The paper develops a method to predict ICU mortality risk across diverse patient populations.
problem Improving patient survival by recognizing risky trajectories during ICU stays.
method Domain adaptation strategies to learn mortality prediction models robust to diverse ICU populations.
result The proposed model outperforms baselines, achieving AUC numbers up to 0.88 for the Cardiac ICU population.
Good predictors of ICU Mortality have the potential to identify high-risk patients earlier, improve ICU resource allocation, or create more accurate population-level risk models. Machine learning practitioners typically make choices about how to represent features in a particular model, but these choices are seldom eva…
WRSE predicts dynamic survival distributions in ICU patients.
problem Dynamic assessment of ICU patient mortality risk.
method Non-parametric weighted-resolution ensemble model combining binary classifiers.
result Competitive results with state-of-the-art models, reducing training time.
Deep learning predicts ICU mortality with enhanced interpretability.
problem Improving mortality prediction accuracy and clinician trust in AI.
method Trained a deep learning model on MIMIC-III to interpret nursing notes.
result Model reaches ROC of 0.8629, outperforming SAPS-II.
This research improves transparency in RNN predictions of ICU mortality risk.
problem Lack of transparency in RNNs' healthcare predictions.
method Introduced Learned Binary Masks (LBM) and KernelSHAP for identifying EMR variables' contributions to RNN risk of mortality predictions.
result Attribution matrices show each input feature's contribution to RNN predictions, facilitating analysis of the model and its predictions.
ICU mortality risk prediction is a tough yet important task. On one hand, due to the complex temporal data collected, it is difficult to identify the effective features and interpret them easily; on the other hand, good prediction can help clinicians take timely actions to prevent the mortality. These correspond to the…
Although timely sepsis diagnosis and prompt interventions in Intensive Care Unit (ICU) patients are associated with reduced mortality, early clinical recognition is frequently impeded by non-specific signs of infection and failure to detect signs of sepsis-induced organ dysfunction in a constellation of dynamically cha…
Paper proposes robust method to detect risk heterogeneity across ethnic groups.
problem Detecting risk heterogeneity across ethnic groups in ICU studies.
method Proposes a robust framework using Neyman orthogonality for inference.
result Demonstrates improved inferential stability and reduced bias compared to standard methods.
Viewing the trajectory of a patient as a dynamical system, a recurrent neural network was developed to learn the course of patient encounters in the Pediatric Intensive Care Unit (PICU) of a major tertiary care center. Data extracted from Electronic Medical Records (EMR) of about 12000 patients who were admitted to the…
Late fusion of clinical notes and physiological data improves ICU mortality prediction.
problem Improving ICU mortality prediction using multimodal data.
method Late fusion of clinical notes and physiological time series data with a deep learning architecture.
result Late fusion approach provides statistically significant improvement in mortality prediction performance.
Improved model predicts ICU readmission and mortality with interpretable results.
problem Lack of clinically interpretable predictions from deep learning models on clinical notes.
method Augmented a convolutional model with an attention mechanism for clinical note prediction.
result Attention mechanism improves prediction performance while providing interpretable results.
Study improves mortality prediction in ICU patients using feature engineering and 1D CNN.
problem Improving mortality prediction in ICU patients with high-dimensional, imbalanced, and missing data.
method Feature engineering, 1D Convolutional Neural Network (1D CNN), traditional machine learning algorithms.
result Best AUC of 0.848 achieved with 1D CNN model.
Enhanced mortality prediction model using EHR and free-text data.
problem Predicting one-year mortality in AMI patients.
method Used deep learning models with word embedding features from free-text discharge summaries.
result Significant improvement in model performance (92.89% accuracy, 0.928 F-measure).
Bayesian neural network improves ICU patient risk prediction and feature selection.
problem Predicting patient outcomes in ICU with limited interpretability.
method Sparse Bayesian neural network with feature selection.
result Model provides interpretable feature importance for mortality prediction.
Bayesian models improve trustworthiness in ICU by providing uncertainty.
problem Uncertainty in machine learning predictions can lead to catastrophic medical decisions.
method Bayesian Neural Network and predictive uncertainty analysis.
result Bayesian models can mitigate prediction loss and identify out-of-domain examples.
