New framework distinguishes lung cancer subtypes using MALDI mass spectrometry.
arXiv research
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Paper presents a method for identifying isotope envelopes in MALDI-ToF data.
Study uses image analysis to predict MSI status in tumors.
Hyperspectral remote sensing images (HSIs) usually have high spectral resolution and low spatial resolution. Conversely, multispectral images (MSIs) usually have low spectral and high spatial resolutions. The problem of inferring images which combine the high spectral and high spatial resolutions of HSIs and MSIs, resp…
The paper presents the application of Variational Autoencoders (VAE) for data dimensionality reduction and explorative analysis of mass spectrometry imaging data (MSI). The results confirm that VAEs are capable of detecting the patterns associated with the different tissue sub-types with performance than standard appro…
Hyperspectral remote sensing images (HSIs) are characterized by having a low spatial resolution and a high spectral resolution, whereas multispectral images (MSIs) are characterized by low spectral and high spatial resolutions. These complementary characteristics have stimulated active research in the inference of imag…
For mass spectra acquired from cancer patients by MALDI or SELDI techniques, automated discrimination between cancer types or stages has often been implemented by machine learnings. These techniques typically generate "black-box" classifiers, which are difficult to interpret biologically. We develop new and efficient s…
Motivated by applications in hyperspectral imaging we investigate methods for approximating a high-dimensional non-negative matrix by a product of two lower-dimensional, non-negative matrices and This so-called non-negative matrix factorization is based…
The paper proposes a new method to improve microcredit decisions by modeling sequential loan interactions.
Standard models assign disease progression to discrete categories or stages based on well-characterized clinical markers. However, such a system is potentially at odds with our understanding of the underlying biology, which in highly complex systems may support a (near-)continuous evolution of disease from inception to…
Microbial identification is a central issue in microbiology, in particular in the fields of infectious diseases diagnosis and industrial quality control. The concept of species is tightly linked to the concept of biological and clinical classification where the proximity between species is generally measured in terms o…