Probabilistic ML improves healthcare data analysis.
problem Insufficient understanding and incomplete data in healthcare.
method Examination of probabilistic machine learning models for healthcare challenges.
result Probabilistic models enhance healthcare data analysis and model building.
Big data analytics improves healthcare through early detection and quality life.
problem Limited access to healthcare data hinders evidence-based decision-making.
method Analysis of healthcare data using various tools and techniques.
result Big data analytics enhances healthcare quality and patient outcomes.
Distributed representations have been used to support downstream tasks in healthcare recently. Healthcare data (e.g., electronic health records) contain multiple modalities of data from heterogeneous sources that can provide complementary information, alongside an added dimension to learning personalized patient repres…
VHGM-MAE generates synthetic humans from healthcare data.
problem Handling high-dimensional, sparse healthcare data with missing values.
method Masked autoencoder (MAE) tailored for healthcare data, addressing heterogeneity, missingness, and high-dimensionality.
result VHGM-MAE outperforms existing methods in missing value imputation and synthetic data generation.
Unsupervised model detects healthcare fraud from patient visit data.
problem Detecting fraudulent healthcare bills from patient visit data.
method Uses LSTM and seq2seq models for anomaly detection, normalizes scores with EDF.
result Improves anomaly detection for high class imbalance problems.
MCRAGE generates synthetic data to balance healthcare datasets.
problem Imbalanced datasets in healthcare lead to biased model performance for minority groups.
method Generative modeling to create synthetic data for underrepresented classes.
result MCRAGE improves model performance on minority groups.
From medical charts to national census, healthcare has traditionally operated under a paper-based paradigm. However, the past decade has marked a long and arduous transformation bringing healthcare into the digital age. Ranging from electronic health records, to digitized imaging and laboratory reports, to public healt…
Deep generative model for healthcare data identifies coherent substructures and mutational clusters.
problem Analytical challenges in healthcare data, including sparsity, missingness, and small sample sizes.
method Proposes a deep generative Bayesian model with collapsed Gibbs sampling for multinomial count data.
result Identifies coherent substructures and biologically meaningful mutational clusters in cancer data.
A broad spectrum of data from different modalities are generated in the healthcare domain every day, including scalar data (e.g., clinical measures collected at hospitals), tensor data (e.g., neuroimages analyzed by research institutes), graph data (e.g., brain connectivity networks), and sequence data (e.g., digital f…
Study improves healthcare time series imputation by considering structured missingness.
problem Structured missingness in clinical data impacts time series imputation models.
method Analysis of different masking strategies on imputation methods using PhysioNet Challenge 2012 dataset.
result Masking choices significantly affect imputation accuracy and clinical prediction.
Research predicts healthcare index movements using historical OHLC data.
problem Predicting the directional movement of healthcare indices based on historical data.
method Supervised classification task with a one-step-ahead rolling window, using a diverse feature set including OHLC ratios.
result Robust predictive performance with accuracy exceeding 0.8 and Matthews correlation coefficients above 0.6, highlighting the importance of nowcasting features.
A new method uses Hamiltonian Monte Carlo for imputation and augmentation of healthcare data.
problem Missing values in clinical studies lead to biased results and loss of statistical power.
method Folded Hamiltonian Monte Carlo (F-HMC) with Bayesian inference to handle high-dimensional, small sample size datasets.
result The method enriches the quality of data in precision, accuracy, recall, F1 score, and propensity metric.
Modeling disease progression in healthcare administrative databases is complicated by the fact that patients are observed only at irregular intervals when they seek healthcare services. In a longitudinal cohort of 76,888 patients with chronic obstructive pulmonary disease (COPD), we used a continuous-time hidden Markov…
Study optimal healthcare spending under Epstein-Zin preferences for longevity.
problem Optimizing healthcare spending to extend longevity under Epstein-Zin preferences.
method Formulated Epstein-Zin utilities over a controllable random horizon using backward stochastic differential equations and HJB equations.
result Calibrated model accurately reflects actual mortality data and compares healthcare efficacy between countries.
Hybrid Bayesian-conformal framework improves uncertainty quantification in healthcare predictions.
problem Jointly satisfying distribution-free coverage guarantees and risk-adaptive precision in clinical decision-making.
method Integrates Bayesian hierarchical random forests with group-aware conformal calibration, using posterior uncertainties to weight conformity scores.
result Achieves target coverage (94.3% vs 95% target) with adaptive precision, 21% narrower intervals for low-uncertainty cases.
