Novel IRL method identifies suboptimal medical decisions in ICU data.
problem Identifying suboptimal medical decisions in clinical settings.
method Incorporates Inverse Reinforcement Learning with a pruning step to identify and remove suboptimal actions.
result Pruning step effectively identifies clinical priorities and values from suboptimal data.
A new framework designs experiments for better decision-making.
problem Suboptimal experimental designs for downstream decision-making.
method Amortized decision-aware Bayesian Experimental Design (BED) with Transformer Neural Decision Process (TNDP).
result TNDP effectively designs experiments and facilitates accurate decision-making.
Many medical decision-making tasks can be framed as partially observed Markov decision processes (POMDPs). However, prevailing two-stage approaches that first learn a POMDP and then solve it often fail because the model that best fits the data may not be well suited for planning. We introduce a new optimization objecti…
Develops new methods for risk-aware decision-making in medical bandits.
problem Risk-averse decision-making in medical contexts with limited data.
method Safe, anytime-valid concentration bounds, risk-aware contextual bandits, nonparametric algorithms.
result Improved decision-making algorithms for postoperative patient follow-up.
Patient journeys are compared to find clusters of similar disease trajectories.
problem Discovering shared health outcomes among patient journeys.
method Comparing longitudinal health data to identify clusters of similar patient trajectories.
result Clusters of patient journeys with similar health outcomes can be identified.
Framework for deferring decisions to experts in sequential medical settings.
problem Myopic and non-adaptive decision-making by ML models in sequential medical contexts.
method Sequential Learning-to-Defer (SLTD) framework using model-based reinforcement learning.
result Adaptive deferral policy improves trade-off between long-term outcomes and deferral frequency.
Prediction models can harm patients even when accurate, leading to self-fulfilling prophecies.
problem Prediction models can lead to harmful decisions that worsen patient outcomes.
method Formal characterization of harmful prediction models and analysis of their impact.
result Well-calibrated models are ineffective for decision-making as they do not change the data distribution.
Study proposes a statistical test for Vision Transformer's attention mechanisms.
problem ViT's attention mechanisms may focus on irrelevant regions, leading to unreliable evidence.
method Selective inference framework to quantify statistical significance of attentions as p-values.
result Proposed method enables reliable quantification of false positive detection probability of attentions.
CASCADE improves uncertainty communication in Parkinson's disease medication management.
problem Uncertainty in clinical decision-making for Parkinson's disease patients.
method CASCADE uses a novel conformal prediction framework to adaptively scale prediction intervals based on classification uncertainty.
result CASCADE produces more efficient and robust prediction intervals for Parkinson's disease patients.
Enhances uncertainty estimation in medical image segmentation.
problem Frequency-related noise in medical imaging leads to biased uncertainty estimates.
method Extends MC-Dropout to the frequency domain for better uncertainty estimation.
result MC-Frequency Dropout improves calibration and uncertainty in semantic segmentation.
Optimal decision-making using prediction sets to minimize risk.
problem Using prediction sets optimally for decision-making in uncertain scenarios.
method Decision-theoretic framework that seeks to minimize expected loss against a worst-case distribution.
result ROCP algorithm reduces critical mistakes compared to baselines, especially in costly out-of-set errors.
In this work, we investigate unsupervised representation learning on medical time series, which bears the promise of leveraging copious amounts of existing unlabeled data in order to eventually assist clinical decision making. By evaluating on the prediction of clinically relevant outcomes, we show that in a practical …
Foundation models alter medical data science workflow, challenging veridical data science principles.
problem Foundation models disrupt traditional data science practices in medicine.
method Critically examined the medical foundation model lifecycle and its deviation from veridical data science principles.
result Foundation models challenge veridical data science principles of predictability, computability, and stability.
Introduction. Case Based Reasoning (CBR) is an emerg- ing decision making paradigm in medical research where new cases are solved relying on previously solved similar cases. Usually, a database of solved cases is provided, and every case is described through a set of attributes (inputs) and a label (output). Extracting…
COMPASS improves uncertainty quantification for medical segmentation metrics.
problem Uncertainty quantification for medical segmentation metrics is crucial for clinical decision-making.
method COMPASS leverages deep neural network inductive biases to generate efficient, metric-based conformal prediction intervals.
result COMPASS produces significantly tighter intervals than traditional conformal prediction methods on medical image segmentation tasks.
