CRN model estimates treatment effects over time using adversarial balancing.
problem Estimating treatment effects over time in medical settings.
method Adversarial domain balancing to remove time-varying confounders.
result CRN achieves lower error in estimating counterfactuals and treatment timing.
The treatment effects of medications play a key role in guiding medical prescriptions. They are usually assessed with randomized controlled trials (RCTs), which are expensive. Recently, large-scale electronic health records (EHRs) have become available, opening up new opportunities for more cost-effective assessments. …
Machine-assisted treatment recommendations hold a promise to reduce physician time and decision errors. We formulate the task as a sequence-to-sequence prediction model that takes the entire time-ordered medical history as input, and predicts a sequence of future clinical procedures and medications. It is built on the …
Medical practitioners use survival models to explore and understand the relationships between patients' covariates (e.g. clinical and genetic features) and the effectiveness of various treatment options. Standard survival models like the linear Cox proportional hazards model require extensive feature engineering or pri…
RL algorithms with medical integration improve personalized treatment recommendations.
problem Developing effective personalized treatment strategies for chronic diseases.
method Integrating medical knowledge into RL algorithms for DTR.
result Enhanced treatment recommendations with increased confidence.
The paper compares methods for estimating individual treatment effects.
problem Estimating the optimal treatment effect for each individual.
method Comparison of machine learning methods for individual treatment effect estimation.
result Combination of Logistic Regression and Difference Score method, as well as Uplift Random Forest method, provides the best prediction accuracy.
New method combines multiple datasets to estimate ATE with valid confidence intervals.
problem Combining multiple observational datasets to estimate ATE with valid confidence intervals.
method Prediction-powered inferences to shrink CIs and provide valid CIs.
result Valid confidence intervals for ATE from multiple datasets.
Deep Bayesian models estimate causal effects for dynamic treatment regimes over long follow-up times.
problem Challenges in causal effect estimation for dynamic treatment regimes with long follow-up times.
method Combining outcome regression models with deep Bayesian models for high-dimensional features.
result Stable and accurate dynamic causal effect estimation from observational data, especially with long-term follow-up.
This paper tackles data-efficient CEE with scarce labelled data, proposing a method to progressively reduce generalization risk.
problem Data scarcity in CEE tasks, especially in high-stake domains like medical treatment effect prediction.
method Develops a principled label acquisition pipeline (MACAL) for CEE tasks, focusing on reducing generalization risk progressively.
result Proposes Model Agnostic Causal Active Learning (MACAL) algorithm for batch-wise label acquisition.
A new method flips class values to address class and treatment imbalance in uplift modeling and HTE.
problem Class and treatment imbalance in imbalanced RCT data.
method Class flipping approach to address imbalance without distorting predictions.
result The method does not distort predicted effects and does not require calibration.
Three approaches learn personalized treatment policies for UTI patients.
problem Learning optimal treatment policies in multiobjective settings with fully observed outcomes.
method Indirect and direct approaches using predictive models and without intermediate models.
result All approaches outperform clinicians in achieving better performance on all outcomes and trade-offs.
Develops a two-stage conformal prediction method for Parkinson's disease medication needs.
problem Heterogeneous disease progression and treatment response in Parkinson's Disease.
method Two-stage conformal prediction framework with statistical guarantees.
result Quantifies uncertainty in medication needs predictions, improving clinical trust and quality of life.
Machine learning has shown much promise in helping improve the quality of medical, legal, and financial decision-making. In these applications, machine learning models must satisfy two important criteria: (i) they must be causal, since the goal is typically to predict individual treatment effects, and (ii) they must be…
When devising a course of treatment for a patient, doctors often have little quantitative evidence on which to base their decisions, beyond their medical education and published clinical trials. Stanford Health Care alone has millions of electronic medical records (EMRs) that are only just recently being leveraged to i…
Novel method to quantify aleatoric uncertainty of treatment effects from observational data.
problem Understanding randomness in treatment effects for medical treatments.
method Partial identification and Neyman-orthogonality to quantify aleatoric uncertainty.
result Developed a novel orthogonal learner (AU-learner) for quantifying aleatoric uncertainty.
Framework assesses treatment effects by risk groups in observational studies.
problem Evaluating treatment effects in observational studies with risk stratification.
method Five-step framework for risk-based assessment of treatment effect heterogeneity.
result Low-risk patients received negligible absolute benefits, while high-risk patients had pronounced effects.