Develops ML-DQA for healthcare data quality assurance.
problem Inconsistent use of real-world data in machine learning projects.
method Develops ML-DQA framework based on RWD best practices.
result Five generalizable practices emerge from ML-DQA implementation.
DMIDAS improves long-term forecasting accuracy in healthcare and electricity data.
problem Challenging long-term forecasting accuracy and computational complexity.
method Smoothness regularization and mixed data sampling techniques integrated into NBEATS architecture.
result Improves prediction accuracy by 5% on long forecasting horizons (1000 timestamps) compared to state-of-the-art models.
Proposes M-CHMM for robust modeling of multivariate healthcare time series.
problem Challenges in analyzing multivariate healthcare time series data.
method Mixture of coupled hidden Markov models (M-CHMM) with two sampling algorithms.
result Improves data fit, handles missing and noisy measurements, and enhances prediction accuracy.
Study finds multi-task learning and pre-training can improve healthcare models on EHR data.
problem Improving model performance on diverse EHR tasks using multi-task learning.
method Examined multi-task learning across various EHR tasks and training schemes, using pre-training and fine-tuning.
result Significant gains in model performance achieved via multi-task pre-training and single-task fine-tuning.
Super learner with Huber loss improves cost prediction and causal effect estimation in healthcare expenditure data.
problem Challenges in modeling healthcare expenditure distributions with standard super learning methods.
method Proposes a super learner using Huber loss, a robust loss function that down-weights outliers.
result Demonstrates appreciable finite-sample gains in cost prediction and causal effect estimation.
Paper addresses data heterogeneity in federated learning for CoxPH models in healthcare.
problem Data heterogeneity in federated learning of CoxPH models for healthcare.
method Feature-based clustering and event-based reporting strategy.
result Enhanced model accuracy and performance in federated survival analysis.
Framework for AI healthcare products from concept to market.
problem Failure of AI products to reach clinics despite promising potential.
method Decision-making framework for AI healthcare product development.
result Guides through a three-phase process to market launch of validated AI products.
Unified framework for imputation and prediction in healthcare time series.
problem Time misalignment and data sparsity in healthcare time series.
method MAGIC (Multi-tAsk Gaussian Process for Imputation and Classification) using hierarchical multi-task Gaussian process and functional logistic regression.
result Superior predictive accuracy compared to existing methods in two healthcare applications.
Proposes a method to improve rare event prediction in healthcare.
problem Rare event classification in healthcare with low prevalence labels.
method Variational disentanglement approach to semi-parametric learning.
result Outperforms existing alternatives in mortality prediction on COVID-19 cohort.
A statistical description and model of individual healthcare expenditures in the US has been developed for measuring value in healthcare. We find evidence that healthcare expenditures are quantifiable as an infusion-diffusion process, which can be thought of intuitively as a steady change in the intensity of treatment …
This study proposes a method to predict ICU infections from imbalanced data using clustering-based undersampling and ensemble classifiers.
problem Predicting healthcare-associated infections in ICU patients from imbalanced data.
method Clustering-based undersampling strategy combined with ensemble classifiers.
result The proposed method outperforms other resampling techniques in predicting ICU infections.
In recent times, machine learning (ML) and artificial intelligence (AI) based systems have evolved and scaled across different industries such as finance, retail, insurance, energy utilities, etc. Among other things, they have been used to predict patterns of customer behavior, to generate pricing models, and to predic…
New method sparsifies hybrid neural ODEs for better performance and stability.
problem Excessive latent states and interactions from mechanistic models lead to training inefficiency and over-fitting.
method Automatic state selection and structure optimization combining domain-informed graph modifications with data-driven regularization.
result Improved predictive performance and robustness with desired sparsity.
New method predicts model performance under selection bias in healthcare.
problem Selection bias limits model generalizability in healthcare.
method Proposes a novel upper bound method for estimating model performance.
result Validates and demonstrates the practical utility of the method.
Study highlights robustness issues in healthcare diagnostic models due to distribution shifts.
problem Robustness of diagnostic models in healthcare is compromised by distribution shifts.
method Theoretical analysis and simulation studies to understand and mitigate shortcuts learned by models.
result Ignoring covariates or using invariant learning approaches leads to non-robust predictors.
Machine learning models fail due to concept and data drift during pandemic.
problem Machine learning models trained before the pandemic are unreliable during the pandemic.
method Detect and diagnose concept and data drift in models.
result Model resilience and robustness are crucial for future predictions.