Modern medicine requires generalised approaches to the synthesis and integration of multimodal data, often at different biological scales, that can be applied to a variety of evidence structures, such as complex disease analyses and epidemiological models. However, current methods are either slow and expensive, or inef…
Machine learning can help personalized decision support by learning models to predict individual treatment effects (ITE). This work studies the reliability of prediction-based decision-making in a task of deciding which action a to take for a target unit after observing its covariates x~ and predicted outcom…
Study benchmarks uncertainty quantification in chest X-ray classification.
problem Reliable uncertainty quantification for medical AI models.
method Evaluation of 13 uncertainty quantification methods on MIMIC-CXR-JPG dataset.
result Insights into effectiveness and disentanglement of epistemic and aleatoric uncertainties.
This guide explains statistical distances for evaluating generative models.
problem Evaluating the quality of samples from generative models.
method Four statistical distances: SW, C2ST, MMD, FID.
result Different distances can yield varying results on similar data.
New method quantifies uncertainty at class level for better decision-making.
problem Improving cost-sensitive decision-making in classification tasks.
method Label-wise decomposition of uncertainty measures based on non-categorical metrics.
result Proposed measures adhere to desirable properties and improve uncertainty quantification.
IML methods improve survival analysis transparency.
problem Limited interpretability in survival analysis models.
method Adapting IML techniques to survival analysis.
result Enhanced understanding of model predictions and risks.
There is a growing trend of applying machine learning methods to medical datasets in order to predict patients' future status. Although some of these methods achieve high performance, challenges still exist in comparing and evaluating different models through their interpretable information. Such analytics can help cli…
Paper uses AI to improve medical diagnosis accuracy.
problem Improving accuracy of medical diagnoses.
method Heuristic frequentist and Bayesian approaches applied to a nationwide dataset.
result Algorithm outperforms human doctors in detecting abnormal births.
A statistical test controls false positives in anomaly localization using diffusion models.
problem Uncertainty and bias in generative models for anomaly localization.
method Selective inference to quantify significance and control false positives.
result The method effectively controls false positive detection rates.
FIGS improves prediction performance while maintaining interpretability, especially in medical domains.
problem Lack of interpretability in machine learning models, particularly in high-stakes domains like medicine.
method Generalizes CART algorithm to grow multiple trees in summation, combining logical rules with addition.
result FIGS achieves state-of-the-art prediction performance and derives interpretable clinical decision instruments (CDIs).
A model for human-machine decision-making with private info and opacity.
problem Optimizing decisions in a human-machine system with private info and opacity.
method Formulated as a two-player learning problem, proved lower and upper bounds on optimality.
result Simple coordination strategy is nearly minimax optimal, efficient learning possible under certain assumptions.
Patient summarization is essential for clinicians to provide coordinated care and practice effective communication. Automated summarization has the potential to save time, standardize notes, aid clinical decision making, and reduce medical errors. Here we provide an upper bound on extractive summarization of discharge …
Deep Bayesian models estimate causal effects for dynamic treatment regimes over long follow-up times.
problem Challenges in causal effect estimation for dynamic treatment regimes with long follow-up times.
method Combining outcome regression models with deep Bayesian models for high-dimensional features.
result Stable and accurate dynamic causal effect estimation from observational data, especially with long-term follow-up.
Study improves confidence measures in medical imaging pipelines by addressing bias.
problem Bias in metric-based imaging pipelines compromises the efficiency of prediction intervals.
method Formalized symmetric and asymmetric CP formulations, analyzed bias effects, and validated empirically.
result Symmetric intervals are inflated by bias, while asymmetric intervals remain unaffected.
Computer-aided detection has been a research area attracting great interest in the past decade. Machine learning algorithms have been utilized extensively for this application as they provide a valuable second opinion to the doctors. Despite several machine learning models being available for medical imaging applicatio…
Machine learning promises to revolutionize clinical decision making and diagnosis. In medical diagnosis a doctor aims to explain a patient's symptoms by determining the diseases \emph{causing} them. However, existing diagnostic algorithms are purely associative, identifying diseases that are strongly correlated with a …
Proposes a method to quantify uncertainty in DNN models for discrete inputs.
problem Uncertainty quantification for DNN models with categorical and discrete feature variables.
method Develops a mathematical framework to quantify prediction uncertainty from discrete input noise and model parameters.
result Identifies risk-sensitive cases prone to misclassification due to discrete predictor errors.
