HiP-MDPs help personalize HIV treatment across patient variations.
problem Physiological variation leads to different responses to treatments.
method Embed tasks in a low-dimensional space, updating HiP-MDP framework.
result Robust personalized medicine strategies developed for HIV treatment.
Paper derives policy rules from observational data for hepatitis C treatment.
problem Improving treatment guidelines for HIV/HCV co-infected patients.
method Weighted K-means algorithm for estimating CATEs, decision tree implementation.
result Identifies a subgroup with high spontaneous HCV clearance rate.
Develops algorithm to find subgroups with different treatment effects in HIV patients.
problem Estimating treatment effects in EHR data with challenges like time-varying confounding.
method SDLD algorithm combining generalized interaction tree and longitudinal targeted maximum likelihood estimation.
result Identifies subgroups of HIV patients at higher risk of weight gain with dolutegravir-containing ARTs.
The paper develops a causal machine learning framework to optimize aid allocation.
problem Optimizing aid allocation to reduce new HIV infections in poor countries.
method The framework uses a balancing autoencoder, counterfactual generator, and inference model to predict heterogeneous treatment effects.
result The framework predicts a reduction of up to 3.3% in new HIV infections, saving 50,000 lives.
Researchers propose improved multivariate prediction models for HIV drug resistance.
problem Predicting drug resistances of HIV from mutation information.
method Revised stacking algorithms to borrow information among multiple prediction tasks.
result Proposed methods outperform other multivariate prediction methods.
Personalized models explain TB treatment outcomes considering patient context.
problem Heterogeneity in TB treatment outcomes due to co-morbidities.
method Multi-task learning approach encoding patient context into personalized models.
result Identifies anemia, age of onset, and HIV as influential for treatment efficacy.
New method combines regional HIV prevention trial data without sharing individual patient info.
problem Regional differences in HIV prevention efficacy, privacy concerns, and data sharing limitations.
method Federated learning approach that combines site-specific estimators via L1-regularization.
result Improved precision in estimating region-specific survival curves.
The paper develops methods to optimize personalized policies in complex causal pathways.
problem Optimizing policies in healthcare settings with entangled causal effects.
method Combining mediation analysis and dynamic treatment regime ideas for longitudinal data.
result Derived methods for learning high-quality policies from observational data.
Deep Bayesian models estimate causal effects for dynamic treatment regimes over long follow-up times.
problem Challenges in causal effect estimation for dynamic treatment regimes with long follow-up times.
method Combining outcome regression models with deep Bayesian models for high-dimensional features.
result Stable and accurate dynamic causal effect estimation from observational data, especially with long-term follow-up.
Develops a novel approach for estimating optimal DTRs with multicategory treatments and censored data.
problem Estimating optimal treatment regimes for chronic diseases with censored data.
method Angle-based multicategory classification algorithm for maximizing conditional survival function.
result The proposed method outperforms existing approaches in maximizing conditional survival function.
Novel method classifies HIV patients based on viral load patterns.
problem Limited methods classify patients by viral load patterns, often specific to study design.
method Four features, centroid-based classification algorithm, radial normalization classification.
result Classifies 1,576 HIV positive clinic patients into five viral load patterns.
System predicts HIV patients at risk of dropping out of care.
problem High non-adherence and dropout rates among HIV patients.
method Predictive machine learning model based on resource constraints, stability, and fairness.
result Model performs 3x better than baseline for clinical use and 2.3x better for city-wide use.
Bayesian fusion forest combines clinical and real-world data to estimate treatment effects.
problem Estimating treatment effects on survival from mixed data sources with confounding.
method Nonparametric Bayesian fusion forest combining randomised and real-world data, relaxing unconfoundedness assumption.
result Fusion identifies treatment benefits not seen in clinical trials alone.
Develops KOM method for optimal GATE estimation.
problem Causal effect estimation sensitivity to model misspecification and practical violations of positivity.
method Kernel Optimal Matching (KOM) for optimal GATE estimation.
result KOM provides uniform control over conditional mean squared error and precision.
CausalLongPFN predicts counterfactual outcomes from time-series data.
problem Predicting future outcomes under varying treatments in time-series data with confounding and heterogeneity.
method Prior-fitted network pretrained on synthetic episodes of temporal structural causal models.
result CausalLongPFN outperforms domain-trained models on factual and counterfactual prediction tasks.
Optimal weighting method for time-varying confounders in MSMs.
problem High-variance estimates and sensitivity to model misspecification in standard MSMs.
method Kernel Optimal Weighting (KOW) approach that optimally balances time-dependent confounders.
result KOW directly minimizes time-dependent confounding error and controls for precision.
