New test identifies specific biological parameters for personalized CVD detection.
problem Ineffectual pathology tests fail to consider platelet activation and inter-individual variability.
method Stochastic platelet deposition model and approximate Bayesian computation with discriminative summary statistics.
result Inferred parameters help identify specific biological parameters for personalized CVD detection.
Paper introduces Functional Effects Models to account for individual heterogeneity in panel data.
problem Accounting for preference heterogeneity in panel data with machine learning.
method Functional Effects Models using gradient boosting decision trees and deep neural networks to learn individual-specific preference parameters.
result Functional Effects Models outperform traditional models in learning inter-individual heterogeneity and predictive performance.
New method aligns brain data across individuals for better brain decoding.
problem Inter-individual variability in brain response patterns limits decoder generalization.
method SpectralOT method that embeds cortical geometry into Laplace-Beltrami eigenmodes.
result SpectralOT strikes balance between aligning functional features and preserving anatomical structure.
The prevalence of wearable sensors (e.g., smart wristband) is creating unprecedented opportunities to not only inform health and wellness states of individuals, but also assess and infer personal attributes, including demographic and personality attributes. However, the data captured from wearables, such as heart rate …
New method aligns brain surfaces based on functional signatures.
problem Inter-individual variability in neuroimaging data.
method Fused Unbalanced Gromov-Wasserstein (FUGW) based on Optimal Transport.
result FUGW significantly increases between-subject correlation of activity.
PerCDL learns personalized dictionaries for physiological signals combining global and local structures.
problem Representing datasets with both global and local structures in human physiological signals.
method Personalized Convolutional Dictionary Learning (PerCDL) that combines a global and personalized local dictionary.
result PerCDL effectively learns interpretable representations for human locomotion data.
Bayesian model predicts mental health symptoms from IAT data, improving accuracy over D-score.
problem Limited predictive performance of D-score method for mental health assessment.
method Sparse hierarchical Bayesian model leveraging multi-modal data.
result AUCs of 0.73 (E-IAT) and 0.76 (PSY-IAT) in best modality configurations, significant after FDR correction.
This work relates the framework of model-based clustering for spatial functional data where the data are surfaces. We first introduce a Bayesian spatial spline regression model with mixed-effects (BSSR) for modeling spatial function data. The BSSR model is based on Nodal basis functions for spatial regression and accom…
Convolutional Neural Networks (CNN) outperform traditional classification methods in many domains. Recently these methods have gained attention in neuroscience and particularly in brain-computer interface (BCI) community. Here, we introduce a CNN optimized for classification of brain states from magnetoencephalographic…
This note is concerned with an accurate and computationally efficient variational bayesian treatment of mixed-effects modelling. We focus on group studies, i.e. empirical studies that report multiple measurements acquired in multiple subjects. When approached from a bayesian perspective, such mixed-effects models typic…
EB-VAE combines tumor growth and dropout data for personalized treatment response modeling.
problem Challenges in integrating longitudinal tumor measurements, dropout information, and genetic covariates.
method Extended EB-VAE framework to jointly model longitudinal and time-to-event data, incorporating dropout hazard and genetic covariates.
result Hybrid decoder formulation yields consistent treatment-effect parameters and prior predictive performance comparable to neural decoder.
The current economic crisis has provoked an active response from the interdisciplinary scientific community. As a result many papers suggesting what can be improved in understanding of the complex socio-economics systems were published. Some of the most prominent papers on the topic include (Bouchaud, 2009; Farmer and …
Automated prediction of valence, one key feature of a person's emotional state, from individuals' personal narratives may provide crucial information for mental healthcare (e.g. early diagnosis of mental diseases, supervision of disease course, etc.). In the Interspeech 2018 ComParE Self-Assessed Affect challenge, the …
Bayesian optimization generates personalized face stimuli for cognitive neuroscience.
problem Lack of personalized face stimuli in cognitive neuroscience studies.
method Combines GANs with Bayesian optimization to identify individual response patterns to faces.
result Algorithm efficiently generates optimal faces maximizing individual subject's response.
Fine-grained atlases improve fMRI analysis of brain activity.
problem Large fMRI datasets require scalable brain network summaries.
method Trained on millions of fMRI volumes, DiFuMo dictionaries of 64-1024 networks.
result Fine-grained atlases enhance classic fMRI analysis pipelines.