Modeling physiological time-series in ICU is of high clinical importance. However, data collected within ICU are irregular in time and often contain missing measurements. Since absence of a measure would signify its lack of importance, the missingness is indeed informative and might reflect the decision making by the c…
Over the past decades, both critical care and cancer care have improved substantially. Due to increased cancer-specific survival, we hypothesized that both the number of cancer patients admitted to the ICU and overall survival have increased since the millennium change. MIMIC-III, a freely accessible critical care data…
Natural language processing predicts ICU readmissions with 74.8% accuracy.
problem Early detection of ICU readmissions to improve patient outcomes and reduce costs.
method Natural language processing of discharge summaries, machine learning classifiers, UMLS standardization.
result Best configuration achieved an AUC of 0.748 for predicting ICU readmissions.
Improved aggregation methods learn from all ICU events without preprocessing for better patient risk analysis.
problem Lack of efficient methods to dynamically assess patient status in ICU.
method Improved aggregation methods for a deep learning architecture that learns from all events without preprocessing.
result Models achieve strong performance (AUROC 0.87) in patient mortality classification.
Early hospital mortality prediction is critical as intensivists strive to make efficient medical decisions about the severely ill patients staying in intensive care units. As a result, various methods have been developed to address this problem based on clinical records. However, some of the laboratory test results are…
Predicting blood lactate levels helps manage ICU patients without invasive tests.
problem Predict blood lactate levels accurately in ICU patients without invasive tests.
method Defined a benchmark problem, evaluated different prediction algorithms, and investigated missing value imputation methods.
result Promising prediction results show the potential of machine learning in ICU care.
AdaptHetero uses MLI to tailor EHR models for subgroup-specific predictions.
problem Lack of subgroup-specific, operationalizable modeling strategies in EHRs.
method Integrates MLI with unsupervised clustering to identify subgroup-specific characteristics.
result Improves predictive performance by up to 174.39 percent across many subpopulations.
ICU mortality scoring systems attempt to predict patient mortality using predictive models with various clinical predictors. Examples of such systems are APACHE, SAPS and MPM. However, most such scoring systems do not actively look for and include interaction terms, despite physicians intuitively taking such interactio…
Study discovers rules linking patient symptoms to unplanned ICU transfers.
problem Identifying patients at risk for unplanned ICU transfers.
method Mixed-integer optimization approach to learn association rules.
result Significant rules discovered for each patient subgroup.
Acute kidney injury (AKI) in critically ill patients is associated with significant morbidity and mortality. Development of novel methods to identify patients with AKI earlier will allow for testing of novel strategies to prevent or reduce the complications of AKI. We developed data-driven prediction models to estimate…
Robust policies improve ICU transfer outcomes by predicting patient deterioration.
problem Higher mortality rates for unplanned ICU transfers.
method Markov Decision Process model to predict patient severity and optimize transfer policies.
result Robust policies are more aggressive in transferring patients than nominal policies, improving overall patient care.
Clinical notes improve ICU patient condition prediction.
problem Predicting ICU patient outcomes and resource planning.
method Joint modeling of time series data and clinical notes.
result Significant improvement in mortality prediction, decompensation modeling, and length of stay forecasting.
Heart disease remains the leading cause of death in the United States. Compared with risk assessment guidelines that require manual calculation of scores, machine learning-based prediction for disease outcomes such as mortality can be utilized to save time and improve prediction accuracy. This study built and evaluated…
DeepAISE predicts sepsis onset with high accuracy and low false alarms.
problem Early prediction of sepsis in ICU patients to improve clinical situational awareness.
method Recurrent neural survival model that combines clinical criteria and treatment policies.
result DeepAISE produces the most accurate predictions (AUC=0.90 and 0.87) and lowest false alarm rates (FAR=0.20 and 0.26) compared to baseline models.
Traditional methods for assessing illness severity and predicting in-hospital mortality among critically ill patients require time-consuming, error-prone calculations using static variable thresholds. These methods do not capitalize on the emerging availability of streaming electronic health record data or capture time…
In healthcare, patient risk stratification models are often learned using time-series data extracted from electronic health records. When extracting data for a clinical prediction task, several formulations exist, depending on how one chooses the time of prediction and the prediction horizon. In this paper, we show how…
Study develops an interpretable model for early mortality prediction in elderly MODS patients.
problem High mortality risk in elderly patients with MODS, unsatisfactory current scoring systems.
method Used eXtreme Gradient Boosting with SHapley Additive exPlanations on MIMIC-III, eICU-CRD, and PLAGH-S datasets.
result Interpretable model outperforms baseline models and clinical scores in predicting hospital mortality.
