Probabilistic ML improves healthcare data analysis.
problem Insufficient understanding and incomplete data in healthcare.
method Examination of probabilistic machine learning models for healthcare challenges.
result Probabilistic models enhance healthcare data analysis and model building.
There is a need of ensuring machine learning models that are interpretable. Higher interpretability of the model means easier comprehension and explanation of future predictions for end-users. Further, interpretable machine learning models allow healthcare experts to make reasonable and data-driven decisions to provide…
From medical charts to national census, healthcare has traditionally operated under a paper-based paradigm. However, the past decade has marked a long and arduous transformation bringing healthcare into the digital age. Ranging from electronic health records, to digitized imaging and laboratory reports, to public healt…
This tutorial evaluates machine learning for healthcare applications.
problem Unrealistic expectations in healthcare AI development.
method Practical guidance on performance evaluation criteria and common mistakes.
result Better understanding and avoidance of common traps in AI healthcare.
Modern electronic health records (EHRs) provide data to answer clinically meaningful questions. The growing data in EHRs makes healthcare ripe for the use of machine learning. However, learning in a clinical setting presents unique challenges that complicate the use of common machine learning methodologies. For example…
This guide introduces machine learning for medical data analysis.
problem Handling large, complex datasets in healthcare.
method Explains common machine learning algorithms and tasks.
result Illustrates machine learning applications in healthcare.
MCRAGE generates synthetic data to balance healthcare datasets.
problem Imbalanced datasets in healthcare lead to biased model performance for minority groups.
method Generative modeling to create synthetic data for underrepresented classes.
result MCRAGE improves model performance on minority groups.
Recent years have witnessed widespread adoption of machine learning (ML)/deep learning (DL) techniques due to their superior performance for a variety of healthcare applications ranging from the prediction of cardiac arrest from one-dimensional heart signals to computer-aided diagnosis (CADx) using multi-dimensional me…
Unsupervised model detects healthcare fraud from patient visit data.
problem Detecting fraudulent healthcare bills from patient visit data.
method Uses LSTM and seq2seq models for anomaly detection, normalizes scores with EDF.
result Improves anomaly detection for high class imbalance problems.
Proposes a method to improve rare event prediction in healthcare.
problem Rare event classification in healthcare with low prevalence labels.
method Variational disentanglement approach to semi-parametric learning.
result Outperforms existing alternatives in mortality prediction on COVID-19 cohort.
Approves updates to machine learning models in healthcare based on accumulating data.
problem Designing policies to autonomously approve updates to machine learning algorithms in non-stationary settings.
method Learning-to-approve (L2A) approach that uses accumulating monitoring data to learn how to approve modifications.
result L2A learns to abstain when performance drops are common and approves beneficial modifications quickly when the distribution is stable.
Machine learning models fail due to concept and data drift during pandemic.
problem Machine learning models trained before the pandemic are unreliable during the pandemic.
method Detect and diagnose concept and data drift in models.
result Model resilience and robustness are crucial for future predictions.
Background: Predictive modeling is a key component of solutions to many healthcare problems. Among all predictive modeling approaches, machine learning methods often achieve the highest prediction accuracy, but suffer from a long-standing open problem precluding their widespread use in healthcare. Most machine learning…
Machine learning and statistical modeling complement each other in healthcare analytics.
problem Choosing between machine learning and statistical modeling for analytics challenges.
method Choosing based on problem, data, and desired outcomes.
result Machine learning and statistical modeling are complementary, using similar principles but different tools.
In recent times, machine learning (ML) and artificial intelligence (AI) based systems have evolved and scaled across different industries such as finance, retail, insurance, energy utilities, etc. Among other things, they have been used to predict patterns of customer behavior, to generate pricing models, and to predic…
Methodology creates holdout and test/train sets for ML studies, preserving data for future research.
problem Preserving data for future research studies that are analysis-naive.
method Modification of k-fold cross-validation, randomization, and three-way split (holdout, test, training).
result Efficiently creates holdout and test/train sets without forcing.
Study finds little progress in medical machine learning benchmarks over 3 years.
problem Lack of meaningful progress in medical machine learning benchmarks for structured healthcare data.
method Comprehensive review and meta-analysis of benchmarks in medical machine learning for structured data.
result Deep recurrent models perform only better than logistic regression on certain clinical prediction tasks.
