The paper develops a method to predict ICU mortality risk across diverse patient populations.
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Good predictors of ICU Mortality have the potential to identify high-risk patients earlier, improve ICU resource allocation, or create more accurate population-level risk models. Machine learning practitioners typically make choices about how to represent features in a particular model, but these choices are seldom eva…
Late fusion of clinical notes and physiological data improves ICU mortality prediction.
Deep learning predicts ICU mortality with enhanced interpretability.
Study improves mortality prediction in ICU patients using feature engineering and 1D CNN.
Over the past decades, both critical care and cancer care have improved substantially. Due to increased cancer-specific survival, we hypothesized that both the number of cancer patients admitted to the ICU and overall survival have increased since the millennium change. MIMIC-III, a freely accessible critical care data…
WRSE predicts dynamic survival distributions in ICU patients.
ICU mortality risk prediction is a tough yet important task. On one hand, due to the complex temporal data collected, it is difficult to identify the effective features and interpret them easily; on the other hand, good prediction can help clinicians take timely actions to prevent the mortality. These correspond to the…
Viewing the trajectory of a patient as a dynamical system, a recurrent neural network was developed to learn the course of patient encounters in the Pediatric Intensive Care Unit (PICU) of a major tertiary care center. Data extracted from Electronic Medical Records (EMR) of about 12000 patients who were admitted to the…
ICU mortality scoring systems attempt to predict patient mortality using predictive models with various clinical predictors. Examples of such systems are APACHE, SAPS and MPM. However, most such scoring systems do not actively look for and include interaction terms, despite physicians intuitively taking such interactio…
Although timely sepsis diagnosis and prompt interventions in Intensive Care Unit (ICU) patients are associated with reduced mortality, early clinical recognition is frequently impeded by non-specific signs of infection and failure to detect signs of sepsis-induced organ dysfunction in a constellation of dynamically cha…
Robust policies improve ICU transfer outcomes by predicting patient deterioration.
Predicting the risk of mortality for patients with acute myocardial infarction (AMI) using electronic health records (EHRs) data can help identify risky patients who might need more tailored care. In our previous work, we built computational models to predict one-year mortality of patients admitted to an intensive care…
Monitoring patients in ICU is a challenging and high-cost task. Hence, predicting the condition of patients during their ICU stay can help provide better acute care and plan the hospital's resources. There has been continuous progress in machine learning research for ICU management, and most of this work has focused on…
Modeling physiological time-series in ICU is of high clinical importance. However, data collected within ICU are irregular in time and often contain missing measurements. Since absence of a measure would signify its lack of importance, the missingness is indeed informative and might reflect the decision making by the c…
Early hospital mortality prediction is critical as intensivists strive to make efficient medical decisions about the severely ill patients staying in intensive care units. As a result, various methods have been developed to address this problem based on clinical records. However, some of the laboratory test results are…
Paper proposes robust method to detect risk heterogeneity across ethnic groups.
Traditional methods for assessing illness severity and predicting in-hospital mortality among critically ill patients require time-consuming, error-prone calculations using static variable thresholds. These methods do not capitalize on the emerging availability of streaming electronic health record data or capture time…
ICU readmission is associated with longer hospitalization, mortality and adverse outcomes. An early recognition of ICU re-admission can help prevent patients from worse situation and lower treatment cost. As the abundance of Electronics Health Records (EHR), it is popular to design clinical decision tools with machine …
AdaptHetero uses MLI to tailor EHR models for subgroup-specific predictions.
Study developed phenotypes for ICU patients' brain dysfunction states.
Electronic Medical Records (EMR) are a rich source of patient information, including measurements reflecting physiologic signs and administered therapies. Identifying which variables are useful in predicting clinical outcomes can be challenging. Advanced algorithms such as deep neural networks were designed to process …
Deep learning has demonstrated success in many applications; however, their use in healthcare has been limited due to the lack of transparency into how they generate predictions. Algorithms such as Recurrent Neural Networks (RNNs) when applied to Electronic Medical Records (EMR) introduce additional barriers to transpa…
Method uses random forest with distance covariance for transfer learning in healthcare.