This study proposes a method to predict ICU infections from imbalanced data using clustering-based undersampling and ensemble classifiers.
problem Predicting healthcare-associated infections in ICU patients from imbalanced data.
method Clustering-based undersampling strategy combined with ensemble classifiers.
result The proposed method outperforms other resampling techniques in predicting ICU infections.
Proposes a fairness criterion for multi-objective optimization in classification.
problem Ensuring fairness in classification models across different groups.
method Formulates a minimax Pareto fairness criterion and provides an optimization algorithm.
result Demonstrates improved fairness compared to existing methods on various real-world datasets.
Study developed phenotypes for ICU patients' brain dysfunction states.
problem Underdiagnosis of acute brain dysfunction in ICU patients.
method Created algorithms to quantify and cluster brain dysfunction states.
result Developed three phenotypes of ICU patients' brain dysfunction states.
Electronic Medical Records (EMR) are a rich source of patient information, including measurements reflecting physiologic signs and administered therapies. Identifying which variables are useful in predicting clinical outcomes can be challenging. Advanced algorithms such as deep neural networks were designed to process …
Study describes severe dengue ICU patients in Brazil, 2012-2024.
problem Characterize severe dengue ICU patients and identify risk factors.
method Prospective study, descriptive statistics, logistic regression, machine learning.
result Advanced age, comorbidities, leukocytes, and platelets are significant risk factors for complications.
Selective prediction-set models improve predictive reliability and uncertainty quantification.
problem Inaccurate and unreliable predictions from black-box models, especially for unfamiliar data.
method Training selective prediction-set models using uncertainty-aware loss minimization, and calculating well-calibrated prediction sets.
result Selective prediction-set models outperform existing approaches in predicting in-hospital mortality and length-of-stay for ICU patients.
Study fair healthcare predictions without harming patients.
problem Balancing fairness and avoiding unnecessary harm in healthcare predictions.
method Formalizes Pareto-optimal approach to minimize risk disparity without causing harm, dynamically re-balancing subgroup risks.
result Demonstrates a method to train neural networks achieving fair predictions without unnecessary harm.
Unsupervised learning summarizes EHR data into a patient status vector.
problem Challenges in modeling electronic health records due to irregularities and varying procedures/diagnoses.
method Two-step unsupervised representation learning scheme using auto-encoders and forecasting tasks.
result Improved generalization performance on mortality and readmission tasks.
Method uses random forest with distance covariance for transfer learning in healthcare.
problem Transfer learning in random forests with sparse differences between source and target.
method Distance covariance-based feature weights in residual random forest.
result Upper bound on mean square error rate for transfer learning in RF.
Many in-hospital mortality risk prediction scores dichotomize predictive variables to simplify the score calculation. However, hard thresholding in these additive stepwise scores of the form "add x points if variable v is above/below threshold t" may lead to critical failures. In this paper, we seek to develop risk pre…
A risk of small defined-benefit pension schemes is that there are too few members to eliminate idiosyncratic mortality risk, that is there are too few members to effectively pool mortality risk. This means that when there are few members in the scheme, there is an increased risk of the liability value deviating signifi…
To improve the performance of Intensive Care Units (ICUs), the field of bio-statistics has developed scores which try to predict the likelihood of negative outcomes. These help evaluate the effectiveness of treatments and clinical practice, and also help to identify patients with unexpected outcomes. However, they have…
New model incorporates long-range dependence in mortality rates for better valuation and risk management.
problem Lack of appropriate models for valuing and managing mortality securities with long-range dependence.
method Proposes a novel class of Volterra mortality models that incorporate LRD, derived in closed-form solution.
result Models provide flexibility and tractability for valuing and hedging mortality-related products.
Develops a bi-variate stochastic framework to model mortality and interest rates with long-range dependence.
problem Captures long-range dependence and instantaneous correlation in mortality and interest rates.
method Mixed fractional Brownian motions, analytical solutions, risk-neutral measure, sequential parameter estimation.
result Explicit pricing of zero-coupon bonds and extreme mortality bonds, practical implications for pricing and risk management.
Deep learning models predict ICU readmission with varying accuracy.
problem Predicting ICU readmission risk using deep learning architectures.
method Several deep learning architectures including attention-based models, recurrent layers, neural ODEs, and embeddings were trained on MIMIC-III data.
result Attention-based models with neural ODEs achieved highest predictive accuracy.
There is growing interest in applying machine learning methods to Electronic Medical Records (EMR). Across different institutions, however, EMR quality can vary widely. This work investigated the impact of this disparity on the performance of three advanced machine learning algorithms: logistic regression, multilayer p…