AM-PPI uses multiple predictors to reduce label cost in healthcare AI.
problem Reduces label cost in post-deployment monitoring of healthcare AI.
method Combines model predictions with a small labeled sample, routing each instance to a cost-appropriate subset of predictors.
result Produces narrower confidence intervals than single-predictor methods.
The paper studies causal effects of multiple treatments in healthcare databases with rare outcomes.
problem Estimating causal effects of multiple treatments in healthcare databases with rare outcomes.
method The paper designs three sets of simulations and compares the operating characteristics of three types of methods: Bayesian Additive Regression Trees (BART), regression adjustment on multivariate spline of generalized propensity scores (RAMS), and inverse probability of treatment weighting (IPTW) with multinomial logistic regression or generalized boosted models.
result BART and RAMS provide lower bias and mean squared error compared to IPTW methods.
A new method uses Hamiltonian Monte Carlo for imputation and augmentation of healthcare data.
problem Missing values in clinical studies lead to biased results and loss of statistical power.
method Folded Hamiltonian Monte Carlo (F-HMC) with Bayesian inference to handle high-dimensional, small sample size datasets.
result The method enriches the quality of data in precision, accuracy, recall, F1 score, and propensity metric.
LogGENE uses log-cosh loss for deep learning in gene expression datasets, improving accuracy and interpretability.
problem Mining large gene expression datasets for reliable deep learning predictions.
method Develops a smooth alternative to check loss (log-cosh) for quantile regression in gene expression datasets.
result Achieves state-of-the-art performance in accuracy and provides robust uncertainty estimates.
New methods for distributed CP improve reliability in healthcare.
problem Post-hoc calibration of models in safety-critical domains.
method Quantile-based and histogram-based distributed conformal prediction via message passing.
result Improved reliability and coverage guarantees in decentralized settings.
Novel framework for Bayesian neural networks incorporating task-specific constraints.
problem Task-specific constraints in supervised model deployment.
method Introduces Output-Constrained BNN (OC-BNN) framework.
result OC-BNNs effectively incorporate prior expert knowledge and desiderata like safety and fairness.
This chapter reviews statistical tools for reinforcement learning.
problem Applying RL algorithms in healthcare and ride-sharing platforms.
method Statistical inference tools for RL, including hypothesis testing and confidence interval construction.
result Highlighting the value of statistical inference in RL for both communities.
Proposes M-CHMM for robust modeling of multivariate healthcare time series.
problem Challenges in analyzing multivariate healthcare time series data.
method Mixture of coupled hidden Markov models (M-CHMM) with two sampling algorithms.
result Improves data fit, handles missing and noisy measurements, and enhances prediction accuracy.
The paper proposes a method to infer multi-objective rewards from preferences.
problem Modeling preferences based on multiple, often competing objectives.
method Modeling priorities lexicographically and inferring multi-objective rewards from observed preferences.
result Lexicographically-ordered rewards provide a better understanding of preferences and improve policies.
NCoRE learns counterfactual representations for combined treatments.
problem Estimating individual response to multiple simultaneous interventions.
method Neural conditional representation with modulators for cross-treatment interactions.
result NCoRE significantly outperforms existing methods in counterfactual treatment effect estimation.
The paper proposes a method to calibrate healthcare AI models for reliability and interpretability.
problem Characterizing model reliability and enabling introspection of model behavior in clinical decision making.
method A calibration-driven learning method combined with interpretability techniques based on counterfactual reasoning.
result Demonstrates the effectiveness of the proposed approach using a lesion classification problem with dermoscopy images.
The study diagnoses fairness issues in healthcare models under distribution shifts.
problem Understanding and diagnosing fairness changes in machine learning models under distribution shifts in healthcare.
method Causal framing and conditional independence tests to characterize distribution shifts.
result Knowledge of distribution shifts helps diagnose fairness transfer failures, including complex cases.
Observational studies are rising in importance due to the widespread accumulation of data in fields such as healthcare, education, employment and ecology. We consider the task of answering counterfactual questions such as, "Would this patient have lower blood sugar had she received a different medication?". We propose …
Study highlights robustness issues in healthcare diagnostic models due to distribution shifts.
problem Robustness of diagnostic models in healthcare is compromised by distribution shifts.
method Theoretical analysis and simulation studies to understand and mitigate shortcuts learned by models.
result Ignoring covariates or using invariant learning approaches leads to non-robust predictors.
