Deep learning model creates patient representations for scalable EHR-based stratification.
problem Challenges in summarizing and representing patient data from EHRs prevent scalable stratification analysis.
method Unsupervised framework based on deep learning (ConvAE) using word embeddings, CNNs, and autoencoders.
result ConvAE significantly outperformed baselines in clustering diverse patient cohorts, identifying clinically relevant subtypes.
A clinician desires to use a risk-stratification method that achieves confident risk-stratification - the risk estimates of the different patients reflect the true risks with a high probability. This allows him/her to use these risks to make accurate predictions about prognosis and decisions about screening, treatments…
Characterizing a patient's progression through stages of sepsis is critical for enabling risk stratification and adaptive, personalized treatment. However, commonly used sepsis diagnostic criteria fail to account for significant underlying heterogeneity, both between patients as well as over time in a single patient. W…
This Perspective provides examples of current and future applications of deep learning in pharmacogenomics, including: (1) identification of novel regulatory variants located in noncoding domains and their function as applied to pharmacoepigenomics; (2) patient stratification from medical records; and (3) prediction of…
Copula-based fusion improves breast cancer risk stratification.
problem Combining clinical and genomic risk scores using simple rules fails to capture their joint relationship.
method Used copulas to model the joint relationship between clinical and genomic risk scores.
result Copula-based fusion improves risk stratification, identifying subgroups with the worst prognosis.
Combines neural networks and logic circuits for interpretable, accurate, and cost-effective learning.
problem Lack of generalizability and interpretability in neural networks and high hardware cost in logic circuits.
method Trains a neural network, then translates it to random forests, and finally to AND-Inverter logic.
result The pipeline maintains greater accuracy and minimizes logic complexity.
Stratifying patients at risk for postoperative complications may facilitate timely and accurate workups and reduce the burden of adverse events on patients and the health system. Currently, a widely-used surgical risk calculator created by the American College of Surgeons, NSQIP, uses 21 preoperative covariates to asse…
Patients who suffer an acute coronary syndrome are at elevated risk for adverse cardiovascular events such as myocardial infarction and cardiovascular death. Accurate assessment of this risk is crucial to their course of care. We focus on estimating a patient's risk of cardiovascular death after an acute coronary syndr…
Longitudinal patient data has the potential to improve clinical risk stratification models for disease. However, chronic diseases that progress slowly over time are often heterogeneous in their clinical presentation. Patients may progress through disease stages at varying rates. This leads to pathophysiological misalig…
Recurrent neural networks (RNNs) are commonly applied to clinical time-series data with the goal of learning patient risk stratification models. Their effectiveness is due, in part, to their use of parameter sharing over time (i.e., cells are repeated hence the name recurrent). We hypothesize, however, that this trait …
Chronic Pulmonary Aspergillosis (CPA) is a complex lung disease caused by infection with Aspergillus. Computed tomography (CT) images are frequently requested in patients with suspected and established disease, but the radiological signs on CT are difficult to quantify making accurate follow-up challenging. We propose …
Italy's daily COVID-19 cases stratified by age groups.
problem Analyzing the spread and impact of COVID-19 across different age groups.
method Stratified daily data of COVID-19 cases by age classes.
result Detailed insights into how age affects COVID-19 outcomes.
Activity and motion analysis has the potential to be used as a diagnostic tool for mental disorders. However, to-date, little work has been performed in turning stratification measures of activity into useful symptom markers. The research presented in this thesis has focused on the identification of objective activity …
Motivation: How do we integratively analyze large-scale multi-platform genomic data that are high dimensional and sparse? Furthermore, how can we incorporate prior knowledge, such as the association between genes, in the analysis systematically? Method: To solve this problem, we propose a Scalable Network Constrained T…
Study improves mortality prediction in hospital patients using comprehensive feature engineering.
problem Accurate prediction of all-cause in-hospital mortality in healthcare.
method Comprehensive feature engineering approach using vital signs, laboratory results, and demographic data.
result Random Forest model achieved highest performance with AUC of 0.94, significantly outperforming other models.
