Study re-evaluates MIMIC-III codes, finding many are under-coded.
problem Validity of MIMIC-III clinical codes is questionable.
method Open-source, reproducible methodology for assessing codes.
result Most frequently assigned codes are under-coded up to 35%
Deep learning predicts patient trajectories in open Mimic-III dataset.
problem Predicting future medical conditions from patient history.
method Two parallel bi-directional Minimal Gated Recurrent Unit networks trained on Mimic-III dataset.
result Significant improvements in automated medical prognosis measured by Recall@k.
Model predicts patient outcomes from EHR data by limiting feature interactions.
problem Predicting patient outcomes from noisy, missing EHR data.
method Recurrent neural network with feature interaction restriction.
result Improvement in AU-ROC for mortality prediction (1.1% improvement, p<0.01).
Scoping review and benchmarking of synthetic EHR data generation methods.
problem Creating realistic synthetic electronic health records for research and training.
method Conducted a scoping review and benchmarked seven methods on open-source EHR datasets.
result GAN-based methods excel in fidelity and utility, while rule-based methods excel in privacy protection.
Study evaluates federated learning with differential privacy on MIMIC-III, improving model performance with careful parameter tuning.
problem Training machine learning models on privacy-sensitive data sets locked in healthcare facilities.
method Extensive evaluation of federated and differential privacy techniques on MIMIC-III dataset, analyzing various parameters.
result Careful parameter tuning is crucial for federated learning with differential privacy, especially for data distribution and communication strategies.
Study develops an interpretable model for early mortality prediction in elderly MODS patients.
problem High mortality risk in elderly patients with MODS, unsatisfactory current scoring systems.
method Used eXtreme Gradient Boosting with SHapley Additive exPlanations on MIMIC-III, eICU-CRD, and PLAGH-S datasets.
result Interpretable model outperforms baseline models and clinical scores in predicting hospital mortality.
Probabilistic survival predictions from models trained with Maximum Likelihood Estimation (MLE) can have high, and sometimes unacceptably high variance. The field of meteorology, where the paradigm of maximizing sharpness subject to calibration is popular, has addressed this problem by using scoring rules beyond MLE, s…
Improves medical note processing by training model on related concepts and global context.
problem Scarce and imbalanced labeled training data limits generalizability of automated abbreviation disambiguation models.
method Data augmentation using related medical concepts and global context information within medical notes.
result Model accuracy improved by almost 14% on CASI dataset and 4% on i2b2 dataset.
Deep learning predicts ICU mortality with enhanced interpretability.
problem Improving mortality prediction accuracy and clinician trust in AI.
method Trained a deep learning model on MIMIC-III to interpret nursing notes.
result Model reaches ROC of 0.8629, outperforming SAPS-II.
We study multiple rule-based and machine learning (ML) models for sepsis detection. We report the first neural network detection and prediction results on three categories of sepsis. We have used the retrospective Medical Information Mart for Intensive Care (MIMIC)-III dataset, restricted to intensive care unit (ICU) p…
MedCAT extracts valuable medical information from unstructured text.
problem Extracting structured information from unstructured biomedical documents.
method Unsupervised machine learning for disambiguation of entities.
result Improved entity detection and linking compared to existing tools.
Improved aggregation methods learn from all ICU events without preprocessing for better patient risk analysis.
problem Lack of efficient methods to dynamically assess patient status in ICU.
method Improved aggregation methods for a deep learning architecture that learns from all events without preprocessing.
result Models achieve strong performance (AUROC 0.87) in patient mortality classification.
Robust machine learning relies on access to data that can be used with standardized frameworks in important tasks and the ability to develop models whose performance can be reasonably reproduced. In machine learning for healthcare, the community faces reproducibility challenges due to a lack of publicly accessible data…
X-CAL improves survival model calibration without sacrificing predictive power.
problem Improving the calibration of survival models to better match observed data.
method Explicit calibration (X-CAL) turns distributional calibration into a differentiable objective for survival modeling.
result X-CAL improves calibration metrics without significantly reducing predictive performance.
Deep learning predicts heart failure readmission from clinical notes.
problem Predicting and preventing heart failure readmission.
method Convolutional Neural Networks (CNN) trained on clinical notes.
result Deep learning models outperform traditional machine learning methods in readmission prediction.
Framework improves clinical timeline reconstruction from text and tables.
problem Temporal precision and event timing in clinical narratives and EHRs.
method Retrieval-augmented multimodal alignment framework.
result Consistently improves absolute timestamp accuracy and temporal concordance.
