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48 results for EHR data

Proposes a method to derive knowledge graphs from EHR data.

problem Challenges in deriving generalizable knowledge from EHR data.
method Infer conditional dependency structure via a latent graphical block model (LGBM).
result Perfect recovery of block structure demonstrated.

Novel imputation method for EHRs with structured and sporadic missingness.

problem Missing data in integrated EHR datasets for clinical applications.
method Macomss, a novel imputation framework for structurally and heterogeneously missing data.
result Macomss outperforms existing methods in imputation and downstream prediction accuracy.

This paper reviews methods for discovering patient subgroups from EHR data.

problem Discovering subgroups of patients and co-occurring medical conditions from EHR data.
method Low-rank data approximation methods like matrix and tensor decompositions.
result These methods provide transparent and interpretable insights into patient phenotypes.

Paper proposes multimodal contrastive learning for EHR data.

problem Separate treatment of structured and unstructured EHR data.
method Proposes a multimodal feature embedding generative model and a multimodal contrastive loss.
result Multimodal learning yields better feature representation than single-modality learning.

WEST uses EHRs and expert cases to improve rare disease phenotyping.

problem Limited labeled data for rare diseases.
method Weakly supervised transformer model trained on probabilistic silver-standard labels.
result WEST outperforms existing methods in phenotype classification and subphenotyping.

Study proposes a multimodal model for cardiovascular risk prediction using EHRs.

problem Lack of comprehensive risk prediction from EHRs due to unstructured text.
method Proposes a multimodal BiLSTM model integrating structured and unstructured EHR data.
result Proposed BiLSTM model outperforms other DNN architectures in cardiovascular risk prediction.

This work generates synthetic EHRs with privacy guarantees for machine learning tasks.

problem Privacy concerns and heterogeneity in EHR data limit their use in machine learning.
method Generative Adversarial Networks (GANs) with differential privacy (DP) for synthetic data generation.
result Synthetic EHRs maintain performance close to real data, even with DP applied.

PEHRT harmonizes EHR data for translational research.

problem Barriers in using EHR data for translational research.
method Common pipeline including open-source code, visualization tools, and detailed documentation.
result PEHRT harmonizes EHR data to standardized ontologies and generates robust embeddings.

Framework harmonizes EHR data across institutions for better analysis.

problem Heterogeneity of medical codes and terminologies hinder EHR data analysis.
method MASH (Multi-source Automated Structured Hierarchy) uses neural optimal transport and learned hyperbolic embeddings to align and structure EHR data.
result MASH generates interpretable hierarchical graphs for unstructured local laboratory codes.

Study finds multi-task learning and pre-training can improve healthcare models on EHR data.

problem Improving model performance on diverse EHR tasks using multi-task learning.
method Examined multi-task learning across various EHR tasks and training schemes, using pre-training and fine-tuning.
result Significant gains in model performance achieved via multi-task pre-training and single-task fine-tuning.

Predicts EHR features that improve prediction, learning coherent topics.

problem Balancing prediction quality and coherence in EHR topic models.
method Prediction-focused topic model that uses supervisory signal to retain relevant features.
result Prediction-focused topic models learn more coherent topics while maintaining competitive predictions.

CEDAR efficiently analyzes distributed EHR data without sharing patient-level info.

problem Analyzing patient-level data from multiple EHRs databases without sharing raw data.
method Tackles by turning problem into missing data, incorporating posterior samples.
result Improves efficiency and privacy of parameter estimates in sparse regressions.

Databases of electronic health records (EHRs) are increasingly used to inform clinical decisions. Machine learning methods can find patterns in EHRs that are predictive of future adverse outcomes. However, statistical models may be built upon patterns of health-seeking behavior that vary across patient subpopulations, …

2018-12-01abs ↗pdf ↗

Approach for modeling EHR data with rare features, improving prediction and interpretation.

problem Challenges in modeling rare binary features in EHR data.
method Tree-guided feature selection and logic aggregation for large-scale regression.
result Improved prediction and model interpretation of suicide risk in EHR data.

Electronic health records (EHR) data provide a cost and time-effective opportunity to conduct cohort studies of the effects of multiple time-point interventions in the diverse patient population found in real-world clinical settings. Because the computational cost of analyzing EHR data at daily (or more granular) scale…

2017-05-27abs ↗pdf ↗

Paper proposes a graph network for EHR data that learns robust representations.

problem Learning robust representations for EHR data with implicit connections.
method Variationally regularized encoder-decoder graph network.
result Model outperforms existing methods in various EHR predictive tasks.

Information in electronic health records (EHR), such as clinical narratives, examination reports, lab measurements, demographics, and other patient encounter entries, can be transformed into appropriate data representations that can be used for downstream clinical machine learning tasks using representation learning. L…

2019-09-19abs ↗pdf ↗

ODVICE augments EHR cohorts using ontology to improve analysis robustness.

problem Limited records in cohorts for rare diseases hamper robust analysis.
method Ontology-driven Monte-Carlo graph spanning algorithm for data augmentation.
result ODVICE augmented cohorts show ~30% improvement in AUC over non-augmented datasets.

A variety of methods existing for generating synthetic electronic health records (EHRs), but they are not capable of generating unstructured text, like emergency department (ED) chief complaints, history of present illness or progress notes. Here, we use the encoder-decoder model, a deep learning algorithm that feature…

2018-06-01abs ↗pdf ↗

Doctor2Vec learns doctor representations from EHRs for better clinical trial recruitment.

problem Identifying the right doctors for clinical trials based on EHR data and trial descriptions.
method Dynamic Memory Network with attention mechanism to learn doctor and trial representations.
result Improved performance by up to 8.7% in PR-AUC on real-world trials and EHR data.

FUALA improves Federated Learning for EHR data, enhancing model uncertainty.

problem Applying ML to EHR data while maintaining privacy and accuracy.
method FUALA embeds uncertainty in federated learning, using ensembling and averaging.
result FUALA outperforms FedAvg on out-of-distribution data in EHR model predictions.

Develops algorithm to find subgroups with different treatment effects in HIV patients.

problem Estimating treatment effects in EHR data with challenges like time-varying confounding.
method SDLD algorithm combining generalized interaction tree and longitudinal targeted maximum likelihood estimation.
result Identifies subgroups of HIV patients at higher risk of weight gain with dolutegravir-containing ARTs.

Deep learning model creates patient representations for scalable EHR-based stratification.

problem Challenges in summarizing and representing patient data from EHRs prevent scalable stratification analysis.
method Unsupervised framework based on deep learning (ConvAE) using word embeddings, CNNs, and autoencoders.
result ConvAE significantly outperformed baselines in clustering diverse patient cohorts, identifying clinically relevant subtypes.