QC-SPHARM detects Alzheimer's Disease early using hippocampal surface geometry.
arXiv research
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Rodent hippocampal population codes represent important spatial information about the environment during navigation. Several computational methods have been developed to uncover the neural representation of spatial topology embedded in rodent hippocampal ensemble spike activity. Here we extend our previous work and pro…
A central problem to understanding intelligence is the concept of generalisation. This allows previously learnt structure to be exploited to solve tasks in novel situations differing in their particularities. We take inspiration from neuroscience, specifically the hippocampal-entorhinal system known to be important for…
We describe a new method to automatically discriminate between patients with Alzheimer's disease (AD) or mild cognitive impairment (MCI) and elderly controls, based on multidimensional classification of hippocampal shape features. This approach uses spherical harmonics (SPHARM) coefficients to model the shape of the hi…
The majority of ML research concerns slow, statistical learning of i.i.d. samples from large, labelled datasets. Animals do not learn this way. An enviable characteristic of animal learning is `episodic' learning - the ability to memorise a specific experience as a composition of existing concepts, after just one exper…
New modifiers improve noisy RNN replay in hippocampal networks.
ConformalHDC improves HDC's uncertainty quantification for neuromorphic learning.
Hippocampal dentate granule cells are among the few neuronal cell types generated throughout adult life in mammals. In the normal brain, new granule cells are generated from progenitors in the subgranular zone and integrate in a typical fashion. During the development of epilepsy, granule cell integration is profoundly…
State of the art deep reinforcement learning algorithms take many millions of interactions to attain human-level performance. Humans, on the other hand, can very quickly exploit highly rewarding nuances of an environment upon first discovery. In the brain, such rapid learning is thought to depend on the hippocampus and…
In this study, we tested the interaction effect of multimodal datasets using a novel method called the kernel method for detecting higher order interactions among biologically relevant mulit-view data. Using a semiparametric method on a reproducing kernel Hilbert space (RKHS), we used a standard mixed-effects linear mo…
We posit that hippocampal place cells encode information about future locations under a transition distribution observed as an agent explores a given (physical or conceptual) space. The encoding of information about the current location, usually associated with place cells, then emerges as a necessary step to achieve t…
Deep model predicts shapes of curves with multiple covariates.
Complex architectures of biological neural circuits, such as parallel processing pathways, has been behaviorally implicated in many cognitive studies. However, the theoretical consequences of circuit complexity on neural computation have only been explored in limited cases. Here, we introduce a mechanism by which direc…
Sequences of correlated binary patterns can represent many time-series data including text, movies, and biological signals. These patterns may be described by weighted combinations of a few dominant structures that underpin specific interactions among the binary elements. To extract the dominant correlation structures …
Model place cells as spatial embeddings for efficient path planning and cognitive map construction.
We discuss memory models which are based on tensor decompositions using latent representations of entities and events. We show how episodic memory and semantic memory can be realized and discuss how new memory traces can be generated from sensory input: Existing memories are the basis for perception and new memories ar…
New methods improve neural connectivity analysis at submillisecond timescales.
Modeling brain dynamics to better understand and control complex behaviors underlying various cognitive brain functions are of interests to engineers, mathematicians, and physicists from the last several decades. With a motivation of developing computationally efficient models of brain dynamics to use in designing cont…
We propose a method to learn a distribution of shape trajectories from longitudinal data, i.e. the collection of individual objects repeatedly observed at multiple time-points. The method allows to compute an average spatiotemporal trajectory of shape changes at the group level, and the individual variations of this tr…
Continual Learning in artificial neural networks suffers from interference and forgetting when different tasks are learned sequentially. This paper introduces the Active Long Term Memory Networks (A-LTM), a model of sequential multi-task deep learning that is able to maintain previously learned association between sens…
Humans and animals show remarkable flexibility in adjusting their behaviour when their goals, or rewards in the environment change. While such flexibility is a hallmark of intelligent behaviour, these multi-task scenarios remain an important challenge for machine learning algorithms and neurobiological models alike. We…
New KNN test improves association analysis of high-dimensional sequencing data.
Study of cuspidal edges on focal surfaces of regular surfaces.
New method glues Scherk surfaces into minimal surfaces, limiting possible outcomes.
Study on focal surfaces of lightcone framed surfaces in Lorentz-Minkowski 3-space.
Introduces hyperbolic generalized framed surfaces and their properties.
The paper studies special surfaces with a new type of support function.
The paper studies knitted surfaces and surface-links, showing their isotopy and closure properties.
We investigate surfaces with constant harmonic-mean curvature one (HMC-1 surfaces) in hyperbolic three-space. We allow them to have certain kinds of singularities, and discuss some global properties. As well as flat surfaces and surfaces with constant mean curvature one (CMC-1 surfaces), HMC-1 surfaces belong to a cert…
Unstable minimal surfaces in n-space link to hyperbolic products.
Researchers generalize Ribaucour-type surfaces with new mathematical representation.
Automorphisms of fine curve graphs match surface homeomorphisms for planar surfaces.
This paper connects Laguerre minimal surfaces to Weierstrass representations.
New surfaces in 4-ball constructed from knits, described by charts.
Study on singular points of translation surfaces under linearly dependent conditions.
Crochet patterns for minimal surfaces created using trigonometry.
New surfaces generalize Dini surfaces in 4D.
Here, we focus on focal surfaces of a tubular surface in Euclidean 3-space E^3: Firstly, we give the tubular surfaces with respect to Frenet and Darboux frames. Then, we define focal surfaces of these tubular surfaces. We get some results for these types of surfaces to become flat and we show that there is no minimal f…
New method classifies HCMU surfaces in 3D space forms as Weingarten surfaces.
Minimal surfaces are the only biharmonic in Sol3.
It is shown that any handle-irreducible summand of every stable-ribbon surface-link is a unique ribbon surface-link up to equivalences, so that every stable-ribbon surface-link is a ribbon surface-link. This is a generalization of a previously observed result for a stably trivial surface-link. Two observations are give…
This paper proves compactness of conformal Chern-minimal surfaces in Hermitian surfaces.
Study proves surfaces with constant curvature are simple shapes.
New surface class defined using osculating circles.
The article constructs Bolza-like surfaces for infinitely many genera and studies their properties.
The Enneper surface and helix surfaces are unique in their geometric properties.
Study on automorphisms of K3 and Enriques surfaces, proving entropy gaps and achirality.
We address the problem of surface inpainting, which aims to fill in holes or missing regions on a Riemann surface based on its surface geometry. In practical situation, surfaces obtained from range scanners often have holes where the 3D models are incomplete. In order to analyze the 3D shapes effectively, restoring the…