NoLimits.jl: Flexible and Composable Nonlinear Mixed-Effects Modeling in Julia
problem Flexible and composable nonlinear mixed-effects modeling
method Macro-based modeling language and unified interface
result Substantially expand the range of nonlinear mixed-effects models
metabeta uses neural networks to speed up Bayesian mixed-effects regression.
problem Bayesian mixed-effects regression is computationally expensive.
method metabeta is a neural network model that pre-trains to estimate posterior distributions.
result metabeta achieves comparable performance to MCMC at a fraction of the time.
Study compares neural and statistical models for Parkinson's disease progression from voice data.
problem Difficult statistical analysis of longitudinal voice biomarkers due to subject correlation, small cohorts, and varied disease trajectories.
method Evaluated Neural Mixed Effects (NME), Generalized Neural Network Mixed Models (GNMMs), and semi-parametric Generalized Additive Mixed Models (GAMMs).
result GAMMs achieve stronger predictive performance and retain interpretable smooth effects and subject-level structure.
New Krylov subspace methods speed up mixed-effects models with crossed random effects.
problem Slow computations for high-dimensional crossed random effects in mixed-effects models.
method Krylov subspace-based methods for generalized mixed-effects models with cross effects.
result Speedups by factors of up to 10,000 in computations for mixed-effects models.
GBMixed boosts mixed models for clustered data, estimating mean and variance flexibly.
problem Flexible estimation of mean and variance components in clustered data.
method Gradient Boosting framework for linear mixed models with likelihood-based gradients.
result GBMixed accurately recovers complex nonlinear fixed effects and covariances.
A new method combines machine learning with mixed-effects models for better repeated measurement analysis.
problem Inference of linear coefficients in partially linear mixed-effects models with complex interactions and high-dimensional variables.
method Double machine learning approach to estimate nonparametrically nonlinear variables, then use standard linear mixed-effects techniques to estimate the linear coefficient.
result The estimated fixed effects coefficient converges at the parametric rate and is semiparametrically efficient.
A scalable Bayesian inference method for mixed-effects models in systems biology.
problem Scalable Bayesian inference for complex hierarchical mixed-effects models in systems biology.
method Constructing amortized approximations of likelihood and posterior distributions, refined for each individual dataset.
result Our method is both fast and competitive in statistical accuracy compared to exact pseudomarginal Bayesian inference.
We link disjoint longitudinal data for rare disease patients using latent representations and mixed-effects regression.
problem Analyzing treatment switches in rare diseases with limited data and changing measurement instruments.
method We embed item values into a shared latent space using variational autoencoders and apply mixed-effects regression to quantify treatment effects.
result Our approach allows for statistical inference and quantifies the impact of treatment switches in spinal muscular atrophy.
MC-GMENN improves neural networks for clustered data using Monte Carlo methods.
problem Improving neural network performance on clustered data with correlations.
method MC-GMENN employs Monte Carlo methods to train generalized mixed effects neural networks.
result MC-GMENN outperforms existing models in generalization and quantifying inter-cluster variance.
Proposes meTS for efficient exploration in correlated bandits.
problem Efficiently explore in bandits with correlated actions.
method Mixed-effect model with Thompson Sampling.
result Bound on Bayes regret with two terms.
The Tweedie Compound Poisson-Gamma model is routinely used for modeling non-negative continuous data with a discrete probability mass at zero. Mixed models with random effects account for the covariance structure related to the grouping hierarchy in the data. An important application of Tweedie mixed models is pricing …
Gradient Boosted Mixed Models estimate mean and variance components for clustered data.
problem Limited flexibility in linear mixed models for complex settings.
method Gradient Boosting extended to mixed models with likelihood-based gradients and flexible base learners.
result Accurate recovery of variance components and improved predictive accuracy.
Many scientific and engineering challenges -- ranging from pharmacokinetic drug dosage allocation and personalized medicine to marketing mix (4Ps) recommendations -- require an understanding of the unobserved heterogeneity in order to develop the best decision making-processes. In this paper, we develop a hypothesis te…
Study improves maize yield prediction using BNs with mixed-effects models.
problem Limited causal inference in agronomic data models.
method Integrates random effects into Bayesian networks, leveraging hierarchical data structure.
result Significantly reduces maize yield prediction error from 28% to 17%.
i-Mix improves contrastive learning across domains without domain-specific augmentations.
problem Improving contrastive representation learning for unlabeled data across diverse domains.
method i-Mix treats contrastive learning as a non-parametric classifier problem, mixing data in input and virtual label spaces.
result i-Mix consistently improves representation quality across image, speech, and tabular data domains.