SurvHTE-Bench benchmarks HTE estimation in survival analysis with diverse datasets.
problem Challenges in estimating HTEs from right-censored survival data.
method Modular synthetic datasets, semi-synthetic datasets, and real-world datasets.
result First rigorous comparison of survival HTE methods under diverse conditions.
Proposes a method to avoid excessive exploration in reinforcement learning.
problem Avoiding excessive exploration in reinforcement learning to deploy it in practice.
method Designs a novel algorithm using UCB reinforcement learning policy with adaptive exploration constraints.
result Proves that the approach remains conservative while minimizing regret in tabular settings and validates on real-world tasks.
New method improves off-policy policy evaluation by balancing policy values.
problem Accurate off-policy policy evaluation in reinforcement learning.
method Developed an MDP model with balanced representation to estimate both individual and average policy values.
result Substantially lower Mean Squared Error (MSE) in various benchmarks and a real-world HIV treatment simulation.
Model identifies key problems in HIV patients' records.
problem Complex and time-consuming task of identifying patient problems from electronic health records.
method Unsupervised phenotyping approach that jointly learns phenotypes from structured and unstructured data.
result Learned phenotypes and their relatedness are clinically valid and surpass existing methods.
Proposes a new Q-learning method for survival outcomes in clinical trials.
problem Incomplete follow-up data and nonlinear covariate effects in clinical trials.
method Combines Buckley-James boosting with flexible base learners for estimating optimal treatment regimes.
result Improves treatment decision accuracy and stability in longitudinal clinical trials.
Method finds optimal binary classification rules under weighted misclassification loss.
problem Optimal binary classification rules for resource-limited settings with cost-sensitive decisions.
method Ensemble learning to derive prediction scores and associated thresholds minimizing weighted misclassification loss.
result Jointly derived score and threshold outperforms methods that derive score first and threshold second.
New framework quantifies variable importance across all good models and is stable across data distribution.
problem Conflicting variable importance conclusions from different models trained on the same data.
method Proposes a new variable importance framework that considers all good models and is stable across data distribution.
result Framework accurately estimates true variable importance and recovers rankings for complex setups.
New algorithms improve MPBART for HIV patient data.
problem Improving inference for multinomial outcomes in HIV patient data.
method Introduced two new algorithms for fitting MPBART.
result Better performance in MCMC convergence and predictive accuracy.
Count data, for example the number of observed cases of a disease in a city, often arise in the fields of healthcare analytics and epidemiology. In this paper, we consider performing regression on multivariate data in which our outcome is a count. Specifically, we derive log-likelihood functions for finite mixtures of …
BSFP method reveals latent patterns in multi-omic data for predicting lung function in HIV-associated OLD.
problem Limited understanding of multi-omic molecular phenomena and clinical outcomes in obstructive lung disease.
method Bayesian Simultaneous Factorization and Prediction (BSFP) method for multi-omic data, accommodating imputation and full posterior inference.
result BSFP reveals distinct clusters of patients with OLD and multi-omic patterns related to lung function decline.
It is the main purpose of this paper to introduce a graph-valued stochastic process in order to model the spread of a communicable infectious disease. The major novelty of the SIR model we promote lies in the fact that the social network on which the epidemics is taking place is not specified in advance but evolves thr…
Affinity propagation is an exemplar-based clustering algorithm that finds a set of data-points that best exemplify the data, and associates each datapoint with one exemplar. We extend affinity propagation in a principled way to solve the hierarchical clustering problem, which arises in a variety of domains including bi…
Motivation: Proteins are known to undergo conformational changes in the course of their functions. The changes in conformation are often attributable to a small fraction of residues within the protein. Therefore identification of these variable regions is important for an understanding of protein function. Results: We …
A new graphical model for discrete data without parametric restrictions.
problem Discrete data modeling with restrictions.
method Additive conditional independence and penalized estimation of precision operator.
result Consistency of the estimator in ultrahigh-dimensional settings.
The aim of this paper is to construct a natural Riemann-Lagrange differential geometry on 1-jet spaces, in the sense of nonlinear connections, generalized Cartan connections, d-torsions, d-curvatures, jet electromagnetic fields and jet electromagnetic Yang-Mills energies, starting from some given nonlinear evolution OD…
M2E embeds multi-view multi-graph brain networks for better clustering.
problem Clustering brain networks from multiple views to understand disease mechanisms.
method Stack multi-graphs into tensors, use tensor techniques to leverage multi-view and multi-graph interactions.
result M2E outperforms existing methods on clustering brain networks.