CAST models time-varying treatment effects in cancer patients.
problem Estimating treatment effects at fixed time points limits understanding of dynamic changes over time.
method CAST combines parametric and non-parametric methods to model continuous time-varying treatment effects.
result CAST reveals how treatment effects rise, peak, and decline over the follow-up period.
Machine learning can help personalized decision support by learning models to predict individual treatment effects (ITE). This work studies the reliability of prediction-based decision-making in a task of deciding which action a to take for a target unit after observing its covariates x~ and predicted outcom…
Efficiently find near-optimal medical treatments with less trial and error.
problem Finding effective medical treatments through trial and error.
method Formalizes the problem, uses a causal inference framework, and proposes model-based dynamic programming and greedy algorithms.
result Our methods compare favorably to model-free reinforcement learning, offering a more transparent trade-off between search time and treatment efficacy.
New method estimates treatment effects from high dimensional data.
problem Estimating treatment effects from high dimensional data with confounders.
method Generative modeling approach to backdoor adjustment in variational inference.
result Empirically, estimates interventional likelihood in high dimensional settings.
Proposes DeepSDRF for continuous treatment recommendation from clinical survival data.
problem Continuous treatment recommendation in medical settings with survival data.
method Deep Survival Dose Response Function (DeepSDRF) for learning conditional average dose response (CADR) function.
result Similar performance of recommender algorithms based on random search and reinforcement learning.
Unified framework for counterfactual survival analysis improves treatment effect estimation.
problem Limited methods for counterfactual inference with survival outcomes.
method Unified framework for survival outcomes, nonparametric hazard ratio metric.
result Significantly outperforms alternatives in survival-outcome prediction and treatment-effect estimation.
Modeling disease progression using irregular time intervals in EHRs.
problem Challenges in analyzing temporal data from EHRs.
method Developed a Markovian generative model using EHR data.
result Model accurately recovers underlying disease progression patterns from irregular time intervals.
With the expeditious advancement of information technologies, health-related data presented unprecedented potentials for medical and health discoveries but at the same time significant challenges for machine learning techniques both in terms of size and complexity. Those challenges include: the structured data with var…
This paper presents the first deep reinforcement learning (DRL) framework to estimate the optimal Dynamic Treatment Regimes from observational medical data. This framework is more flexible and adaptive for high dimensional action and state spaces than existing reinforcement learning methods to model real-life complexit…
This paper investigates robust and efficient DR/RDR estimators for WATEs.
problem Lack of systematic investigation into robustness and efficiency conditions for WATE estimation.
method Proposes three RDR estimators using semiparametric efficient influence function and double/debiased machine learning.
result Demonstrates the practical relevance of the methods in medical and social sciences.
Study estimates treatment effect on survival outcomes using targeted maximum likelihood estimation.
problem Estimating treatment effect on time-to-event outcomes in clinical settings.
method Divided into three phases: estimation, feature selection, and targeted maximum likelihood estimation.
result Method performs well in high sample size or event rate conditions.
We propose a Bayesian model that predicts recovery curves based on information available before the disruptive event. A recovery curve of interest is the quantified sexual function of prostate cancer patients after prostatectomy surgery. We illustrate the utility of our model as a pre-treatment medical decision aid, pr…
Study on how imprecise medical data affects predictions in hyperthyroidism.
problem Impact of imprecise medical data on prediction results.
method Formulated a model for data imprecisions, generated imprecise samples, defined measures to evaluate impacts, and performed experiments.
result Small imprecisions can lead to large ranges of predicted results, potentially causing mis-labeling and inappropriate actions.
Develops a new RL algorithm for medical treatment regimes.
problem Optimal dose determination in continuous action environments.
method Quasi-optimal learning algorithm for near-optimal actions.
result Guaranteed convergence and effectiveness in real applications.
Adherence can be defined as "the extent to which patients take their medications as prescribed by their healthcare providers"[Osterberg and Blaschke, 2005]. World Health Organization's reports point out that, in developed countries, only about 50% of patients with chronic diseases correctly follow their treatments. Thi…
Proposes DSW for unbiased ITE estimation with dynamic confounders.
problem Estimating ITE from dynamic observational data with time-varying confounders.
method Deep Sequential Weighting (DSW) infers hidden confounders using current treatment assignments and historical information.
result DSW generates unbiased and accurate treatment effects.