In recent times, machine learning (ML) and artificial intelligence (AI) based systems have evolved and scaled across different industries such as finance, retail, insurance, energy utilities, etc. Among other things, they have been used to predict patterns of customer behavior, to generate pricing models, and to predic…
Probabilistic ML improves healthcare data analysis.
problem Insufficient understanding and incomplete data in healthcare.
method Examination of probabilistic machine learning models for healthcare challenges.
result Probabilistic models enhance healthcare data analysis and model building.
A statistical description and model of individual healthcare expenditures in the US has been developed for measuring value in healthcare. We find evidence that healthcare expenditures are quantifiable as an infusion-diffusion process, which can be thought of intuitively as a steady change in the intensity of treatment …
Study decomposes racial healthcare disparities via shifts in mediator distributions.
problem Racial disparities in healthcare expenditures and their underlying drivers.
method Framework decomposing disparities into mediator distribution shifts and residual components, using MEPS data.
result Substantial disparities persist even when mediators are equalized, suggesting unmeasured or structural factors.
The paper proposes a fair reinforcement learning framework to prevent healthcare disparities.
problem Unfair reinforcement learning policies in healthcare can lead to socioeconomically-disadvantaged subgroups being underprivileged.
method The paper introduces a counterfactual fairness framework and a sequential data preprocessing algorithm to achieve fair sequential decision making.
result The proposed approach greatly enhances fair access to counseling in a digital health dataset designed to reduce opioid misuse.
Big data analytics improves healthcare through early detection and quality life.
problem Limited access to healthcare data hinders evidence-based decision-making.
method Analysis of healthcare data using various tools and techniques.
result Big data analytics enhances healthcare quality and patient outcomes.
New method handles uncertainty in causal effect estimation for better decision-making.
problem Handling uncertainty in causal effect estimation, especially in high-dimensional data and covariate shift.
method Integrates uncertainty estimation into neural network methods for individual-level causal estimates.
result Uncertainty-aware methods improve decision-making by alerting when predictions are not reliable.
Databases in domains such as healthcare are routinely released to the public in aggregated form. Unfortunately, naive modeling with aggregated data may significantly diminish the accuracy of inferences at the individual level. This paper addresses the scenario where features are provided at the individual level, but th…
Learning representations for counterfactual inference from observational data is of high practical relevance for many domains, such as healthcare, public policy and economics. Counterfactual inference enables one to answer "What if...?" questions, such as "What would be the outcome if we gave this patient treatment $t_…
Optimizes data labeling for causal effect estimation with missing outcomes.
problem Estimating causal effects with missing outcome data and budget constraints.
method Optimizes batch sampling probability to minimize variance of causal inference estimator.
result Achieves lower mean-squared error with fewer labeled data points.
Proposes a new Alzheimer's disease simulator for causal effect estimation.
problem Lack of suitable benchmarks for evaluating causal effect estimators in real-world healthcare data.
method Developed a simulator of Alzheimer's disease using ADNI dataset, incorporating various parameters to model complexities.
result Compared estimators of average and conditional treatment effects using the new simulator.
One of the main issues affecting the Italian NHS is the healthcare deficit: according to current agreements between the Italian State and its Regions, public funding of regional NHS is now limited to the amount of regional deficit and is subject to previous assessment of strict adherence to constraint on regional healt…
This paper solves the problem of optimal dynamic consumption, investment, and healthcare spending with isoelastic utility, when natural mortality grows exponentially to reflect Gompertz' law and investment opportunities are constant. Healthcare slows the natural growth of mortality, indirectly increasing utility from c…
Study optimal healthcare spending under Epstein-Zin preferences for longevity.
problem Optimizing healthcare spending to extend longevity under Epstein-Zin preferences.
method Formulated Epstein-Zin utilities over a controllable random horizon using backward stochastic differential equations and HJB equations.
result Calibrated model accurately reflects actual mortality data and compares healthcare efficacy between countries.
Several methods exist to infer causal networks from massive volumes of observational data. However, almost all existing methods require a considerable length of time series data to capture cause and effect relationships. In contrast, memory-less transition networks or Markov Chain data, which refers to one-step transit…
Study improves conformal prediction for EEG classification in healthcare, enhancing coverage.
problem Uncertainty quantification in clinical predictions, especially in distribution-shifted settings.
method Personalized calibration strategies to improve coverage of prediction sets.
result Coverage improved by over 20 percentage points with comparable prediction set sizes.
A recommendation framework helps users choose healthcare interventions.
problem Choice overload in online healthcare communities.
method Multi-Armed Bandit (MAB) approach with innovative model components.
result Our recommendation design outperforms state-of-the-art systems.