New MMM captures hierarchical marketing effects and sign restrictions.
problem Measuring effectiveness of marketing activities with hierarchical structure and sign constraints.
method Proposes a constrained maximum likelihood approach using Hamiltonian Monte Carlo algorithm.
result Demonstrates superior performance on real datasets compared to multi-stage methods.
Paper develops federated GLMM algorithms for analyzing hierarchical data.
problem Analyzing hierarchical data with non-independent observations in a federated setting.
method Developed two federated GLMM algorithms using Laplace and Gaussian Hermite approximations.
result Federated GLMM can handle hierarchical data and achieve comparable or superior performance.
MOMENT selects and estimates mixed-effects models using moment identities.
problem Selecting and estimating random-effects covariance matrix and fixed-effects coefficients in multiresponse linear mixed-effects models.
method MOMENT is a stage-wise moment-based framework that reduces the random-effects selection problem to a smooth constrained convex optimization problem.
result MOMENT performs competitively and can outperform separate univariate analyses for correlated responses.
This note is concerned with an accurate and computationally efficient variational bayesian treatment of mixed-effects modelling. We focus on group studies, i.e. empirical studies that report multiple measurements acquired in multiple subjects. When approached from a bayesian perspective, such mixed-effects models typic…
SelectMix improves deep learning robustness against noisy labels.
problem Deep neural networks memorize noisy labels, degrading performance.
method Confidence-guided targeted sample mixing with soft labels.
result SelectMix consistently outperforms baseline methods on noisy label datasets.
Neural models improve GLMMs for complex data.
problem Nonlinear relationships in grouped data.
method Replaced linear function with neural networks.
result Improved performance on synthetic and real-world data.
The paper analyzes oversmoothing in GNNs and quantifies the effects of mixing and denoising.
problem Oversmoothing in Graph Neural Networks (GNNs).
method Non-asymptotic analysis of graph convolutions and effects of mixing and denoising.
result The number of layers required for oversmoothing to occur is O(logN/log(logN)) for dense graphs. ARMED models improve deep learning interpretability and generalize better on clustered data.
problem Clustered data leads to spurious associations and poor model fitting.
method Adversarial regularization and mixed effects subnetworks.
result ARMED models outperform conventional methods in accuracy and generalization.
Functional determinant for mixed signature sphere products depends on sphere dimensions and parity.
problem Determining the functional determinant for scalar fields on mixed signature sphere products.
method Analyzing the GJMS operator on SqimesSp to derive the functional determinant. result The functional determinant depends only on the total dimension and parity of the sphere dimensions.
CausalMix generates synthetic data with causal controls for mixed-type tables.
problem Synthetic data for causal inference with mixed-type and multimodal tabular data.
method CausalMix combines Gaussian latent priors with data-type-specific decoders for control over overlap, confounding, and treatment effect heterogeneity.
result CausalMix achieves state-of-the-art distributional metrics and stable causal control.
We develop an HMC algorithm to easily marginalize random effects in LMMs.
problem Bayesian inference in LMMs is challenging, especially marginalizing random effects.
method Developed an HMC algorithm to marginalize random effects in LMMs efficiently.
result Marginalization is always beneficial when applicable and improves various models, especially cognitive science models.
Proposes a convex model for mixed logit to handle individual heterogeneity.
problem Non-convex optimization in mixed logit models for individual heterogeneity.
method Sparse and low-rank decomposition for convex formulation.
result Convex formulation avoids simulation-based approximation and unstable model interpretation.
Combines boosting with Gaussian process and mixed effects models.
problem Model misspecifications and independence assumptions in boosting.
method Relaxes zero or linearity assumption in Gaussian process and mixed effects models, and independence assumption in boosting.
result Increased prediction accuracy compared to existing approaches.
In this paper we use game theory to model poisoning attack scenarios. We prove the non-existence of pure strategy Nash Equilibrium in the attacker and defender game. We then propose a mixed extension of our game model and an algorithm to approximate the Nash Equilibrium strategy for the defender. We then demonstrate th…
This paper concerns the development of an inferential framework for high-dimensional linear mixed effect models. These are suitable models, for instance, when we have n repeated measurements for M subjects. We consider a scenario where the number of fixed effects p is large (and may be larger than M), but the n…
Bayesian test assesses dependence between mixed data types.
problem Assessing dependence between text, image, and sound data.
method Bayesian kernelised correlation test using Dirichlet process model.
result Demonstrated effectiveness compared to other methods.
New method optimizes mixed integer optimization for hierarchical modeling of clustered and longitudinal data.
problem Optimizing subset selection in hierarchical models with clustered and longitudinal data.
method Distribution-free mixed-integer optimization approach for cluster-aware regression.
result The method efficiently solves problems within minutes and outperforms traditional models in generating sparse solutions with high predictive power.