The study diagnoses fairness issues in healthcare models under distribution shifts.
problem Understanding and diagnosing fairness changes in machine learning models under distribution shifts in healthcare.
method Causal framing and conditional independence tests to characterize distribution shifts.
result Knowledge of distribution shifts helps diagnose fairness transfer failures, including complex cases.
auton-survival simplifies survival analysis for healthcare data.
problem Handling censored time-to-event data in healthcare.
method Open-source package for survival regression, adjustment, counterfactual estimation, phenotyping, and treatment effects.
result Demonstrates auton-survival's ability to support complex health and epidemiological questions.
Study improves mortality prediction in hospital patients using comprehensive feature engineering.
problem Accurate prediction of all-cause in-hospital mortality in healthcare.
method Comprehensive feature engineering approach using vital signs, laboratory results, and demographic data.
result Random Forest model achieved highest performance with AUC of 0.94, significantly outperforming other models.
New diagnostics detect variability in individual risk estimates from machine learning models in healthcare.
problem Variability in individual risk estimates from machine learning models in healthcare, leading to unreliable treatment decisions.
method Proposed evaluation framework using empirical prediction interval width and empirical decision flip rate diagnostics.
result Randomness in optimization and initialization can lead to substantial individual-level variability in risk estimates, affecting clinical decisions.
Develops ML-DQA for healthcare data quality assurance.
problem Inconsistent use of real-world data in machine learning projects.
method Develops ML-DQA framework based on RWD best practices.
result Five generalizable practices emerge from ML-DQA implementation.
While artificial intelligence (AI) and other automation technologies might lead to enormous progress in healthcare, they may also have undesired consequences for people working in the field. In this interdisciplinary study, we capture empirical evidence of not only what healthcare work could be automated, but also what…
Deep learning models (aka Deep Neural Networks) have revolutionized many fields including computer vision, natural language processing, speech recognition, and is being increasingly used in clinical healthcare applications. However, few works exist which have benchmarked the performance of the deep learning models with…
Paper analyzes uncertainty metrics in ensemble learning for healthcare AI.
problem Selecting appropriate uncertainty metrics for ensemble learners in healthcare AI.
method Rigorous analysis of two uncertainty metrics: ensemble mean and variance.
result Ensemble mean is preferable to ensemble variance for decision making in healthcare AI.
YouTube presents an unprecedented opportunity to explore how machine learning methods can improve healthcare information dissemination. We propose an interdisciplinary lens that synthesizes machine learning methods with healthcare informatics themes to address the critical issue of developing a scalable algorithmic sol…
Study examines impact of fairness penalties on clinical risk prediction models.
problem Widespread health disparities in machine learning-guided clinical decision-making.
method Empirical study across multiple databases, outcomes, and sensitive attributes.
result Penalizing fairness violations nearly universally degrades model performance and fairness metrics.
A broad spectrum of data from different modalities are generated in the healthcare domain every day, including scalar data (e.g., clinical measures collected at hospitals), tensor data (e.g., neuroimages analyzed by research institutes), graph data (e.g., brain connectivity networks), and sequence data (e.g., digital f…
This study proposes a method to predict ICU infections from imbalanced data using clustering-based undersampling and ensemble classifiers.
problem Predicting healthcare-associated infections in ICU patients from imbalanced data.
method Clustering-based undersampling strategy combined with ensemble classifiers.
result The proposed method outperforms other resampling techniques in predicting ICU infections.
Study finds multi-task learning and pre-training can improve healthcare models on EHR data.
problem Improving model performance on diverse EHR tasks using multi-task learning.
method Examined multi-task learning across various EHR tasks and training schemes, using pre-training and fine-tuning.
result Significant gains in model performance achieved via multi-task pre-training and single-task fine-tuning.
New method predicts model performance under selection bias in healthcare.
problem Selection bias limits model generalizability in healthcare.
method Proposes a novel upper bound method for estimating model performance.
result Validates and demonstrates the practical utility of the method.
This paper reviews counterfactual explanations for machine learning models.
problem Making machine learning models understandable to humans.
method Categorization and evaluation of counterfactual explanation algorithms.
result A rubric for evaluating counterfactual explanations.