In the following short article we adapt a new and popular machine learning model for inference on medical data sets. Our method is based on the Variational AutoEncoder (VAE) framework that we adapt to survival analysis on small data sets with missing values. In our model, the true health status appears as a set of late…
Framework improves health by planning actionable treatment processes.
problem Developing objective treatment processes in clinical settings.
method Surrogate Bayesian model combined with ML for personalized health improvement.
result Computed treatment processes are actionable and consistent with clinical knowledge.
This work abstracts deep neural networks into concept graphs for better interpretability in medical tasks.
problem Lack of interpretability in deep learning models, especially in medical domains.
method Developed a graphical representation of medical image processing models to understand concept-based reasoning.
result Extracted a concept-level graph that reveals the decision-making process of deep learning models.
CPR models complex decision processes by breaking them into context-specific policies, improving interpretability and accuracy.
problem Interpreting dynamic human decision-making processes in medical contexts.
method Develops Contextualized Policy Recovery (CPR) framework for multi-task learning, modeling each context-specific policy as a linear map.
result Achieves state-of-the-art performance in predicting medical decisions, closing the gap between interpretable and black-box methods.
This work advances collaborative decision making by combining human and AI strengths in uncertainty quantification.
problem Current AI lacks robust decision-making capabilities under uncertainty, especially in high-stakes contexts.
method Introduces Human AI Collaborative Uncertainty Quantification (HACUQ) framework, formalizing AI-human collaboration and developing calibration algorithms.
result Optimal collaborative prediction sets follow a two-threshold structure, and online adaptation algorithms can adapt to evolving human behavior.
Deep learning skin lesion classifier explained using CAVs.
problem Limited acceptance of deep learning CAD systems due to opaque decision-making.
method Mapped human understandable concepts to RECOD model using CAVs.
result Classifier learns and encodes disease-related concepts in its latent representation.
The Intensive Care Unit (ICU) is a hospital department where machine learning has the potential to provide valuable assistance in clinical decision making. Classical machine learning models usually only provide point-estimates and no uncertainty of predictions. In practice, uncertain predictions should be presented to …
Simplifies decision-making during medical exams with cost-efficient feature acquisition.
problem Guiding physicians during examination acquisition for accurate and efficient diagnosis.
method Dropout at input layer and integrated gradients at test-time for dynamic feature importance.
result More cost- and feature-efficient than prior approaches, achieving higher overall accuracy.
Method trains neural network for optimal decisions from stochastic simulators.
problem Suboptimal decisions from SBI approximations of posterior distributions.
method Trains neural network on simulated data to predict optimal actions.
result Induces similar cost as true posterior for optimal actions.
Explanations for deep neural network predictions in terms of domain-related concepts can be valuable in medical applications, where justifications are important for confidence in the decision-making. In this work, we propose a methodology to exploit continuous concept measures as Regression Concept Vectors (RCVs) in th…
Many applied decision-making problems have a dynamic component: The policymaker needs not only to choose whom to treat, but also when to start which treatment. For example, a medical doctor may choose between postponing treatment (watchful waiting) and prescribing one of several available treatments during the many vis…
This work debiases deep chest X-ray classifiers using intra- and post-processing methods.
problem Bias in deep neural networks for chest X-ray classification.
method Intra-processing techniques (fine-tuning and pruning) and post-processing methods.
result Successfully mitigates biases in fully connected and convolutional neural networks, offering stable performance.
The paper proposes a method to explain expert decisions by modeling preferences with 'what if' outcomes.
problem Interpreting and auditing decision-making policies in institutions.
method Integrating counterfactual reasoning into batch inverse reinforcement learning.
result The method effectively recovers accurate and interpretable descriptions of expert behavior.
Regularizes attention scores in vision transformers using bootstrapping.
problem Noisy and diffused attention maps in ViT limit interpretability.
method Statistical learning techniques, bootstrapping of attention scores.
result Improves shrinkage and sparsity of attention scores.
This paper explores interpretability techniques for two of the most successful learning algorithms in medical decision-making literature: deep neural networks and random forests. We applied these algorithms in a real-world medical dataset containing information about patients with cancer, where we learn models that try…
A primary goal of computational phenotype research is to conduct medical diagnosis. In hospital, physicians rely on massive clinical data to make diagnosis decisions, among which laboratory tests are one of the most important resources. However, the longitudinal and incomplete nature of laboratory test data casts a sig…