CausalLongPFN predicts counterfactual outcomes from time-series data.
problem Predicting future outcomes under varying treatments in time-series data with confounding and heterogeneity.
method Prior-fitted network pretrained on synthetic episodes of temporal structural causal models.
result CausalLongPFN outperforms domain-trained models on factual and counterfactual prediction tasks.
A novel memory network improves interpretability and training for EHR analysis.
problem Limited interpretability and training difficulty in traditional memory networks for EHR analysis.
method Proposes a hybrid memory architecture with explicit and blurred memory blocks for improved interpretability and training efficiency.
result The model performs comparably to state-of-the-art methods and enables ready interpretation of results.
This study improves AKI prediction precision using CNN on EHR data.
problem Improving early prediction of AKI in ICU patients.
method Convolutional Neural Network (CNN) on EHR data.
result Best AUROC up to 0.988 on MIMIC-III and 0.936 on eICU data sets.
This paper operationalizes the Exponential Mechanism using Normalizing Flows for private optimization.
problem Improving privacy in machine learning while maintaining accuracy and efficiency.
method Using Normalizing Flows to approximate sampling from the Exponential Mechanism for private optimization.
result ExpM+NF provides more privacy than non-private SGD but not as much as DPSGD.
In this work, we utilize Machine Learning for early recognition of patients at high risk of acute respiratory distress syndrome (ARDS), which is critical for successful prevention strategies for this devastating syndrome. The difficulty in early ARDS recognition stems from its complex and heterogenous nature. In this s…
Health care is one of the most exciting frontiers in data mining and machine learning. Successful adoption of electronic health records (EHRs) created an explosion in digital clinical data available for analysis, but progress in machine learning for healthcare research has been difficult to measure because of the absen…
Effective representation learning of electronic health records is a challenging task and is becoming more important as the availability of such data is becoming pervasive. The data contained in these records are irregular and contain multiple modalities such as notes, and medical codes. They are preempted by medical co…
dnamite simplifies NAMs for feature selection and survival analysis.
problem Handling complex machine learning tasks on large-scale data.
method Python package implementing Neural Additive Models (NAMs) for feature selection and survival analysis.
result dnamite provides a scikit-learn style interface for training NAMs.
Improved patient classification using preprocessed clinical notes.
problem Classifying patient discharges with clinical notes, which are often messy and hard to process.
method Pretrained hierarchical recurrent neural network model that parses clinical notes without preprocessing.
result The model improves discharge diagnosis classification performance on MIMIC-III dataset.
This study presents a multimodal machine learning model to predict ICD-10 diagnostic codes. We developed separate machine learning models that can handle data from different modalities, including unstructured text, semi-structured text and structured tabular data. We further employed an ensemble method to integrate all…
Acute kidney injury (AKI) in critically ill patients is associated with significant morbidity and mortality. Development of novel methods to identify patients with AKI earlier will allow for testing of novel strategies to prevent or reduce the complications of AKI. We developed data-driven prediction models to estimate…
A new method uses sinusoidal functions to represent timestamps as dense vectors for improving irregularly sampled time series learning.
problem Challenges in supervised learning with irregularly sampled time series due to irregular time intervals.
method Proposes a novel method to represent timestamps as dense vectors using sinusoidal functions, called Time Embeddings.
result Improves LSTM-based and classical machine learning models, especially with very irregular data.
Unified Bayesian framework for missing data imputation and prediction in clinical time series.
problem High prevalence of missing values in clinical time series data.
method Unified Bayesian recurrent framework for imputation and prediction.
result Strong performance gains over state-of-the-art methods on mortality prediction tasks.
Heart disease remains the leading cause of death in the United States. Compared with risk assessment guidelines that require manual calculation of scores, machine learning-based prediction for disease outcomes such as mortality can be utilized to save time and improve prediction accuracy. This study built and evaluated…
Predicting the risk of mortality for patients with acute myocardial infarction (AMI) using electronic health records (EHRs) data can help identify risky patients who might need more tailored care. In our previous work, we built computational models to predict one-year mortality of patients admitted to an intensive care…
Framework generates private synthetic data for unlabeled mixed-type data.
problem Generating private synthetic data for unlabeled mixed-type data.
method Combines autoencoders and GANs for differential privacy.
result Learned model generates synthetic data with similar statistical properties.