We train and validate a semi-supervised, multi-task LSTM on 57,675 person-weeks of data from off-the-shelf wearable heart rate sensors, showing high accuracy at detecting multiple medical conditions, including diabetes (0.8451), high cholesterol (0.7441), high blood pressure (0.8086), and sleep apnea (0.8298). We compa…
A new method boosts survival analysis by stratifying patients and removing noise covariates.
problem Weak detection of treatment differences in randomized clinical trials due to patient heterogeneity.
method 5-Step Stratified Testing and Amalgamation Routine (5-STAR) using elastic net Cox regression and conditional inference trees.
result The 5-STAR routine significantly improves power in detecting treatment effects compared to traditional methods.
We prove the existence of Verdier stratifications for sets definable in any o-minimal structure on (R, +, .). It is also shown that the Verdier condition (w) implies the Whitney condition (b) in o-minimal structures on (R, +, .). As a consequence the Whitney Stratification Theorem holds. The existence of (wf)-stratific…
Synthetic medical data which preserves privacy while maintaining utility can be used as an alternative to real medical data, which has privacy costs and resource constraints associated with it. At present, most models focus on generating cross-sectional health data which is not necessarily representative of real data. …
The paper studies HKKN stratifications for non-compact spaces and proves convexity properties.
problem Proving convexity properties of moment maps for non-compact subsets.
method Algebraic and analytical study of HKKN stratifications for a vector space and compact Kähler manifold, then applying to non-compact subsets.
result Convexity properties of moment maps for invariant subsets are proven.
Sparse GFA identifies disease factors in FTD subgroups.
problem Heterogeneity in neurological disorders hinders understanding and treatment.
method Sparse Group Factor Analysis (GFA) with regularised horseshoe priors.
result Identified latent disease factors differentially expressed in FTD subgroups.
Stratifies representation varieties of twisted Hopf links.
problem Stratifying representation varieties of twisted Hopf links.
method Using stratification of AGLr(C)-representation varieties of the fundamental group of the complement of a twisted Hopf link. result Explicit description and computation of motives for ranks 1 and 2.
The paper defines a stratification for Lie groupoids in a tame topology context.
problem Presenting a tame topology counterpart to canonical stratification of Lie groupoids.
method Using Shiota's isotopy lemma and approximation theorem, the paper defines a canonical Whitney stratification of definable Lie groupoids into invariant strata.
result A canonical Whitney stratification of the Lie groupoid into definable strata invariant under the groupoid action.
Paper confirms MCS spaces are equivalent to CS sets.
problem Understanding the equivalence of MCS and CS sets.
method Analyzing the MCS stratification and intrinsic stratification.
result MCS spaces are equivalent to CS sets with respect to their stratification.
Study develops a dynamic risk model for COVID-19 mortality using UK Biobank data.
problem Developing tools to monitor high-risk patients during the COVID-19 pandemic.
method Data-driven random forest classification model using baseline characteristics and symptoms.
result Model predicts COVID-19 mortality with excellent performance (AUC: 0.91), identifying novel predictors.
Alexandrov spaces have a special stratification that maps to spheres.
problem Characterizing the structure of Alexandrov spaces.
method Extremal stratification and space of directions analysis.
result Alexandrov spaces are homeomorphic to spheres in their space of directions.
Bayesian networks and ML improve COVID-19 symptom classification and severity analysis.
problem Understanding the relationship between COVID-19 symptoms and demographic variables.
method Bayesian network structure learning followed by unsupervised clustering and demographic symptom identification.
result 99.99% testing accuracy compared to 41.15% for a heuristic method.
Investigates properties of moment maps and stratifications on Lie groups.
problem Understanding moment maps and stratifications on real reductive Lie groups.
method Functorial, algebraic approach to moment map and Kirwan-Ness stratification.
result Properties and properties of moment maps and stratifications established.
Optimizes biharmonic map regularity using stratification methods.
problem Improving the known almost optimal regularity of biharmonic maps.
method Quantitative stratification method.
result Optimal regularity results for minimizing biharmonic maps.
New stratification reveals intrinsic singularity types of orbit spaces.
problem Understanding the intrinsic structure of orbit spaces under Lie group actions.
method Introduced the isostabilizer decomposition and established a map to Klein strata.
result A new canonical stratification on the manifold clarifies the relationship with classical structures.
The aim of this paper is to compare stratifications of moduli spaces given by group actions in the case of similarity of matrices introduced by Arnold and the author's stratification by projective orbifolds, and its relation to deformations o elements in the moduli space.
