Big data analytics improves healthcare through early detection and quality life.
problem Limited access to healthcare data hinders evidence-based decision-making.
method Analysis of healthcare data using various tools and techniques.
result Big data analytics enhances healthcare quality and patient outcomes.
Machine learning and statistical modeling complement each other in healthcare analytics.
problem Choosing between machine learning and statistical modeling for analytics challenges.
method Choosing based on problem, data, and desired outcomes.
result Machine learning and statistical modeling are complementary, using similar principles but different tools.
TRACER improves interpretability in high stakes analytics.
problem Interpreting complex models in high stakes applications.
method TRACER framework with TITV model for healthcare analytics.
result TRACER facilitates both accurate and interpretable analytics.
Healthcare companies must submit pharmaceutical drugs or medical devices to regulatory bodies before marketing new technology. Regulatory bodies frequently require transparent and interpretable computational modelling to justify a new healthcare technology, but researchers may have several competing models for a biolog…
While artificial intelligence (AI) and other automation technologies might lead to enormous progress in healthcare, they may also have undesired consequences for people working in the field. In this interdisciplinary study, we capture empirical evidence of not only what healthcare work could be automated, but also what…
Deep generative model for healthcare data identifies coherent substructures and mutational clusters.
problem Analytical challenges in healthcare data, including sparsity, missingness, and small sample sizes.
method Proposes a deep generative Bayesian model with collapsed Gibbs sampling for multinomial count data.
result Identifies coherent substructures and biologically meaningful mutational clusters in cancer data.
LMM predicts healthcare costs and risks with improved accuracy.
problem Wasteful healthcare spending and inefficiencies in risk prediction.
method Generative pre-trained transformer trained on patient event sequences.
result Improves cost prediction by 14.1% and chronic conditions prediction by 1.9%.
A new method synthesizes expressions from characteristics using GAN for healthcare.
problem Synthesizing expressions from given characteristics in high-dimensional space.
method Generative Adversarial Network (GAN) based selective ensemble learning.
result The proposed SE-CTES method effectively handles deterministic and stochastic patterns.
Representation learning methods that transform encoded data (e.g., diagnosis and drug codes) into continuous vector spaces (i.e., vector embeddings) are critical for the application of deep learning in healthcare. Initial work in this area explored the use of variants of the word2vec algorithm to learn embeddings for m…
Develops privacy-preserving methods for equivalence testing in healthcare.
problem Protecting patient data in healthcare studies.
method Differential privacy techniques for simulation-based calibration.
result Maintains type-I error control and comparable power to non-private methods.
Machine learning models fail due to concept and data drift during pandemic.
problem Machine learning models trained before the pandemic are unreliable during the pandemic.
method Detect and diagnose concept and data drift in models.
result Model resilience and robustness are crucial for future predictions.
This work is motivated by the needs of predictive analytics on healthcare data as represented by Electronic Medical Records. Such data is invariably problematic: noisy, with missing entries, with imbalance in classes of interests, leading to serious bias in predictive modeling. Since standard data mining methods often …
Probabilistic ML improves healthcare data analysis.
problem Insufficient understanding and incomplete data in healthcare.
method Examination of probabilistic machine learning models for healthcare challenges.
result Probabilistic models enhance healthcare data analysis and model building.
A statistical description and model of individual healthcare expenditures in the US has been developed for measuring value in healthcare. We find evidence that healthcare expenditures are quantifiable as an infusion-diffusion process, which can be thought of intuitively as a steady change in the intensity of treatment …
With the emergence of the Hospital Readmission Reduction Program of the Center for Medicare and Medicaid Services on October 1, 2012, forecasting unplanned patient readmission risk became crucial to the healthcare domain. There are tangible works in the literature emphasizing on developing readmission risk prediction m…
One of the main issues affecting the Italian NHS is the healthcare deficit: according to current agreements between the Italian State and its Regions, public funding of regional NHS is now limited to the amount of regional deficit and is subject to previous assessment of strict adherence to constraint on regional healt…
This paper solves the problem of optimal dynamic consumption, investment, and healthcare spending with isoelastic utility, when natural mortality grows exponentially to reflect Gompertz' law and investment opportunities are constant. Healthcare slows the natural growth of mortality, indirectly increasing utility from c…
HOLMES improves real-time model serving for ICU patients, balancing accuracy and speed.
problem Real-time model serving is crucial in ICU due to urgency and cost.
method Online model ensemble serving framework for healthcare applications.
result HOLMES achieves high accuracy and sub-second latency for model ensemble serving.
