Develops a method to estimate average hazard under non-proportional hazards without relying on proportional hazards assumption.
problem Estimation of treatment effects when hazards are non-proportional, leading to unstable hazard ratios.
method Semiparametric, doubly robust framework for covariate-adjusted average hazard estimation.
result Valid sqrt{n} inference with small bias and near-nominal confidence-interval coverage across proportional and non-proportional hazards settings.
Federated Cox model handles non-proportional hazards in siloed data.
problem Handling non-proportional hazards in federated healthcare data.
method Developed a federated Cox model that relaxes proportional hazards assumption.
result Federated model performs similarly to standard models on clinical datasets.
Flexible DNN for survival data, avoiding proportional hazards assumption.
problem Survival analysis with complex interactions and non-proportional hazards.
method Partially linear DNN model with a flexible nonparametric component.
result FLEXI-Haz achieves optimal convergence rates and asymptotic efficiency.
Paper connects Plackett-Luce and Cox models for preference estimation.
problem Estimating preferences from annotated data.
method Connects Plackett-Luce model to Cox Proportional Hazards model.
result Implications of the connection between the two models.
This paper proposes a decorrelation-based approach to test hypotheses and construct confidence intervals for the low dimensional component of high dimensional proportional hazards models. Motivated by the geometric projection principle, we propose new decorrelated score, Wald and partial likelihood ratio statistics. Wi…
CoxSE combines deep learning with self-explaining neural networks for survival analysis.
problem Improving predictive power of Cox Proportional Hazards model while maintaining explainability.
method Proposes CoxSE, a locally explainable Cox proportional hazards model using SENN, and CoxSENAM, a hybrid model with NAM.
result CoxSE provides more stable and consistent explanations while maintaining predictive power.
SVB method provides scalable Bayesian proportional hazards model for high-dimensional gene expression data.
problem Bayesian methods for high-dimensional sparse survival data often sacrifice uncertainty quantification or computational scalability.
method Mean-field variational approximation for scalable Bayesian proportional hazards model.
result SVB method offers posterior distribution for parameters and variable selection via posterior inclusion probabilities.
Semi-parametric survival analysis methods like the Cox Proportional Hazards (CPH) regression (Cox, 1972) are a popular approach for survival analysis. These methods involve fitting of the log-proportional hazard as a function of the covariates and are convenient as they do not require estimation of the baseline hazard …
We investigate the effect of the proportional hazards assumption on prognostic and predictive models of the survival time of patients suffering from amyotrophic lateral sclerosis (ALS). We theoretically compare the underlying model formulations of several variants of survival forests and implementations thereof, includ…
New method estimates survival risks without strong proportional hazard assumptions.
problem Time-to-event prediction with censored data and competing risks.
method Jointly learns deep nonlinear representations for fully parametric survival regression.
result Demonstrates benefits in real-world datasets with different censoring levels.
ICODEN models survival data with interval-censored times using neural networks and ODEs.
problem Predicting time-to-event outcomes with interval-censored data, especially when models require strong assumptions or cannot handle high-dimensional predictors.
method ICODEN uses ordinary differential equations and deep neural networks to model the hazard function and cumulative hazard without proportional hazards assumption.
result ICODEN achieves satisfactory predictive accuracy across various simulation and real-world applications, handling high-dimensional predictors robustly.
The method integrates survival constraints into NMF for identifying survival-associated gene clusters.
problem Understanding and interpreting high-dimensional biological data for disease markers.
method Cox proportional hazards regression integrated with NMF via proportional hazards non-negative matrix factorization.
result The method can uncover survival-associated gene clusters in cancer gene expression data.
New optimization methods improve Cox Proportional Hazards model training for high-dimensional data.
problem Vanishing second order derivatives in Newton method prevent convergence for high-dimensional CPH model training.
method Construct and minimize surrogate functions exploiting hidden mathematical structures of CPH model.
result Global convergence and monotonic loss decrease, leading to sparse and high-quality models.
Study compares Cox model and RSF for predicting patient survival, finding RSF superior in certain scenarios.
problem Comparing predictive accuracy of Cox proportional hazards model and Random Survival Forest for patient-specific survival probabilities.
method Conducted a comprehensive comparison study using simulation scenarios and real-world datasets.
result RSF outperforms Cox model in nonproportional hazards settings and with treatment-covariate interactions.