Statistical inference is considered for variables of interest, called primary variables, when auxiliary variables are observed along with the primary variables. We consider the setting of incomplete data analysis, where some primary variables are not observed. Utilizing a parametric model of joint distribution of prima…
VC-PCR improves prediction by clustering correlated variables.
problem Decreased prediction accuracy due to cluster structure in predictor variables.
method Supervised variable selection and clustering to integrate cluster information into a sparse modeling process.
result VC-PCR achieves better prediction, variable selection, and clustering performance.
In this paper, we propose multi-variable LSTM capable of accurate forecasting and variable importance interpretation for time series with exogenous variables. Current attention mechanism in recurrent neural networks mostly focuses on the temporal aspect of data and falls short of characterizing variable importance. To …
Variable importance is central to scientific studies, including the social sciences and causal inference, healthcare, and other domains. However, current notions of variable importance are often tied to a specific predictive model. This is problematic: what if there were multiple well-performing predictive models, and …
A neural network finds causal relationships among latent variables.
problem Learning causal structure among latent variables in high-dimensional data.
method Redundant Input Neural Network (RINN) with modified architecture and regularized objective function.
result The RINN method successfully recovers latent causal structure between input and output variables.
Derives derivatives and geometric framework for functions with non-independent variables.
problem Characterizing functions with non-independent variables in probabilistic models.
method Derives actual and dependent partial derivatives, dependent Jacobian matrix, and tensor metric.
result Derives gradient, Hessian, and Taylor expansion for functions with non-independent variables.
A new distance for mixed-variable, hierarchical datasets with meta variables.
problem Heterogeneous datasets limit generalizability and performance in machine learning and optimization.
method Developed a modeling framework for mixed-variable and hierarchical domains with meta variables, and a novel distance function.
result The novel distance function allows comparison of heterogeneous datasets, improving model performance.
Unified Bayesian Optimisation for mixed variables improves performance.
problem Efficient optimisation of problems with both categorical and continuous variables.
method Derive value proposals from the Expected Improvement criterion to optimise both categorical and continuous variables under a single acquisition metric.
result Unified approach significantly outperforms existing methods across mixed-variable tasks.
In this paper, we propose an interpretable LSTM recurrent neural network, i.e., multi-variable LSTM for time series with exogenous variables. Currently, widely used attention mechanism in recurrent neural networks mostly focuses on the temporal aspect of data and falls short of characterizing variable importance. To th…
Random Forest variable importance is improved by class balancing techniques.
problem Class imbalance problem in machine learning.
method Proposed a variable selection algorithm using RF variable importance and its confidence interval.
result Our algorithm efficiently selects an optimal feature set, leading to improved prediction performance.
Variable selection for Gaussian process models is often done using automatic relevance determination, which uses the inverse length-scale parameter of each input variable as a proxy for variable relevance. This implicitly determined relevance has several drawbacks that prevent the selection of optimal input variables i…
Knoop enhances variable selection with over-parameterization and knockoffs.
problem Challenges of variable selection in high-dimensional datasets.
method Generates knockoff variables, integrates them into an over-parameterized model, and uses anomaly-based significance tests.
result Superior performance in variable selection compared to existing methods.
A serious problem in learning probabilistic models is the presence of hidden variables. These variables are not observed, yet interact with several of the observed variables. Detecting hidden variables poses two problems: determining the relations to other variables in the model and determining the number of states of …
New method for fitting graphical models with latent variables using regularized conditional likelihood.
problem Graphical modeling with latent variables and confounding dependencies.
method Regularized conditional likelihood for exponential family graphical models.
result Framework applicable to broader settings without knowing latent variables' distribution.
CIB compresses variables causally, preserving key causal interactions.
problem Constructing causal variable abstractions in complex systems.
method Causal Information Bottleneck (CIB) method, extending IB to include causal structures.
result CIB produces causally interpretable abstractions that accurately capture causal relations.
We generalize to the finite-state case the notion of the extreme effect variable Y that accumulates all the effect of a variant variable V observed in changes of another variable X. We conduct theoretical analysis and turn the problem of finding of an effect variable into a problem of a simultaneous decomposition…
Discond-VAE separates continuous and discrete factors in data.
problem Separating shared and class-specific variations in real-world data.
method Introduces private and public latent variables to represent continuous and discrete factors, respectively.
result Discond-VAE successfully disentangles class-dependent continuous factors from discrete factors.