Study optimal healthcare spending under Epstein-Zin preferences for longevity.
problem Optimizing healthcare spending to extend longevity under Epstein-Zin preferences.
method Formulated Epstein-Zin utilities over a controllable random horizon using backward stochastic differential equations and HJB equations.
result Calibrated model accurately reflects actual mortality data and compares healthcare efficacy between countries.
Study improves conformal prediction for EEG classification in healthcare, enhancing coverage.
problem Uncertainty quantification in clinical predictions, especially in distribution-shifted settings.
method Personalized calibration strategies to improve coverage of prediction sets.
result Coverage improved by over 20 percentage points with comparable prediction set sizes.
A recommendation framework helps users choose healthcare interventions.
problem Choice overload in online healthcare communities.
method Multi-Armed Bandit (MAB) approach with innovative model components.
result Our recommendation design outperforms state-of-the-art systems.
Deep Claim predicts payer responses from claims data using deep learning.
problem Predicting payer responses from claims data to improve healthcare performance.
method Learning complex dependencies in claim inputs to create a compact representation, then using deep learning to predict responses.
result Deep Claim improves claim denial prediction by 22.21%.
Study optimizes health incentives to balance efficiency and fairness.
problem Designing health incentives to balance efficiency and fairness.
method Inverse behavioral optimization framework integrating QALY-based incentives and adaptive learning.
result Modern health systems operate near an efficiency-saturated frontier, with small fairness adjustments yielding diminishing returns.
Distributed representations have been used to support downstream tasks in healthcare recently. Healthcare data (e.g., electronic health records) contain multiple modalities of data from heterogeneous sources that can provide complementary information, alongside an added dimension to learning personalized patient repres…
Reducing ICD-10 code granularity improves cost model accuracy and stability.
problem High-dimensional regression with ICD-10 codes leads to unstable coefficient estimates.
method Log-linear analytics approach to cost model regularization through diagnostic code merging.
result Reducing ICD-10 code granularity from 7 characters to 6 or fewer improves model interpretability and consistency.
Study improves healthcare time series imputation by considering structured missingness.
problem Structured missingness in clinical data impacts time series imputation models.
method Analysis of different masking strategies on imputation methods using PhysioNet Challenge 2012 dataset.
result Masking choices significantly affect imputation accuracy and clinical prediction.
Recent years have witnessed widespread adoption of machine learning (ML)/deep learning (DL) techniques due to their superior performance for a variety of healthcare applications ranging from the prediction of cardiac arrest from one-dimensional heart signals to computer-aided diagnosis (CADx) using multi-dimensional me…
Unified framework for imputation and prediction in healthcare time series.
problem Time misalignment and data sparsity in healthcare time series.
method MAGIC (Multi-tAsk Gaussian Process for Imputation and Classification) using hierarchical multi-task Gaussian process and functional logistic regression.
result Superior predictive accuracy compared to existing methods in two healthcare applications.
Study analyzes factors influencing healthcare providers' engagement with SMS campaigns.
problem Understanding what drives healthcare providers to engage with SMS campaigns.
method Used logistic regression, random forest, and neural network models to analyze data.
result Identified key factors influencing engagement with SMS campaigns.
MCRAGE generates synthetic data to balance healthcare datasets.
problem Imbalanced datasets in healthcare lead to biased model performance for minority groups.
method Generative modeling to create synthetic data for underrepresented classes.
result MCRAGE improves model performance on minority groups.
Modeling disease progression in healthcare administrative databases is complicated by the fact that patients are observed only at irregular intervals when they seek healthcare services. In a longitudinal cohort of 76,888 patients with chronic obstructive pulmonary disease (COPD), we used a continuous-time hidden Markov…
Research predicts healthcare index movements using historical OHLC data.
problem Predicting the directional movement of healthcare indices based on historical data.
method Supervised classification task with a one-step-ahead rolling window, using a diverse feature set including OHLC ratios.
result Robust predictive performance with accuracy exceeding 0.8 and Matthews correlation coefficients above 0.6, highlighting the importance of nowcasting features.
Unsupervised model detects healthcare fraud from patient visit data.
problem Detecting fraudulent healthcare bills from patient visit data.
method Uses LSTM and seq2seq models for anomaly detection, normalizes scores with EDF.
result Improves anomaly detection for high class imbalance problems.