Paper compares different models for time-to-event analysis.
problem Comparing models for time-to-event analysis.
method Experimental comparison of semi-parametric, parametric, and machine learning models.
result Models' performance evaluated using concordance index.
Paper addresses data heterogeneity in federated learning for CoxPH models in healthcare.
problem Data heterogeneity in federated learning of CoxPH models for healthcare.
method Feature-based clustering and event-based reporting strategy.
result Enhanced model accuracy and performance in federated survival analysis.
To better understand the interplay of censoring and sparsity we develop finite sample properties of nonparametric Cox proportional hazard's model. Due to high impact of sequencing data, carrying genetic information of each individual, we work with over-parametrized problem and propose general class of group penalties s…
Enhances Cox model for survival analysis with symbolic non-linear log-risk functions.
problem Limited interpretability and non-linearity in traditional Cox models.
method Introduces GCPH model using Kolmogorov-Arnold Networks for symbolic non-linear log-risk functions.
result GCPH achieves competitive performance and superior interpretability.
High throughput genetic sequencing arrays with thousands of measurements per sample and a great amount of related censored clinical data have increased demanding need for better measurement specific model selection. In this paper we establish strong oracle properties of nonconcave penalized methods for nonpolynomial (N…
Variable selection in high dimensional space has challenged many contemporary statistical problems from many frontiers of scientific disciplines. Recent technology advance has made it possible to collect a huge amount of covariate information such as microarray, proteomic and SNP data via bioimaging technology while ob…
We introduce a semi-parametric Bayesian model for survival analysis. The model is centred on a parametric baseline hazard, and uses a Gaussian process to model variations away from it nonparametrically, as well as dependence on covariates. As opposed to many other methods in survival analysis, our framework does not im…
Research studies have shown that a large proportion of hazards remain unrecognized, which expose construction workers to unanticipated safety risks. Recent studies have also found that a strong correlation exists between viewing patterns of workers, captured using eye-tracking devices, and their hazard recognition perf…
Medical practitioners use survival models to explore and understand the relationships between patients' covariates (e.g. clinical and genetic features) and the effectiveness of various treatment options. Standard survival models like the linear Cox proportional hazards model require extensive feature engineering or pri…
Study uses machine learning and survival analysis to predict CKD progression.
problem Early detection and management of CKD to reduce ESRD risk.
method Combines machine learning and classical statistical models to identify novel CKD progression predictors.
result Deep learning models outperform other methods in predicting CKD progression.
Proposes FarmHazard model for hazard regression with correlated covariates.
problem Model selection challenges in high-dimensional data with correlated covariates.
method Factor-Augmented Regularized Model for Hazard Regression (FarmHazard) that learns latent factors and idiosyncratic components.
result Proves model selection and estimation consistency under mild conditions.
Deep learning improves CVD risk prediction from health records.
problem Predicting cardiovascular disease risk from administrative health data.
method Combined survival analysis and deep learning models.
result Deep learning models outperform traditional Cox models in accuracy and explained time-to-event occurrence.
SurvLIMEpy is a Python package for computing feature importance in survival analysis.
problem Computing feature importance in survival analysis models.
method Parallelized implementation of the SurvLIME algorithm for various survival models.
result SurvLIMEpy accurately captures feature importance in survival analysis models.
New methods for time-to-event prediction are proposed by extending the Cox proportional hazards model with neural networks. Building on methodology from nested case-control studies, we propose a loss function that scales well to large data sets, and enables fitting of both proportional and non-proportional extensions o…
A new neural network model for predicting event times without distributional assumptions.
problem Predicting event times from censored data with complex assumptions.
method Deep AFT Rank-regression model (DART) using Gehan's rank statistic.
result DART significantly improves performance on various benchmark datasets.
An accurate model of patient-specific kidney graft survival distributions can help to improve shared-decision making in the treatment and care of patients. In this paper, we propose a deep learning method that directly models the survival function instead of estimating the hazard function to predict survival times for …
Study uses ML to predict HL survival, outperforming CoxPH.
problem Improving survival prediction for HL patients.
method Compared multiple ML algorithms to CoxPH model.
result ML models outperform CoxPH in predicting HL survival.