Method uses semi-supervised learning to estimate optimal treatment regimes from medical records.
problem Estimating optimal treatment regimes from electronic medical records.
method Imputation-based semi-supervised method using unlabeled data.
result Proposed method yields more efficient estimators of optimal treatment regimes.
Clinical notes are text documents that are created by clinicians for each patient encounter. They are typically accompanied by medical codes, which describe the diagnosis and treatment. Annotating these codes is labor intensive and error prone; furthermore, the connection between the codes and the text is not annotated…
Study uses machine learning to analyze patient survey data for Lyme disease.
problem Understanding patient responses to treatment and disease progression.
method Applied various machine learning techniques to a patient registry.
result Identified key features that predict patient responses to antibiotic treatment.
Smart bin monitors predict medication adherence with high accuracy.
problem Predicting chronic medication adherence to improve healthcare efficiency.
method Machine learning models trained on IoT device data.
result High predictive performance (ROC AUC 0.86).
Proposes an interpretable machine learning framework for multi-arm HTE estimation.
problem Challenges in estimating heterogeneous treatment effects in multi-arm settings.
method Rule-based ensemble approach for HTE estimation in multi-arm trials.
result Achieved lower bias and higher estimation accuracy compared to existing methods.
New method estimates treatment effects over time with unobserved confounders.
problem Estimating treatment effects from observational data with unobserved confounders.
method Sequential Deconfounder using Gaussian process latent variable model.
result Unbiased estimates of individualized treatment responses over time.
It is crucial to provide compatible treatment schemes for a disease according to various symptoms at different stages. However, most classification methods might be ineffective in accurately classifying a disease that holds the characteristics of multiple treatment stages, various symptoms, and multi-pathogenesis. More…
We study the problem of learning to choose from m discrete treatment options (e.g., news item or medical drug) the one with best causal effect for a particular instance (e.g., user or patient) where the training data consists of passive observations of covariates, treatment, and the outcome of the treatment. The standa…
Study finds non-adherence to schizophrenia meds leads to earlier adverse events.
problem Impact of medication non-adherence on adverse outcomes in schizophrenia patients.
method Survival analysis, causal inference methods (T-learner, S-learner, nearest neighbor matching), different amounts of longitudinal information.
result Non-adherence to schizophrenia meds advances adverse events by 1 to 4 months.
Model predicts VKA dosage for Indian patients, aiding in safe medication.
problem Safe and accurate dosing of VKA drugs for Indian patients.
method Support Vector Machine (SVM) Regression model trained on patient data.
result Predicted dosages closely match actual dosages.
A new DML method for continuous treatments uncovers causal mediation effects.
problem Estimating causal mediation effects with continuous treatments.
method Double machine learning (DML) algorithm using kernel-based doubly robust moment function.
result Asymptotic normality with nonparametric convergence rate for estimating mediated response curve.
Multi-output Gaussian processes (GPs) are a flexible Bayesian nonparametric framework that has proven useful in jointly modeling the physiological states of patients in medical time series data. However, capturing the short-term effects of drugs and therapeutic interventions on patient physiological state remains chall…
Sepsis is a dangerous condition that is a leading cause of patient mortality. Treating sepsis is highly challenging, because individual patients respond very differently to medical interventions and there is no universally agreed-upon treatment for sepsis. In this work, we explore the use of continuous state-space mode…
Bayesian CNN estimates uncertainty in COVID-19 detection.
problem Uncertainty in deep learning predictions for medical diagnosis.
method Drop-weight based Bayesian Convolutional Neural Networks (BCNN).
result Uncertainty correlates with prediction accuracy.
Novel strategy benchmarks observational studies against randomized trials.
problem Benchmarking observational studies for treatment effect bias.
method Statistical test for null hypothesis of treatment effect difference.
result Valid lower bound on maximum bias strength for any subgroup.
The paper estimates personalized treatment effects in medical settings with competing risks.
problem Estimating treatment effectiveness for specific events in the presence of alternative event types.
method Meta-learners combining Cox regression or random survival forests for risk modeling and elastic net regression or random forests for direct CATE modeling.
result Compared meta-learners in multiple simulation settings, providing practical guidance for model selection.