Combines k-means and hill climbing for stratification and allocation.
problem Optimizing stratification and sample allocation for complex surveys.
method Combining k-means type algorithms with hill climbing.
result Multi-stage combination algorithms generally perform well compared to recent methods.
Guidelines for the management of atherosclerotic cardiovascular disease (ASCVD) recommend the use of risk stratification models to identify patients most likely to benefit from cholesterol-lowering and other therapies. These models have differential performance across race and gender groups with inconsistent behavior a…
Social media enhances or diminishes scientific status, depending on usage.
problem Impact of social media on scientific stratification and mobility.
method Logistic Attribution Analysis combining statistical and machine learning methods.
result Social media promotes stratification and mobility, but beyond a threshold, it negatively impacts status.
Standard models assign disease progression to discrete categories or stages based on well-characterized clinical markers. However, such a system is potentially at odds with our understanding of the underlying biology, which in highly complex systems may support a (near-)continuous evolution of disease from inception to…
We give a geometric proof of existence of Whitney stratifications of definable sets in o-minimal structures.
Study clarifies variance of stratification estimators for causal effects.
problem Estimating average causal effects with discrete covariates.
method Combines insights from potential outcomes, causal diagrams, and structural models.
result Derives expressions for the variance of stratification estimators.
This paper provides a stratification of semi-algebraic sets in the plane with finitely many geodesic segments.
problem How to stratify semi-algebraic sets in the plane with finitely many geodesic segments.
method Develops a semi-algebraic stratification of a real semi-algebraic set in the plane with open cells having the finiteness property.
result Provides insights for high-dimensional stratifications of semi-algebraic sets in connection with geodesics.
The Bialynicki-Birula decomposition of the space of lambda-connections restricts to the Morse stratification on the moduli space of Higgs bundles and to the partial oper stratification on the de Rham moduli space of holomorphic connections. For both the Morse and partial oper stratifications, every stratum is a holomor…
We study the topology of the inertia space of a smooth G-manifold M where G is a compact Lie group. We construct an explicit Whitney stratification of the inertia space, demonstrating that the inertia space is a triangulable differentiable stratified space. In addition, we demonstrate a de Rham theorem for differ…
In healthcare, the highest risk individuals for morbidity and mortality are rarely those with the greatest modifiable risk. By contrast, many machine learning formulations implicitly attend to the highest risk individuals. We focus on this problem in point processes, a popular modeling technique for the analysis of the…
Machine learning models for medical image analysis often suffer from poor performance on important subsets of a population that are not identified during training or testing. For example, overall performance of a cancer detection model may be high, but the model still consistently misses a rare but aggressive cancer su…
In healthcare, patient risk stratification models are often learned using time-series data extracted from electronic health records. When extracting data for a clinical prediction task, several formulations exist, depending on how one chooses the time of prediction and the prediction horizon. In this paper, we show how…
The paper studies harmonic map flows and proves rectifiability of singular sets.
problem Understanding the structure of singular sets in harmonic map flows.
method Investigates the stratification theory for suitable solutions using tangent measures.
result Each time slice of the singular set is rectifiable.
The paper describes a stratification of a compactified Hurwitz space using combinatorial trees.
problem Describing the boundary stratification of a compactified Hurwitz space.
method Using decorated trees to describe the boundary strata and their containment relations.
result The boundary strata of the compactified Hurwitz space are in bijection with decorated trees, and containment is given by edge contraction.
The complement of a complex hyperplane arrangement is known to be homotopic to a minimal CW complex. There are several approaches to the minimality. In this paper, we restrict our attention to real two dimensional cases, and introduce the "dual" objects so called minimal stratifications. The strata are explicitly descr…
Let G be a Lie group, and let (M,ω) be a symplectic manifold. If G admits a Hamiltonian action on (M,ω) with momentum map μ, then M, the zero-level set of μ, the orbit space, and the corresponding symplectic quotient all have induced stratifications. We push this setting into the language of differential …
The paper offers simple, near-optimal algorithms for multi-group learning.
problem Learning predictors within subgroups of a population, addressing fairness and hidden stratification.
method Studies the structure of solutions and provides simple, near-optimal algorithms.
result Simple and near-optimal algorithms for multi-group learning.