A scalable model for high-dimensional longitudinal data.
problem Modeling high-dimensional, non-linear, time-varying longitudinal data.
method LMM-VAE, combining linear mixed models and amortized variational inference.
result Competitive performance across simulated and real-world datasets.
Proposes a new model for mortality forecasting considering age groups and cohort effects.
problem Longevity risk due to ageing population.
method Mixed-effects time-series approach with age groups dependency and random cohort effects.
result Remarkable improvements in forecast accuracy compared to the CBD model.
A new method for efficient inference in sequential latent-variable models.
problem Computational challenges in integrating subject-specific random effects.
method Anchored variational inference framework to approximate posterior distributions.
result The method achieves accurate estimation with significant computational gains.
Proposes integrating random effects into deep neural networks for better predictive performance.
problem Correlated data in real-life applications are not handled well by traditional deep neural networks.
method Uses mixed models with random effects to handle correlations in deep neural networks, minimizing Gaussian negative log-likelihood with SGD.
result Improves predictive performance over natural competitors in various correlation scenarios.
Proposes an efficient algorithm for mHealth that makes real-time physical activity suggestions.
problem Training complex models efficiently in real-time mHealth applications.
method Streamlined empirical Bayes procedure for fitting linear mixed effects models.
result Improves accuracy and speed over state-of-the-art approaches in mHealth applications.
Extends co-clustering to mixed numerical and binary data.
problem Co-clustering of mixed data types (numerical and binary).
method Latent block models for mixed data types.
result Effectiveness of the proposed approach on simulated data.
New model clusters mixed-type data with missing values, improving air quality analysis.
problem Clustering mixed-type data with missing values and regime persistence.
method Statistical jump model incorporating regime persistence and handling missing data.
result Superior performance in inferring persistent air quality regimes compared to traditional methods.
Bayesian optimisation tackles high-dimensional categorical and mixed search spaces.
problem Bayesian optimisation on high-dimensional categorical and mixed search spaces is challenging.
method Combining local optimisation with a tailored kernel design.
result Empirically outperforms current baselines in performance and computational costs.
MMbeddings reduces categorical embeddings by treating them as latent effects, significantly decreasing parameters and mitigating overfitting.
problem Large cardinalities in categorical embeddings lead to high parameter counts and overfitting.
method MMbeddings treats embeddings as latent random effects in a variational autoencoder framework, reducing parameter count and mitigating overfitting.
result MMbeddings consistently outperforms traditional embeddings across various tasks, demonstrating its potential in machine learning applications.
New method detects essential tori in mixed singularity links.
problem Detecting essential tori in mixed singularity link complements.
method Analyzing properties of defining mixed polynomials.
result Explicit criteria for essential tori existence.
Paper extends LME models to allow sign constraints on coefficients with SDTN random effects.
problem Inference with sign constraints on random effects in LME models.
method Proposes SDTN distribution for random effects and develops likelihood-based approaches for estimation.
result Proposed constrained model improves real-world interpretations and achieves satisfactory performance.
Joint sparsity offers powerful structural cues for feature selection, especially for variables that are expected to demonstrate a "grouped" behavior. Such behavior is commonly modeled via group-lasso, multitask lasso, and related methods where feature selection is effected via mixed-norms. Several mixed-norm based spar…
The optimization of expensive to evaluate, black-box, mixed-variable functions, i.e. functions that have continuous and discrete inputs, is a difficult and yet pervasive problem in science and engineering. In Bayesian optimization (BO), special cases of this problem that consider fully continuous or fully discrete doma…
We study the stochastic multi-armed bandit problem in the case when the arm samples are dependent over time and generated from so-called weak $\cC$-mixing processes. We establish a $\cC-$Mix Improved UCB agorithm and provide both problem-dependent and independent regret analysis in two different scenarios. In the first…
New Riemannian optimization improves variance estimation in mixed models.
problem Challenges in estimating variance parameters in linear mixed models due to constraints.
method Formulated as an optimization problem on a Riemannian manifold, using Riemannian gradient and Hessian.
result Yields higher quality variance parameter estimates compared to existing methods.
Transformers improve Alzheimer's disease progression prediction by accounting for irregular biomarker histories.
problem Difficult prediction of medium-horizon Alzheimer's disease progression due to tied clinical scores and irregular biomarker observations.
method Developed a residual gap-aware transformer that combines statistical reference with transformer-based residual learning.
result The proposed model reduces mean error and improves prediction-observation correlation compared to baseline models.