Interpretability of ML models improves healthcare decisions.
problem Ensuring machine learning models are understandable for healthcare users.
method Classifying interpretability into local and global approaches, and model-specific vs. model-agnostic methods.
result Examples of practical interpretability in healthcare, including prediction and treatment optimization.
New method narrows prediction intervals for individual treatment effects.
problem Insufficiently conservative prediction intervals for individual treatment effects.
method Conformal inference using conditional density estimates.
result Narrower prediction intervals compared to existing methods.
EDICT learns evidential distributions for irregular time series, improving predictions and uncertainty quantification.
problem Challenges in predicting and characterizing uncertainty for irregular time series data.
method EDICT (Evidential Distributions for Irregular Time Series) learns a continuous-time evidential distribution.
result EDICT achieves competitive performance on time series classification tasks and provides better uncertainty quantification.
Variational inference has become a widely used method to approximate posteriors in complex latent variables models. However, deriving a variational inference algorithm generally requires significant model-specific analysis, and these efforts can hinder and deter us from quickly developing and exploring a variety of mod…
Distributed representations have been used to support downstream tasks in healthcare recently. Healthcare data (e.g., electronic health records) contain multiple modalities of data from heterogeneous sources that can provide complementary information, alongside an added dimension to learning personalized patient repres…
Transformer model handles causal inference with DAG integration.
problem Complex causal structures and adaptability across various scenarios.
method Integrates DAGs into transformer's attention mechanism.
result Surpasses existing methods in estimating causal effects.
BBCI uses meta prediction to estimate causal effects from datasets.
problem Estimating causal effects from observed data.
method Meta prediction to learn causal effect estimation.
result BBCI accurately estimates ATEs and CATEs across various causal inference problems.
LMM predicts healthcare costs and risks with improved accuracy.
problem Wasteful healthcare spending and inefficiencies in risk prediction.
method Generative pre-trained transformer trained on patient event sequences.
result Improves cost prediction by 14.1% and chronic conditions prediction by 1.9%.
Study improves healthcare time series imputation by considering structured missingness.
problem Structured missingness in clinical data impacts time series imputation models.
method Analysis of different masking strategies on imputation methods using PhysioNet Challenge 2012 dataset.
result Masking choices significantly affect imputation accuracy and clinical prediction.
Recent years have witnessed widespread adoption of machine learning (ML)/deep learning (DL) techniques due to their superior performance for a variety of healthcare applications ranging from the prediction of cardiac arrest from one-dimensional heart signals to computer-aided diagnosis (CADx) using multi-dimensional me…
Bayesian neural network (BNN) priors are defined in parameter space, making it hard to encode prior knowledge expressed in function space. We formulate a prior that incorporates functional constraints about what the output can or cannot be in regions of the input space. Output-Constrained BNNs (OC-BNN) represent an int…
While artificial intelligence (AI) and other automation technologies might lead to enormous progress in healthcare, they may also have undesired consequences for people working in the field. In this interdisciplinary study, we capture empirical evidence of not only what healthcare work could be automated, but also what…
Unified framework for imputation and prediction in healthcare time series.
problem Time misalignment and data sparsity in healthcare time series.
method MAGIC (Multi-tAsk Gaussian Process for Imputation and Classification) using hierarchical multi-task Gaussian process and functional logistic regression.
result Superior predictive accuracy compared to existing methods in two healthcare applications.
Study finds racial bias in pulse oximeter readings has minimal impact on ICU ventilation rates.
problem Racial disparities in pulse oximeter readings affect clinical decisions in ICU settings.
method Causal inference using path-specific effects and doubly robust estimator.
result Minimal impact of racial discrepancies on invasive ventilation rates, but more pronounced on ventilation duration.
Causal inference analysis is the estimation of the effects of actions on outcomes. In the context of healthcare data this means estimating the outcome of counter-factual treatments (i.e. including treatments that were not observed) on a patient's outcome. Compared to classic machine learning methods, evaluation and val…
Privacy-preserving inference for clinical trials using differential privacy.
problem Balancing knowledge sharing and privacy in healthcare data.
method Differential privacy (DP) applied to log-linear belief updates in distributed settings.
result Differentially private, distributed inference methods outperform existing techniques.
Study analyzes factors influencing healthcare providers' engagement with SMS campaigns.
problem Understanding what drives healthcare providers to engage with SMS campaigns.
method Used logistic regression, random forest, and neural network models to analyze data.
result Identified key factors influencing engagement with SMS campaigns.