The global financial crisis, beginning in 2008, took an historic toll on national economies around the world. Following equity market crashes, unemployment rates rose significantly in many countries: Italy was among those. What will be the impact of such large shocks on Italian healthcare finances? An empirical model f…
auton-survival simplifies survival analysis for healthcare data.
problem Handling censored time-to-event data in healthcare.
method Open-source package for survival regression, adjustment, counterfactual estimation, phenotyping, and treatment effects.
result Demonstrates auton-survival's ability to support complex health and epidemiological questions.
Study uses healthcare claims data to identify Covid-19 risk factors without prior selection.
problem Identify risk factors for severe Covid-19 cases.
method Fine-grained hierarchical information from medical classification systems used to analyze over 33,000 covariates.
result Method has better predictive ability than pre-specified morbidity groups.
There is a need of ensuring machine learning models that are interpretable. Higher interpretability of the model means easier comprehension and explanation of future predictions for end-users. Further, interpretable machine learning models allow healthcare experts to make reasonable and data-driven decisions to provide…
This tutorial evaluates machine learning for healthcare applications.
problem Unrealistic expectations in healthcare AI development.
method Practical guidance on performance evaluation criteria and common mistakes.
result Better understanding and avoidance of common traps in AI healthcare.
Adding data can sometimes hurt model performance in multi-source healthcare tasks.
problem Identifying when adding more data helps or hinders model outcomes in multi-source healthcare tasks.
method Identified the Data Addition Dilemma, demonstrated empirically observed trade-offs, introduced distribution shift heuristics.
result Adding data can sometimes reduce model performance due to distribution shift.
The rapid growth of Electronic Health Records (EHRs), as well as the accompanied opportunities in Data-Driven Healthcare (DDH), has been attracting widespread interests and attentions. Recent progress in the design and applications of deep learning methods has shown promising results and is forcing massive changes in h…
Enhances understanding of patient healthcare journeys using self-attention.
problem Capturing hidden dependencies in multi-level patient journey data.
method Proposes a multi-level self-attention network (MusaNet) for encoding patient journeys.
result MusaNet produces higher-quality representations than state-of-the-art methods.
One of the main issues affecting the Italian NHS is the healthcare deficit: according to current agreements between the Italian State and its Regions, public funding of regional NHS is now limited to the amount of regional deficit and is subject to previous assessment of strict adherence to constraint on regional healt…
Improves off-policy evaluation with imperfect annotations.
problem Limited dataset coverage for evaluating new policies.
method Doubly robust estimators combining IS and DM, incorporating counterfactual annotations.
result Using annotations within the DM component yields the most desirable theoretical results.
In this paper we present a method for the unsupervised clustering of high-dimensional binary data, with a special focus on electronic healthcare records. We present a robust and efficient heuristic to face this problem using tensor decomposition. We present the reasons why this approach is preferable for tasks such as …
This paper solves the problem of optimal dynamic consumption, investment, and healthcare spending with isoelastic utility, when natural mortality grows exponentially to reflect Gompertz' law and investment opportunities are constant. Healthcare slows the natural growth of mortality, indirectly increasing utility from c…
Approves updates to machine learning models in healthcare based on accumulating data.
problem Designing policies to autonomously approve updates to machine learning algorithms in non-stationary settings.
method Learning-to-approve (L2A) approach that uses accumulating monitoring data to learn how to approve modifications.
result L2A learns to abstain when performance drops are common and approves beneficial modifications quickly when the distribution is stable.
Modern electronic health records (EHRs) provide data to answer clinically meaningful questions. The growing data in EHRs makes healthcare ripe for the use of machine learning. However, learning in a clinical setting presents unique challenges that complicate the use of common machine learning methodologies. For example…
SurvCORN predicts survival curves using conditional ordinal ranking networks.
problem Challenges in survival analysis with censored data.
method SurvCORN: Conditional Ordinal Ranking Neural Network.
result SurvCORN improves accuracy in predicting time-to-event outcomes.
Deep learning models exhibit state-of-the-art performance for many predictive healthcare tasks using electronic health records (EHR) data, but these models typically require training data volume that exceeds the capacity of most healthcare systems. External resources such as medical ontologies are used to bridge the da…
Study improves conformal prediction for EEG classification in healthcare, enhancing coverage.
problem Uncertainty quantification in clinical predictions, especially in distribution-shifted settings.
method Personalized calibration strategies to improve coverage of prediction sets.
result Coverage improved by over 20 percentage points with comparable prediction set sizes.