A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.
Study compares GNNs and classical molecular featurisations for molecular property and cliff prediction.
BERT learns molecular substructures for chemistry problems.
The problem of accelerating drug discovery relies heavily on automatic tools to optimize precursor molecules to afford them with better biochemical properties. Our work in this paper substantially extends prior state-of-the-art on graph-to-graph translation methods for molecular optimization. In particular, we realize …
Graph Polish optimizes molecular structures by minimizing changes and maximizing preservation.
Generative model learns to create molecules with multiple properties using interpretable substructures.
Neural network learns from higher-order connections in molecules.
We seek to automate the design of molecules based on specific chemical properties. In computational terms, this task involves continuous embedding and generation of molecular graphs. Our primary contribution is the direct realization of molecular graphs, a task previously approached by generating linear SMILES strings …
Graph neural networks struggle with counting certain substructures in graphs.
Graph Substructure Networks (GSN) improves GNN expressivity by counting subgraph isomorphisms.
Functional groups (FGs) are molecular substructures that are served as a foundation for analyzing and predicting chemical properties of molecules. Automatic discovery of FGs will impact various fields of research, including medicinal chemistry and material sciences, by reducing the amount of lab experiments required fo…
Recent work in graph neural networks (GNNs) has led to improvements in molecular activity and property prediction tasks. Unfortunately, GNNs often fail to capture the relative importance of interactions between molecular substructures, in part due to the absence of efficient intermediate pooling steps. To address these…
Searching new molecules in areas like drug discovery often starts from the core structures of candidate molecules to optimize the properties of interest. The way as such has called for a strategy of designing molecules retaining a particular scaffold as a substructure. On this account, our present work proposes a scaff…
A new deep model generates molecules by fragments, improving validity and uniqueness.
HiGraphDTI learns drug and target representations from molecular graphs to predict DTIs.
This paper studies learning the representations of whole graphs in both unsupervised and semi-supervised scenarios. Graph-level representations are critical in a variety of real-world applications such as predicting the properties of molecules and community analysis in social networks. Traditional graph kernel based me…
STNN-DDI predicts drug interactions using substructure-aware neural networks.
Molecule optimization is about generating molecule with more desirable properties based on an input molecule . The state-of-the-art approaches partition the molecules into a large set of substructures and grow the new molecule structure by iteratively predicting which substructure from to add. However, s…
DHGAK aligns substructures for better graph kernel performance.
The subtle and unique imprint of dark matter substructure on extended arcs in strong lensing systems contains a wealth of information about the properties and distribution of dark matter on small scales and, consequently, about the underlying particle physics. However, teasing out this effect poses a significant challe…
Chemical structure elucidation is a serious bottleneck in analytical chemistry today. We address the problem of identifying an unknown chemical threat given its mass spectrum and its chemical formula, a task which might take well trained chemists several days to complete. Given a chemical formula, there could be over a…
We analyze geometrical structures necessary to represent bulk and surface interactions of standard and substructural nature in complex bodies. Our attention is mainly focused on the influence of diffuse interfaces on sharp discontinuity surfaces. In analyzing this phenomenon, we prove the covariance of surface balances…
In a previous article, we defined a very flexible notion of suborbifold and characterized those suborbifolds which can arise as the images of orbifold embeddings. In particular, suborbifolds are images of orbifold embeddings precisely when they are saturated and split. This article addresses the problem of orbifold str…
Framework tackles OOD challenges in molecule property prediction by modeling environments.
AutoGraph uses transformers to efficiently generate graphs as sequences.
AWARE improves graph prediction by aggregating walks with attention schemes.
The recent state-of-the-art deep learning methods have significantly improved brain tumor segmentation. However, fully supervised training requires a large amount of manually labeled masks, which is highly time-consuming and needs domain expertise. Weakly supervised learning with scribbles provides a good trade-off bet…
Non-invasive detection of cardiovascular disorders from radiology scans requires quantitative image analysis of the heart and its substructures. There are well-established measurements that radiologists use for diseases assessment such as ejection fraction, volume of four chambers, and myocardium mass. These measuremen…
Geo2DR learns graph representations using substructure patterns.
SFP prunes ID features to improve OOD generalization without domain data.
An important question that discrete approaches to quantum gravity must address is how continuum features of spacetime can be recovered from the discrete substructure. Here, we examine this question within the causal set approach to quantum gravity, where the substructure replacing the spacetime continuum is a locally f…
A new model designs molecular latent vectors for drug discovery.
MoFlow generates chemically valid molecular graphs from latent representations.
New method uses contrastively trained GNNs for more reliable graph model evaluation.
Spectral algorithms solve optimal community detection and related problems.
New method unfolds distribution moments directly from data without binning.
We propose a molecular generative model based on the conditional variational autoencoder for de novo molecular design. It is specialized to control multiple molecular properties simultaneously by imposing them on a latent space. As a proof of concept, we demonstrate that it can be used to generate drug-like molecules w…
Novel RL approach for molecular design using quantum mechanics.
Jets from boosted heavy particles have a typical angular scale which can be used to distinguish them from QCD jets. We introduce a machine learning strategy for jet substructure analysis using a spectral function on the angular scale. The angular spectrum allows us to scan energy deposits over the angle between a pair …
Generative models are becoming a tool of choice for exploring the molecular space. These models learn on a large training dataset and produce novel molecular structures with similar properties. Generated structures can be utilized for virtual screening or training semi-supervised predictive models in the downstream tas…
LSS learns molecular trajectories from MD data.
We introduce the notion of left (and right) quasi-Loday algebroids and a "universal space" for them, called a left (right) omni-Loday algebroid, in such a way that Lie algebroids, omni-Lie algebras and omni-Loday algebroids are particular substructures.
Properties of data are frequently seen to vary depending on the sampled situations, which usually changes along a time evolution or owing to environmental effects. One way to analyze such data is to find invariances, or representative features kept constant over changes. The aim of this paper is to identify one such fe…
AniDS improves molecular force field modeling by learning anisotropic noise.
Machine learning models simulate molecular spectra and reactions in solvents.
Deep generative model for healthcare data identifies coherent substructures and mutational clusters.
Framework for training-free guidance in discrete diffusion models for molecular generation.
Most graph kernels are an instance of the class of -Convolution kernels, which measure the similarity of objects by comparing their substructures. Despite their empirical success, most graph kernels use a naive aggregation of the final set of substructures, usually a sum or average, thereby potentially dis…
Optimizes molecular generation for chemist preferences.