This study shows unstructured clinical notes can improve mortality prediction.
problem Lack of effective use of unstructured clinical notes in mortality prediction.
method Used a hierarchical architecture with convolutional and recurrent layers to predict in-hospital mortality from unprocessed clinical notes.
result Achieved higher metrics in mortality prediction compared to structured data approaches.
Cardea automates machine learning for EHRs, improving model building efficiency.
problem Lack of a trusted, open-source framework for automated machine learning in EHRs.
method Uses FHIR for data structure, AUTOML frameworks for feature engineering, model selection, and tuning, and an adaptive data assembler.
result Demonstrates framework's effectiveness on 5 prediction tasks, highlighting its flexibility and human competitiveness.
Deep learning models (aka Deep Neural Networks) have revolutionized many fields including computer vision, natural language processing, speech recognition, and is being increasingly used in clinical healthcare applications. However, few works exist which have benchmarked the performance of the deep learning models with…
The Intensive Care Unit (ICU) is a hospital department where machine learning has the potential to provide valuable assistance in clinical decision making. Classical machine learning models usually only provide point-estimates and no uncertainty of predictions. In practice, uncertain predictions should be presented to …
Generating datasets that "look like" given real ones is an interesting tasks for healthcare applications of ML and many other fields of science and engineering. In this paper we propose a new method of general application to binary datasets based on a method for learning the parameters of a latent variable moment that …
Improves representation learning for individual treatment effect estimation.
problem Estimating individual treatment effects with high accuracy.
method Introduces a structure keeper to maintain correlation between baseline covariates and representations, trains a discriminator to balance representation and information loss.
result Proposed SMRL algorithm minimizes treatment estimation error and outperforms state-of-the-art methods.
ButterflyFlow uses butterfly matrices for efficient invertible layers in normalizing flows.
problem Building efficient invertible layers for complex probability distributions.
method Proposes butterfly layers for invertible linear layers, leveraging their ability to capture complex structures.
result ButterflyFlow achieves strong density estimation and significantly better log-likelihoods on various datasets.
ODVICE augments EHR cohorts using ontology to improve analysis robustness.
problem Limited records in cohorts for rare diseases hamper robust analysis.
method Ontology-driven Monte-Carlo graph spanning algorithm for data augmentation.
result ODVICE augmented cohorts show ~30% improvement in AUC over non-augmented datasets.
Study examines biases in clinical word embeddings, revealing performance gaps across groups.
problem Biases in clinical word embeddings leading to performance differences across groups.
method Pretrained BERT models on MIMIC-III, fill-in-the-blank method, fairness evaluation on clinical tasks.
result Classifiers trained from BERT representations exhibit statistically significant differences in performance across groups.
CATR rationalizes text data to stabilize causal effect estimation.
problem Observational positivity violation in high-dimensional text data.
method Confounding-Aware Token Rationalization (CATR) selects necessary subset of tokens.
result CATR yields more accurate and stable causal effect estimates.
With large volumes of health care data comes the research area of computational phenotyping, making use of techniques such as machine learning to describe illnesses and other clinical concepts from the data itself. The "traditional" approach of using supervised learning relies on a domain expert, and has two main limit…
The hypothesis that computational models can be reliable enough to be adopted in prognosis and patient care is revolutionizing healthcare. Deep learning, in particular, has been a game changer in building predictive models, thus leading to community-wide data curation efforts. However, due to inherent variabilities in …
With widespread adoption of electronic health records, there is an increased emphasis for predictive models that can effectively deal with clinical time-series data. Powered by Recurrent Neural Network (RNN) architectures with Long Short-Term Memory (LSTM) units, deep neural networks have achieved state-of-the-art resu…
Develops a neural model to predict event occurrence and timing.
problem Standard event time models ignore the distinction between event occurrence probability and predicted time.
method Introduces a conditional event time model using a neural network with a binary stochastic layer.
result Shows superior event occurrence and timing predictions on various datasets.
Multivariate time series data in practical applications, such as health care, geoscience, and biology, are characterized by a variety of missing values. In time series prediction and other related tasks, it has been noted that missing values and their missing patterns are often correlated with the target labels, a.k.a.…
Study improves mortality prediction in hospital patients using comprehensive feature engineering.
problem Accurate prediction of all-cause in-hospital mortality in healthcare.
method Comprehensive feature engineering approach using vital signs, laboratory results, and demographic data.
result Random Forest model achieved highest performance with AUC of 0.94, significantly outperforming other models.