Black box machine learning models are currently being used for high stakes decision-making throughout society, causing problems throughout healthcare, criminal justice, and in other domains. People have hoped that creating methods for explaining these black box models will alleviate some of these problems, but trying t…
Adding data can sometimes hurt model performance in multi-source healthcare tasks.
problem Identifying when adding more data helps or hinders model outcomes in multi-source healthcare tasks.
method Identified the Data Addition Dilemma, demonstrated empirically observed trade-offs, introduced distribution shift heuristics.
result Adding data can sometimes reduce model performance due to distribution shift.
LMM predicts healthcare costs and risks with improved accuracy.
problem Wasteful healthcare spending and inefficiencies in risk prediction.
method Generative pre-trained transformer trained on patient event sequences.
result Improves cost prediction by 14.1% and chronic conditions prediction by 1.9%.
DyS model improves survival analysis accuracy and interpretability.
problem Accurate and interpretable survival analysis models for healthcare.
method Feature-sparse Generalized Additive Model combining feature selection and interpretable prediction.
result DyS model outperforms other survival analysis models in interpretability and accuracy.
MCU-Net combines U-Net and Monte Carlo Dropout for uncertainty in medical image segmentation.
problem Lack of uncertainty representation in deep learning methods for patient-centered healthcare decisions.
method MCU-Net framework using U-Net and Monte Carlo Dropout with four uncertainty metrics.
result MCU-Net maximizes automated performance and refers truly uncertain cases.
Predicting an individual's risk of experiencing a future clinical outcome is a statistical task with important consequences for both practicing clinicians and public health experts. Modern observational databases such as electronic health records (EHRs) provide an alternative to the longitudinal cohort studies traditio…
Due to escalating healthcare costs, accurately predicting which patients will incur high costs is an important task for payers and providers of healthcare. High-cost claimants (HiCCs) are patients who have annual costs above $\$250,000$ and who represent just 0.16% of the insured population but currently account for 9%…
Integrates ML with operations knowledge to improve distributional forecasts in healthcare.
problem Challenges of ML in operational settings, especially lack of distributional information and integration of operations literature.
method Introduces Boosted Generalized Normal Distribution (bGND) using gradient boosting with tree learners. result Improves wait and service time forecasting by 6% and 9% compared to ML benchmarks.
DNAMite creates interpretable, calibrated survival analysis models.
problem Limited interpretability in survival analysis models, especially for healthcare applications.
method Feature discretization and kernel smoothing in embedding module for flexible shape functions.
result DNAMite produces calibrated shape functions interpretable as contributions to cumulative incidence function.
This chapter reviews statistical tools for reinforcement learning.
problem Applying RL algorithms in healthcare and ride-sharing platforms.
method Statistical inference tools for RL, including hypothesis testing and confidence interval construction.
result Highlighting the value of statistical inference in RL for both communities.
Machine learning models benefit from large and diverse datasets. Using such datasets, however, often requires trusting a centralized data aggregator. For sensitive applications like healthcare and finance this is undesirable as it could compromise patient privacy or divulge trade secrets. Recent advances in secure and …
A new method uses Hamiltonian Monte Carlo for imputation and augmentation of healthcare data.
problem Missing values in clinical studies lead to biased results and loss of statistical power.
method Folded Hamiltonian Monte Carlo (F-HMC) with Bayesian inference to handle high-dimensional, small sample size datasets.
result The method enriches the quality of data in precision, accuracy, recall, F1 score, and propensity metric.
In this paper, a Wide Learning architecture is proposed that attempts to automate the feature engineering portion of the machine learning (ML) pipeline. Feature engineering is widely considered as the most time consuming and expert knowledge demanding portion of any ML task. The proposed feature recommendation approach…
As machine learning (ML) models, trained on real-world datasets, become common practice, it is critical to measure and quantify their potential biases. In this paper, we focus on renal failure and compare a commonly used traditional risk score, Tangri, with a more powerful machine learning model, which has access to a …
It is not clear how to target patients who are most likely to benefit from digital care management programs ex-ante, a shortcoming of current risk score based approaches. This study focuses on defining impactability by identifying those patients most likely to benefit from technology enabled care management, delivered …
Study proposes BFEL framework for privacy-preserving FL in personalized healthcare.
problem Privacy and security concerns in traditional cloud-centric ML, especially in wearable devices.
method Develops a blockchain-enhanced federated edge learning (BFEL) framework based on FedCurv, incorporating fisher information matrix and public key encryption.
result Significant reduction in communication cost and high efficiency for federated training on non-iid and heterogeneous data.