To improve the performance of Intensive Care Units (ICUs), the field of bio-statistics has developed scores which try to predict the likelihood of negative outcomes. These help evaluate the effectiveness of treatments and clinical practice, and also help to identify patients with unexpected outcomes. However, they have…
The Intensive Care Unit (ICU) is a hospital department where machine learning has the potential to provide valuable assistance in clinical decision making. Classical machine learning models usually only provide point-estimates and no uncertainty of predictions. In practice, uncertain predictions should be presented to …
After admission to emergency department (ED), patients with critical illnesses are transferred to intensive care unit (ICU) due to unexpected clinical deterioration occurrence. Identifying such unplanned ICU transfers is urgently needed for medical physicians to achieve two-fold goals: improving critical care quality a…
Heart disease remains the leading cause of death in the United States. Compared with risk assessment guidelines that require manual calculation of scores, machine learning-based prediction for disease outcomes such as mortality can be utilized to save time and improve prediction accuracy. This study built and evaluated…
There is growing interest in applying machine learning methods to Electronic Medical Records (EMR). Across different institutions, however, EMR quality can vary widely. This work investigated the impact of this disparity on the performance of three advanced machine learning algorithms: logistic regression, multilayer p…
New model predicts ICU patient stays more accurately.
Effective modeling of electronic health records presents many challenges as they contain large amounts of irregularity most of which are due to the varying procedures and diagnosis a patient may have. Despite the recent progress in machine learning, unsupervised learning remains largely at open, especially in the healt…
CARRNN tackles deep learning for sporadic data, improving prediction errors in healthcare.
In healthcare, patient risk stratification models are often learned using time-series data extracted from electronic health records. When extracting data for a clinical prediction task, several formulations exist, depending on how one chooses the time of prediction and the prediction horizon. In this paper, we show how…
Acute kidney injury (AKI) in critically ill patients is associated with significant morbidity and mortality. Development of novel methods to identify patients with AKI earlier will allow for testing of novel strategies to prevent or reduce the complications of AKI. We developed data-driven prediction models to estimate…
This study proposes a method to predict ICU infections from imbalanced data using clustering-based undersampling and ensemble classifiers.
Dynamic assessment of patient status (e.g. by an automated, continuously updated assessment of outcome) in the Intensive Care Unit (ICU) is of paramount importance for early alerting, decision support and resource allocation. Extraction and cleaning of expert-selected clinical variables discards information and protrac…
Study develops an interpretable model for early mortality prediction in elderly MODS patients.
Sepsis is the leading cause of mortality in the ICU. It is challenging to manage because individual patients respond differently to treatment. Thus, tailoring treatment to the individual patient is essential for the best outcomes. In this paper, we take steps toward this goal by applying a mixture-of-experts framework …
Clinical decision making is challenging because of pathological complexity, as well as large amounts of heterogeneous data generated as part of routine clinical care. In recent years, machine learning tools have been developed to aid this process. Intensive care unit (ICU) admissions represent the most data dense and t…
Sepsis, a dysregulated immune system response to infection, is among the leading causes of morbidity, mortality, and cost overruns in the Intensive Care Unit (ICU). Early prediction of sepsis can improve situational awareness amongst clinicians and facilitate timely, protective interventions. While the application of p…
With the improvement of medical data capturing, vast amount of continuous patient monitoring data, e.g., electrocardiogram (ECG), real-time vital signs and medications, become available for clinical decision support at intensive care units (ICUs). However, it becomes increasingly challenging to model such data, due to …
Imagine a patient in critical condition. What and when should be measured to forecast detrimental events, especially under the budget constraints? We answer this question by deep reinforcement learning (RL) that jointly minimizes the measurement cost and maximizes predictive gain, by scheduling strategically-timed meas…
Deep neural networks have achieved remarkable success in various challenging tasks. However, the black-box nature of such networks is not acceptable to critical applications, such as healthcare. In particular, the existence of adversarial examples and their overgeneralization to irrelevant, out-of-distribution inputs w…
This study improves AKI prediction precision using CNN on EHR data.
Machine learning approaches have been effective in predicting adverse outcomes in different clinical settings. These models are often developed and evaluated on datasets with heterogeneous patient populations. However, good predictive performance on the aggregate population does not imply good performance for specific …
Analyzes COVID-19 data to predict mortality, forecast spread, and optimize resource allocation.
CoI framework models clinical feature interactions, revealing temporal dependencies and enhancing transparency.
Blood lactate concentration is a strong indicator of mortality risk in critically ill patients. While frequent lactate measurements are necessary to assess patient's health state, the measurement is an invasive procedure that can increase risk of hospital-acquired infections. For this reason we formally define the prob…