A new method selects important variables for clustering from dependency networks.
problem Variable selection for clustering in high-cost data scenarios.
method Create dependency networks, rank variables by centrality, select top-n variables.
result Top-n variables improve clustering performance compared to existing methods.
The paper introduces methods to identify key variables discriminating between two datasets.
problem Identifying variables that distinguish between two datasets.
method Introduces a mathematical notion of discriminating variables and proposes two methods for their selection.
result Proposed methods improve upon existing techniques in two-sample variable selection.
Electronic Medical Records (EMR) are a rich source of patient information, including measurements reflecting physiologic signs and administered therapies. Identifying which variables are useful in predicting clinical outcomes can be challenging. Advanced algorithms such as deep neural networks were designed to process …
This work presents entropic constraints from DAGs with hidden variables.
problem Characterizing causal relations in systems with hidden variables.
method Entropic inequality constraints derived from e-separation relations. result These constraints can learn about true causal models from observed data.
For recurrent neural networks trained on time series with target and exogenous variables, in addition to accurate prediction, it is also desired to provide interpretable insights into the data. In this paper, we explore the structure of LSTM recurrent neural networks to learn variable-wise hidden states, with the aim t…
Proposes a two-stage method for selecting correlated predictors in high-dimensional data.
problem Selecting correlated predictors in high-dimensional data with unknown group structures.
method Two-stage approach: variable clustering followed by group selection.
result The two-stage method improves prediction accuracy and active predictor selection.
We propose a novel application of the Simultaneous Orthogonal Matching Pursuit (S-OMP) procedure for sparsistant variable selection in ultra-high dimensional multi-task regression problems. Screening of variables, as introduced in \cite{fan08sis}, is an efficient and highly scalable way to remove many irrelevant variab…
New method better identifies irrelevant variables for more accurate treatment effect estimation.
problem Handling irrelevant variables in treatment effect estimation with deep disentanglement.
method Deep embedding method to disentangle pre-treatment variables, explicitly identify and represent irrelevant variables, and orthogonalize them.
result Better identification and representation of irrelevant variables lead to more precise treatment effect prediction.
The paper proposes a method to stabilize predictions by identifying causal variables using a seed variable.
problem Stable prediction across unknown test data with potential spurious correlations.
method Conditional independence test based algorithm using a seed variable to separate causal from non-causal variables.
result The algorithm precisely separates causal and non-causal variables for stable prediction across test data.
Random forest hyperparameters affect variable selection in omics studies.
problem Impact of hyperparameters on variable selection in random forests.
method Two simulation studies using theoretical and empirical data.
result Hyperparameters influence variable selection more than the splitting strategy and sample fraction.
Variable selection for optimal treatment regime in a clinical trial or an observational study is getting more attention. Most existing variable selection techniques focused on selecting variables that are important for prediction, therefore some variables that are poor in prediction but are critical for decision-making…
A new variable importance measure for DRFs detects broader impacts on output distributions.
problem Estimating full conditional distributions of multivariate outputs given inputs.
method Based on the drop and relearn principle and MMD distance.
result Consistent and high-performing variable importance measure for DRFs.
The paper investigates causal relationships in heart failure prediction using machine learning.
problem Understanding the causal relationships between clinical variables and heart failure.
method Proposes a new computational framework for causal structure discovery (CSD) of mixed-type clinical variables for binary disease outcomes.
result Feature importance from nonlinear classifiers strongly correlates with causal strength of variables, but not differentiating cause and effect.
This review explores the use of machine learning in discovering collective variables for biomolecular dynamics.
problem Understanding the conformational dynamics and molecular recognition in biomolecules.
method Statistical analysis of high-dimensional spatiotemporal data generated from molecular dynamics simulations.
result Machine learning algorithms can be used to discover abstract collective variables that describe biomolecular dynamics.
Researchers identify latent variables and causal structures from nonlinear hierarchical models.
problem Challenging task of identifying latent variables and causal structures from observational data, especially when relationships are nonlinear.
method Investigated nonlinear latent hierarchical causal models, developed identification criterion, and constructed an estimation procedure.
result Identifiability of causal structures and latent variables achieved under mild assumptions.
We propose a procedure for assigning a relevance measure to each explanatory variable in a complex predictive model. We assume that we have a training set to fit the model and a test set to check the out of sample performance. First, the individual relevance of each variable is computed by comparing the predictions in …