Bayesian nonparametric method partitions shapes using curves.
problem Capturing complex shapes in multi-dimensional data.
method Proposes a novel spline partitioning approach using curves.
result Demonstrates improved shape modeling compared to existing methods.
A new method combines machine learning with mixed-effects models for better repeated measurement analysis.
problem Inference of linear coefficients in partially linear mixed-effects models with complex interactions and high-dimensional variables.
method Double machine learning approach to estimate nonparametrically nonlinear variables, then use standard linear mixed-effects techniques to estimate the linear coefficient.
result The estimated fixed effects coefficient converges at the parametric rate and is semiparametrically efficient.
SpINNEr uses matrix regression to analyze brain connectivity, improving accuracy over other methods.
problem Analyzing multi-dimensional data like brain imaging arrays using traditional scalar regression methods.
method SpINNEr applies matrix regression with nuclear norm and lasso norms to encourage low rank and sparse solutions.
result SpINNEr outperforms other methods in estimating brain connectivity, especially in well-connected regions.
Paper develops robust confidence intervals for high-dimensional censored data.
problem Censored data in high-dimensional settings, especially HIV-1 study.
method Smoothed estimating equations and one-step estimator for robustness.
result Asymptotic distribution of one-step estimator matches simple linear models.
Exact selective inference with randomization for Gaussian regression models.
problem Exact selective inference in Gaussian regression models.
method Introduces a pivot for exact selective inference with randomization, reducing the problem to a bivariate truncated Gaussian distribution.
result Our pivot leads to exact inference and produces narrower confidence intervals than related methods.
This paper proposes a new method for estimating sparse precision matrices in the high dimensional setting. It has been popular to study fast computation and adaptive procedures for this problem. We propose a novel approach, called Sparse Column-wise Inverse Operator, to address these two issues. We analyze an adaptive …
Tree regularization improves deep model interpretability without sacrificing accuracy.
problem Lack of interpretability in deep models hinders their adoption.
method Explicitly regularizes deep models to be closely modeled by decision trees with few nodes.
result Tree-regularized models are easier for humans to simulate than simpler penalties without sacrificing accuracy.
Framework evaluates AI proposals for drug discovery, finds no LLM advantage.
problem No principled framework exists for evaluating AI-guided scientific selection under budget constraints.
method Formally verified metric (BSDS/DQS) penalizes false discoveries and excessive abstention.
result LLMs provide no marginal value over existing classifiers in drug discovery.
GraphITE estimates individual effects of graph-structured treatments.
problem Estimating individual effects of complex treatment structures.
method Graph neural networks and Hilbert-Schmidt Independence Criterion regularization.
result GraphITE outperforms baselines in estimating treatment effects for large numbers of treatments.
M3E2 neural network estimates multiple treatment effects.
problem Estimating effects of multiple treatments simultaneously.
method Multi-task learning neural network model for multiple treatments, continuous and binary.
result M3E2 outperforms baselines in synthetic datasets.
Proposes a new method to estimate continuous treatment policies and match treatments effectively.
problem Current methods struggle with continuous treatment policies and complex matching.
method Formulates treatment effectiveness as a parametrizable model, using deep learning for optimization.
result Significant improvement in treatment effectiveness and matching efficiency.
Optimal policy for sequential treatment allocation minimizing risk.
problem Minimizing risk in sequential treatment allocation.
method Proposes a minimax optimal regret policy for unknown number of treatments.
result Regret grows slowly with the number of treatments.
PSICA identifies best treatments for patients with categorical therapies.
problem Identifying best treatments for patients with categorical therapies.
method Decision tree approach for subgroup identification in categorical treatment scenarios.
result Outputs a decision tree showing probabilities of best treatments for patient subgroups.
Framework generates personalized insulin treatment strategies using deep models.
problem Developing optimal personalized treatment strategies for diabetes patients.
method Combines deep generative time series models with decision theory.
result Demonstrated improved personalized insulin treatment strategies for diabetes patients.
Develops deep jump learning for continuous treatment OPE.
problem Estimating mean outcomes under new treatment rules using historical data from different rules.
method Adaptive deep discretization of continuous treatment space using deep learning and multi-scale change point detection.
result Validated method through theoretical results, simulations, and real application to Warfarin Dosing.
Method controls treatment risk in learning beneficial allocations.
problem Learning beneficial treatment allocations with risk control in precision medicine.
method Proposes a certifiable learning method that controls treatment risk with finite samples in the partially identified setting.
result Illustrates method using both simulated and real data.