Paper uses TDA for automated Parkinson's disease classification and severity assessment.
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Unified deep learning predicts Parkinson's disease from medical images.
This study evaluates handwriting features to diagnose Parkinson's disease.
Paper presents a light-weight CNN model for Parkinson's disease diagnosis.
Study compares neural and statistical models for Parkinson's disease progression from voice data.
Paper classifies Parkinson's disease from speech in three languages using CNNs and transfer learning.
Study uses GMM-UBM and i-vectors to assess Parkinson's patients via speech, handwriting, and gait.
Web-based framework detects Parkinson's disease from speech recordings.
This paper presents a new method for medical diagnosis of neurodegenerative diseases, such as Parkinson's, by extracting and using latent information from trained Deep convolutional, or convolutional-recurrent Neural Networks (DNNs). In particular, our approach adopts a combination of transfer learning, k-means cluster…
Pre-trained model from healthy ADLs improves gait pattern classification for Parkinson's disease.
Accurate diagnosis is crucial for preventing the progression of Parkinson's, as well as improving the quality of life with individuals with Parkinson's disease. In this paper, we develop a sex-specific and age-dependent classification method to diagnose the Parkinson's disease using the online handwriting recorded from…
Parkinson's Disease (PD) is a neurodegenerative disease that currently does not have a cure. In order to facilitate disease management and reduce the speed of symptom progression, early diagnosis is essential. The current clinical, diagnostic approach is to have radiologists perform human visual analysis of the degener…
Develops a two-stage conformal prediction method for Parkinson's disease medication needs.
Machine learning classifies Parkinson's Disease stages from walker sensors data.
One major challenge in the medication of Parkinson's disease is that the severity of the disease, reflected in the patients' motor state, cannot be measured using accessible biomarkers. Therefore, we develop and examine a variety of statistical models to detect the motor state of such patients based on sensor data from…
Machine learning aids in diagnosing Parkinson's disease with higher accuracy.
CASCADE improves uncertainty communication in Parkinson's disease medication management.
DC-SIS selects features faster than mRMR for Parkinson's vocal diagnosis.
The assessment of Parkinson's disease (PD) poses a significant challenge as it is influenced by various factors which lead to a complex and fluctuating symptom manifestation. Thus, a frequent and objective PD assessment is highly valuable for effective health management of people with Parkinson's disease (PwP). Here, w…
With the arrival of the big data era, more and more data are becoming readily available in various real-world applications and those data are usually highly heterogeneous. Taking computational medicine as an example, we have both Electronic Health Records (EHR) and medical images for each patient. For complicated disea…
We search for digital biomarkers from Parkinson's Disease by observing approximate repetitive patterns matching hypothesized step and stride periodic cycles. These observations were modeled as a cycle of hidden states with randomness allowing deviation from a canonical pattern of transitions and emissions, under the hy…
Background: Parkinson's disease (PD) is a prevalent long-term neurodegenerative disease. Though the diagnostic criteria of PD are relatively well defined, the current medical imaging diagnostic procedures are expertise-demanding, and thus call for a higher-integrated AI-based diagnostic algorithm. Methods: In this pape…
Clinical researchers use disease progression models to understand patient status and characterize progression patterns from longitudinal health records. One approach for disease progression modeling is to describe patient status using a small number of states that represent distinctive distributions over a set of obser…
We develop a model to cluster time-series data with interval censoring, improving disease phenotyping.
A model learns symptom-drug relations for PD patients.
Freezing of gait (FoG) is a common gait disability in Parkinson's disease, that usually appears in its advanced stage. Freeze episodes are associated with falls, injuries, and psychological consequences, negatively affecting the patients' quality of life. For detecting FoG episodes automatically, a highly accurate dete…
Motion Code models time series dynamics with sparse approximations.
1-D CNNs classify pupil size variations in scotopic conditions.
Paper uses deep learning to make predictions transparently.
In the past few years, there are several researches on Parkinson's disease (PD) recognition using single-photon emission computed tomography (SPECT) images with deep learning (DL) approach. However, the DL model's complexity usually results in difficult model interpretation when used in clinical. Even though there are …
Recordings of electrical brain activity carry information about a person's cognitive health. For recording EEG signals, a very common setting is for a subject to be at rest with its eyes closed. Analysis of these recordings often involve a dimensionality reduction step in which electrodes are grouped into 10 or more re…
Deep learning model creates patient representations for scalable EHR-based stratification.
Comparative statistical properties of Parkinson, Garman-Klass, Roger-Satchell and bridge oscillation estimators are discussed. Point and interval estimations, related with mentioned estimators are considered
Framework combines HMM and MTGCN for spatiotemporal causal inference in clinical data.
Early and accurate identification of parkinsonian syndromes (PS) involving presynaptic degeneration from non-degenerative variants such as Scans Without Evidence of Dopaminergic Deficit (SWEDD) and tremor disorders, is important for effective patient management as the course, therapy and prognosis differ substantially …
Drawing an inspiration from behavioral studies of human decision making, we propose here a general parametric framework for a reinforcement learning problem, which extends the standard Q-learning approach to incorporate a two-stream framework of reward processing with biases biologically associated with several neurolo…
Modern medicine requires generalised approaches to the synthesis and integration of multimodal data, often at different biological scales, that can be applied to a variety of evidence structures, such as complex disease analyses and epidemiological models. However, current methods are either slow and expensive, or inef…
Clinical patient records are an example of high-dimensional data that is typically collected from disparate sources and comprises of multiple likelihoods with noisy as well as missing values. In this work, we propose an unsupervised generative model that can learn a low-dimensional representation among the observations…
Selecting important features in non-linear or kernel spaces is a difficult challenge in both classification and regression problems. When many of the features are irrelevant, kernel methods such as the support vector machine and kernel ridge regression can sometimes perform poorly. We propose weighting the features wit…
This paper explores the impact of metric choice on Fréchet regression.
The paper presents Imbalance-XGBoost, a Python package that combines the powerful XGBoost software with weighted and focal losses to tackle binary label-imbalanced classification tasks. Though a small-scale program in terms of size, the package is, to the best of the authors' knowledge, the first of its kind which prov…
Resource-efficient oblique trees reduce neural signal classification costs.
Evidence suggests Rapid-Eye-Movement (REM) Sleep Behaviour Disorder (RBD) is an early predictor of Parkinson's disease. This study proposes a fully-automated framework for RBD detection consisting of automated sleep staging followed by RBD identification. Analysis was assessed using a limited polysomnography montage fr…
Semi-pessimistic RL tackles distributional shift and data scarcity in offline RL.
We present a theory of homogeneous volatility bridge estimators for log-price stochastic processes. The main tool of our theory is the parsimonious encoding of the information contained in the open, high and low prices of incomplete bridge, corresponding to given log-price stochastic process, and in its close value, fo…
Deep brain stimulation (DBS) is a surgical treatment for Parkinson's Disease. Static models based on quasi-static approximation are common approaches for DBS modeling. While this simplification has been validated for bioelectric sources, its application to rapid stimulation pulses, which contain more high-frequency pow…
Bayesian hypergraph inference models disease pathways from EHR data.
In this paper we introduce a new feature selection algorithm to remove the irrelevant or redundant features in the data sets. In this algorithm the importance of a feature is based on its fitting to the Catastrophe model. Akaike information crite- rion value is used for ranking the features in the data set. The propose…