Market activity scales near a constant of 0.632 in intrinsic time.
problem Understanding the stability of market scaling laws.
method Modeling market directional changes as a memoryless exponential hazard process and identifying the intrinsic time scaling constant.
result The intrinsic time scaling constant is 1−1/e=0.632. SurvLIME-KS improves survival model explanations robustly.
problem Improving explanations of unreliable survival models.
method SurvLIME-KS combines Cox proportional hazards model and Kolmogorov-Smirnov bounds for robust optimization.
result SurvLIME-KS minimizes average distance and maximizes distance in approximating cumulative hazard functions.
This work improves confidence intervals for Cox model test error using nested CV.
problem Insufficient understanding of confidence intervals for cross-validation in Cox model.
method Generalized nested cross-validation to Cox proportional hazards model.
result Improved coverage of confidence intervals for Cox model test error.
A new model avoids the PH assumption for right-censored survival data.
problem Inflexibility of Cox model when PH assumption fails.
method Deep partially linear transformation model (DPLTM) for right-censored data.
result The DPLTM avoids the curse of dimensionality and retains interpretability.
Bayesian model improves cure fraction estimation in survival analysis.
problem Estimating cure fraction in survival analysis.
method Hierarchical Bayesian framework for semiparametric mixture cure model.
result Improved accuracy in capturing unobserved heterogeneity.
Proposes a flexible neural model for multi-state survival analysis.
problem Limited applicability of Cox models for multi-state and competing events.
method Uses neural ordinary differential equations to solve Kolmogorov forward equations.
result Demonstrates state-of-the-art performance and interpretability.
Paper develops a method to predict cancer patient survival using molecular profiles.
problem Accurately predicting cancer patient survival with complex survival-molecular profile relationships.
method Kernel Cox partially linear regression with a novel regularized garrotized kernel machine (RegGKM) method.
result The proposed method outperforms other methods in predicting survival accuracy.
The paper examines how risk reduction and insurance choices interact under convex premium principles.
problem Interaction between self-protection and insurance demand under convex premium principles.
method Investigates optimal prevention efforts and insurance shares using distortion risk measures.
result Self-protection and insurance are complementary, but ex ante moral hazard can turn this into a substitution effect.
This study analyses the duration dependence of events that trigger volatility persistence in stock markets. Such events, in our context, are monthly spells of contiguous price decline or negative returns for the S&P500 stock market index over the last 145 years. Factors known to affect the duration of these spells are …
SurvLIME-Inf simplifies explanation of survival models using a linear programming approach.
problem Explain complex survival models using simple linear programming.
method Uses L∞-norm for feature importance and explains black-box models. result SurvLIME-Inf outperforms SurvLIME in small training set scenarios.
SurvLIME explains survival models by approximating them with Cox models.
problem Explaining complex survival models in machine learning.
method Applies Cox proportional hazards model to approximate survival model locally.
result Demonstrates efficiency through numerical experiments.
Proposes a new Q-learning method for survival outcomes in clinical trials.
problem Incomplete follow-up data and nonlinear covariate effects in clinical trials.
method Combines Buckley-James boosting with flexible base learners for estimating optimal treatment regimes.
result Improves treatment decision accuracy and stability in longitudinal clinical trials.
Bias - variance decomposition of the expected error defined for regression and classification problems is an important tool to study and compare different algorithms, to find the best areas for their application. Here the decomposition is introduced for the survival analysis problem. In our experiments, we study bias -…
Study compares LSTM, Transformer, and Mamba for bladder cancer recurrence analysis.
problem Complex time-dependent data in bladder cancer recurrence analysis.
method Evaluation of LSTM, Transformer, and Mamba models using Cox proportional hazards model.
result LSTM-Cox model outperforms Transformer-Cox and Mamba-Cox models in prediction accuracy.
TraCeR uses transformers to analyze survival data with longitudinal covariates.
problem Handling longitudinal covariates and assessing model calibration in survival analysis.
method Transformer-based survival analysis framework with factorized self-attention architecture.
result TraCeR achieves significant performance improvements over state-of-the-art methods.
Adapts bandit algorithms for online survival analysis under Cox PH model.
problem Online survival analysis challenges in a bandit framework.
method Adapts three bandit algorithms to balance exploration and exploitation.
result Demonstrates sublinear regret bounds and effective learning of treatment policies.
Temporal Point Processes (TPP) with partial likelihoods involving a latent structure often entail an intractable marginalization, thus making inference hard. We propose a novel approach to Maximum Likelihood Estimation (MLE) involving approximate inference over the latent variables by minimizing a tight upper bound on …