
One of the challenges of using machine learning techniques with medical data is the frequent dearth of source image data on which to train. A representative example is automated lung cancer diagnosis, where nodule images need to be classified as suspicious or benign. In this work we propose an automatic synthetic lung …
Characterization of lung nodules as benign or malignant is one of the most important tasks in lung cancer diagnosis, staging and treatment planning. While the variation in the appearance of the nodules remains large, there is a need for a fast and robust computer aided system. In this work, we propose an end-to-end tra…
One of the problems on the way to successful implementation of neural networks is the quality of annotation. For instance, different annotators can annotate images in a different way and very often their decisions do not match exactly and in extreme cases are even mutually exclusive which results in noisy annotations a…
The state of the art lung nodule detection studies rely on computationally expensive multi-stage frameworks to detect nodules from CT scans. To address this computational challenge and provide better performance, in this paper we propose S4ND, a new deep learning based method for lung nodule detection. Our approach use…
GAN normalizes CT scans for consistent radiomic feature values.
End-to-end CAD system for thyroid nodule classification using multimodal data and expert guidance.
This work introduces an integrative approach based on Q-analysis with machine learning. The new approach, called Neural Hypernetwork, has been applied to a case study of pulmonary embolism diagnosis. The objective of the application of neural hyper-network to pulmonary embolism (PE) is to improve diagnose for reducing …
Computer aided diagnostic (CAD) system is crucial for modern med-ical imaging. But almost all CAD systems operate on reconstructed images, which were optimized for radiologists. Computer vision can capture features that is subtle to human observers, so it is desirable to design a CAD system op-erating on the raw data. …
We explore several oversampling techniques for an imbalanced multi-label classification problem, a setting often encountered when developing models for Computer-Aided Diagnosis (CADx) systems. While most CADx systems aim to optimize classifiers for overall accuracy without considering the relative distribution of each …
Smartphone app diagnoses pulmonary diseases from chest X-rays.
New method uses probabilistic independence to discover disease signatures from medical records.
CNNs accurately measure airways and vessels on CT images, improving lung disease diagnosis.
Pulmonary embolisms (PE) are known to be one of the leading causes for cardiac-related mortality. Due to inherent variabilities in how PE manifests and the cumbersome nature of manual diagnosis, there is growing interest in leveraging AI tools for detecting PE. In this paper, we build a two-stage detection pipeline tha…
Anatomical and biophysical modeling of left atrium (LA) and proximal pulmonary veins (PPVs) is important for clinical management of several cardiac diseases. Magnetic resonance imaging (MRI) allows qualitative assessment of LA and PPVs through visualization. However, there is a strong need for an advanced image segment…
Modeling disease progression in healthcare administrative databases is complicated by the fact that patients are observed only at irregular intervals when they seek healthcare services. In a longitudinal cohort of 76,888 patients with chronic obstructive pulmonary disease (COPD), we used a continuous-time hidden Markov…
WEST uses EHRs and expert cases to improve rare disease phenotyping.
Proposes a tool to contrast global vs personalized models in clinical prediction.
Bayesian optimization (BO) is a popular algorithm for solving challenging optimization tasks. It is designed for problems where the objective function is expensive to evaluate, perhaps not available in exact form, without gradient information and possibly returning noisy values. Different versions of the algorithm vary…
The accurate estimation of predictive uncertainty carries importance in medical scenarios such as lung node segmentation. Unfortunately, most existing works on predictive uncertainty do not return calibrated uncertainty estimates, which could be used in practice. In this work we exploit multi-grader annotation variabil…
Study uses data to analyze COPD patients' impact on hospital systems.
The paper uses geometric methods to classify medical data histograms.
The chest X-ray (CXR) is by far the most commonly performed radiological examination for screening and diagnosis of many cardiac and pulmonary diseases. There is an immense world-wide shortage of physicians capable of providing rapid and accurate interpretation of this study. A radiologist-driven analysis of over two m…
Lung segmentation from abnormal CXRs using data imputation.
We correct for sampling bias in training models to improve real-world performance.
In this paper, we present UNet++, a new, more powerful architecture for medical image segmentation. Our architecture is essentially a deeply-supervised encoder-decoder network where the encoder and decoder sub-networks are connected through a series of nested, dense skip pathways. The re-designed skip pathways aim at r…
Chronic Pulmonary Aspergillosis (CPA) is a complex lung disease caused by infection with Aspergillus. Computed tomography (CT) images are frequently requested in patients with suspected and established disease, but the radiological signs on CT are difficult to quantify making accurate follow-up challenging. We propose …
Chronic obstructive pulmonary disease (COPD) is a lung disease where early detection benefits the survival rate. COPD can be quantified by classifying patches of computed tomography images, and combining patch labels into an overall diagnosis for the image. As labeled patches are often not available, image labels are p…
New methods improve genetic studies of complex diseases.
Localization of chest pathologies in chest X-ray images is a challenging task because of their varying sizes and appearances. We propose a novel weakly supervised method to localize chest pathologies using class aware deep multiscale feature learning. Our method leverages intermediate feature maps from CNN layers at di…
Atrial Fibrillation (AF) is a common electro-physiological cardiac disorder that causes changes in the anatomy of the atria. A better characterization of these changes is desirable for the definition of clinical biomarkers, furthermore, thus there is a need for its fully automatic segmentation from clinical images. In …
Clinical researchers use disease progression models to understand patient status and characterize progression patterns from longitudinal health records. One approach for disease progression modeling is to describe patient status using a small number of states that represent distinctive distributions over a set of obser…
Proposes a novel anomaly detection method for echocardiogram videos.