Proposes a method to improve rare event prediction in healthcare.
problem Rare event classification in healthcare with low prevalence labels.
method Variational disentanglement approach to semi-parametric learning.
result Outperforms existing alternatives in mortality prediction on COVID-19 cohort.
VHGM-MAE generates synthetic humans from healthcare data.
problem Handling high-dimensional, sparse healthcare data with missing values.
method Masked autoencoder (MAE) tailored for healthcare data, addressing heterogeneity, missingness, and high-dimensionality.
result VHGM-MAE outperforms existing methods in missing value imputation and synthetic data generation.
Optimal healthcare investment timing in a dynamic model with mortality risk.
problem Optimal timing of healthcare investment to reduce mortality risk.
method Dynamic framework, stochastic control, optimal stopping problem, dual transformation.
result Characterization of the optimal investment boundary and numerical solutions.
From medical charts to national census, healthcare has traditionally operated under a paper-based paradigm. However, the past decade has marked a long and arduous transformation bringing healthcare into the digital age. Ranging from electronic health records, to digitized imaging and laboratory reports, to public healt…
Hybrid Bayesian-conformal framework improves uncertainty quantification in healthcare predictions.
problem Jointly satisfying distribution-free coverage guarantees and risk-adaptive precision in clinical decision-making.
method Integrates Bayesian hierarchical random forests with group-aware conformal calibration, using posterior uncertainties to weight conformity scores.
result Achieves target coverage (94.3% vs 95% target) with adaptive precision, 21% narrower intervals for low-uncertainty cases.
Framework for AI healthcare products from concept to market.
problem Failure of AI products to reach clinics despite promising potential.
method Decision-making framework for AI healthcare product development.
result Guides through a three-phase process to market launch of validated AI products.
The global financial crisis, beginning in 2008, took an historic toll on national economies around the world. Following equity market crashes, unemployment rates rose significantly in many countries: Italy was among those. What will be the impact of such large shocks on Italian healthcare finances? An empirical model f…
There is a need of ensuring machine learning models that are interpretable. Higher interpretability of the model means easier comprehension and explanation of future predictions for end-users. Further, interpretable machine learning models allow healthcare experts to make reasonable and data-driven decisions to provide…
This tutorial evaluates machine learning for healthcare applications.
problem Unrealistic expectations in healthcare AI development.
method Practical guidance on performance evaluation criteria and common mistakes.
result Better understanding and avoidance of common traps in AI healthcare.
For highly sensitive real-world predictive analytic applications such as healthcare and medicine, having good prediction accuracy alone is often not enough. These kinds of applications require a decision making process which uses uncertainty estimation as input whenever possible. Quality of uncertainty estimation is a …
RL platform enhances user journeys in healthcare apps.
problem Improving user experience and personalization in healthcare apps.
method Reinforcement learning framework for adaptive interventions.
result Significant increase in basket size through personalized recommendations.
Strategic feature selection in high-stakes domains like healthcare.
problem Strategic manipulation of input features in algorithmic predictors.
method Formal study of strategic classification through feature selection and ridge regularization.
result Excluding individual features based on manipulability is generally suboptimal.
Super learner with Huber loss improves cost prediction and causal effect estimation in healthcare expenditure data.
problem Challenges in modeling healthcare expenditure distributions with standard super learning methods.
method Proposes a super learner using Huber loss, a robust loss function that down-weights outliers.
result Demonstrates appreciable finite-sample gains in cost prediction and causal effect estimation.
The paper studies causal effects of multiple treatments in healthcare databases with rare outcomes.
problem Estimating causal effects of multiple treatments in healthcare databases with rare outcomes.
method The paper designs three sets of simulations and compares the operating characteristics of three types of methods: Bayesian Additive Regression Trees (BART), regression adjustment on multivariate spline of generalized propensity scores (RAMS), and inverse probability of treatment weighting (IPTW) with multinomial logistic regression or generalized boosted models.
result BART and RAMS provide lower bias and mean squared error compared to IPTW methods.
A broad spectrum of data from different modalities are generated in the healthcare domain every day, including scalar data (e.g., clinical measures collected at hospitals), tensor data (e.g., neuroimages analyzed by research institutes), graph data (e.g., brain connectivity networks), and sequence data (e.g., digital f…