Reinforcement Learning improves insulin bolus decisions for type-I diabetes patients.
problem Optimal insulin bolus decisions for type-I diabetes patients are not well-established.
method Applied Reinforcement Learning to simulated T1DM data.
result Optimal bolus rule differs from standard advisors and can prevent hypoglycemia.
Study discovers patterns in insulin needs for T1D patients.
problem Finding the right insulin dose and time for T1D patients is challenging.
method Used OpenAPS Data Commons dataset and time series techniques like matrix profile and multi-variate clustering.
result Identified temporal patterns in insulin needs driven by factors like carbohydrates and possibly others.
Framework generates personalized insulin treatment strategies using deep models.
problem Developing optimal personalized treatment strategies for diabetes patients.
method Combines deep generative time series models with decision theory.
result Demonstrated improved personalized insulin treatment strategies for diabetes patients.
New model predicts blood glucose in diabetics with improved accuracy.
problem Forecasting blood glucose in type 1 diabetics with high accuracy.
method Integrates machine learning with existing biomedical model to capture time-varying dynamics.
result Improved long-term forecasting of blood glucose up to 6 hours.
Machine learning detects subtle glucose changes for early diabetes diagnosis.
problem Challenging early-stage diabetes diagnosis due to subtle glucose changes.
method Applied machine learning to synthetic glucose profiles generated by a biophysical model.
result High accuracy (above 85%) in detecting insulin resistance using various neural networks.
Paper uses imitation learning to create efficient insulin policies from MPC demonstrations.
problem Resource-constrained medical devices struggle with complex MPC optimizations and state estimation errors.
method Imitation learning of neural network policies from MPC-computed demonstrations, using Bayesian inference with Monte Carlo Dropout.
result Trained policies generalize well to different patient cohorts, outperforming traditional MPC with state estimation.
HAD-Net forecasts glucose levels with insights into insulin and carbs diffusion.
problem Inaccurate predictions in glucose level forecasting without context understanding.
method Hybrid model combining deep learning and physiological models, using recurrent attention network.
result Achieves competitive performance in glucose level forecasting with plausible diffusion insights.
Determining whether hypotensive patients in intensive care units (ICUs) should receive fluid bolus therapy (FBT) has been an extremely challenging task for intensive care physicians as the corresponding increase in blood pressure has been hard to predict. Our study utilized regression models and attention-based recurre…
\begin{abstract} We model individual T2DM patient blood glucose level (BGL) by stochastic process with discrete number of states mainly but not solely governed by medication regimen (e.g. insulin injections). BGL states change otherwise according to various physiological triggers which render a stochastic, statisticall…
Deep RL improves blood glucose control for T1D patients.
problem Managing blood glucose levels for people with type 1 diabetes.
method Developed deep reinforcement learning techniques for automated blood glucose control.
result Deep RL approach outperforms baseline control algorithms, reducing glycemic risk and hypoglycemia.
Patients with Type I Diabetes (T1D) must take insulin injections to prevent the serious long term effects of hyperglycemia - high blood glucose (BG). Patients must also be careful not to inject too much insulin because this could induce hypoglycemia (low BG), which can potentially be fatal. Patients therefore follow a …
Neural system optimizes glucose levels in diabetics.
problem Limited research on continuous glucose maintenance devices.
method Differential predictive control with neural policy and differentiable modeling.
result Improves glucose level optimization in real-time.
SODA-RL learns diverse treatment options for hypotension from data.
problem Identifying the best treatment for acute hypotension from observational data.
method SODA-RL: Safely Optimized, Diverse, and Accurate Reinforcement Learning.
result SODA-RL identifies distinct, plausible treatment options from observational data.
New model predicts multiple outputs with missing labels.
problem Missing group labels in multi-output regression.
method Weakly-supervised multi-output model using correlated Gaussian processes.
result Model excels in multi-output settings with missing labels.
Paper proposes a DRL-based controller for networked AP systems that reduces communication frequency.
problem Reduce communication frequency in networked AP systems while maintaining control performance.
method Develops a DRL-based controller that avoids explicit update timing learning, using a semi-Markov decision process (SMDP).
result Improves communication efficiency without sacrificing control performance.
Study robust best-arm identification in linear bandits with lower bounds and algorithms.
problem Identify a near-optimal robust arm in linear bandits with adversarial actions.
method Propose instance-dependent lower bounds and both static and adaptive bandit algorithms.
result Sample complexity matches the lower bound and algorithms effectively identify robust arms.
Paper presents estimators for entropy and information in probabilistic models.
problem Estimating entropy and mutual information in high dimensions is challenging.
method EEVI uses importance sampling with proposal distributions like amortized variational inference and sequential Monte Carlo.
result EEVI delivers accurate upper and lower bounds on information quantities.
A method models continuous-time glucose distributions in children with diabetes.
problem Capturing subtle temporal changes in glucose distributions.
method Probabilistic framework using Gaussian mixtures and neural ODEs.
result Detects treatment-related improvements in glucose dynamics.
Hybrid model learns interpretable meal-level glycemic control.
problem Lack of flexible, interpretable meal-level glycemic control methods.
method Hybrid variational autoencoder grounding latent space to mechanistic differential equation.
result Unsupervised representation discovers separation between individuals based on disease severity.
Modern treatments for Type 1 diabetes (T1D) use devices known as artificial pancreata (APs), which combine an insulin pump with a continuous glucose monitor (CGM) operating in a closed-loop manner to control blood glucose levels. In practice, poor performance of APs (frequent hyper- or hypoglycemic events) is common en…
RETAIN model improves glucose forecasting for diabetics, offering both accuracy and interpretability.
problem Inability of deep learning models to interpret their predictions in healthcare.
method Two-level attention mechanism in a recurrent neural network (RETAIN) architecture.
result RETAIN model achieves comparable accuracy to LSTM and FCN models while being highly interpretable.
CBDL uses credal sets to improve uncertainty quantification in deep learning.
problem Uncertainty in predictions and robustness to distribution shifts in deep learning.
method Train an infinite ensemble of Bayesian Neural Networks using credal sets.
result CBDL distinguishes between aleatoric and epistemic uncertainties and quantifies them better than single BNNs.